EF-hand domain/EF-hand domain pair, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEC5_LEIDO

TriTrypDb:

LdBPK_181420.1 , LdCL_180019600 , LDHU3_18.1810

Length:

233

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEC5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.499
CLV_NRD_NRD_1	188	190	PF00675	0.534
CLV_NRD_NRD_1	196	198	PF00675	0.392
CLV_NRD_NRD_1	204	206	PF00675	0.402
CLV_NRD_NRD_1	60	62	PF00675	0.774
CLV_NRD_NRD_1	67	69	PF00675	0.771
CLV_PCSK_KEX2_1	188	190	PF00082	0.457
CLV_PCSK_KEX2_1	196	198	PF00082	0.480
CLV_PCSK_KEX2_1	60	62	PF00082	0.700
CLV_PCSK_KEX2_1	67	69	PF00082	0.721
CLV_PCSK_SKI1_1	129	133	PF00082	0.562
CLV_PCSK_SKI1_1	216	220	PF00082	0.477
CLV_PCSK_SKI1_1	32	36	PF00082	0.604
CLV_PCSK_SKI1_1	60	64	PF00082	0.802
DOC_CKS1_1	41	46	PF01111	0.574
DOC_MAPK_gen_1	196	204	PF00069	0.484
DOC_USP7_MATH_1	36	40	PF00917	0.646
DOC_WW_Pin1_4	40	45	PF00397	0.551
LIG_14-3-3_CanoR_1	20	28	PF00244	0.554
LIG_14-3-3_CanoR_1	216	225	PF00244	0.546
LIG_eIF4E_1	140	146	PF01652	0.530
LIG_FHA_1	140	146	PF00498	0.527
LIG_FHA_1	172	178	PF00498	0.450
LIG_FHA_1	41	47	PF00498	0.623
LIG_LIR_Gen_1	109	118	PF02991	0.518
LIG_LIR_Gen_1	144	153	PF02991	0.427
LIG_LIR_Gen_1	158	168	PF02991	0.410
LIG_LIR_Gen_1	73	83	PF02991	0.741
LIG_LIR_Nem_3	109	114	PF02991	0.545
LIG_LIR_Nem_3	12	16	PF02991	0.615
LIG_LIR_Nem_3	127	131	PF02991	0.513
LIG_LIR_Nem_3	143	149	PF02991	0.425
LIG_LIR_Nem_3	158	163	PF02991	0.399
LIG_LIR_Nem_3	219	225	PF02991	0.662
LIG_LIR_Nem_3	73	78	PF02991	0.734
LIG_LYPXL_yS_3	222	225	PF13949	0.660
LIG_Pex14_1	79	83	PF04695	0.583
LIG_Pex14_2	146	150	PF04695	0.422
LIG_Pex14_2	75	79	PF04695	0.562
LIG_SH2_SRC	50	53	PF00017	0.527
LIG_SH2_STAP1	111	115	PF00017	0.538
LIG_SH2_STAT5	147	150	PF00017	0.492
LIG_SH2_STAT5	176	179	PF00017	0.489
LIG_SH2_STAT5	209	212	PF00017	0.524
LIG_SH2_STAT5	50	53	PF00017	0.523
LIG_SH3_3	38	44	PF00018	0.650
LIG_TRAF2_1	102	105	PF00917	0.812
LIG_UBA3_1	198	206	PF00899	0.455
LIG_WRC_WIRS_1	125	130	PF05994	0.496
MOD_GlcNHglycan	38	41	PF01048	0.661
MOD_GSK3_1	36	43	PF00069	0.677
MOD_NEK2_1	28	33	PF00069	0.637
MOD_NEK2_1	78	83	PF00069	0.790
MOD_NEK2_2	124	129	PF00069	0.526
MOD_NMyristoyl	1	7	PF02799	0.766
MOD_PIKK_1	216	222	PF00454	0.538
MOD_PKA_2	19	25	PF00069	0.446
MOD_PKA_2	3	9	PF00069	0.712
MOD_Plk_2-3	19	25	PF00069	0.637
MOD_Plk_4	70	76	PF00069	0.747
MOD_ProDKin_1	40	46	PF00069	0.549
MOD_SUMO_rev_2	162	169	PF00179	0.549
TRG_DiLeu_BaEn_1	194	199	PF01217	0.455
TRG_DiLeu_BaEn_1	213	218	PF01217	0.455
TRG_DiLeu_BaEn_3	23	29	PF01217	0.586
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.643
TRG_DiLeu_LyEn_5	213	218	PF01217	0.508
TRG_ENDOCYTIC_2	111	114	PF00928	0.530
TRG_ENDOCYTIC_2	13	16	PF00928	0.614
TRG_ENDOCYTIC_2	147	150	PF00928	0.521
TRG_ENDOCYTIC_2	209	212	PF00928	0.547
TRG_ENDOCYTIC_2	222	225	PF00928	0.660
TRG_ER_diArg_1	187	189	PF00400	0.534
TRG_ER_diArg_1	196	198	PF00400	0.445
TRG_ER_diArg_1	60	62	PF00400	0.762
TRG_ER_diArg_1	67	69	PF00400	0.752
TRG_ER_diLys_1	228	233	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.769

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC76	Leptomonas seymouri	70%	100%
A0A0S4JR21	Bodo saltans	38%	91%
A0A1X0P714	Trypanosomatidae	54%	100%
A0A422NIP8	Trypanosoma rangeli	56%	100%
A4H9P7	Leishmania braziliensis	84%	100%
A4HY14	Leishmania infantum	100%	100%
D0A578	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ARS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	98%
Q4QDP5	Leishmania major	93%	100%