Intraflagellar transport protein 43, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Intraflagellar transport protein 43, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE97_LEIDO

TriTrypDb:

LdBPK_271880.1 , LdCL_270026000 , LDHU3_27.2860

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	3
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A0A3Q8IE97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.719
CLV_C14_Caspase3-7	256	260	PF00656	0.701
CLV_NRD_NRD_1	128	130	PF00675	0.842
CLV_NRD_NRD_1	131	133	PF00675	0.794
CLV_NRD_NRD_1	288	290	PF00675	0.684
CLV_NRD_NRD_1	341	343	PF00675	0.761
CLV_NRD_NRD_1	376	378	PF00675	0.731
CLV_PCSK_FUR_1	129	133	PF00082	0.764
CLV_PCSK_KEX2_1	128	130	PF00082	0.813
CLV_PCSK_KEX2_1	131	133	PF00082	0.765
CLV_PCSK_KEX2_1	290	292	PF00082	0.682
CLV_PCSK_KEX2_1	294	296	PF00082	0.651
CLV_PCSK_KEX2_1	378	380	PF00082	0.768
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.805
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.786
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.768
DEG_SPOP_SBC_1	36	40	PF00917	0.737
DEG_SPOP_SBC_1	365	369	PF00917	0.732
DEG_SPOP_SBC_1	371	375	PF00917	0.662
DEG_SPOP_SBC_1	399	403	PF00917	0.715
DOC_USP7_MATH_1	12	16	PF00917	0.788
DOC_USP7_MATH_1	27	31	PF00917	0.775
DOC_USP7_MATH_1	335	339	PF00917	0.762
DOC_USP7_MATH_1	352	356	PF00917	0.559
DOC_USP7_MATH_1	371	375	PF00917	0.564
DOC_USP7_MATH_1	381	385	PF00917	0.722
DOC_USP7_MATH_1	397	401	PF00917	0.706
DOC_USP7_MATH_1	422	426	PF00917	0.682
DOC_USP7_MATH_1	50	54	PF00917	0.823
DOC_USP7_MATH_1	82	86	PF00917	0.843
DOC_USP7_MATH_1	90	94	PF00917	0.728
DOC_USP7_UBL2_3	290	294	PF12436	0.728
DOC_USP7_UBL2_3	319	323	PF12436	0.857
DOC_USP7_UBL2_3	339	343	PF12436	0.761
DOC_USP7_UBL2_3	426	430	PF12436	0.792
DOC_WW_Pin1_4	15	20	PF00397	0.727
DOC_WW_Pin1_4	191	196	PF00397	0.679
DOC_WW_Pin1_4	325	330	PF00397	0.846
DOC_WW_Pin1_4	37	42	PF00397	0.797
DOC_WW_Pin1_4	71	76	PF00397	0.799
LIG_14-3-3_CanoR_1	219	227	PF00244	0.700
LIG_14-3-3_CanoR_1	295	305	PF00244	0.700
LIG_14-3-3_CanoR_1	342	349	PF00244	0.762
LIG_14-3-3_CanoR_1	43	48	PF00244	0.745
LIG_14-3-3_CanoR_1	91	95	PF00244	0.741
LIG_BIR_II_1	1	5	PF00653	0.758
LIG_BRCT_BRCA1_1	135	139	PF00533	0.820
LIG_BRCT_BRCA1_1	424	428	PF00533	0.714
LIG_BRCT_BRCA1_2	424	430	PF00533	0.716
LIG_FHA_1	229	235	PF00498	0.719
LIG_FHA_2	281	287	PF00498	0.813
LIG_FHA_2	311	317	PF00498	0.743
LIG_FHA_2	343	349	PF00498	0.761
LIG_LIR_Gen_1	211	221	PF02991	0.691
LIG_LIR_Nem_3	136	141	PF02991	0.606
LIG_LIR_Nem_3	211	217	PF02991	0.701
LIG_LIR_Nem_3	269	274	PF02991	0.672
