Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE98_LEIDO

TriTrypDb:

LdBPK_290500.1 , LdCL_290009800 , LDHU3_29.0700

Length:

364

Annotations

LeishMANIAdb annotations

Specific to Kinetoplastids, with fairly unique fold and uncertain topology

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3Q8IE98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	241	243	PF00675	0.459
CLV_NRD_NRD_1	329	331	PF00675	0.535
CLV_NRD_NRD_1	70	72	PF00675	0.449
CLV_PCSK_KEX2_1	189	191	PF00082	0.651
CLV_PCSK_KEX2_1	241	243	PF00082	0.445
CLV_PCSK_KEX2_1	50	52	PF00082	0.556
CLV_PCSK_KEX2_1	70	72	PF00082	0.400
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.651
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.556
CLV_PCSK_SKI1_1	20	24	PF00082	0.531
CLV_PCSK_SKI1_1	242	246	PF00082	0.482
DEG_Nend_Nbox_1	1	3	PF02207	0.660
DOC_AGCK_PIF_2	164	169	PF00069	0.404
DOC_MAPK_gen_1	47	56	PF00069	0.670
DOC_MAPK_MEF2A_6	107	115	PF00069	0.588
DOC_MAPK_MEF2A_6	47	56	PF00069	0.655
DOC_PP4_FxxP_1	41	44	PF00568	0.673
DOC_USP7_MATH_1	125	129	PF00917	0.617
DOC_USP7_MATH_1	203	207	PF00917	0.365
DOC_USP7_MATH_1	265	269	PF00917	0.734
DOC_WW_Pin1_4	181	186	PF00397	0.457
DOC_WW_Pin1_4	55	60	PF00397	0.745
LIG_14-3-3_CanoR_1	202	208	PF00244	0.418
LIG_14-3-3_CanoR_1	249	255	PF00244	0.616
LIG_14-3-3_CanoR_1	294	300	PF00244	0.619
LIG_BRCT_BRCA1_1	102	106	PF00533	0.642
LIG_BRCT_BRCA1_1	247	251	PF00533	0.705
LIG_BRCT_BRCA1_1	56	60	PF00533	0.712
LIG_FHA_1	100	106	PF00498	0.619
LIG_FHA_1	226	232	PF00498	0.522
LIG_FHA_1	310	316	PF00498	0.716
LIG_FHA_2	21	27	PF00498	0.725
LIG_FHA_2	297	303	PF00498	0.615
LIG_FHA_2	88	94	PF00498	0.689
LIG_IBAR_NPY_1	324	326	PF08397	0.640
LIG_LIR_Apic_2	346	351	PF02991	0.621
LIG_LIR_Gen_1	166	175	PF02991	0.358
LIG_LIR_Gen_1	57	65	PF02991	0.703
LIG_LIR_Nem_3	166	170	PF02991	0.361
LIG_LIR_Nem_3	206	211	PF02991	0.311
LIG_LIR_Nem_3	248	254	PF02991	0.680
LIG_LIR_Nem_3	57	63	PF02991	0.651
LIG_Pex14_1	116	120	PF04695	0.557
LIG_Pex14_2	216	220	PF04695	0.425
LIG_Pex14_2	37	41	PF04695	0.720
LIG_PTB_Apo_2	321	328	PF02174	0.610
LIG_REV1ctd_RIR_1	213	223	PF16727	0.490
LIG_SH2_CRK	252	256	PF00017	0.694
LIG_SH2_GRB2like	117	120	PF00017	0.577
LIG_SH2_GRB2like	326	329	PF00017	0.639
LIG_SH2_SRC	237	240	PF00017	0.548
LIG_SH2_STAP1	165	169	PF00017	0.344
LIG_SH2_STAP1	213	217	PF00017	0.313
LIG_SH2_STAP1	252	256	PF00017	0.639
LIG_SH2_STAT3	72	75	PF00017	0.678
LIG_SH2_STAT5	120	123	PF00017	0.567
LIG_SH2_STAT5	163	166	PF00017	0.350
LIG_SH2_STAT5	169	172	PF00017	0.348
LIG_SH2_STAT5	199	202	PF00017	0.390
LIG_SH2_STAT5	254	257	PF00017	0.648
LIG_SH2_STAT5	292	295	PF00017	0.621
LIG_SH2_STAT5	326	329	PF00017	0.656
LIG_SH2_STAT5	96	99	PF00017	0.607
LIG_SH3_3	15	21	PF00018	0.730
LIG_SH3_3	53	59	PF00018	0.660
LIG_SUMO_SIM_par_1	52	58	PF11976	0.655
LIG_TRAF2_1	90	93	PF00917	0.663
LIG_TYR_ITIM	250	255	PF00017	0.701
MOD_CK1_1	306	312	PF00069	0.724
MOD_CK1_1	99	105	PF00069	0.589
MOD_CK2_1	20	26	PF00069	0.728
MOD_CK2_1	80	86	PF00069	0.644
MOD_CK2_1	87	93	PF00069	0.641
MOD_GlcNHglycan	127	130	PF01048	0.439
MOD_GlcNHglycan	222	225	PF01048	0.432
MOD_GlcNHglycan	245	248	PF01048	0.453
MOD_GlcNHglycan	296	299	PF01048	0.431
MOD_GSK3_1	125	132	PF00069	0.701
MOD_GSK3_1	296	303	PF00069	0.607
MOD_GSK3_1	96	103	PF00069	0.645
MOD_N-GLC_1	129	134	PF02516	0.470
MOD_N-GLC_1	283	288	PF02516	0.425
MOD_N-GLC_1	306	311	PF02516	0.439
MOD_NEK2_1	139	144	PF00069	0.614
MOD_NEK2_1	225	230	PF00069	0.538
MOD_NEK2_1	245	250	PF00069	0.568
MOD_NEK2_1	293	298	PF00069	0.603
MOD_NEK2_1	300	305	PF00069	0.594
MOD_NEK2_1	63	68	PF00069	0.624
MOD_NEK2_2	203	208	PF00069	0.357
MOD_PIKK_1	257	263	PF00454	0.691
MOD_PIKK_1	309	315	PF00454	0.689
MOD_PK_1	283	289	PF00069	0.649
MOD_PKA_2	293	299	PF00069	0.603
MOD_Plk_1	283	289	PF00069	0.667
MOD_Plk_4	203	209	PF00069	0.317
MOD_Plk_4	250	256	PF00069	0.717
MOD_Plk_4	300	306	PF00069	0.606
MOD_ProDKin_1	181	187	PF00069	0.454
MOD_ProDKin_1	55	61	PF00069	0.742
MOD_SUMO_for_1	11	14	PF00179	0.688
TRG_ENDOCYTIC_2	167	170	PF00928	0.354
TRG_ENDOCYTIC_2	213	216	PF00928	0.297
TRG_ENDOCYTIC_2	252	255	PF00928	0.694
TRG_ENDOCYTIC_2	292	295	PF00928	0.610
TRG_ENDOCYTIC_2	39	42	PF00928	0.677
TRG_ER_diArg_1	178	181	PF00400	0.404
TRG_ER_diArg_1	70	72	PF00400	0.718
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I199	Leptomonas seymouri	77%	100%
A0A0S4JHX1	Bodo saltans	44%	100%
A0A1X0P043	Trypanosomatidae	65%	99%
A0A422NUJ6	Trypanosoma rangeli	62%	99%
A4HH50	Leishmania braziliensis	91%	100%
A4I4A1	Leishmania infantum	100%	100%
C9ZKM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ADQ0	Leishmania major	99%	100%
E9AM30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5DLE6	Trypanosoma cruzi	65%	99%