Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE95_LEIDO

TriTrypDb:

LdBPK_341280.1 , LdCL_340018800 , LDHU3_34.2010

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	191	193	PF00675	0.694
CLV_NRD_NRD_1	207	209	PF00675	0.522
CLV_NRD_NRD_1	475	477	PF00675	0.585
CLV_NRD_NRD_1	51	53	PF00675	0.626
CLV_NRD_NRD_1	60	62	PF00675	0.507
CLV_PCSK_KEX2_1	18	20	PF00082	0.757
CLV_PCSK_KEX2_1	191	193	PF00082	0.664
CLV_PCSK_KEX2_1	207	209	PF00082	0.517
CLV_PCSK_KEX2_1	272	274	PF00082	0.758
CLV_PCSK_KEX2_1	339	341	PF00082	0.659
CLV_PCSK_KEX2_1	475	477	PF00082	0.585
CLV_PCSK_KEX2_1	51	53	PF00082	0.626
CLV_PCSK_KEX2_1	60	62	PF00082	0.507
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.767
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.758
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.659
CLV_PCSK_SKI1_1	483	487	PF00082	0.514
CLV_PCSK_SKI1_1	52	56	PF00082	0.688
CLV_PCSK_SKI1_1	575	579	PF00082	0.509
CLV_PCSK_SKI1_1	60	64	PF00082	0.565
DEG_SCF_FBW7_1	139	145	PF00400	0.704
DOC_CKS1_1	139	144	PF01111	0.735
DOC_CKS1_1	345	350	PF01111	0.699
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.663
DOC_MAPK_gen_1	207	215	PF00069	0.672
DOC_MAPK_gen_1	450	458	PF00069	0.508
DOC_MAPK_HePTP_8	154	166	PF00069	0.520
DOC_MAPK_MEF2A_6	157	166	PF00069	0.534
DOC_MAPK_MEF2A_6	208	217	PF00069	0.627
DOC_MAPK_MEF2A_6	413	422	PF00069	0.452
DOC_MAPK_MEF2A_6	452	460	PF00069	0.599
DOC_MAPK_MEF2A_6	514	522	PF00069	0.615
DOC_PP4_FxxP_1	150	153	PF00568	0.548
DOC_PP4_FxxP_1	376	379	PF00568	0.517
DOC_USP7_MATH_1	168	172	PF00917	0.623
DOC_USP7_MATH_1	200	204	PF00917	0.749
DOC_USP7_MATH_1	260	264	PF00917	0.555
DOC_USP7_MATH_1	346	350	PF00917	0.670
DOC_USP7_MATH_1	40	44	PF00917	0.709
DOC_USP7_MATH_1	523	527	PF00917	0.614
DOC_USP7_MATH_1	565	569	PF00917	0.616
DOC_USP7_MATH_1	81	85	PF00917	0.768
DOC_USP7_MATH_1	92	96	PF00917	0.520
DOC_USP7_UBL2_3	136	140	PF12436	0.606
DOC_WW_Pin1_4	135	140	PF00397	0.681
DOC_WW_Pin1_4	142	147	PF00397	0.679
DOC_WW_Pin1_4	149	154	PF00397	0.497
DOC_WW_Pin1_4	254	259	PF00397	0.549
DOC_WW_Pin1_4	340	345	PF00397	0.768
DOC_WW_Pin1_4	474	479	PF00397	0.544
LIG_14-3-3_CanoR_1	176	180	PF00244	0.647
LIG_14-3-3_CanoR_1	191	195	PF00244	0.538
LIG_14-3-3_CanoR_1	238	242	PF00244	0.636
LIG_14-3-3_CanoR_1	305	313	PF00244	0.612
LIG_14-3-3_CanoR_1	314	322	PF00244	0.583
LIG_14-3-3_CanoR_1	553	557	PF00244	0.549
LIG_14-3-3_CanoR_1	66	72	PF00244	0.760
LIG_14-3-3_CanoR_1	7	16	PF00244	0.670
LIG_BIR_III_2	341	345	PF00653	0.685
LIG_CaM_IQ_9	265	281	PF13499	0.525
LIG_CaM_IQ_9	53	68	PF13499	0.650
LIG_deltaCOP1_diTrp_1	361	372	PF00928	0.597
LIG_eIF4E_1	182	188	PF01652	0.723
LIG_FHA_1	315	321	PF00498	0.630
LIG_FHA_1	366	372	PF00498	0.460
LIG_FHA_1	404	410	PF00498	0.555
LIG_FHA_1	535	541	PF00498	0.415
LIG_FHA_1	80	86	PF00498	0.658
LIG_FHA_2	280	286	PF00498	0.661
LIG_FHA_2	306	312	PF00498	0.686
LIG_FHA_2	581	587	PF00498	0.517
LIG_FHA_2	7	13	PF00498	0.592
LIG_GSK3_LRP6_1	142	147	PF00069	0.669
LIG_GSK3_LRP6_1	344	350	PF00069	0.584
LIG_LIR_Apic_2	331	336	PF02991	0.554
LIG_LIR_Gen_1	414	424	PF02991	0.448
LIG_LIR_LC3C_4	537	541	PF02991	0.481
LIG_LIR_Nem_3	369	375	PF02991	0.595
LIG_LIR_Nem_3	414	420	PF02991	0.451
LIG_LYPXL_S_1	372	376	PF13949	0.423
LIG_NRBOX	583	589	PF00104	0.600
LIG_Pex14_2	372	376	PF04695	0.598
LIG_SH2_CRK	322	326	PF00017	0.474
LIG_SH2_STAT5	46	49	PF00017	0.592
LIG_SH3_1	136	142	PF00018	0.713
LIG_SH3_3	136	142	PF00018	0.650
LIG_SH3_3	23	29	PF00018	0.661
LIG_SH3_3	34	40	PF00018	0.564
LIG_SH3_3	342	348	PF00018	0.593
LIG_SH3_3	376	382	PF00018	0.526
LIG_SUMO_SIM_anti_2	537	542	PF11976	0.491
LIG_TRAF2_1	274	277	PF00917	0.697
LIG_TRAF2_1	282	285	PF00917	0.620
LIG_TRAF2_1	470	473	PF00917	0.545
LIG_TRFH_1	254	258	PF08558	0.664
LIG_TYR_ITIM	320	325	PF00017	0.492
LIG_UBA3_1	375	381	PF00899	0.471
LIG_WRC_WIRS_1	419	424	PF05994	0.446
MOD_CDK_SPK_2	135	140	PF00069	0.685
MOD_CK1_1	10	16	PF00069	0.668
MOD_CK1_1	138	144	PF00069	0.691
MOD_CK1_1	169	175	PF00069	0.568
MOD_CK1_1	239	245	PF00069	0.717
MOD_CK1_1	290	296	PF00069	0.738
MOD_CK1_1	349	355	PF00069	0.668
MOD_CK1_1	402	408	PF00069	0.594
MOD_CK1_1	434	440	PF00069	0.596
MOD_CK1_1	555	561	PF00069	0.593
MOD_CK1_1	564	570	PF00069	0.682
MOD_CK2_1	190	196	PF00069	0.663
MOD_CK2_1	279	285	PF00069	0.594
MOD_CK2_1	305	311	PF00069	0.723
MOD_CK2_1	65	71	PF00069	0.570
MOD_Cter_Amidation	337	340	PF01082	0.635
MOD_GlcNHglycan	168	171	PF01048	0.593
MOD_GlcNHglycan	172	175	PF01048	0.568
MOD_GlcNHglycan	203	206	PF01048	0.710
MOD_GlcNHglycan	241	244	PF01048	0.743
MOD_GlcNHglycan	249	252	PF01048	0.574
MOD_GlcNHglycan	258	261	PF01048	0.458
MOD_GlcNHglycan	262	265	PF01048	0.531
MOD_GlcNHglycan	289	292	PF01048	0.752
MOD_GlcNHglycan	33	36	PF01048	0.730
MOD_GlcNHglycan	361	366	PF01048	0.589
MOD_GlcNHglycan	401	404	PF01048	0.613
MOD_GlcNHglycan	414	417	PF01048	0.415
MOD_GlcNHglycan	433	436	PF01048	0.325
MOD_GlcNHglycan	483	486	PF01048	0.555
MOD_GlcNHglycan	563	566	PF01048	0.659
MOD_GlcNHglycan	579	583	PF01048	0.520
MOD_GlcNHglycan	75	78	PF01048	0.784
MOD_GlcNHglycan	92	95	PF01048	0.433
MOD_GSK3_1	138	145	PF00069	0.738
MOD_GSK3_1	162	169	PF00069	0.545
MOD_GSK3_1	237	244	PF00069	0.720
MOD_GSK3_1	256	263	PF00069	0.438
MOD_GSK3_1	340	347	PF00069	0.688
MOD_GSK3_1	361	368	PF00069	0.503
MOD_GSK3_1	398	405	PF00069	0.680
MOD_GSK3_1	407	414	PF00069	0.535
MOD_GSK3_1	452	459	PF00069	0.550
MOD_GSK3_1	551	558	PF00069	0.566
MOD_GSK3_1	561	568	PF00069	0.749
MOD_GSK3_1	6	13	PF00069	0.620
MOD_GSK3_1	66	73	PF00069	0.633
MOD_N-GLC_1	398	403	PF02516	0.622
MOD_N-GLC_1	407	412	PF02516	0.439
MOD_NEK2_1	115	120	PF00069	0.642
MOD_NEK2_1	162	167	PF00069	0.524
MOD_NEK2_1	265	270	PF00069	0.642
MOD_NEK2_1	411	416	PF00069	0.471
MOD_NEK2_1	418	423	PF00069	0.435
MOD_NEK2_1	456	461	PF00069	0.637
MOD_NEK2_1	551	556	PF00069	0.578
MOD_NEK2_1	578	583	PF00069	0.613
MOD_NEK2_2	190	195	PF00069	0.661
MOD_PIKK_1	265	271	PF00454	0.580
MOD_PIKK_1	280	286	PF00454	0.646
MOD_PIKK_1	434	440	PF00454	0.619
MOD_PKA_2	175	181	PF00069	0.641
MOD_PKA_2	190	196	PF00069	0.539
MOD_PKA_2	237	243	PF00069	0.639
MOD_PKA_2	304	310	PF00069	0.579
MOD_PKA_2	552	558	PF00069	0.491
MOD_PKA_2	6	12	PF00069	0.719
MOD_PKA_2	65	71	PF00069	0.758
MOD_Plk_1	127	133	PF00069	0.685
MOD_Plk_1	361	367	PF00069	0.607
MOD_Plk_1	407	413	PF00069	0.468
MOD_Plk_4	130	136	PF00069	0.727
MOD_Plk_4	213	219	PF00069	0.741
MOD_Plk_4	249	255	PF00069	0.682
MOD_Plk_4	354	360	PF00069	0.679
MOD_Plk_4	407	413	PF00069	0.530
MOD_Plk_4	418	424	PF00069	0.454
MOD_Plk_4	523	529	PF00069	0.602
MOD_Plk_4	534	540	PF00069	0.369
MOD_Plk_4	81	87	PF00069	0.644
MOD_Plk_4	92	98	PF00069	0.611
MOD_ProDKin_1	135	141	PF00069	0.679
MOD_ProDKin_1	142	148	PF00069	0.678
MOD_ProDKin_1	149	155	PF00069	0.487
MOD_ProDKin_1	254	260	PF00069	0.554
MOD_ProDKin_1	340	346	PF00069	0.768
MOD_ProDKin_1	474	480	PF00069	0.532
MOD_SUMO_rev_2	193	200	PF00179	0.661
MOD_SUMO_rev_2	281	289	PF00179	0.588
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.731
TRG_ENDOCYTIC_2	182	185	PF00928	0.580
TRG_ENDOCYTIC_2	322	325	PF00928	0.471
TRG_ENDOCYTIC_2	373	376	PF00928	0.430
TRG_ER_diArg_1	190	192	PF00400	0.662
TRG_ER_diArg_1	206	208	PF00400	0.520
TRG_ER_diArg_1	474	476	PF00400	0.572
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6C8	Leptomonas seymouri	33%	89%
A4HAN7	Leishmania braziliensis	60%	100%
A4I9T0	Leishmania infantum	99%	100%
E9B4U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q385	Leishmania major	88%	100%