LeishMANIAdb
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High mobility group protein-like tdp-1, putative

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
High mobility group protein-like tdp-1, putative
Gene product:
High mobility group protein TDP1
Species:
Leishmania donovani
UniProt:
A0A3Q8IEB8_LEIDO
TriTrypDb:
LdBPK_290890.1 , LdCL_290013700 , LDHU3_29.1200
Length:
302

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, high mobility group homolog tdp-1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0005730 nucleolus 5 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IEB8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEB8

Function

Biological processes
Term Name Level Count
GO:0010468 regulation of gene expression 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0050789 regulation of biological process 2 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003677 DNA binding 4 12
GO:0005488 binding 1 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0000182 rDNA binding 7 1
GO:0000217 DNA secondary structure binding 5 1
GO:0000400 four-way junction DNA binding 6 1
GO:0000402 crossed form four-way junction DNA binding 7 1
GO:0003690 double-stranded DNA binding 5 1
GO:0008301 DNA binding, bending 5 1
GO:0043565 sequence-specific DNA binding 5 1
GO:1990837 sequence-specific double-stranded DNA binding 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 289 293 PF00656 0.613
CLV_C14_Caspase3-7 294 298 PF00656 0.614
CLV_NRD_NRD_1 36 38 PF00675 0.433
CLV_NRD_NRD_1 83 85 PF00675 0.489
CLV_PCSK_FUR_1 84 88 PF00082 0.610
CLV_PCSK_KEX2_1 192 194 PF00082 0.505
CLV_PCSK_KEX2_1 199 201 PF00082 0.483
CLV_PCSK_KEX2_1 211 213 PF00082 0.145
CLV_PCSK_KEX2_1 264 266 PF00082 0.223
CLV_PCSK_KEX2_1 35 37 PF00082 0.429
CLV_PCSK_KEX2_1 83 85 PF00082 0.433
CLV_PCSK_KEX2_1 86 88 PF00082 0.449
CLV_PCSK_PC1ET2_1 192 194 PF00082 0.476
CLV_PCSK_PC1ET2_1 199 201 PF00082 0.483
CLV_PCSK_PC1ET2_1 211 213 PF00082 0.145
CLV_PCSK_PC1ET2_1 264 266 PF00082 0.223
CLV_PCSK_PC1ET2_1 86 88 PF00082 0.463
CLV_PCSK_SKI1_1 117 121 PF00082 0.236
CLV_PCSK_SKI1_1 15 19 PF00082 0.494
CLV_PCSK_SKI1_1 196 200 PF00082 0.652
CLV_PCSK_SKI1_1 211 215 PF00082 0.134
CLV_PCSK_SKI1_1 59 63 PF00082 0.350
CLV_PCSK_SKI1_1 83 87 PF00082 0.653
DEG_SPOP_SBC_1 286 290 PF00917 0.657
DEG_SPOP_SBC_1 291 295 PF00917 0.662
DOC_CKS1_1 61 66 PF01111 0.468
DOC_MAPK_MEF2A_6 117 126 PF00069 0.419
DOC_USP7_MATH_1 268 272 PF00917 0.450
DOC_USP7_MATH_1 282 286 PF00917 0.524
DOC_USP7_MATH_1 291 295 PF00917 0.675
DOC_USP7_MATH_1 5 9 PF00917 0.647
DOC_USP7_UBL2_3 107 111 PF12436 0.446
DOC_USP7_UBL2_3 133 137 PF12436 0.499
DOC_USP7_UBL2_3 192 196 PF12436 0.455
DOC_USP7_UBL2_3 199 203 PF12436 0.473
DOC_USP7_UBL2_3 95 99 PF12436 0.566
DOC_WW_Pin1_4 118 123 PF00397 0.422
DOC_WW_Pin1_4 44 49 PF00397 0.355
DOC_WW_Pin1_4 60 65 PF00397 0.515
DOC_WW_Pin1_4 87 92 PF00397 0.459
LIG_14-3-3_CanoR_1 212 220 PF00244 0.400
LIG_BIR_II_1 1 5 PF00653 0.482
LIG_FHA_1 142 148 PF00498 0.374
LIG_FHA_1 48 54 PF00498 0.469
LIG_FHA_1 61 67 PF00498 0.472
LIG_FHA_2 60 66 PF00498 0.344
LIG_LIR_Gen_1 121 127 PF02991 0.366
