Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEB2_LEIDO

TriTrypDb:

LdBPK_271390.1 , LdCL_270020700 , LDHU3_27.2130

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.577
CLV_C14_Caspase3-7	369	373	PF00656	0.563
CLV_C14_Caspase3-7	627	631	PF00656	0.561
CLV_NRD_NRD_1	208	210	PF00675	0.618
CLV_NRD_NRD_1	293	295	PF00675	0.581
CLV_NRD_NRD_1	348	350	PF00675	0.692
CLV_NRD_NRD_1	355	357	PF00675	0.642
CLV_NRD_NRD_1	361	363	PF00675	0.630
CLV_NRD_NRD_1	455	457	PF00675	0.495
CLV_NRD_NRD_1	535	537	PF00675	0.436
CLV_PCSK_KEX2_1	208	210	PF00082	0.618
CLV_PCSK_KEX2_1	348	350	PF00082	0.692
CLV_PCSK_KEX2_1	355	357	PF00082	0.642
CLV_PCSK_KEX2_1	360	362	PF00082	0.634
CLV_PCSK_KEX2_1	445	447	PF00082	0.473
CLV_PCSK_KEX2_1	455	457	PF00082	0.478
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.453
CLV_PCSK_PC7_1	356	362	PF00082	0.644
CLV_PCSK_SKI1_1	283	287	PF00082	0.516
CLV_PCSK_SKI1_1	295	299	PF00082	0.590
CLV_PCSK_SKI1_1	445	449	PF00082	0.516
CLV_PCSK_SKI1_1	512	516	PF00082	0.524
CLV_PCSK_SKI1_1	537	541	PF00082	0.528
DEG_APCC_DBOX_1	437	445	PF00400	0.459
DEG_SPOP_SBC_1	265	269	PF00917	0.610
DOC_CKS1_1	643	648	PF01111	0.663
DOC_CYCLIN_RxL_1	443	453	PF00134	0.480
DOC_MAPK_gen_1	228	237	PF00069	0.671
DOC_MAPK_gen_1	294	301	PF00069	0.615
DOC_MAPK_gen_1	34	42	PF00069	0.421
DOC_MAPK_gen_1	466	474	PF00069	0.504
DOC_MAPK_MEF2A_6	231	239	PF00069	0.675
DOC_MAPK_MEF2A_6	294	301	PF00069	0.561
DOC_MAPK_MEF2A_6	468	476	PF00069	0.519
DOC_MAPK_NFAT4_5	294	302	PF00069	0.562
DOC_PP2B_LxvP_1	192	195	PF13499	0.607
DOC_PP2B_LxvP_1	299	302	PF13499	0.667
DOC_PP2B_LxvP_1	480	483	PF13499	0.566
DOC_PP4_FxxP_1	238	241	PF00568	0.569
DOC_PP4_MxPP_1	185	188	PF00568	0.522
DOC_SPAK_OSR1_1	121	125	PF12202	0.361
DOC_USP7_MATH_1	16	20	PF00917	0.444
DOC_USP7_MATH_1	241	245	PF00917	0.677
DOC_USP7_MATH_1	265	269	PF00917	0.610
DOC_USP7_MATH_1	302	306	PF00917	0.656
DOC_USP7_MATH_1	336	340	PF00917	0.572
DOC_USP7_MATH_1	573	577	PF00917	0.720
DOC_USP7_MATH_1	583	587	PF00917	0.586
DOC_USP7_MATH_1	592	596	PF00917	0.523
DOC_USP7_MATH_1	604	608	PF00917	0.596
DOC_USP7_MATH_1	615	619	PF00917	0.683
DOC_USP7_MATH_1	635	639	PF00917	0.597
DOC_USP7_MATH_1	658	662	PF00917	0.574
DOC_USP7_UBL2_3	537	541	PF12436	0.451
DOC_WW_Pin1_4	179	184	PF00397	0.667
DOC_WW_Pin1_4	201	206	PF00397	0.608
DOC_WW_Pin1_4	217	222	PF00397	0.743
DOC_WW_Pin1_4	258	263	PF00397	0.702
DOC_WW_Pin1_4	289	294	PF00397	0.664
DOC_WW_Pin1_4	52	57	PF00397	0.399
DOC_WW_Pin1_4	593	598	PF00397	0.636
DOC_WW_Pin1_4	631	636	PF00397	0.642
DOC_WW_Pin1_4	642	647	PF00397	0.603
DOC_WW_Pin1_4	673	678	PF00397	0.595
DOC_WW_Pin1_4	83	88	PF00397	0.465
LIG_14-3-3_CanoR_1	123	129	PF00244	0.400
LIG_14-3-3_CanoR_1	266	274	PF00244	0.617
LIG_14-3-3_CanoR_1	355	364	PF00244	0.769
LIG_14-3-3_CanoR_1	419	427	PF00244	0.445
LIG_14-3-3_CanoR_1	508	516	PF00244	0.547
LIG_14-3-3_CanoR_1	616	620	PF00244	0.616
LIG_14-3-3_CanoR_1	649	657	PF00244	0.586
LIG_14-3-3_CanoR_1	681	689	PF00244	0.607
LIG_Actin_WH2_2	271	288	PF00022	0.497
LIG_CSL_BTD_1	399	402	PF09270	0.588
LIG_FHA_1	187	193	PF00498	0.666
LIG_FHA_1	211	217	PF00498	0.681
LIG_FHA_1	469	475	PF00498	0.542
LIG_FHA_1	49	55	PF00498	0.375
LIG_FHA_2	159	165	PF00498	0.590
LIG_FHA_2	523	529	PF00498	0.389
LIG_HCF-1_HBM_1	116	119	PF13415	0.447
LIG_LIR_Apic_2	104	110	PF02991	0.443
LIG_LIR_Apic_2	182	187	PF02991	0.533
LIG_LIR_Gen_1	116	125	PF02991	0.358
LIG_LIR_Gen_1	669	677	PF02991	0.769
LIG_LIR_Nem_3	116	122	PF02991	0.373
LIG_SH2_CRK	184	188	PF00017	0.584
LIG_SH2_CRK	643	647	PF00017	0.666
LIG_SH2_GRB2like	134	137	PF00017	0.378
LIG_SH2_PTP2	49	52	PF00017	0.306
LIG_SH2_SRC	526	529	PF00017	0.509
LIG_SH2_STAT5	119	122	PF00017	0.484
LIG_SH2_STAT5	318	321	PF00017	0.555
LIG_SH2_STAT5	49	52	PF00017	0.334
LIG_SH2_STAT5	526	529	PF00017	0.523
LIG_SH2_STAT5	670	673	PF00017	0.648
LIG_SH2_STAT5	72	75	PF00017	0.436
LIG_SH3_3	188	194	PF00018	0.776
LIG_SH3_3	396	402	PF00018	0.640
LIG_SH3_3	471	477	PF00018	0.576
LIG_SH3_3	481	487	PF00018	0.496
LIG_SH3_3	513	519	PF00018	0.502
LIG_SH3_3	53	59	PF00018	0.394
LIG_SUMO_SIM_par_1	137	142	PF11976	0.419
LIG_SUMO_SIM_par_1	50	55	PF11976	0.335
LIG_SUMO_SIM_par_1	559	564	PF11976	0.414
LIG_SUMO_SIM_par_1	687	692	PF11976	0.564
LIG_SUMO_SIM_par_1	77	83	PF11976	0.371
LIG_TRAF2_1	7	10	PF00917	0.459
LIG_UBA3_1	274	283	PF00899	0.537
LIG_UBA3_1	284	289	PF00899	0.488
LIG_UBA3_1	546	552	PF00899	0.514
LIG_WRC_WIRS_1	125	130	PF05994	0.387
MOD_CDC14_SPxK_1	292	295	PF00782	0.619
MOD_CDK_SPK_2	289	294	PF00069	0.596
MOD_CDK_SPxK_1	289	295	PF00069	0.618
MOD_CDK_SPxxK_3	201	208	PF00069	0.615
MOD_CDK_SPxxK_3	289	296	PF00069	0.597
MOD_CDK_SPxxK_3	642	649	PF00069	0.752
MOD_CK1_1	159	165	PF00069	0.573
MOD_CK1_1	186	192	PF00069	0.564
MOD_CK1_1	220	226	PF00069	0.707
MOD_CK1_1	269	275	PF00069	0.578
MOD_CK1_1	27	33	PF00069	0.397
MOD_CK1_1	309	315	PF00069	0.651
MOD_CK1_1	371	377	PF00069	0.651
MOD_CK1_1	575	581	PF00069	0.623
MOD_CK1_1	595	601	PF00069	0.524
MOD_CK1_1	633	639	PF00069	0.583
MOD_CK1_1	83	89	PF00069	0.390
MOD_CK2_1	309	315	PF00069	0.658
MOD_CK2_1	362	368	PF00069	0.607
MOD_CK2_1	405	411	PF00069	0.601
MOD_CK2_1	418	424	PF00069	0.481
MOD_CK2_1	522	528	PF00069	0.389
MOD_CMANNOS	66	69	PF00535	0.425
MOD_GlcNHglycan	157	161	PF01048	0.562
MOD_GlcNHglycan	170	173	PF01048	0.766
MOD_GlcNHglycan	176	179	PF01048	0.532
MOD_GlcNHglycan	213	216	PF01048	0.688
MOD_GlcNHglycan	229	234	PF01048	0.790
MOD_GlcNHglycan	243	246	PF01048	0.598
MOD_GlcNHglycan	308	311	PF01048	0.670
MOD_GlcNHglycan	329	333	PF01048	0.634
MOD_GlcNHglycan	338	341	PF01048	0.591
MOD_GlcNHglycan	364	367	PF01048	0.645
MOD_GlcNHglycan	375	378	PF01048	0.636
MOD_GlcNHglycan	407	410	PF01048	0.521
MOD_GlcNHglycan	420	423	PF01048	0.487
MOD_GlcNHglycan	488	491	PF01048	0.591
MOD_GlcNHglycan	575	578	PF01048	0.679
MOD_GlcNHglycan	608	611	PF01048	0.650
MOD_GlcNHglycan	652	655	PF01048	0.739
MOD_GlcNHglycan	660	663	PF01048	0.631
MOD_GlcNHglycan	82	85	PF01048	0.384
MOD_GlcNHglycan	90	93	PF01048	0.439
MOD_GSK3_1	179	186	PF00069	0.632
MOD_GSK3_1	217	224	PF00069	0.774
MOD_GSK3_1	265	272	PF00069	0.601
MOD_GSK3_1	302	309	PF00069	0.646
MOD_GSK3_1	48	55	PF00069	0.394
MOD_GSK3_1	522	529	PF00069	0.389
MOD_GSK3_1	571	578	PF00069	0.477
MOD_GSK3_1	602	609	PF00069	0.740
MOD_GSK3_1	630	637	PF00069	0.642
MOD_GSK3_1	645	652	PF00069	0.583
MOD_LATS_1	353	359	PF00433	0.699
MOD_N-GLC_1	341	346	PF02516	0.656
MOD_N-GLC_1	362	367	PF02516	0.791
MOD_NEK2_1	379	384	PF00069	0.645
MOD_NEK2_1	430	435	PF00069	0.466
MOD_NEK2_1	572	577	PF00069	0.560
MOD_NEK2_1	647	652	PF00069	0.549
MOD_PIKK_1	101	107	PF00454	0.378
MOD_PIKK_1	269	275	PF00454	0.501
MOD_PIKK_1	595	601	PF00454	0.643
MOD_PK_1	559	565	PF00069	0.443
MOD_PKA_1	355	361	PF00069	0.621
MOD_PKA_2	265	271	PF00069	0.627
MOD_PKA_2	354	360	PF00069	0.692
MOD_PKA_2	418	424	PF00069	0.488
MOD_PKA_2	507	513	PF00069	0.563
MOD_PKA_2	615	621	PF00069	0.652
MOD_PKA_2	680	686	PF00069	0.623
MOD_PKB_1	121	129	PF00069	0.397
MOD_PKB_1	360	368	PF00069	0.707
MOD_Plk_1	410	416	PF00069	0.525
MOD_Plk_1	439	445	PF00069	0.458
MOD_Plk_2-3	311	317	PF00069	0.637
MOD_Plk_4	130	136	PF00069	0.399
MOD_Plk_4	187	193	PF00069	0.727
MOD_Plk_4	439	445	PF00069	0.487
MOD_Plk_4	526	532	PF00069	0.440
MOD_Plk_4	615	621	PF00069	0.609
MOD_Plk_4	666	672	PF00069	0.644
MOD_ProDKin_1	179	185	PF00069	0.667
MOD_ProDKin_1	201	207	PF00069	0.607
MOD_ProDKin_1	217	223	PF00069	0.744
MOD_ProDKin_1	258	264	PF00069	0.701
MOD_ProDKin_1	289	295	PF00069	0.664
MOD_ProDKin_1	52	58	PF00069	0.394
MOD_ProDKin_1	593	599	PF00069	0.636
MOD_ProDKin_1	631	637	PF00069	0.642
MOD_ProDKin_1	642	648	PF00069	0.600
MOD_ProDKin_1	673	679	PF00069	0.596
MOD_ProDKin_1	83	89	PF00069	0.469
MOD_SUMO_rev_2	277	285	PF00179	0.543
MOD_SUMO_rev_2	488	498	PF00179	0.619
MOD_SUMO_rev_2	528	535	PF00179	0.510
TRG_ENDOCYTIC_2	119	122	PF00928	0.431
TRG_ENDOCYTIC_2	49	52	PF00928	0.306
TRG_ENDOCYTIC_2	670	673	PF00928	0.790
TRG_ER_diArg_1	207	209	PF00400	0.614
TRG_ER_diArg_1	360	362	PF00400	0.726
TRG_NES_CRM1_1	439	451	PF08389	0.458
TRG_NES_CRM1_1	553	566	PF08389	0.446
TRG_NLS_MonoExtN_4	293	298	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C9	Leptomonas seymouri	45%	100%
A4HFS5	Leishmania braziliensis	65%	99%
A4I365	Leishmania infantum	100%	100%
E9ADC8	Leishmania major	92%	100%
E9AZ53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%