Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEA6_LEIDO

TriTrypDb:

LdBPK_181170.1 , LdCL_180016900 , LDHU3_18.1490

Length:

109

Annotations

LeishMANIAdb annotations

A short 2TM protein that is likely part of some larger complex. Multiple distant relatives exist in kinetoplastid genomes.. Very loosely similar to the V-type proton ATPase subunit F

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8IEA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	75	77	PF00675	0.346
CLV_PCSK_KEX2_1	75	77	PF00082	0.346
CLV_PCSK_PC7_1	71	77	PF00082	0.338
CLV_PCSK_SKI1_1	81	85	PF00082	0.343
DOC_CYCLIN_yCln2_LP_2	97	100	PF00134	0.669
DOC_MAPK_RevD_3	62	76	PF00069	0.311
DOC_PP1_RVXF_1	29	36	PF00149	0.345
DOC_PP1_RVXF_1	69	75	PF00149	0.493
DOC_PP2B_LxvP_1	96	99	PF13499	0.662
DOC_USP7_MATH_1	100	104	PF00917	0.639
LIG_14-3-3_CanoR_1	26	35	PF00244	0.441
LIG_FHA_1	59	65	PF00498	0.329
LIG_LIR_Gen_1	34	40	PF02991	0.378
LIG_LIR_Gen_1	63	73	PF02991	0.329
LIG_LIR_Nem_3	63	68	PF02991	0.329
LIG_Pex14_2	24	28	PF04695	0.311
LIG_RPA_C_Fungi	71	83	PF08784	0.501
LIG_SH2_STAP1	3	7	PF00017	0.514
LIG_SH2_STAP1	60	64	PF00017	0.403
LIG_SH2_STAT5	60	63	PF00017	0.403
LIG_SH2_STAT5	73	76	PF00017	0.457
LIG_UBA3_1	23	31	PF00899	0.483
MOD_CK1_1	103	109	PF00069	0.664
MOD_CK1_1	5	11	PF00069	0.353
MOD_GSK3_1	100	107	PF00069	0.627
MOD_GSK3_1	60	67	PF00069	0.329
MOD_NEK2_1	64	69	PF00069	0.311
MOD_NEK2_2	60	65	PF00069	0.311
MOD_Plk_4	60	66	PF00069	0.372
MOD_SUMO_rev_2	41	50	PF00179	0.436
TRG_DiLeu_BaEn_1	92	97	PF01217	0.486
TRG_ER_diArg_1	74	76	PF00400	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE18	Leptomonas seymouri	85%	100%
A0A1X0P8F4	Trypanosomatidae	61%	100%
A0A3R7P1K9	Trypanosoma rangeli	59%	100%
A4H9M6	Leishmania braziliensis	90%	100%
A4HXZ0	Leishmania infantum	100%	100%
E9ARQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QDS6	Leishmania major	99%	100%