BILBO1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEA2_LEIDO

TriTrypDb:

LdBPK_301960.1 , LdCL_300024900 , LDHU3_30.2690

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	403	409	PF00089	0.511
CLV_NRD_NRD_1	111	113	PF00675	0.513
CLV_NRD_NRD_1	265	267	PF00675	0.626
CLV_NRD_NRD_1	48	50	PF00675	0.374
CLV_PCSK_KEX2_1	265	267	PF00082	0.651
CLV_PCSK_KEX2_1	396	398	PF00082	0.533
CLV_PCSK_KEX2_1	48	50	PF00082	0.267
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.533
CLV_PCSK_SKI1_1	212	216	PF00082	0.564
CLV_PCSK_SKI1_1	239	243	PF00082	0.573
CLV_PCSK_SKI1_1	349	353	PF00082	0.569
CLV_PCSK_SKI1_1	393	397	PF00082	0.525
CLV_PCSK_SKI1_1	87	91	PF00082	0.355
DEG_Nend_UBRbox_2	1	3	PF02207	0.386
DEG_SPOP_SBC_1	24	28	PF00917	0.296
DEG_SPOP_SBC_1	241	245	PF00917	0.594
DEG_SPOP_SBC_1	277	281	PF00917	0.606
DOC_CYCLIN_RxL_1	84	92	PF00134	0.296
DOC_MAPK_gen_1	215	223	PF00069	0.525
DOC_MAPK_gen_1	370	379	PF00069	0.429
DOC_MAPK_MEF2A_6	372	381	PF00069	0.426
DOC_PP2B_LxvP_1	224	227	PF13499	0.554
DOC_PP4_FxxP_1	164	167	PF00568	0.579
DOC_SPAK_OSR1_1	163	167	PF12202	0.636
DOC_USP7_MATH_1	131	135	PF00917	0.682
DOC_USP7_MATH_1	183	187	PF00917	0.704
DOC_USP7_MATH_1	276	280	PF00917	0.663
DOC_USP7_MATH_1	424	428	PF00917	0.580
DOC_USP7_MATH_2	333	339	PF00917	0.605
DOC_WW_Pin1_4	126	131	PF00397	0.661
DOC_WW_Pin1_4	136	141	PF00397	0.579
DOC_WW_Pin1_4	172	177	PF00397	0.553
DOC_WW_Pin1_4	222	227	PF00397	0.608
DOC_WW_Pin1_4	301	306	PF00397	0.620
DOC_WW_Pin1_4	310	315	PF00397	0.599
DOC_WW_Pin1_4	329	334	PF00397	0.717
DOC_WW_Pin1_4	405	410	PF00397	0.566
DOC_WW_Pin1_4	419	424	PF00397	0.472
DOC_WW_Pin1_4	75	80	PF00397	0.296
LIG_14-3-3_CanoR_1	147	157	PF00244	0.562
LIG_14-3-3_CanoR_1	212	221	PF00244	0.627
LIG_14-3-3_CanoR_1	239	248	PF00244	0.598
LIG_14-3-3_CanoR_1	25	30	PF00244	0.296
LIG_14-3-3_CanoR_1	265	275	PF00244	0.649
LIG_14-3-3_CanoR_1	297	301	PF00244	0.640
LIG_14-3-3_CanoR_1	31	36	PF00244	0.261
LIG_14-3-3_CanoR_1	425	429	PF00244	0.466
LIG_Actin_WH2_2	381	398	PF00022	0.521
LIG_BRCT_BRCA1_1	215	219	PF00533	0.551
LIG_BRCT_BRCA1_1	36	40	PF00533	0.355
LIG_Clathr_ClatBox_1	378	382	PF01394	0.415
LIG_eIF4E_1	84	90	PF01652	0.296
LIG_FHA_1	136	142	PF00498	0.630
LIG_FHA_1	24	30	PF00498	0.355
LIG_FHA_1	390	396	PF00498	0.508
LIG_FHA_2	182	188	PF00498	0.671
LIG_FHA_2	25	31	PF00498	0.267
LIG_FHA_2	396	402	PF00498	0.469
LIG_Integrin_RGD_1	361	363	PF01839	0.538
LIG_LIR_Apic_2	269	275	PF02991	0.687
LIG_LIR_Gen_1	197	205	PF02991	0.616
LIG_LIR_Gen_1	30	40	PF02991	0.291
LIG_LIR_Gen_1	78	86	PF02991	0.415
LIG_LIR_Nem_3	197	202	PF02991	0.623
LIG_LIR_Nem_3	2	6	PF02991	0.334
LIG_LIR_Nem_3	30	35	PF02991	0.315
LIG_LIR_Nem_3	37	43	PF02991	0.282
LIG_LIR_Nem_3	78	83	PF02991	0.394
LIG_NRBOX	398	404	PF00104	0.468
LIG_Pex14_2	86	90	PF04695	0.355
LIG_SH2_CRK	272	276	PF00017	0.671
LIG_SH2_NCK_1	272	276	PF00017	0.583
LIG_SH2_PTP2	260	263	PF00017	0.554
LIG_SH2_STAT5	260	263	PF00017	0.631
LIG_SH2_STAT5	59	62	PF00017	0.296
LIG_SH2_STAT5	84	87	PF00017	0.296
LIG_SH3_1	272	278	PF00018	0.609
LIG_SH3_3	272	278	PF00018	0.615
LIG_SH3_3	283	289	PF00018	0.488
LIG_SH3_3	311	317	PF00018	0.575
LIG_SH3_3	327	333	PF00018	0.654
LIG_SUMO_SIM_par_1	104	111	PF11976	0.504
LIG_WW_3	422	426	PF00397	0.465
MOD_CDC14_SPxK_1	139	142	PF00782	0.574
MOD_CDC14_SPxK_1	422	425	PF00782	0.463
MOD_CDK_SPK_2	301	306	PF00069	0.620
MOD_CDK_SPK_2	329	334	PF00069	0.554
MOD_CDK_SPxK_1	136	142	PF00069	0.579
MOD_CDK_SPxK_1	419	425	PF00069	0.474
MOD_CDK_SPxxK_3	301	308	PF00069	0.623
MOD_CDK_SPxxK_3	405	412	PF00069	0.526
MOD_CK1_1	134	140	PF00069	0.629
MOD_CK1_1	279	285	PF00069	0.693
MOD_CK1_1	296	302	PF00069	0.579
MOD_CK1_1	321	327	PF00069	0.596
MOD_CK1_1	34	40	PF00069	0.296
MOD_CK1_1	405	411	PF00069	0.658
MOD_CK2_1	181	187	PF00069	0.627
MOD_CK2_1	279	285	PF00069	0.585
MOD_CK2_1	329	335	PF00069	0.553
MOD_DYRK1A_RPxSP_1	306	310	PF00069	0.598
MOD_GlcNHglycan	203	206	PF01048	0.645
MOD_GlcNHglycan	281	284	PF01048	0.710
MOD_GlcNHglycan	320	323	PF01048	0.716
MOD_GlcNHglycan	358	361	PF01048	0.603
MOD_GlcNHglycan	55	58	PF01048	0.398
MOD_GSK3_1	101	108	PF00069	0.459
MOD_GSK3_1	131	138	PF00069	0.641
MOD_GSK3_1	183	190	PF00069	0.649
MOD_GSK3_1	288	295	PF00069	0.501
MOD_GSK3_1	296	303	PF00069	0.553
MOD_GSK3_1	306	313	PF00069	0.641
MOD_GSK3_1	335	342	PF00069	0.599
MOD_GSK3_1	352	359	PF00069	0.535
MOD_LATS_1	387	393	PF00433	0.426
MOD_N-GLC_1	132	137	PF02516	0.613
MOD_N-GLC_1	172	177	PF02516	0.549
MOD_N-GLC_1	239	244	PF02516	0.572
MOD_N-GLC_1	419	424	PF02516	0.534
MOD_NEK2_1	101	106	PF00069	0.455
MOD_NEK2_1	132	137	PF00069	0.608
MOD_NEK2_1	268	273	PF00069	0.617
MOD_NEK2_1	318	323	PF00069	0.665
MOD_NEK2_1	395	400	PF00069	0.544
MOD_NEK2_1	402	407	PF00069	0.565
MOD_PIKK_1	101	107	PF00454	0.435
MOD_PIKK_1	148	154	PF00454	0.566
MOD_PIKK_1	227	233	PF00454	0.584
MOD_PIKK_1	312	318	PF00454	0.602
MOD_PIKK_1	339	345	PF00454	0.601
MOD_PIKK_1	72	78	PF00454	0.355
MOD_PK_1	31	37	PF00069	0.267
MOD_PK_1	361	367	PF00069	0.483
MOD_PKA_2	187	193	PF00069	0.621
MOD_PKA_2	24	30	PF00069	0.296
MOD_PKA_2	296	302	PF00069	0.772
MOD_PKA_2	424	430	PF00069	0.470
MOD_PKB_1	337	345	PF00069	0.603
MOD_Plk_1	101	107	PF00069	0.464
MOD_Plk_1	72	78	PF00069	0.355
MOD_Plk_4	121	127	PF00069	0.603
MOD_Plk_4	165	171	PF00069	0.568
MOD_Plk_4	324	330	PF00069	0.570
MOD_Plk_4	361	367	PF00069	0.512
MOD_Plk_4	414	420	PF00069	0.639
MOD_Plk_4	424	430	PF00069	0.607
MOD_ProDKin_1	126	132	PF00069	0.666
MOD_ProDKin_1	136	142	PF00069	0.580
MOD_ProDKin_1	172	178	PF00069	0.554
MOD_ProDKin_1	222	228	PF00069	0.610
MOD_ProDKin_1	301	307	PF00069	0.621
MOD_ProDKin_1	310	316	PF00069	0.598
MOD_ProDKin_1	329	335	PF00069	0.719
MOD_ProDKin_1	405	411	PF00069	0.568
MOD_ProDKin_1	419	425	PF00069	0.471
MOD_ProDKin_1	75	81	PF00069	0.296
MOD_SUMO_rev_2	108	114	PF00179	0.472
TRG_DiLeu_BaEn_2	1	7	PF01217	0.405
TRG_DiLeu_BaEn_4	390	396	PF01217	0.519
TRG_ENDOCYTIC_2	61	64	PF00928	0.355
TRG_ER_diArg_1	161	164	PF00400	0.612
TRG_ER_diArg_1	264	266	PF00400	0.569
TRG_ER_diArg_1	305	308	PF00400	0.821
TRG_ER_diArg_1	370	373	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML8	Leptomonas seymouri	34%	96%
A4HID0	Leishmania braziliensis	54%	100%
A4I5M3	Leishmania infantum	99%	100%
E9B0W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%