LIG_LIR_Gen_1 163 169 PF02991 0.479
LIG_LIR_Nem_3 121 126 PF02991 0.357
LIG_LIR_Nem_3 163 168 PF02991 0.433
LIG_LIR_Nem_3 215 220 PF02991 0.379
LIG_LIR_Nem_3 45 49 PF02991 0.551
LIG_RPA_C_Fungi 181 193 PF08784 0.349
LIG_SH2_CRK 165 169 PF00017 0.243
LIG_SH2_STAP1 176 180 PF00017 0.207
LIG_SH2_STAP1 255 259 PF00017 0.181
LIG_SH2_STAT5 123 126 PF00017 0.193
LIG_SH2_STAT5 183 186 PF00017 0.449
LIG_SH2_STAT5 217 220 PF00017 0.237
LIG_SH3_2 207 212 PF14604 0.504
LIG_SH3_3 204 210 PF00018 0.497
LIG_SH3_3 274 280 PF00018 0.483
LIG_SUMO_SIM_anti_2 16 23 PF11976 0.458
LIG_TRAF2_1 157 160 PF00917 0.179
LIG_TRAF2_1 248 251 PF00917 0.320
LIG_TRAF2_1 254 257 PF00917 0.333
LIG_UBA3_1 146 155 PF00899 0.209
MOD_CK1_1 27 33 PF00069 0.391
MOD_CK1_1 275 281 PF00069 0.566
MOD_CK1_1 285 291 PF00069 0.654
MOD_CK1_1 293 299 PF00069 0.570
MOD_CK1_1 90 96 PF00069 0.545
MOD_CK2_1 13 19 PF00069 0.383
MOD_CK2_1 155 161 PF00069 0.326
MOD_CK2_1 245 251 PF00069 0.276
MOD_CK2_1 59 65 PF00069 0.461
MOD_Cter_Amidation 105 108 PF01082 0.440
MOD_Cter_Amidation 194 197 PF01082 0.469
MOD_GlcNHglycan 1 4 PF01048 0.545
MOD_GlcNHglycan 102 105 PF01048 0.710
MOD_GlcNHglycan 247 250 PF01048 0.439
MOD_GlcNHglycan 269 273 PF01048 0.546
MOD_GlcNHglycan 284 287 PF01048 0.768
MOD_GlcNHglycan 289 292 PF01048 0.642
MOD_GlcNHglycan 78 83 PF01048 0.477
MOD_GSK3_1 141 148 PF00069 0.308
MOD_GSK3_1 268 275 PF00069 0.601
MOD_GSK3_1 282 289 PF00069 0.550
MOD_GSK3_1 291 298 PF00069 0.601
MOD_GSK3_1 87 94 PF00069 0.605
MOD_N-GLC_1 5 10 PF02516 0.426
MOD_NEK2_1 13 18 PF00069 0.491
MOD_PIKK_1 275 281 PF00454 0.456
MOD_PKA_1 155 161 PF00069 0.207
MOD_PKA_2 272 278 PF00069 0.448
MOD_PKB_1 87 95 PF00069 0.613
MOD_Plk_1 13 19 PF00069 0.385
MOD_Plk_1 160 166 PF00069 0.207
MOD_Plk_4 13 19 PF00069 0.369
MOD_ProDKin_1 118 124 PF00069 0.272
MOD_ProDKin_1 44 50 PF00069 0.355
MOD_ProDKin_1 60 66 PF00069 0.508
MOD_ProDKin_1 87 93 PF00069 0.462
MOD_SUMO_for_1 198 201 PF00179 0.642
MOD_SUMO_for_1 85 88 PF00179 0.562
MOD_SUMO_rev_2 103 112 PF00179 0.439
MOD_SUMO_rev_2 158 163 PF00179 0.351
MOD_SUMO_rev_2 170 174 PF00179 0.253
MOD_SUMO_rev_2 248 254 PF00179 0.238
TRG_DiLeu_BaEn_1 52 57 PF01217 0.333
TRG_ENDOCYTIC_2 123 126 PF00928 0.193
TRG_ENDOCYTIC_2 165 168 PF00928 0.224
TRG_ENDOCYTIC_2 217 220 PF00928 0.193
TRG_ENDOCYTIC_2 255 258 PF00928 0.193
TRG_ER_diArg_1 34 37 PF00400 0.326
TRG_ER_diArg_1 83 85 PF00400 0.401
TRG_NLS_Bipartite_1 83 99 PF00514 0.529
TRG_NLS_MonoExtC_3 195 200 PF00514 0.599
TRG_NLS_MonoExtC_3 94 99 PF00514 0.638
TRG_NLS_MonoExtN_4 193 200 PF00514 0.604
TRG_Pf-PMV_PEXEL_1 83 88 PF00026 0.419

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8C9 Leptomonas seymouri 69% 100%
A0A0S4KNH5 Bodo saltans 37% 78%
A0A1X0NZM0 Trypanosomatidae 43% 100%
A0A3R7KR63 Trypanosoma rangeli 45% 100%
A4HH93 Leishmania braziliensis 86% 100%
A4I4D9 Leishmania infantum 100% 100%
C9ZL24 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9ADT8 Leishmania major 96% 100%
E9ALZ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
P26586 Trypanosoma brucei rhodesiense 42% 100%
V5B1M8 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS