LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3Q8IEA3_LEIDO
TriTrypDb:
LdBPK_271270.1 * , LdCL_270019200 , LDHU3_27.1960
Length:
315

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEA3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEA3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 113 117 PF00656 0.629
CLV_C14_Caspase3-7 155 159 PF00656 0.690
CLV_C14_Caspase3-7 83 87 PF00656 0.718
CLV_NRD_NRD_1 13 15 PF00675 0.699
CLV_NRD_NRD_1 165 167 PF00675 0.729
CLV_NRD_NRD_1 186 188 PF00675 0.823
CLV_NRD_NRD_1 279 281 PF00675 0.796
CLV_NRD_NRD_1 283 285 PF00675 0.741
CLV_PCSK_KEX2_1 13 15 PF00082 0.816
CLV_PCSK_KEX2_1 174 176 PF00082 0.758
CLV_PCSK_KEX2_1 186 188 PF00082 0.671
CLV_PCSK_KEX2_1 279 281 PF00082 0.812
CLV_PCSK_KEX2_1 283 285 PF00082 0.722
CLV_PCSK_PC1ET2_1 174 176 PF00082 0.715
CLV_PCSK_PC7_1 279 285 PF00082 0.644
CLV_PCSK_SKI1_1 175 179 PF00082 0.719
DEG_COP1_1 217 226 PF00400 0.629
DEG_Nend_Nbox_1 1 3 PF02207 0.771
DOC_CKS1_1 231 236 PF01111 0.728
DOC_CYCLIN_yCln2_LP_2 160 163 PF00134 0.682
DOC_PP2B_LxvP_1 160 163 PF13499 0.682
DOC_PP4_FxxP_1 293 296 PF00568 0.735
DOC_USP7_MATH_1 199 203 PF00917 0.840
DOC_USP7_MATH_1 246 250 PF00917 0.666
DOC_USP7_MATH_1 99 103 PF00917 0.636
DOC_WW_Pin1_4 202 207 PF00397 0.769
DOC_WW_Pin1_4 210 215 PF00397 0.721
DOC_WW_Pin1_4 222 227 PF00397 0.759
DOC_WW_Pin1_4 23 28 PF00397 0.549
DOC_WW_Pin1_4 230 235 PF00397 0.786
DOC_WW_Pin1_4 242 247 PF00397 0.649
DOC_WW_Pin1_4 251 256 PF00397 0.681
LIG_14-3-3_CanoR_1 166 171 PF00244 0.651
LIG_14-3-3_CanoR_1 216 226 PF00244 0.769
LIG_14-3-3_CanoR_1 261 271 PF00244 0.684
LIG_Actin_WH2_2 56 73 PF00022 0.733
LIG_BIR_III_4 250 254 PF00653 0.643
LIG_BRCT_BRCA1_1 96 100 PF00533 0.749
LIG_CtBP_PxDLS_1 81 85 PF00389 0.595
LIG_FHA_1 123 129 PF00498 0.663
LIG_FHA_1 31 37 PF00498 0.603
LIG_FHA_2 62 68 PF00498 0.727
LIG_FHA_2 88 94 PF00498 0.783
LIG_IBAR_NPY_1 180 182 PF08397 0.800
LIG_LIR_Apic_2 228 234 PF02991 0.807
LIG_LIR_Gen_1 116 127 PF02991 0.427
LIG_LIR_Gen_1 97 108 PF02991 0.736
LIG_LIR_Nem_3 116 122 PF02991 0.426
LIG_LIR_Nem_3 97 103 PF02991 0.737
LIG_LYPXL_SIV_4 181 189 PF13949 0.692
LIG_SH2_CRK 119 123 PF00017 0.736
LIG_SH2_CRK 182 186 PF00017 0.663
LIG_SH2_CRK 231 235 PF00017 0.807
LIG_SH2_NCK_1 231 235 PF00017 0.807
LIG_SH2_STAT3 144 147 PF00017 0.731
LIG_SH2_STAT5 241 244 PF00017 0.703
LIG_SH2_STAT5 30 33 PF00017 0.681
LIG_SH3_2 9 14 PF14604 0.805
LIG_SH3_3 203 209 PF00018 0.649
LIG_SH3_3 220 226 PF00018 0.661
LIG_SH3_3 293 299 PF00018 0.635
LIG_SH3_3 3 9 PF00018 0.817
LIG_SH3_3 76 82 PF00018 0.721
LIG_TRAF2_1 109 112 PF00917 0.639
LIG_WW_3 10 14 PF00397 0.797
MOD_CDC14_SPxK_1 213 216 PF00782 0.769
MOD_CDC14_SPxK_1 254 257 PF00782 0.739
MOD_CDK_SPxK_1 210 216 PF00069 0.768
MOD_CDK_SPxK_1 251 257 PF00069 0.740
MOD_CK1_1 202 208 PF00069 0.837
MOD_CK1_1 218 224 PF00069 0.561
MOD_CK1_1 225 231 PF00069 0.702
MOD_CK1_1 245 251 PF00069 0.652
MOD_CK1_1 256 262 PF00069 0.653
MOD_GlcNHglycan 197 200 PF01048 0.634
MOD_GlcNHglycan 201 204 PF01048 0.786
MOD_GlcNHglycan 220 223 PF01048 0.573
MOD_GlcNHglycan 39 42 PF01048 0.703
MOD_GSK3_1 191 198 PF00069 0.771
MOD_GSK3_1 210 217 PF00069 0.684
MOD_GSK3_1 218 225 PF00069 0.618
MOD_GSK3_1 242 249 PF00069 0.629
MOD_GSK3_1 82 89 PF00069 0.591
MOD_GSK3_1 99 106 PF00069 0.573
MOD_NEK2_1 1 6 PF00069 0.835
MOD_NEK2_1 122 127 PF00069 0.721
MOD_NEK2_1 152 157 PF00069 0.756
MOD_NEK2_1 37 42 PF00069 0.674
MOD_NEK2_1 61 66 PF00069 0.611
MOD_NEK2_2 181 186 PF00069 0.663
MOD_PIKK_1 111 117 PF00454 0.665
MOD_PIKK_1 133 139 PF00454 0.661
MOD_PIKK_1 264 270 PF00454 0.698
MOD_PIKK_1 43 49 PF00454 0.711
MOD_PK_1 166 172 PF00069 0.723
MOD_PKA_1 166 172 PF00069 0.723
MOD_PKA_2 215 221 PF00069 0.804
MOD_PKA_2 256 262 PF00069 0.778
MOD_PKA_2 37 43 PF00069 0.542
MOD_ProDKin_1 202 208 PF00069 0.768
MOD_ProDKin_1 210 216 PF00069 0.721
MOD_ProDKin_1 222 228 PF00069 0.759
MOD_ProDKin_1 23 29 PF00069 0.540
MOD_ProDKin_1 230 236 PF00069 0.784
MOD_ProDKin_1 242 248 PF00069 0.650
MOD_ProDKin_1 251 257 PF00069 0.682
MOD_SUMO_rev_2 54 62 PF00179 0.725
TRG_ENDOCYTIC_2 119 122 PF00928 0.730
TRG_ENDOCYTIC_2 182 185 PF00928 0.659
TRG_ENDOCYTIC_2 312 315 PF00928 0.820
TRG_ER_diArg_1 12 14 PF00400 0.817
TRG_ER_diArg_1 185 187 PF00400 0.679
TRG_ER_diArg_1 279 281 PF00400 0.770
TRG_ER_diArg_1 282 284 PF00400 0.736

Homologs

Protein Taxonomy Sequence identity Coverage
A4HFR2 Leishmania braziliensis 55% 100%
A4I2T8 Leishmania infantum 100% 100%
E9ADB6 Leishmania major 87% 100%
E9AZ41 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS