Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IED4_LEIDO

TriTrypDb:

LdBPK_271690.1 , LdCL_270024000 , LDHU3_27.2610

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IED4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IED4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.568
CLV_C14_Caspase3-7	437	441	PF00656	0.617
CLV_NRD_NRD_1	300	302	PF00675	0.585
CLV_NRD_NRD_1	331	333	PF00675	0.622
CLV_NRD_NRD_1	363	365	PF00675	0.627
CLV_NRD_NRD_1	406	408	PF00675	0.642
CLV_NRD_NRD_1	416	418	PF00675	0.569
CLV_NRD_NRD_1	462	464	PF00675	0.700
CLV_NRD_NRD_1	478	480	PF00675	0.510
CLV_NRD_NRD_1	508	510	PF00675	0.697
CLV_NRD_NRD_1	614	616	PF00675	0.531
CLV_NRD_NRD_1	623	625	PF00675	0.412
CLV_NRD_NRD_1	724	726	PF00675	0.783
CLV_NRD_NRD_1	87	89	PF00675	0.457
CLV_PCSK_FUR_1	506	510	PF00082	0.707
CLV_PCSK_KEX2_1	300	302	PF00082	0.585
CLV_PCSK_KEX2_1	331	333	PF00082	0.622
CLV_PCSK_KEX2_1	406	408	PF00082	0.642
CLV_PCSK_KEX2_1	416	418	PF00082	0.569
CLV_PCSK_KEX2_1	462	464	PF00082	0.700
CLV_PCSK_KEX2_1	478	480	PF00082	0.510
CLV_PCSK_KEX2_1	508	510	PF00082	0.697
CLV_PCSK_KEX2_1	614	616	PF00082	0.510
CLV_PCSK_KEX2_1	623	625	PF00082	0.423
CLV_PCSK_KEX2_1	724	726	PF00082	0.725
CLV_PCSK_SKI1_1	195	199	PF00082	0.450
CLV_PCSK_SKI1_1	614	618	PF00082	0.532
CLV_PCSK_SKI1_1	624	628	PF00082	0.418
CLV_PCSK_SKI1_1	685	689	PF00082	0.459
CLV_PCSK_SKI1_1	698	702	PF00082	0.460
CLV_PCSK_SKI1_1	80	84	PF00082	0.436
DEG_APCC_DBOX_1	134	142	PF00400	0.529
DEG_APCC_DBOX_1	660	668	PF00400	0.462
DEG_Nend_UBRbox_4	1	3	PF02207	0.544
DEG_SCF_FBW7_1	387	393	PF00400	0.573
DEG_SPOP_SBC_1	241	245	PF00917	0.616
DEG_SPOP_SBC_1	408	412	PF00917	0.670
DEG_SPOP_SBC_1	555	559	PF00917	0.632
DOC_CKS1_1	387	392	PF01111	0.572
DOC_CYCLIN_RxL_1	682	692	PF00134	0.451
DOC_MAPK_FxFP_2	826	829	PF00069	0.684
DOC_MAPK_gen_1	77	85	PF00069	0.382
DOC_MAPK_JIP1_4	835	841	PF00069	0.578
DOC_MAPK_MEF2A_6	77	85	PF00069	0.382
DOC_PP1_RVXF_1	683	690	PF00149	0.450
DOC_PP1_RVXF_1	700	706	PF00149	0.471
DOC_PP4_FxxP_1	826	829	PF00568	0.684
DOC_SPAK_OSR1_1	704	708	PF12202	0.513
DOC_USP7_MATH_1	137	141	PF00917	0.421
DOC_USP7_MATH_1	173	177	PF00917	0.501
DOC_USP7_MATH_1	212	216	PF00917	0.457
DOC_USP7_MATH_1	275	279	PF00917	0.688
DOC_USP7_MATH_1	311	315	PF00917	0.661
DOC_USP7_MATH_1	330	334	PF00917	0.847
DOC_USP7_MATH_1	346	350	PF00917	0.585
DOC_USP7_MATH_1	781	785	PF00917	0.640
DOC_USP7_MATH_1	822	826	PF00917	0.788
DOC_USP7_MATH_2	482	488	PF00917	0.665
DOC_WW_Pin1_4	179	184	PF00397	0.603
DOC_WW_Pin1_4	226	231	PF00397	0.607
DOC_WW_Pin1_4	242	247	PF00397	0.474
DOC_WW_Pin1_4	260	265	PF00397	0.621
DOC_WW_Pin1_4	270	275	PF00397	0.676
DOC_WW_Pin1_4	277	282	PF00397	0.679
DOC_WW_Pin1_4	336	341	PF00397	0.640
DOC_WW_Pin1_4	342	347	PF00397	0.639
DOC_WW_Pin1_4	386	391	PF00397	0.602
DOC_WW_Pin1_4	399	404	PF00397	0.635
DOC_WW_Pin1_4	536	541	PF00397	0.591
DOC_WW_Pin1_4	551	556	PF00397	0.732
DOC_WW_Pin1_4	558	563	PF00397	0.778
DOC_WW_Pin1_4	573	578	PF00397	0.575
DOC_WW_Pin1_4	59	64	PF00397	0.477
DOC_WW_Pin1_4	709	714	PF00397	0.741
DOC_WW_Pin1_4	725	730	PF00397	0.533
DOC_WW_Pin1_4	803	808	PF00397	0.727
DOC_WW_Pin1_4	812	817	PF00397	0.622
DOC_WW_Pin1_4	820	825	PF00397	0.530
LIG_14-3-3_CanoR_1	135	145	PF00244	0.493
LIG_14-3-3_CanoR_1	213	223	PF00244	0.599
LIG_14-3-3_CanoR_1	276	280	PF00244	0.788
LIG_14-3-3_CanoR_1	462	466	PF00244	0.591
LIG_14-3-3_CanoR_1	655	661	PF00244	0.474
LIG_14-3-3_CanoR_1	66	73	PF00244	0.430
LIG_14-3-3_CanoR_1	724	729	PF00244	0.638
LIG_14-3-3_CanoR_1	835	840	PF00244	0.617
LIG_APCC_ABBAyCdc20_2	685	691	PF00400	0.453
LIG_BRCT_BRCA1_1	685	689	PF00533	0.459
LIG_BRCT_BRCA1_1	822	826	PF00533	0.685
LIG_CSL_BTD_1	710	713	PF09270	0.625
LIG_CtBP_PxDLS_1	340	344	PF00389	0.702
LIG_CtBP_PxDLS_1	836	840	PF00389	0.631
LIG_FHA_1	37	43	PF00498	0.415
LIG_FHA_1	392	398	PF00498	0.673
LIG_FHA_1	537	543	PF00498	0.625
LIG_FHA_1	60	66	PF00498	0.488
LIG_FHA_1	607	613	PF00498	0.512
LIG_FHA_1	651	657	PF00498	0.481
LIG_FHA_2	11	17	PF00498	0.618
LIG_FHA_2	117	123	PF00498	0.503
LIG_FHA_2	585	591	PF00498	0.695
LIG_FHA_2	641	647	PF00498	0.520
LIG_FHA_2	733	739	PF00498	0.624
LIG_FHA_2	754	760	PF00498	0.634
LIG_FHA_2	783	789	PF00498	0.692
LIG_Integrin_isoDGR_2	504	506	PF01839	0.630
LIG_LIR_Apic_2	475	480	PF02991	0.634
LIG_LIR_Apic_2	823	829	PF02991	0.682
LIG_LIR_Gen_1	464	473	PF02991	0.495
LIG_LIR_Gen_1	759	768	PF02991	0.569
LIG_LIR_Nem_3	280	285	PF02991	0.585
LIG_LIR_Nem_3	464	469	PF02991	0.525
LIG_LIR_Nem_3	471	477	PF02991	0.509
LIG_LIR_Nem_3	78	82	PF02991	0.390
LIG_NRBOX	149	155	PF00104	0.406
LIG_NRBOX	156	162	PF00104	0.416
LIG_PDZ_Class_2	836	841	PF00595	0.599
LIG_Pex14_1	758	762	PF04695	0.575
LIG_Pex14_2	701	705	PF04695	0.433
LIG_REV1ctd_RIR_1	19	28	PF16727	0.492
LIG_RPA_C_Fungi	208	220	PF08784	0.490
LIG_RPA_C_Fungi	650	662	PF08784	0.535
LIG_SH2_CRK	477	481	PF00017	0.653
LIG_SH2_CRK	79	83	PF00017	0.376
LIG_SH2_GRB2like	126	129	PF00017	0.546
LIG_SH2_GRB2like	72	75	PF00017	0.392
LIG_SH2_SRC	126	129	PF00017	0.546
LIG_SH2_SRC	240	243	PF00017	0.560
LIG_SH2_SRC	72	75	PF00017	0.392
LIG_SH2_SRC	730	733	PF00017	0.643
LIG_SH2_STAT5	126	129	PF00017	0.546
LIG_SH2_STAT5	240	243	PF00017	0.560
LIG_SH2_STAT5	531	534	PF00017	0.525
LIG_SH2_STAT5	72	75	PF00017	0.403
LIG_SH2_STAT5	730	733	PF00017	0.643
LIG_SH3_2	267	272	PF14604	0.624
LIG_SH3_3	12	18	PF00018	0.563
LIG_SH3_3	186	192	PF00018	0.473
LIG_SH3_3	220	226	PF00018	0.661
LIG_SH3_3	258	264	PF00018	0.656
LIG_SH3_3	293	299	PF00018	0.619
LIG_SH3_3	394	400	PF00018	0.633
LIG_SH3_3	571	577	PF00018	0.648
LIG_SH3_3	818	824	PF00018	0.636
LIG_SUMO_SIM_par_1	32	39	PF11976	0.422
LIG_TRAF2_1	119	122	PF00917	0.632
LIG_TRAF2_1	144	147	PF00917	0.504
LIG_TRAF2_1	736	739	PF00917	0.579
LIG_TRAF2_2	577	582	PF00917	0.624
LIG_UBA3_1	81	89	PF00899	0.404
LIG_WW_3	273	277	PF00397	0.730
MOD_CDC14_SPxK_1	273	276	PF00782	0.653
MOD_CDC14_SPxK_1	345	348	PF00782	0.638
MOD_CDC14_SPxK_1	806	809	PF00782	0.663
MOD_CDK_SPK_2	226	231	PF00069	0.630
MOD_CDK_SPK_2	260	265	PF00069	0.621
MOD_CDK_SPK_2	573	578	PF00069	0.607
MOD_CDK_SPK_2	709	714	PF00069	0.629
MOD_CDK_SPxK_1	270	276	PF00069	0.656
MOD_CDK_SPxK_1	342	348	PF00069	0.640
MOD_CDK_SPxK_1	803	809	PF00069	0.669
MOD_CDK_SPxxK_3	277	284	PF00069	0.773
MOD_CDK_SPxxK_3	399	406	PF00069	0.692
MOD_CDK_SPxxK_3	573	580	PF00069	0.608
MOD_CDK_SPxxK_3	59	66	PF00069	0.479
MOD_CK1_1	211	217	PF00069	0.549
MOD_CK1_1	218	224	PF00069	0.654
MOD_CK1_1	229	235	PF00069	0.525
MOD_CK1_1	263	269	PF00069	0.683
MOD_CK1_1	277	283	PF00069	0.584
MOD_CK1_1	32	38	PF00069	0.453
MOD_CK1_1	367	373	PF00069	0.594
MOD_CK1_1	431	437	PF00069	0.650
MOD_CK1_1	487	493	PF00069	0.607
MOD_CK1_1	561	567	PF00069	0.768
MOD_CK1_1	606	612	PF00069	0.622
MOD_CK1_1	712	718	PF00069	0.649
MOD_CK1_1	763	769	PF00069	0.606
MOD_CK1_1	802	808	PF00069	0.840
MOD_CK1_1	815	821	PF00069	0.563
MOD_CK1_1	827	833	PF00069	0.780
MOD_CK1_1	99	105	PF00069	0.491
MOD_CK2_1	10	16	PF00069	0.620
MOD_CK2_1	116	122	PF00069	0.532
MOD_CK2_1	141	147	PF00069	0.492
MOD_CK2_1	229	235	PF00069	0.608
MOD_CK2_1	336	342	PF00069	0.802
MOD_CK2_1	491	497	PF00069	0.682
MOD_CK2_1	584	590	PF00069	0.632
MOD_CK2_1	732	738	PF00069	0.707
MOD_CK2_1	744	750	PF00069	0.667
MOD_CK2_1	782	788	PF00069	0.691
MOD_CK2_1	802	808	PF00069	0.708
MOD_Cter_Amidation	362	365	PF01082	0.651
MOD_Cter_Amidation	460	463	PF01082	0.552
MOD_Cter_Amidation	722	725	PF01082	0.614
MOD_GlcNHglycan	210	213	PF01048	0.479
MOD_GlcNHglycan	214	217	PF01048	0.507
MOD_GlcNHglycan	371	374	PF01048	0.784
MOD_GlcNHglycan	378	381	PF01048	0.655
MOD_GlcNHglycan	411	414	PF01048	0.775
MOD_GlcNHglycan	420	423	PF01048	0.750
MOD_GlcNHglycan	426	431	PF01048	0.587
MOD_GlcNHglycan	494	497	PF01048	0.668
MOD_GlcNHglycan	691	696	PF01048	0.569
MOD_GlcNHglycan	721	724	PF01048	0.654
MOD_GlcNHglycan	750	756	PF01048	0.557
MOD_GSK3_1	137	144	PF00069	0.487
MOD_GSK3_1	175	182	PF00069	0.709
MOD_GSK3_1	208	215	PF00069	0.492
MOD_GSK3_1	242	249	PF00069	0.688
MOD_GSK3_1	270	277	PF00069	0.691
MOD_GSK3_1	311	318	PF00069	0.650
MOD_GSK3_1	32	39	PF00069	0.414
MOD_GSK3_1	332	339	PF00069	0.709
MOD_GSK3_1	342	349	PF00069	0.612
MOD_GSK3_1	367	374	PF00069	0.649
MOD_GSK3_1	386	393	PF00069	0.536
MOD_GSK3_1	45	52	PF00069	0.564
MOD_GSK3_1	484	491	PF00069	0.653
MOD_GSK3_1	551	558	PF00069	0.686
MOD_GSK3_1	578	585	PF00069	0.703
MOD_GSK3_1	602	609	PF00069	0.654
MOD_GSK3_1	795	802	PF00069	0.636
MOD_GSK3_1	811	818	PF00069	0.609
MOD_GSK3_1	820	827	PF00069	0.606
MOD_GSK3_1	96	103	PF00069	0.528
MOD_N-GLC_2	680	682	PF02516	0.440
MOD_NEK2_1	36	41	PF00069	0.387
MOD_NEK2_1	640	645	PF00069	0.539
MOD_NEK2_1	647	652	PF00069	0.453
MOD_NEK2_1	656	661	PF00069	0.384
MOD_NEK2_1	683	688	PF00069	0.450
MOD_NEK2_1	744	749	PF00069	0.556
MOD_NEK2_1	782	787	PF00069	0.623
MOD_PIKK_1	148	154	PF00454	0.469
MOD_PIKK_1	175	181	PF00454	0.604
MOD_PIKK_1	324	330	PF00454	0.624
MOD_PIKK_1	484	490	PF00454	0.628
MOD_PIKK_1	49	55	PF00454	0.520
MOD_PIKK_1	582	588	PF00454	0.683
MOD_PIKK_1	632	638	PF00454	0.368
MOD_PIKK_1	712	718	PF00454	0.613
MOD_PK_1	96	102	PF00069	0.484
MOD_PKA_1	364	370	PF00069	0.588
MOD_PKA_1	724	730	PF00069	0.612
MOD_PKA_2	212	218	PF00069	0.563
MOD_PKA_2	275	281	PF00069	0.682
MOD_PKA_2	322	328	PF00069	0.782
MOD_PKA_2	330	336	PF00069	0.688
MOD_PKA_2	347	353	PF00069	0.619
MOD_PKA_2	356	362	PF00069	0.613
MOD_PKA_2	376	382	PF00069	0.541
MOD_PKA_2	408	414	PF00069	0.770
MOD_PKA_2	431	437	PF00069	0.648
MOD_PKA_2	461	467	PF00069	0.532
MOD_PKA_2	521	527	PF00069	0.620
MOD_PKA_2	672	678	PF00069	0.615
MOD_PKA_2	724	730	PF00069	0.708
MOD_PKA_2	782	788	PF00069	0.628
MOD_PKA_2	795	801	PF00069	0.642
MOD_PKB_1	407	415	PF00069	0.637
MOD_Plk_1	173	179	PF00069	0.538
MOD_Plk_1	367	373	PF00069	0.650
MOD_Plk_1	691	697	PF00069	0.505
MOD_Plk_1	758	764	PF00069	0.783
MOD_Plk_2-3	603	609	PF00069	0.551
MOD_Plk_4	29	35	PF00069	0.495
MOD_Plk_4	647	653	PF00069	0.464
MOD_Plk_4	683	689	PF00069	0.453
MOD_ProDKin_1	179	185	PF00069	0.602
MOD_ProDKin_1	226	232	PF00069	0.604
MOD_ProDKin_1	242	248	PF00069	0.475
MOD_ProDKin_1	260	266	PF00069	0.621
MOD_ProDKin_1	270	276	PF00069	0.677
MOD_ProDKin_1	277	283	PF00069	0.670
MOD_ProDKin_1	336	342	PF00069	0.641
MOD_ProDKin_1	386	392	PF00069	0.602
MOD_ProDKin_1	399	405	PF00069	0.634
MOD_ProDKin_1	536	542	PF00069	0.592
MOD_ProDKin_1	551	557	PF00069	0.700
MOD_ProDKin_1	558	564	PF00069	0.717
MOD_ProDKin_1	573	579	PF00069	0.576
MOD_ProDKin_1	59	65	PF00069	0.472
MOD_ProDKin_1	709	715	PF00069	0.743
MOD_ProDKin_1	725	731	PF00069	0.533
MOD_ProDKin_1	803	809	PF00069	0.728
MOD_ProDKin_1	812	818	PF00069	0.621
MOD_ProDKin_1	820	826	PF00069	0.531
MOD_SUMO_rev_2	619	629	PF00179	0.508
TRG_DiLeu_BaEn_1	194	199	PF01217	0.520
TRG_DiLeu_BaEn_1	78	83	PF01217	0.396
TRG_ENDOCYTIC_2	79	82	PF00928	0.381
TRG_ER_diArg_1	299	301	PF00400	0.573
TRG_ER_diArg_1	330	332	PF00400	0.608
TRG_ER_diArg_1	405	407	PF00400	0.634
TRG_ER_diArg_1	477	479	PF00400	0.643
TRG_ER_diArg_1	506	509	PF00400	0.685
TRG_ER_diArg_1	577	580	PF00400	0.637
TRG_ER_diArg_1	614	616	PF00400	0.510
TRG_ER_diArg_1	622	624	PF00400	0.426
TRG_ER_diArg_1	701	704	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	615	619	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P552	Leptomonas seymouri	37%	87%
A4HFV2	Leishmania braziliensis	69%	99%
A4I2Y5	Leishmania infantum	100%	100%
E9ADF6	Leishmania major	88%	100%
E9AZ79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%