Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEB1_LEIDO

TriTrypDb:

LdBPK_302140.1 , LdCL_300026900 , LDHU3_30.2900

Length:

988

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEB1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010941	regulation of cell death	4	1
GO:0016567	protein ubiquitination	7	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0042981	regulation of apoptotic process	6	1
GO:0043067	regulation of programmed cell death	5	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008270	zinc ion binding	6	9
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	609	613	PF00656	0.534
CLV_NRD_NRD_1	535	537	PF00675	0.694
CLV_NRD_NRD_1	572	574	PF00675	0.414
CLV_NRD_NRD_1	661	663	PF00675	0.636
CLV_NRD_NRD_1	7	9	PF00675	0.419
CLV_NRD_NRD_1	77	79	PF00675	0.362
CLV_NRD_NRD_1	790	792	PF00675	0.451
CLV_NRD_NRD_1	844	846	PF00675	0.419
CLV_PCSK_KEX2_1	535	537	PF00082	0.694
CLV_PCSK_KEX2_1	7	9	PF00082	0.419
CLV_PCSK_KEX2_1	77	79	PF00082	0.403
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.419
CLV_PCSK_SKI1_1	131	135	PF00082	0.586
CLV_PCSK_SKI1_1	231	235	PF00082	0.319
CLV_PCSK_SKI1_1	236	240	PF00082	0.294
CLV_PCSK_SKI1_1	249	253	PF00082	0.244
CLV_PCSK_SKI1_1	342	346	PF00082	0.289
CLV_PCSK_SKI1_1	408	412	PF00082	0.615
CLV_PCSK_SKI1_1	48	52	PF00082	0.311
CLV_PCSK_SKI1_1	507	511	PF00082	0.731
CLV_PCSK_SKI1_1	573	577	PF00082	0.577
CLV_PCSK_SKI1_1	640	644	PF00082	0.636
CLV_PCSK_SKI1_1	792	796	PF00082	0.539
CLV_PCSK_SKI1_1	969	973	PF00082	0.419
DEG_APCC_DBOX_1	637	645	PF00400	0.590
DEG_Nend_UBRbox_2	1	3	PF02207	0.452
DEG_SPOP_SBC_1	488	492	PF00917	0.544
DOC_ANK_TNKS_1	7	14	PF00023	0.419
DOC_CKS1_1	270	275	PF01111	0.307
DOC_CYCLIN_RxL_1	457	465	PF00134	0.688
DOC_CYCLIN_RxL_1	636	646	PF00134	0.578
DOC_MAPK_gen_1	102	112	PF00069	0.604
DOC_MAPK_gen_1	236	245	PF00069	0.307
DOC_MAPK_gen_1	24	34	PF00069	0.381
DOC_MAPK_gen_1	48	56	PF00069	0.320
DOC_MAPK_gen_1	636	644	PF00069	0.491
DOC_MAPK_gen_1	662	672	PF00069	0.478
DOC_MAPK_MEF2A_6	48	56	PF00069	0.311
DOC_PP1_RVXF_1	458	465	PF00149	0.691
DOC_PP1_RVXF_1	977	983	PF00149	0.522
DOC_PP2B_LxvP_1	514	517	PF13499	0.679
DOC_PP2B_LxvP_1	550	553	PF13499	0.470
DOC_USP7_MATH_1	125	129	PF00917	0.672
DOC_USP7_MATH_1	135	139	PF00917	0.639
DOC_USP7_MATH_1	309	313	PF00917	0.326
DOC_USP7_MATH_1	353	357	PF00917	0.425
DOC_USP7_MATH_1	372	376	PF00917	0.622
DOC_USP7_MATH_1	380	384	PF00917	0.594
DOC_USP7_MATH_1	471	475	PF00917	0.713
DOC_USP7_MATH_1	488	492	PF00917	0.631
DOC_USP7_MATH_1	517	521	PF00917	0.629
DOC_USP7_MATH_1	655	659	PF00917	0.741
DOC_USP7_MATH_1	722	726	PF00917	0.741
DOC_USP7_MATH_1	728	732	PF00917	0.745
DOC_USP7_MATH_1	81	85	PF00917	0.629
DOC_USP7_MATH_1	865	869	PF00917	0.419
DOC_USP7_MATH_1	87	91	PF00917	0.612
DOC_WW_Pin1_4	269	274	PF00397	0.307
DOC_WW_Pin1_4	351	356	PF00397	0.306
DOC_WW_Pin1_4	366	371	PF00397	0.537
DOC_WW_Pin1_4	448	453	PF00397	0.722
DOC_WW_Pin1_4	466	471	PF00397	0.816
DOC_WW_Pin1_4	600	605	PF00397	0.442
DOC_WW_Pin1_4	610	615	PF00397	0.423
DOC_WW_Pin1_4	720	725	PF00397	0.790
DOC_WW_Pin1_4	792	797	PF00397	0.508
LIG_14-3-3_CanoR_1	24	34	PF00244	0.486
LIG_14-3-3_CanoR_1	266	274	PF00244	0.419
LIG_14-3-3_CanoR_1	425	433	PF00244	0.658
LIG_14-3-3_CanoR_1	478	482	PF00244	0.788
LIG_14-3-3_CanoR_1	729	733	PF00244	0.729
LIG_14-3-3_CanoR_1	979	983	PF00244	0.482
LIG_APCC_ABBAyCdc20_2	231	237	PF00400	0.368
LIG_BIR_III_2	793	797	PF00653	0.445
LIG_BIR_III_4	815	819	PF00653	0.362
LIG_BRCT_BRCA1_1	505	509	PF00533	0.634
LIG_Clathr_ClatBox_1	641	645	PF01394	0.611
LIG_eIF4E_1	64	70	PF01652	0.307
LIG_FHA_1	154	160	PF00498	0.625
LIG_FHA_1	259	265	PF00498	0.377
LIG_FHA_1	386	392	PF00498	0.654
LIG_FHA_1	580	586	PF00498	0.487
LIG_FHA_1	588	594	PF00498	0.456
LIG_FHA_1	793	799	PF00498	0.502
LIG_FHA_1	889	895	PF00498	0.376
LIG_FHA_2	302	308	PF00498	0.307
LIG_FHA_2	36	42	PF00498	0.425
LIG_FHA_2	671	677	PF00498	0.521
LIG_FHA_2	956	962	PF00498	0.368
LIG_GBD_Chelix_1	176	184	PF00786	0.419
LIG_GBD_Chelix_1	337	345	PF00786	0.425
LIG_GSK3_LRP6_1	720	725	PF00069	0.570
LIG_LIR_Apic_2	272	278	PF02991	0.307
LIG_LIR_Gen_1	506	517	PF02991	0.651
LIG_LIR_Gen_1	63	71	PF02991	0.307
LIG_LIR_Gen_1	756	765	PF02991	0.470
LIG_LIR_Gen_1	821	829	PF02991	0.467
LIG_LIR_Nem_3	246	251	PF02991	0.368
LIG_LIR_Nem_3	506	512	PF02991	0.658
LIG_LIR_Nem_3	63	67	PF02991	0.307
LIG_LIR_Nem_3	756	760	PF02991	0.478
LIG_LIR_Nem_3	821	825	PF02991	0.457
LIG_LRP6_Inhibitor_1	867	873	PF00058	0.307
LIG_LRP6_Inhibitor_1	913	919	PF00058	0.419
LIG_MAD2	51	59	PF02301	0.368
LIG_NRBOX	298	304	PF00104	0.419
LIG_NRBOX	336	342	PF00104	0.333
LIG_PCNA_yPIPBox_3	187	198	PF02747	0.422
LIG_Pex14_2	67	71	PF04695	0.307
LIG_PTB_Apo_2	114	121	PF02174	0.488
LIG_SH2_CRK	248	252	PF00017	0.425
LIG_SH2_CRK	822	826	PF00017	0.455
LIG_SH2_NCK_1	526	530	PF00017	0.546
LIG_SH2_NCK_1	822	826	PF00017	0.455
LIG_SH2_STAP1	30	34	PF00017	0.419
LIG_SH2_STAP1	333	337	PF00017	0.425
LIG_SH2_STAT5	275	278	PF00017	0.307
LIG_SH2_STAT5	64	67	PF00017	0.322
LIG_SH2_STAT5	904	907	PF00017	0.307
LIG_SH3_3	267	273	PF00018	0.322
LIG_SH3_3	482	488	PF00018	0.629
LIG_SH3_3	661	667	PF00018	0.635
LIG_SH3_3	718	724	PF00018	0.740
LIG_SUMO_SIM_par_1	296	301	PF11976	0.307
LIG_SUMO_SIM_par_1	584	591	PF11976	0.414
LIG_SUMO_SIM_par_1	606	613	PF11976	0.434
LIG_TRAF2_1	197	200	PF00917	0.362
LIG_TRAF2_1	38	41	PF00917	0.399
LIG_TRFH_1	274	278	PF08558	0.368
LIG_UBA3_1	378	386	PF00899	0.682
MOD_CDK_SPK_2	792	797	PF00069	0.508
MOD_CDK_SPxxK_3	792	799	PF00069	0.504
MOD_CK1_1	157	163	PF00069	0.558
MOD_CK1_1	26	32	PF00069	0.425
MOD_CK1_1	424	430	PF00069	0.714
MOD_CK1_1	474	480	PF00069	0.720
MOD_CK1_1	489	495	PF00069	0.730
MOD_CK1_1	524	530	PF00069	0.711
MOD_CK1_1	60	66	PF00069	0.419
MOD_CK1_1	665	671	PF00069	0.560
MOD_CK1_1	690	696	PF00069	0.414
MOD_CK1_1	701	707	PF00069	0.657
MOD_CK1_1	978	984	PF00069	0.512
MOD_CK2_1	113	119	PF00069	0.632
MOD_CK2_1	205	211	PF00069	0.472
MOD_CK2_1	213	219	PF00069	0.307
MOD_CK2_1	301	307	PF00069	0.419
MOD_CK2_1	35	41	PF00069	0.489
MOD_CK2_1	519	525	PF00069	0.630
MOD_CK2_1	670	676	PF00069	0.563
MOD_CK2_1	682	688	PF00069	0.421
MOD_CK2_1	865	871	PF00069	0.333
MOD_CK2_1	894	900	PF00069	0.388
MOD_Cter_Amidation	533	536	PF01082	0.581
MOD_GlcNHglycan	127	130	PF01048	0.665
MOD_GlcNHglycan	147	150	PF01048	0.495
MOD_GlcNHglycan	267	270	PF01048	0.423
MOD_GlcNHglycan	374	377	PF01048	0.717
MOD_GlcNHglycan	448	451	PF01048	0.688
MOD_GlcNHglycan	537	541	PF01048	0.707
MOD_GlcNHglycan	620	623	PF01048	0.427
MOD_GlcNHglycan	657	660	PF01048	0.750
MOD_GlcNHglycan	688	692	PF01048	0.384
MOD_GlcNHglycan	710	713	PF01048	0.677
MOD_GlcNHglycan	780	783	PF01048	0.427
MOD_GlcNHglycan	815	819	PF01048	0.362
MOD_GlcNHglycan	838	841	PF01048	0.419
MOD_GlcNHglycan	89	92	PF01048	0.774
MOD_GlcNHglycan	896	899	PF01048	0.372
MOD_GSK3_1	111	118	PF00069	0.641
MOD_GSK3_1	131	138	PF00069	0.714
MOD_GSK3_1	153	160	PF00069	0.594
MOD_GSK3_1	201	208	PF00069	0.376
MOD_GSK3_1	22	29	PF00069	0.432
MOD_GSK3_1	265	272	PF00069	0.307
MOD_GSK3_1	361	368	PF00069	0.503
MOD_GSK3_1	424	431	PF00069	0.686
MOD_GSK3_1	432	439	PF00069	0.632
MOD_GSK3_1	442	449	PF00069	0.552
MOD_GSK3_1	458	465	PF00069	0.742
MOD_GSK3_1	466	473	PF00069	0.754
MOD_GSK3_1	486	493	PF00069	0.707
MOD_GSK3_1	503	510	PF00069	0.574
MOD_GSK3_1	517	524	PF00069	0.621
MOD_GSK3_1	618	625	PF00069	0.418
MOD_GSK3_1	697	704	PF00069	0.730
MOD_GSK3_1	708	715	PF00069	0.685
MOD_N-GLC_1	431	436	PF02516	0.744
MOD_N-GLC_1	471	476	PF02516	0.725
MOD_N-GLC_1	579	584	PF02516	0.531
MOD_N-GLC_1	708	713	PF02516	0.632
MOD_NEK2_1	111	116	PF00069	0.577
MOD_NEK2_1	201	206	PF00069	0.468
MOD_NEK2_1	258	263	PF00069	0.333
MOD_NEK2_1	331	336	PF00069	0.307
MOD_NEK2_1	374	379	PF00069	0.713
MOD_NEK2_1	403	408	PF00069	0.627
MOD_NEK2_1	462	467	PF00069	0.763
MOD_NEK2_1	587	592	PF00069	0.523
MOD_NEK2_1	768	773	PF00069	0.512
MOD_NEK2_1	881	886	PF00069	0.307
MOD_NEK2_1	926	931	PF00069	0.311
MOD_PK_1	361	367	PF00069	0.569
MOD_PK_1	57	63	PF00069	0.419
MOD_PKA_1	662	668	PF00069	0.553
MOD_PKA_2	23	29	PF00069	0.425
MOD_PKA_2	265	271	PF00069	0.307
MOD_PKA_2	424	430	PF00069	0.657
MOD_PKA_2	477	483	PF00069	0.788
MOD_PKA_2	622	628	PF00069	0.410
MOD_PKA_2	665	671	PF00069	0.521
MOD_PKA_2	682	688	PF00069	0.273
MOD_PKA_2	715	721	PF00069	0.742
MOD_PKA_2	728	734	PF00069	0.760
MOD_PKA_2	978	984	PF00069	0.481
MOD_PKB_1	419	427	PF00069	0.679
MOD_Plk_1	431	437	PF00069	0.698
MOD_Plk_1	524	530	PF00069	0.711
MOD_Plk_2-3	301	307	PF00069	0.307
MOD_Plk_2-3	744	750	PF00069	0.563
MOD_Plk_4	106	112	PF00069	0.687
MOD_Plk_4	154	160	PF00069	0.691
MOD_Plk_4	213	219	PF00069	0.307
MOD_Plk_4	309	315	PF00069	0.376
MOD_Plk_4	320	326	PF00069	0.297
MOD_Plk_4	354	360	PF00069	0.268
MOD_Plk_4	374	380	PF00069	0.679
MOD_Plk_4	432	438	PF00069	0.689
MOD_Plk_4	545	551	PF00069	0.503
MOD_Plk_4	57	63	PF00069	0.325
MOD_Plk_4	722	728	PF00069	0.677
MOD_Plk_4	753	759	PF00069	0.444
MOD_Plk_4	978	984	PF00069	0.461
MOD_ProDKin_1	269	275	PF00069	0.307
MOD_ProDKin_1	351	357	PF00069	0.306
MOD_ProDKin_1	366	372	PF00069	0.543
MOD_ProDKin_1	448	454	PF00069	0.721
MOD_ProDKin_1	466	472	PF00069	0.815
MOD_ProDKin_1	600	606	PF00069	0.435
MOD_ProDKin_1	610	616	PF00069	0.416
MOD_ProDKin_1	720	726	PF00069	0.790
MOD_ProDKin_1	792	798	PF00069	0.503
MOD_SUMO_rev_2	246	251	PF00179	0.307
TRG_DiLeu_BaEn_1	49	54	PF01217	0.307
TRG_ENDOCYTIC_2	248	251	PF00928	0.368
TRG_ENDOCYTIC_2	64	67	PF00928	0.307
TRG_ENDOCYTIC_2	822	825	PF00928	0.457
TRG_ENDOCYTIC_2	946	949	PF00928	0.307
TRG_ER_diArg_1	76	78	PF00400	0.362
TRG_ER_diArg_1	796	799	PF00400	0.500
TRG_NES_CRM1_1	291	301	PF08389	0.419
TRG_NLS_MonoExtC_3	6	12	PF00514	0.419
TRG_NLS_MonoExtN_4	842	849	PF00514	0.419
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	496	501	PF00026	0.736
TRG_Pf-PMV_PEXEL_1	772	776	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFF2	Leptomonas seymouri	72%	99%
A0A1X0P1U2	Trypanosomatidae	45%	100%
A0A422N709	Trypanosoma rangeli	48%	100%
A4HIE5	Leishmania braziliensis	85%	99%
A4I5P2	Leishmania infantum	100%	100%
E9B0Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q9NE58	Leishmania major	95%	99%
V5DCX1	Trypanosoma cruzi	47%	100%