LIG_SH2_PTP2	271	274	PF00017	0.789
LIG_SH2_SRC	271	274	PF00017	0.789
LIG_SH2_STAT5	271	274	PF00017	0.672
LIG_SH3_1	57	63	PF00018	0.679
LIG_SH3_2	60	65	PF14604	0.775
LIG_SH3_3	138	144	PF00018	0.664
LIG_SH3_3	57	63	PF00018	0.777
MOD_CDC14_SPxK_1	18	21	PF00782	0.766
MOD_CDC14_SPxK_1	40	43	PF00782	0.731
MOD_CDK_SPxK_1	15	21	PF00069	0.768
MOD_CDK_SPxK_1	37	43	PF00069	0.735
MOD_CK1_1	10	16	PF00069	0.688
MOD_CK1_1	228	234	PF00069	0.716
MOD_CK1_1	296	302	PF00069	0.728
MOD_CK1_1	367	373	PF00069	0.817
MOD_CK1_1	37	43	PF00069	0.799
MOD_CK1_1	400	406	PF00069	0.757
MOD_CK1_1	414	420	PF00069	0.521
MOD_CK1_1	46	52	PF00069	0.759
MOD_CK1_1	53	59	PF00069	0.649
MOD_CK1_1	93	99	PF00069	0.766
MOD_CK2_1	280	286	PF00069	0.810
MOD_CK2_1	310	316	PF00069	0.750
MOD_Cter_Amidation	129	132	PF01082	0.780
MOD_Cter_Amidation	355	358	PF01082	0.647
MOD_GlcNHglycan	29	32	PF01048	0.809
MOD_GlcNHglycan	354	357	PF01048	0.636
MOD_GlcNHglycan	379	382	PF01048	0.690
MOD_GlcNHglycan	385	388	PF01048	0.692
MOD_GSK3_1	103	110	PF00069	0.692
MOD_GSK3_1	113	120	PF00069	0.680
MOD_GSK3_1	189	196	PF00069	0.674
MOD_GSK3_1	225	232	PF00069	0.556
MOD_GSK3_1	32	39	PF00069	0.745
MOD_GSK3_1	366	373	PF00069	0.837
MOD_GSK3_1	377	384	PF00069	0.673
MOD_GSK3_1	405	412	PF00069	0.633
MOD_GSK3_1	422	429	PF00069	0.741
MOD_GSK3_1	46	53	PF00069	0.842
MOD_GSK3_1	78	85	PF00069	0.856
MOD_GSK3_1	93	100	PF00069	0.638
MOD_N-GLC_1	107	112	PF02516	0.738
MOD_N-GLC_1	371	376	PF02516	0.819
MOD_N-GLC_1	397	402	PF02516	0.813
MOD_NEK2_1	1	6	PF00069	0.839
MOD_NEK2_1	198	203	PF00069	0.595
MOD_NEK2_1	208	213	PF00069	0.577
MOD_NEK2_1	225	230	PF00069	0.638
MOD_NEK2_1	34	39	PF00069	0.734
MOD_PKA_1	294	300	PF00069	0.761
MOD_PKA_1	342	348	PF00069	0.762
MOD_PKA_1	377	383	PF00069	0.734
MOD_PKA_2	294	300	PF00069	0.692
MOD_PKA_2	359	365	PF00069	0.775
MOD_PKA_2	90	96	PF00069	0.739
MOD_Plk_1	225	231	PF00069	0.717
MOD_Plk_2-3	134	140	PF00069	0.742
MOD_Plk_4	134	140	PF00069	0.742
MOD_ProDKin_1	15	21	PF00069	0.729
MOD_ProDKin_1	191	197	PF00069	0.682
MOD_ProDKin_1	325	331	PF00069	0.843
MOD_ProDKin_1	37	43	PF00069	0.797
MOD_ProDKin_1	71	77	PF00069	0.799
MOD_SUMO_rev_2	407	415	PF00179	0.747
MOD_SUMO_rev_2	74	82	PF00179	0.645
TRG_ENDOCYTIC_2	271	274	PF00928	0.672
TRG_ER_diArg_1	128	131	PF00400	0.764
TRG_NLS_Bipartite_1	342	361	PF00514	0.675
TRG_NLS_MonoExtN_4	354	361	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.749

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HFX1	Leishmania braziliensis	60%	100%
A4I303	Leishmania infantum	100%	100%
E9ADH6	Leishmania major	91%	100%
E9AZA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%