Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEA8_LEIDO

TriTrypDb:

LdBPK_290730.1 , LdCL_290012000 , LDHU3_29.1000

Length:

711

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.545
CLV_C14_Caspase3-7	219	223	PF00656	0.528
CLV_C14_Caspase3-7	330	334	PF00656	0.554
CLV_C14_Caspase3-7	338	342	PF00656	0.561
CLV_MEL_PAP_1	348	354	PF00089	0.362
CLV_NRD_NRD_1	146	148	PF00675	0.713
CLV_NRD_NRD_1	533	535	PF00675	0.540
CLV_NRD_NRD_1	708	710	PF00675	0.672
CLV_NRD_NRD_1	97	99	PF00675	0.687
CLV_PCSK_FUR_1	93	97	PF00082	0.675
CLV_PCSK_KEX2_1	146	148	PF00082	0.605
CLV_PCSK_KEX2_1	533	535	PF00082	0.592
CLV_PCSK_KEX2_1	92	94	PF00082	0.710
CLV_PCSK_KEX2_1	95	97	PF00082	0.740
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.634
CLV_PCSK_PC7_1	93	99	PF00082	0.605
CLV_PCSK_SKI1_1	434	438	PF00082	0.508
CLV_PCSK_SKI1_1	439	443	PF00082	0.498
CLV_PCSK_SKI1_1	546	550	PF00082	0.345
CLV_PCSK_SKI1_1	566	570	PF00082	0.524
CLV_PCSK_SKI1_1	73	77	PF00082	0.521
DEG_APCC_KENBOX_2	150	154	PF00400	0.533
DEG_SPOP_SBC_1	272	276	PF00917	0.525
DEG_SPOP_SBC_1	46	50	PF00917	0.531
DOC_CYCLIN_RxL_1	540	550	PF00134	0.435
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	493	499	PF00134	0.576
DOC_MAPK_DCC_7	204	214	PF00069	0.474
DOC_MAPK_gen_1	592	601	PF00069	0.532
DOC_MAPK_MEF2A_6	377	385	PF00069	0.443
DOC_PP1_RVXF_1	202	209	PF00149	0.489
DOC_PP1_RVXF_1	541	548	PF00149	0.540
DOC_PP2B_LxvP_1	468	471	PF13499	0.496
DOC_PP4_FxxP_1	442	445	PF00568	0.422
DOC_USP7_MATH_1	160	164	PF00917	0.777
DOC_USP7_MATH_1	165	169	PF00917	0.697
DOC_USP7_MATH_1	18	22	PF00917	0.459
DOC_USP7_MATH_1	26	30	PF00917	0.442
DOC_USP7_MATH_1	51	55	PF00917	0.631
DOC_USP7_MATH_1	584	588	PF00917	0.463
DOC_USP7_MATH_1	632	636	PF00917	0.652
DOC_USP7_MATH_1	644	648	PF00917	0.612
DOC_USP7_MATH_1	661	665	PF00917	0.615
DOC_USP7_MATH_1	697	701	PF00917	0.719
DOC_WW_Pin1_4	13	18	PF00397	0.498
LIG_14-3-3_CanoR_1	138	145	PF00244	0.769
LIG_14-3-3_CanoR_1	146	151	PF00244	0.584
LIG_14-3-3_CanoR_1	252	256	PF00244	0.595
LIG_14-3-3_CanoR_1	263	267	PF00244	0.680
LIG_14-3-3_CanoR_1	32	41	PF00244	0.529
LIG_14-3-3_CanoR_1	351	359	PF00244	0.405
LIG_14-3-3_CanoR_1	439	445	PF00244	0.442
LIG_14-3-3_CanoR_1	456	465	PF00244	0.395
LIG_14-3-3_CanoR_1	546	555	PF00244	0.427
LIG_14-3-3_CanoR_1	633	639	PF00244	0.675
LIG_14-3-3_CanoR_1	78	84	PF00244	0.452
LIG_Actin_WH2_2	280	295	PF00022	0.561
LIG_APCC_ABBAyCdc20_2	495	501	PF00400	0.505
LIG_BIR_III_4	341	345	PF00653	0.577
LIG_BIR_III_4	577	581	PF00653	0.612
LIG_Clathr_ClatBox_1	326	330	PF01394	0.379
LIG_deltaCOP1_diTrp_1	299	307	PF00928	0.329
LIG_FHA_1	101	107	PF00498	0.711
LIG_FHA_1	272	278	PF00498	0.679
LIG_FHA_1	316	322	PF00498	0.430
LIG_FHA_1	367	373	PF00498	0.540
LIG_FHA_1	380	386	PF00498	0.445
LIG_FHA_1	453	459	PF00498	0.453
LIG_FHA_1	670	676	PF00498	0.538
LIG_FHA_1	74	80	PF00498	0.508
LIG_FHA_2	105	111	PF00498	0.679
LIG_FHA_2	273	279	PF00498	0.730
LIG_FHA_2	441	447	PF00498	0.393
LIG_FHA_2	616	622	PF00498	0.637
LIG_LIR_Apic_2	510	516	PF02991	0.502
LIG_LIR_Apic_2	549	554	PF02991	0.445
LIG_LIR_Gen_1	7	17	PF02991	0.349
LIG_LIR_Nem_3	19	25	PF02991	0.366
LIG_LIR_Nem_3	253	258	PF02991	0.635
LIG_LIR_Nem_3	491	497	PF02991	0.449
LIG_LIR_Nem_3	7	12	PF02991	0.448
LIG_LYPXL_yS_3	255	258	PF13949	0.630
LIG_PCNA_yPIPBox_3	293	301	PF02747	0.469
LIG_Pex14_2	547	551	PF04695	0.446
LIG_SH2_CRK	378	382	PF00017	0.494
LIG_SH2_CRK	494	498	PF00017	0.438
LIG_SH2_NCK_1	23	27	PF00017	0.471
LIG_SH2_SRC	378	381	PF00017	0.444
LIG_SH2_SRC	513	516	PF00017	0.624
LIG_SH2_STAP1	23	27	PF00017	0.461
LIG_SH2_STAT5	27	30	PF00017	0.429
LIG_SH2_STAT5	453	456	PF00017	0.497
LIG_SH2_STAT5	513	516	PF00017	0.593
LIG_SH3_3	261	267	PF00018	0.678
LIG_SH3_3	382	388	PF00018	0.426
LIG_SH3_3	475	481	PF00018	0.728
LIG_SH3_3	662	668	PF00018	0.602
LIG_Sin3_3	8	15	PF02671	0.423
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.375
LIG_SUMO_SIM_par_1	101	107	PF11976	0.630
LIG_TRAF2_1	559	562	PF00917	0.469
LIG_TRAF2_2	242	247	PF00917	0.487
LIG_UBA3_1	83	92	PF00899	0.521
MOD_CK1_1	130	136	PF00069	0.805
MOD_CK1_1	137	143	PF00069	0.787
MOD_CK1_1	21	27	PF00069	0.423
MOD_CK1_1	231	237	PF00069	0.673
MOD_CK1_1	251	257	PF00069	0.593
MOD_CK1_1	271	277	PF00069	0.500
MOD_CK1_1	4	10	PF00069	0.556
MOD_CK1_1	45	51	PF00069	0.586
MOD_CK1_1	457	463	PF00069	0.572
MOD_CK1_1	647	653	PF00069	0.692
MOD_CK1_1	700	706	PF00069	0.750
MOD_CK2_1	104	110	PF00069	0.667
MOD_CK2_1	146	152	PF00069	0.623
MOD_CK2_1	160	166	PF00069	0.602
MOD_CK2_1	272	278	PF00069	0.745
MOD_CK2_1	440	446	PF00069	0.369
MOD_CK2_1	615	621	PF00069	0.666
MOD_Cter_Amidation	93	96	PF01082	0.619
MOD_GlcNHglycan	100	103	PF01048	0.794
MOD_GlcNHglycan	114	117	PF01048	0.526
MOD_GlcNHglycan	129	132	PF01048	0.666
MOD_GlcNHglycan	140	143	PF01048	0.734
MOD_GlcNHglycan	157	160	PF01048	0.544
MOD_GlcNHglycan	166	170	PF01048	0.642
MOD_GlcNHglycan	191	195	PF01048	0.461
MOD_GlcNHglycan	233	236	PF01048	0.705
MOD_GlcNHglycan	270	273	PF01048	0.650
MOD_GlcNHglycan	278	282	PF01048	0.590
MOD_GlcNHglycan	28	31	PF01048	0.409
MOD_GlcNHglycan	36	39	PF01048	0.534
MOD_GlcNHglycan	482	485	PF01048	0.505
MOD_GlcNHglycan	699	702	PF01048	0.673
MOD_GSK3_1	100	107	PF00069	0.695
MOD_GSK3_1	126	133	PF00069	0.709
MOD_GSK3_1	134	141	PF00069	0.767
MOD_GSK3_1	229	236	PF00069	0.790
MOD_GSK3_1	268	275	PF00069	0.674
MOD_GSK3_1	311	318	PF00069	0.534
MOD_GSK3_1	364	371	PF00069	0.492
MOD_GSK3_1	42	49	PF00069	0.568
MOD_GSK3_1	515	522	PF00069	0.651
MOD_GSK3_1	644	651	PF00069	0.719
MOD_GSK3_1	73	80	PF00069	0.555
MOD_N-GLC_1	507	512	PF02516	0.436
MOD_NEK2_1	1	6	PF00069	0.617
MOD_NEK2_1	104	109	PF00069	0.715
MOD_NEK2_1	125	130	PF00069	0.765
MOD_NEK2_1	250	255	PF00069	0.620
MOD_NEK2_1	292	297	PF00069	0.474
MOD_NEK2_1	322	327	PF00069	0.482
MOD_NEK2_1	366	371	PF00069	0.502
MOD_NEK2_1	42	47	PF00069	0.359
MOD_NEK2_2	18	23	PF00069	0.484
MOD_NEK2_2	51	56	PF00069	0.567
MOD_NEK2_2	541	546	PF00069	0.379
MOD_PIKK_1	240	246	PF00454	0.538
MOD_PIKK_1	315	321	PF00454	0.435
MOD_PIKK_1	359	365	PF00454	0.347
MOD_PIKK_1	400	406	PF00454	0.545
MOD_PIKK_1	418	424	PF00454	0.517
MOD_PIKK_1	584	590	PF00454	0.441
MOD_PIKK_1	700	706	PF00454	0.656
MOD_PK_1	146	152	PF00069	0.599
MOD_PKA_1	146	152	PF00069	0.608
MOD_PKA_2	126	132	PF00069	0.683
MOD_PKA_2	133	139	PF00069	0.725
MOD_PKA_2	146	152	PF00069	0.686
MOD_PKA_2	251	257	PF00069	0.569
MOD_PKA_2	262	268	PF00069	0.584
MOD_PKA_2	292	298	PF00069	0.422
MOD_PKA_2	350	356	PF00069	0.407
MOD_PKA_2	632	638	PF00069	0.639
MOD_PKA_2	77	83	PF00069	0.447
MOD_PKB_1	96	104	PF00069	0.610
MOD_Plk_1	18	24	PF00069	0.482
MOD_Plk_1	190	196	PF00069	0.410
MOD_Plk_1	434	440	PF00069	0.536
MOD_Plk_1	507	513	PF00069	0.428
MOD_Plk_1	541	547	PF00069	0.445
MOD_Plk_1	669	675	PF00069	0.547
MOD_Plk_4	18	24	PF00069	0.409
MOD_Plk_4	292	298	PF00069	0.464
MOD_Plk_4	322	328	PF00069	0.437
MOD_Plk_4	42	48	PF00069	0.490
MOD_Plk_4	420	426	PF00069	0.585
MOD_Plk_4	508	514	PF00069	0.574
MOD_Plk_4	51	57	PF00069	0.485
MOD_Plk_4	515	521	PF00069	0.567
MOD_Plk_4	661	667	PF00069	0.673
MOD_ProDKin_1	13	19	PF00069	0.499
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.461
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.542
TRG_ENDOCYTIC_2	255	258	PF00928	0.630
TRG_ENDOCYTIC_2	310	313	PF00928	0.465
TRG_ENDOCYTIC_2	378	381	PF00928	0.493
TRG_ENDOCYTIC_2	39	42	PF00928	0.417
TRG_ENDOCYTIC_2	494	497	PF00928	0.525
TRG_ER_diArg_1	145	147	PF00400	0.602
TRG_ER_diArg_1	533	535	PF00400	0.487
TRG_ER_diArg_1	65	68	PF00400	0.523
TRG_ER_diArg_1	93	96	PF00400	0.678
TRG_Pf-PMV_PEXEL_1	533	537	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	546	550	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE66	Leptomonas seymouri	40%	100%
A0A1X0NZK2	Trypanosomatidae	25%	100%
A0A3R7NL89	Trypanosoma rangeli	26%	100%
A4HH77	Leishmania braziliensis	67%	97%
A4I4C3	Leishmania infantum	99%	100%
E9ADS2	Leishmania major	89%	100%
E9AM08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%