Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEA0_LEIDO

TriTrypDb:

LdBPK_220820.1 , LdCL_220015600 , LDHU3_22.1330

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.743
CLV_NRD_NRD_1	162	164	PF00675	0.745
CLV_NRD_NRD_1	318	320	PF00675	0.671
CLV_NRD_NRD_1	458	460	PF00675	0.772
CLV_PCSK_KEX2_1	162	164	PF00082	0.745
CLV_PCSK_KEX2_1	318	320	PF00082	0.710
CLV_PCSK_KEX2_1	458	460	PF00082	0.772
CLV_PCSK_SKI1_1	203	207	PF00082	0.749
CLV_PCSK_SKI1_1	318	322	PF00082	0.611
CLV_PCSK_SKI1_1	444	448	PF00082	0.490
DEG_SPOP_SBC_1	102	106	PF00917	0.693
DEG_SPOP_SBC_1	121	125	PF00917	0.501
DEG_SPOP_SBC_1	75	79	PF00917	0.727
DOC_CKS1_1	363	368	PF01111	0.631
DOC_CKS1_1	65	70	PF01111	0.751
DOC_CYCLIN_RxL_1	441	450	PF00134	0.503
DOC_MAPK_MEF2A_6	580	587	PF00069	0.637
DOC_PP1_RVXF_1	48	55	PF00149	0.599
DOC_PP2B_PxIxI_1	438	444	PF00149	0.541
DOC_PP4_FxxP_1	201	204	PF00568	0.752
DOC_SPAK_OSR1_1	580	584	PF12202	0.558
DOC_USP7_MATH_1	120	124	PF00917	0.773
DOC_USP7_MATH_1	164	168	PF00917	0.726
DOC_USP7_MATH_1	191	195	PF00917	0.682
DOC_USP7_MATH_1	271	275	PF00917	0.776
DOC_USP7_MATH_1	30	34	PF00917	0.477
DOC_USP7_MATH_1	311	315	PF00917	0.636
DOC_USP7_MATH_1	379	383	PF00917	0.612
DOC_USP7_MATH_1	391	395	PF00917	0.735
DOC_USP7_MATH_1	411	415	PF00917	0.580
DOC_USP7_MATH_1	424	428	PF00917	0.691
DOC_USP7_MATH_1	437	441	PF00917	0.419
DOC_USP7_MATH_1	53	57	PF00917	0.772
DOC_USP7_MATH_1	76	80	PF00917	0.726
DOC_WW_Pin1_4	146	151	PF00397	0.769
DOC_WW_Pin1_4	267	272	PF00397	0.712
DOC_WW_Pin1_4	362	367	PF00397	0.592
DOC_WW_Pin1_4	377	382	PF00397	0.601
DOC_WW_Pin1_4	42	47	PF00397	0.691
DOC_WW_Pin1_4	422	427	PF00397	0.725
DOC_WW_Pin1_4	429	434	PF00397	0.541
DOC_WW_Pin1_4	530	535	PF00397	0.527
DOC_WW_Pin1_4	64	69	PF00397	0.789
LIG_14-3-3_CanoR_1	122	131	PF00244	0.696
LIG_14-3-3_CanoR_1	197	205	PF00244	0.675
LIG_14-3-3_CanoR_1	293	299	PF00244	0.579
LIG_14-3-3_CanoR_1	359	364	PF00244	0.604
LIG_14-3-3_CanoR_1	484	490	PF00244	0.606
LIG_14-3-3_CanoR_1	508	517	PF00244	0.517
LIG_Actin_WH2_2	495	512	PF00022	0.513
LIG_BRCT_BRCA1_1	21	25	PF00533	0.586
LIG_BRCT_BRCA1_1	99	103	PF00533	0.672
LIG_CSL_BTD_1	534	537	PF09270	0.503
LIG_deltaCOP1_diTrp_1	6	12	PF00928	0.559
LIG_FHA_1	183	189	PF00498	0.744
LIG_FHA_1	200	206	PF00498	0.630
LIG_FHA_1	362	368	PF00498	0.668
LIG_FHA_1	440	446	PF00498	0.601
LIG_FHA_1	564	570	PF00498	0.525
LIG_FHA_1	70	76	PF00498	0.589
LIG_FHA_2	131	137	PF00498	0.803
LIG_FHA_2	378	384	PF00498	0.567
LIG_HP1_1	325	329	PF01393	0.578
LIG_LIR_Apic_2	199	204	PF02991	0.754
LIG_LIR_Gen_1	194	201	PF02991	0.723
LIG_LIR_Gen_1	22	32	PF02991	0.602
LIG_LIR_Gen_1	432	443	PF02991	0.522
LIG_LIR_Gen_1	559	569	PF02991	0.630
LIG_LIR_Nem_3	10	15	PF02991	0.558
LIG_LIR_Nem_3	153	159	PF02991	0.741
LIG_LIR_Nem_3	194	198	PF02991	0.728
LIG_LIR_Nem_3	22	28	PF02991	0.542
LIG_LIR_Nem_3	432	438	PF02991	0.532
LIG_LIR_Nem_3	488	494	PF02991	0.535
LIG_LIR_Nem_3	559	565	PF02991	0.536
LIG_MAD2	38	46	PF02301	0.738
LIG_PCNA_PIPBox_1	1	10	PF02747	0.577
LIG_PDZ_Class_2	582	587	PF00595	0.533
LIG_Pex14_1	8	12	PF04695	0.560
LIG_PTAP_UEV_1	329	334	PF05743	0.447
LIG_RPA_C_Fungi	253	265	PF08784	0.590
LIG_SH2_CRK	156	160	PF00017	0.650
LIG_SH2_NCK_1	31	35	PF00017	0.484
LIG_SH2_NCK_1	547	551	PF00017	0.613
LIG_SH2_NCK_1	562	566	PF00017	0.401
LIG_SH2_PTP2	435	438	PF00017	0.528
LIG_SH2_STAP1	296	300	PF00017	0.644
LIG_SH2_STAP1	401	405	PF00017	0.467
LIG_SH2_STAT5	195	198	PF00017	0.711
LIG_SH2_STAT5	296	299	PF00017	0.644
LIG_SH2_STAT5	435	438	PF00017	0.528
LIG_SH3_3	114	120	PF00018	0.641
LIG_SH3_3	181	187	PF00018	0.725
LIG_SH3_3	299	305	PF00018	0.651
LIG_SH3_3	324	330	PF00018	0.662
LIG_SH3_3	360	366	PF00018	0.558
LIG_SH3_3	385	391	PF00018	0.746
LIG_SH3_3	433	439	PF00018	0.530
LIG_SH3_3	45	51	PF00018	0.751
LIG_SH3_3	531	537	PF00018	0.488
LIG_SH3_3	62	68	PF00018	0.700
LIG_SUMO_SIM_par_1	325	331	PF11976	0.633
LIG_SUMO_SIM_par_1	342	349	PF11976	0.546
LIG_SUMO_SIM_par_1	444	450	PF11976	0.521
LIG_SUMO_SIM_par_1	528	533	PF11976	0.605
LIG_TRAF2_1	3	6	PF00917	0.580
LIG_TYR_ITIM	560	565	PF00017	0.647
MOD_CDC14_SPxK_1	149	152	PF00782	0.616
MOD_CDK_SPxK_1	146	152	PF00069	0.753
MOD_CK1_1	123	129	PF00069	0.768
MOD_CK1_1	146	152	PF00069	0.647
MOD_CK1_1	199	205	PF00069	0.632
MOD_CK1_1	210	216	PF00069	0.762
MOD_CK1_1	241	247	PF00069	0.476
MOD_CK1_1	361	367	PF00069	0.711
MOD_CK1_1	382	388	PF00069	0.689
MOD_CK1_1	414	420	PF00069	0.617
MOD_CK1_1	42	48	PF00069	0.706
MOD_CK1_1	425	431	PF00069	0.595
MOD_CK1_1	462	468	PF00069	0.674
MOD_CK1_1	512	518	PF00069	0.502
MOD_CK1_1	70	76	PF00069	0.677
MOD_CK1_1	77	83	PF00069	0.632
MOD_CK2_1	130	136	PF00069	0.804
MOD_CK2_1	273	279	PF00069	0.797
MOD_GlcNHglycan	125	128	PF01048	0.782
MOD_GlcNHglycan	145	148	PF01048	0.570
MOD_GlcNHglycan	172	175	PF01048	0.616
MOD_GlcNHglycan	238	241	PF01048	0.748
MOD_GlcNHglycan	260	263	PF01048	0.606
MOD_GlcNHglycan	265	268	PF01048	0.665
MOD_GlcNHglycan	308	311	PF01048	0.649
MOD_GlcNHglycan	32	35	PF01048	0.484
MOD_GlcNHglycan	393	396	PF01048	0.741
MOD_GlcNHglycan	417	420	PF01048	0.722
MOD_GlcNHglycan	427	430	PF01048	0.591
MOD_GlcNHglycan	463	467	PF01048	0.749
MOD_GlcNHglycan	470	474	PF01048	0.698
MOD_GlcNHglycan	511	514	PF01048	0.504
MOD_GlcNHglycan	9	12	PF01048	0.565
MOD_GSK3_1	122	129	PF00069	0.724
MOD_GSK3_1	165	172	PF00069	0.752
MOD_GSK3_1	199	206	PF00069	0.763
MOD_GSK3_1	210	217	PF00069	0.641
MOD_GSK3_1	263	270	PF00069	0.685
MOD_GSK3_1	271	278	PF00069	0.751
MOD_GSK3_1	358	365	PF00069	0.619
MOD_GSK3_1	379	386	PF00069	0.636
MOD_GSK3_1	409	416	PF00069	0.632
MOD_GSK3_1	425	432	PF00069	0.646
MOD_GSK3_1	476	483	PF00069	0.784
MOD_GSK3_1	561	568	PF00069	0.534
MOD_GSK3_1	70	77	PF00069	0.627
MOD_GSK3_1	97	104	PF00069	0.681
MOD_N-GLC_1	236	241	PF02516	0.735
MOD_N-GLC_1	272	277	PF02516	0.704
MOD_N-GLC_1	480	485	PF02516	0.659
MOD_NEK2_1	101	106	PF00069	0.700
MOD_NEK2_1	231	236	PF00069	0.670
MOD_NEK2_1	306	311	PF00069	0.733
MOD_NEK2_1	346	351	PF00069	0.564
MOD_NEK2_1	447	452	PF00069	0.517
MOD_NEK2_1	464	469	PF00069	0.672
MOD_NEK2_1	471	476	PF00069	0.684
MOD_NEK2_1	509	514	PF00069	0.511
MOD_NEK2_1	561	566	PF00069	0.543
MOD_NEK2_2	439	444	PF00069	0.516
MOD_NEK2_2	556	561	PF00069	0.503
MOD_PIKK_1	464	470	PF00454	0.775
MOD_PK_1	359	365	PF00069	0.612
MOD_PKA_2	121	127	PF00069	0.738
MOD_PKA_2	151	157	PF00069	0.733
MOD_PKA_2	196	202	PF00069	0.690
MOD_PKA_2	241	247	PF00069	0.588
MOD_PKA_2	358	364	PF00069	0.596
MOD_PKA_2	509	515	PF00069	0.509
MOD_Plk_1	140	146	PF00069	0.644
MOD_Plk_1	231	237	PF00069	0.581
MOD_Plk_1	272	278	PF00069	0.706
MOD_Plk_1	382	388	PF00069	0.672
MOD_Plk_1	87	93	PF00069	0.607
MOD_Plk_4	151	157	PF00069	0.712
MOD_Plk_4	191	197	PF00069	0.731
MOD_Plk_4	346	352	PF00069	0.556
MOD_Plk_4	404	410	PF00069	0.659
MOD_Plk_4	452	458	PF00069	0.623
MOD_Plk_4	493	499	PF00069	0.504
MOD_Plk_4	512	518	PF00069	0.506
MOD_Plk_4	538	544	PF00069	0.529
MOD_Plk_4	556	562	PF00069	0.513
MOD_Plk_4	77	83	PF00069	0.676
MOD_ProDKin_1	146	152	PF00069	0.772
MOD_ProDKin_1	267	273	PF00069	0.717
MOD_ProDKin_1	362	368	PF00069	0.594
MOD_ProDKin_1	377	383	PF00069	0.602
MOD_ProDKin_1	42	48	PF00069	0.692
MOD_ProDKin_1	422	428	PF00069	0.721
MOD_ProDKin_1	429	435	PF00069	0.530
MOD_ProDKin_1	530	536	PF00069	0.530
MOD_ProDKin_1	64	70	PF00069	0.787
TRG_DiLeu_BaLyEn_6	441	446	PF01217	0.599
TRG_ENDOCYTIC_2	156	159	PF00928	0.747
TRG_ENDOCYTIC_2	195	198	PF00928	0.728
TRG_ENDOCYTIC_2	435	438	PF00928	0.528
TRG_ENDOCYTIC_2	562	565	PF00928	0.637
TRG_ER_diArg_1	318	320	PF00400	0.594
TRG_ER_diArg_1	457	459	PF00400	0.771
TRG_ER_diArg_1	508	511	PF00400	0.631
TRG_NES_CRM1_1	493	505	PF08389	0.532
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	444	449	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA8	Leptomonas seymouri	49%	100%
A4HCC4	Leishmania braziliensis	74%	99%
A4HZX3	Leishmania infantum	99%	100%
E9AVT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QBP7	Leishmania major	91%	100%