Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IED0_LEIDO

TriTrypDb:

LdBPK_341850.1 , LdCL_340026200 , LDHU3_34.3170

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IED0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IED0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.447
CLV_C14_Caspase3-7	349	353	PF00656	0.781
CLV_C14_Caspase3-7	406	410	PF00656	0.716
CLV_NRD_NRD_1	183	185	PF00675	0.712
CLV_NRD_NRD_1	190	192	PF00675	0.638
CLV_NRD_NRD_1	2	4	PF00675	0.659
CLV_NRD_NRD_1	221	223	PF00675	0.566
CLV_NRD_NRD_1	36	38	PF00675	0.550
CLV_NRD_NRD_1	401	403	PF00675	0.573
CLV_NRD_NRD_1	496	498	PF00675	0.479
CLV_NRD_NRD_1	544	546	PF00675	0.632
CLV_NRD_NRD_1	547	549	PF00675	0.566
CLV_NRD_NRD_1	654	656	PF00675	0.587
CLV_NRD_NRD_1	671	673	PF00675	0.376
CLV_NRD_NRD_1	742	744	PF00675	0.569
CLV_NRD_NRD_1	8	10	PF00675	0.683
CLV_NRD_NRD_1	825	827	PF00675	0.646
CLV_PCSK_FUR_1	545	549	PF00082	0.563
CLV_PCSK_KEX2_1	182	184	PF00082	0.714
CLV_PCSK_KEX2_1	261	263	PF00082	0.627
CLV_PCSK_KEX2_1	401	403	PF00082	0.573
CLV_PCSK_KEX2_1	496	498	PF00082	0.479
CLV_PCSK_KEX2_1	544	546	PF00082	0.568
CLV_PCSK_KEX2_1	547	549	PF00082	0.601
CLV_PCSK_KEX2_1	671	673	PF00082	0.489
CLV_PCSK_KEX2_1	729	731	PF00082	0.517
CLV_PCSK_KEX2_1	827	829	PF00082	0.649
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.445
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.636
CLV_PCSK_PC1ET2_1	729	731	PF00082	0.517
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.649
CLV_PCSK_PC7_1	545	551	PF00082	0.552
CLV_PCSK_SKI1_1	222	226	PF00082	0.763
CLV_PCSK_SKI1_1	381	385	PF00082	0.688
CLV_PCSK_SKI1_1	632	636	PF00082	0.474
CLV_PCSK_SKI1_1	672	676	PF00082	0.497
CLV_PCSK_SKI1_1	716	720	PF00082	0.451
CLV_Separin_Metazoa	79	83	PF03568	0.394
DEG_APCC_DBOX_1	670	678	PF00400	0.461
DEG_APCC_DBOX_1	715	723	PF00400	0.390
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DEG_SCF_FBW7_1	209	215	PF00400	0.679
DEG_SPOP_SBC_1	185	189	PF00917	0.768
DEG_SPOP_SBC_1	224	228	PF00917	0.464
DEG_SPOP_SBC_1	88	92	PF00917	0.643
DOC_ANK_TNKS_1	659	666	PF00023	0.627
DOC_CDC14_PxL_1	99	107	PF14671	0.483
DOC_CKS1_1	209	214	PF01111	0.721
DOC_CKS1_1	48	53	PF01111	0.514
DOC_CYCLIN_RxL_1	669	680	PF00134	0.584
DOC_MAPK_gen_1	112	120	PF00069	0.505
DOC_MAPK_gen_1	235	243	PF00069	0.605
DOC_MAPK_gen_1	259	269	PF00069	0.629
DOC_MAPK_gen_1	283	291	PF00069	0.673
DOC_MAPK_gen_1	582	591	PF00069	0.486
DOC_MAPK_gen_1	625	635	PF00069	0.634
DOC_MAPK_gen_1	655	661	PF00069	0.622
DOC_MAPK_gen_1	671	677	PF00069	0.370
DOC_MAPK_gen_1	729	735	PF00069	0.512
DOC_MAPK_gen_1	826	834	PF00069	0.608
DOC_MAPK_HePTP_8	780	792	PF00069	0.600
DOC_MAPK_MEF2A_6	783	792	PF00069	0.612
DOC_MAPK_MEF2A_6	826	834	PF00069	0.607
DOC_PP2B_LxvP_1	771	774	PF13499	0.582
DOC_PP2B_LxvP_1	790	793	PF13499	0.558
DOC_PP4_FxxP_1	151	154	PF00568	0.687
DOC_PP4_FxxP_1	486	489	PF00568	0.564
DOC_USP7_MATH_1	13	17	PF00917	0.614
DOC_USP7_MATH_1	212	216	PF00917	0.691
DOC_USP7_MATH_1	341	345	PF00917	0.690
DOC_USP7_MATH_1	354	358	PF00917	0.630
DOC_USP7_MATH_1	643	647	PF00917	0.672
DOC_USP7_MATH_1	66	70	PF00917	0.587
DOC_USP7_MATH_1	666	670	PF00917	0.629
DOC_USP7_MATH_1	754	758	PF00917	0.754
DOC_USP7_MATH_1	759	763	PF00917	0.588
DOC_USP7_MATH_2	463	469	PF00917	0.724
DOC_WW_Pin1_4	106	111	PF00397	0.571
DOC_WW_Pin1_4	208	213	PF00397	0.708
DOC_WW_Pin1_4	456	461	PF00397	0.725
DOC_WW_Pin1_4	47	52	PF00397	0.468
DOC_WW_Pin1_4	512	517	PF00397	0.553
DOC_WW_Pin1_4	527	532	PF00397	0.474
DOC_WW_Pin1_4	533	538	PF00397	0.586
LIG_14-3-3_CanoR_1	183	193	PF00244	0.731
LIG_14-3-3_CanoR_1	222	232	PF00244	0.705
LIG_14-3-3_CanoR_1	441	448	PF00244	0.596
LIG_14-3-3_CanoR_1	466	474	PF00244	0.725
LIG_14-3-3_CanoR_1	476	481	PF00244	0.784
LIG_14-3-3_CanoR_1	645	650	PF00244	0.728
LIG_14-3-3_CanoR_1	743	750	PF00244	0.682
LIG_14-3-3_CanoR_1	758	764	PF00244	0.457
LIG_Actin_WH2_2	267	285	PF00022	0.626
LIG_Actin_WH2_2	69	84	PF00022	0.520
LIG_APCC_ABBA_1	731	736	PF00400	0.579
LIG_APCC_ABBAyCdc20_2	730	736	PF00400	0.503
LIG_BIR_III_4	159	163	PF00653	0.591
LIG_BRCT_BRCA1_1	798	802	PF00533	0.526
LIG_Clathr_ClatBox_1	148	152	PF01394	0.670
LIG_Clathr_ClatBox_1	391	395	PF01394	0.589
LIG_Clathr_ClatBox_1	674	678	PF01394	0.463
LIG_CSK_EPIYA_1	164	168	PF00017	0.745
LIG_CtBP_PxDLS_1	240	244	PF00389	0.562
LIG_CtBP_PxDLS_1	33	38	PF00389	0.574
LIG_deltaCOP1_diTrp_1	558	563	PF00928	0.573
LIG_eIF4E_1	238	244	PF01652	0.538
LIG_FHA_1	24	30	PF00498	0.560
LIG_FHA_1	269	275	PF00498	0.560
LIG_FHA_1	386	392	PF00498	0.720
LIG_FHA_1	62	68	PF00498	0.435
LIG_FHA_1	89	95	PF00498	0.589
LIG_FHA_2	154	160	PF00498	0.705
LIG_FHA_2	373	379	PF00498	0.667
LIG_FHA_2	404	410	PF00498	0.793
LIG_FHA_2	48	54	PF00498	0.510
LIG_FHA_2	512	518	PF00498	0.603
LIG_FHA_2	759	765	PF00498	0.577
LIG_FHA_2	795	801	PF00498	0.501
LIG_FXI_DFP_1	148	152	PF00024	0.670
LIG_KLC1_Yacidic_2	732	736	PF13176	0.587
LIG_LIR_Apic_2	150	154	PF02991	0.683
LIG_LIR_Apic_2	30	34	PF02991	0.608
LIG_LIR_Apic_2	484	489	PF02991	0.578
LIG_LIR_Gen_1	271	280	PF02991	0.495
LIG_LIR_Gen_1	687	698	PF02991	0.573
LIG_LIR_Nem_3	100	105	PF02991	0.442
LIG_LIR_Nem_3	122	127	PF02991	0.462
LIG_LIR_Nem_3	236	241	PF02991	0.585
LIG_LIR_Nem_3	271	276	PF02991	0.501
LIG_LIR_Nem_3	344	348	PF02991	0.651
LIG_LIR_Nem_3	558	564	PF02991	0.470
LIG_LIR_Nem_3	56	61	PF02991	0.521
LIG_LIR_Nem_3	567	573	PF02991	0.470
LIG_LIR_Nem_3	583	588	PF02991	0.526
LIG_LIR_Nem_3	687	693	PF02991	0.577
LIG_LIR_Nem_3	799	805	PF02991	0.508
LIG_LYPXL_yS_3	102	105	PF13949	0.407
LIG_MAD2	660	668	PF02301	0.554
LIG_Pex14_1	246	250	PF04695	0.450
LIG_REV1ctd_RIR_1	540	549	PF16727	0.608
LIG_SH2_CRK	238	242	PF00017	0.570
LIG_SH2_CRK	585	589	PF00017	0.531
LIG_SH2_NCK_1	690	694	PF00017	0.560
LIG_SH2_PTP2	273	276	PF00017	0.576
LIG_SH2_SRC	273	276	PF00017	0.592
LIG_SH2_SRC	607	610	PF00017	0.538
LIG_SH2_SRC	690	693	PF00017	0.562
LIG_SH2_STAP1	629	633	PF00017	0.625
LIG_SH2_STAP1	690	694	PF00017	0.560
LIG_SH2_STAT5	108	111	PF00017	0.596
LIG_SH2_STAT5	273	276	PF00017	0.532
LIG_SH2_STAT5	31	34	PF00017	0.536
LIG_SH2_STAT5	48	51	PF00017	0.298
LIG_SH2_STAT5	494	497	PF00017	0.542
LIG_SH2_STAT5	607	610	PF00017	0.499
LIG_SH2_STAT5	704	707	PF00017	0.517
LIG_SH2_STAT5	734	737	PF00017	0.609
LIG_SH2_STAT5	815	818	PF00017	0.449
LIG_SH3_1	204	210	PF00018	0.567
LIG_SH3_3	204	210	PF00018	0.544
LIG_SH3_3	306	312	PF00018	0.764
LIG_SH3_3	454	460	PF00018	0.717
LIG_SH3_3	54	60	PF00018	0.510
LIG_SH3_3	616	622	PF00018	0.525
LIG_SH3_3	630	636	PF00018	0.441
LIG_SH3_3	676	682	PF00018	0.445
LIG_SH3_3	695	701	PF00018	0.326
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.605
LIG_SUMO_SIM_par_1	673	678	PF11976	0.472
LIG_TRAF2_1	335	338	PF00917	0.768
LIG_TRAF2_1	489	492	PF00917	0.581
LIG_TRAF2_1	762	765	PF00917	0.627
LIG_TYR_ITIM	688	693	PF00017	0.563
LIG_TYR_ITSM	269	276	PF00017	0.505
LIG_UBA3_1	279	284	PF00899	0.593
LIG_UBA3_1	80	86	PF00899	0.606
LIG_ULM_U2AF65_1	547	552	PF00076	0.556
LIG_WRC_WIRS_1	667	672	PF05994	0.545
MOD_CDK_SPxK_1	106	112	PF00069	0.605
MOD_CK1_1	315	321	PF00069	0.696
MOD_CK1_1	344	350	PF00069	0.713
MOD_CK1_1	530	536	PF00069	0.606
MOD_CK1_1	90	96	PF00069	0.613
MOD_CK2_1	158	164	PF00069	0.705
MOD_CK2_1	393	399	PF00069	0.530
MOD_CK2_1	47	53	PF00069	0.483
MOD_CK2_1	758	764	PF00069	0.663
MOD_DYRK1A_RPxSP_1	208	212	PF00069	0.733
MOD_GlcNHglycan	158	163	PF01048	0.614
MOD_GlcNHglycan	297	300	PF01048	0.735
MOD_GlcNHglycan	314	317	PF01048	0.578
MOD_GlcNHglycan	349	352	PF01048	0.707
MOD_GlcNHglycan	356	359	PF01048	0.761
MOD_GlcNHglycan	600	604	PF01048	0.544
MOD_GlcNHglycan	644	648	PF01048	0.666
MOD_GSK3_1	138	145	PF00069	0.659
MOD_GSK3_1	208	215	PF00069	0.751
MOD_GSK3_1	23	30	PF00069	0.556
MOD_GSK3_1	403	410	PF00069	0.706
MOD_GSK3_1	519	526	PF00069	0.608
MOD_GSK3_1	754	761	PF00069	0.714
MOD_N-GLC_1	185	190	PF02516	0.674
MOD_NEK2_1	510	515	PF00069	0.706
MOD_NEK2_1	725	730	PF00069	0.464
MOD_NEK2_1	788	793	PF00069	0.576
MOD_PIKK_1	13	19	PF00454	0.633
MOD_PIKK_1	138	144	PF00454	0.633
MOD_PIKK_1	186	192	PF00454	0.671
MOD_PIKK_1	213	219	PF00454	0.728
MOD_PIKK_1	268	274	PF00454	0.596
MOD_PIKK_1	465	471	PF00454	0.685
MOD_PK_1	192	198	PF00069	0.656
MOD_PK_1	262	268	PF00069	0.522
MOD_PKA_1	743	749	PF00069	0.619
MOD_PKA_2	465	471	PF00069	0.690
MOD_PKA_2	613	619	PF00069	0.682
MOD_PKB_1	182	190	PF00069	0.630
MOD_Plk_1	262	268	PF00069	0.425
MOD_Plk_1	327	333	PF00069	0.656
MOD_Plk_1	820	826	PF00069	0.591
MOD_Plk_2-3	407	413	PF00069	0.769
MOD_Plk_4	262	268	PF00069	0.489
MOD_Plk_4	27	33	PF00069	0.536
MOD_Plk_4	341	347	PF00069	0.662
MOD_Plk_4	393	399	PF00069	0.530
MOD_Plk_4	523	529	PF00069	0.539
MOD_Plk_4	645	651	PF00069	0.602
MOD_ProDKin_1	106	112	PF00069	0.588
MOD_ProDKin_1	208	214	PF00069	0.713
MOD_ProDKin_1	456	462	PF00069	0.727
MOD_ProDKin_1	47	53	PF00069	0.465
MOD_ProDKin_1	512	518	PF00069	0.550
MOD_ProDKin_1	527	533	PF00069	0.474
MOD_SUMO_rev_2	226	233	PF00179	0.728
MOD_SUMO_rev_2	648	658	PF00179	0.586
TRG_DiLeu_BaEn_1	292	297	PF01217	0.674
TRG_DiLeu_BaEn_1	692	697	PF01217	0.524
TRG_DiLeu_BaEn_2	653	659	PF01217	0.634
TRG_DiLeu_BaEn_4	389	395	PF01217	0.731
TRG_ENDOCYTIC_2	102	105	PF00928	0.416
TRG_ENDOCYTIC_2	238	241	PF00928	0.580
TRG_ENDOCYTIC_2	273	276	PF00928	0.487
TRG_ENDOCYTIC_2	570	573	PF00928	0.463
TRG_ENDOCYTIC_2	585	588	PF00928	0.418
TRG_ENDOCYTIC_2	690	693	PF00928	0.562
TRG_ENDOCYTIC_2	704	707	PF00928	0.363
TRG_ENDOCYTIC_2	815	818	PF00928	0.499
TRG_ER_diArg_1	181	184	PF00400	0.771
TRG_ER_diArg_1	495	497	PF00400	0.466
TRG_ER_diArg_1	543	545	PF00400	0.589
TRG_ER_diArg_1	547	550	PF00400	0.611
TRG_ER_diArg_1	670	672	PF00400	0.545
TRG_ER_diArg_1	826	829	PF00400	0.662
TRG_ER_diArg_1	832	835	PF00400	0.344
TRG_NES_CRM1_1	765	778	PF08389	0.572
TRG_NLS_Bipartite_1	729	747	PF00514	0.540
TRG_NLS_MonoExtC_3	547	552	PF00514	0.556
TRG_NLS_MonoExtN_4	545	552	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	496	501	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	810	814	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P998	Leptomonas seymouri	44%	80%
A0A0S4JAQ4	Bodo saltans	28%	79%
A0A1X0PAE2	Trypanosomatidae	32%	76%
A0A3R7KV38	Trypanosoma rangeli	32%	82%
A4HAS2	Leishmania braziliensis	74%	100%
A4I9Y6	Leishmania infantum	100%	100%
C9ZMQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	82%
E9B4Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q2Z1	Leishmania major	92%	100%