Tryparedoxin-like_protein/GeneDB:LmjF.29.1130

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IE94_LEIDO

TriTrypDb:

LdBPK_291220.1 , LdCL_290017300 , LDHU3_29.1680

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IE94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.665
CLV_NRD_NRD_1	147	149	PF00675	0.718
CLV_NRD_NRD_1	193	195	PF00675	0.579
CLV_NRD_NRD_1	288	290	PF00675	0.722
CLV_NRD_NRD_1	361	363	PF00675	0.407
CLV_NRD_NRD_1	94	96	PF00675	0.611
CLV_NRD_NRD_1	99	101	PF00675	0.613
CLV_PCSK_FUR_1	227	231	PF00082	0.629
CLV_PCSK_KEX2_1	107	109	PF00082	0.665
CLV_PCSK_KEX2_1	166	168	PF00082	0.689
CLV_PCSK_KEX2_1	19	21	PF00082	0.569
CLV_PCSK_KEX2_1	193	195	PF00082	0.596
CLV_PCSK_KEX2_1	229	231	PF00082	0.649
CLV_PCSK_KEX2_1	288	290	PF00082	0.722
CLV_PCSK_KEX2_1	360	362	PF00082	0.436
CLV_PCSK_KEX2_1	94	96	PF00082	0.611
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.682
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.569
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.572
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.436
CLV_PCSK_SKI1_1	216	220	PF00082	0.607
CLV_PCSK_SKI1_1	236	240	PF00082	0.568
CLV_PCSK_SKI1_1	362	366	PF00082	0.383
CLV_PCSK_SKI1_1	80	84	PF00082	0.475
CLV_Separin_Metazoa	11	15	PF03568	0.310
DEG_Nend_UBRbox_3	1	3	PF02207	0.371
DOC_CKS1_1	290	295	PF01111	0.464
DOC_CYCLIN_yCln2_LP_2	239	242	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.596
DOC_MAPK_FxFP_2	218	221	PF00069	0.346
DOC_MAPK_gen_1	166	173	PF00069	0.458
DOC_MAPK_gen_1	330	339	PF00069	0.285
DOC_MAPK_MEF2A_6	216	225	PF00069	0.326
DOC_MAPK_MEF2A_6	27	36	PF00069	0.268
DOC_PP2B_LxvP_1	239	242	PF13499	0.476
DOC_PP2B_LxvP_1	255	258	PF13499	0.409
DOC_PP2B_LxvP_1	365	368	PF13499	0.585
DOC_PP4_FxxP_1	218	221	PF00568	0.346
DOC_SPAK_OSR1_1	310	314	PF12202	0.322
DOC_USP7_MATH_1	181	185	PF00917	0.551
DOC_USP7_MATH_1	251	255	PF00917	0.531
DOC_USP7_MATH_1	264	268	PF00917	0.517
DOC_USP7_MATH_1	272	276	PF00917	0.513
DOC_WW_Pin1_4	154	159	PF00397	0.495
DOC_WW_Pin1_4	275	280	PF00397	0.547
DOC_WW_Pin1_4	289	294	PF00397	0.469
DOC_WW_Pin1_4	38	43	PF00397	0.411
LIG_14-3-3_CanoR_1	153	158	PF00244	0.553
LIG_14-3-3_CanoR_1	216	221	PF00244	0.373
LIG_14-3-3_CanoR_1	230	237	PF00244	0.456
LIG_14-3-3_CanoR_1	361	368	PF00244	0.596
LIG_CSL_BTD_1	261	264	PF09270	0.481
LIG_EVH1_1	240	244	PF00568	0.478
LIG_FHA_1	290	296	PF00498	0.455
LIG_FHA_1	344	350	PF00498	0.335
LIG_HP1_1	30	34	PF01393	0.260
LIG_IRF3_LxIS_1	350	357	PF10401	0.475
LIG_LIR_Apic_2	351	355	PF02991	0.485
LIG_LIR_Gen_1	28	38	PF02991	0.275
LIG_LIR_Gen_1	321	329	PF02991	0.397
LIG_LIR_Gen_1	45	55	PF02991	0.275
LIG_LIR_Nem_3	219	223	PF02991	0.324
LIG_LIR_Nem_3	28	34	PF02991	0.275
LIG_LIR_Nem_3	299	304	PF02991	0.381
LIG_LIR_Nem_3	45	50	PF02991	0.275
LIG_LYPXL_yS_3	220	223	PF13949	0.307
LIG_LYPXL_yS_3	301	304	PF13949	0.344
LIG_MYND_1	237	241	PF01753	0.480
LIG_Pex14_1	197	201	PF04695	0.311
LIG_Pex14_2	36	40	PF04695	0.275
LIG_SH2_NCK_1	201	205	PF00017	0.335
LIG_SH2_NCK_1	73	77	PF00017	0.275
LIG_SH2_PTP2	31	34	PF00017	0.275
LIG_SH2_SRC	201	204	PF00017	0.336
LIG_SH2_STAT3	3	6	PF00017	0.358
LIG_SH2_STAT5	3	6	PF00017	0.358
LIG_SH2_STAT5	31	34	PF00017	0.275
LIG_SH2_STAT5	68	71	PF00017	0.275
LIG_SH3_3	184	190	PF00018	0.519
LIG_SH3_3	204	210	PF00018	0.440
LIG_SH3_3	238	244	PF00018	0.514
LIG_SH3_3	292	298	PF00018	0.501
LIG_SUMO_SIM_anti_2	346	351	PF11976	0.388
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.383
LIG_SUMO_SIM_par_1	340	346	PF11976	0.345
LIG_SxIP_EBH_1	153	167	PF03271	0.485
LIG_TYR_ITIM	199	204	PF00017	0.326
LIG_TYR_ITIM	29	34	PF00017	0.275
LIG_WRC_WIRS_1	79	84	PF05994	0.278
LIG_WW_2	241	244	PF00397	0.480
MOD_CDK_SPxxK_3	275	282	PF00069	0.469
MOD_CK1_1	152	158	PF00069	0.501
MOD_CK1_1	275	281	PF00069	0.456
MOD_CK2_1	140	146	PF00069	0.498
MOD_CK2_1	5	11	PF00069	0.407
MOD_CK2_1	71	77	PF00069	0.275
MOD_Cter_Amidation	191	194	PF01082	0.601
MOD_GlcNHglycan	109	112	PF01048	0.704
MOD_GlcNHglycan	177	180	PF01048	0.717
MOD_GlcNHglycan	231	234	PF01048	0.661
MOD_GlcNHglycan	270	273	PF01048	0.682
MOD_GlcNHglycan	316	320	PF01048	0.576
MOD_GlcNHglycan	88	91	PF01048	0.608
MOD_GSK3_1	148	155	PF00069	0.538
MOD_GSK3_1	264	271	PF00069	0.524
MOD_GSK3_1	67	74	PF00069	0.275
MOD_GSK3_1	78	85	PF00069	0.275
MOD_LATS_1	147	153	PF00433	0.455
MOD_LATS_1	214	220	PF00433	0.351
MOD_N-GLC_1	153	158	PF02516	0.653
MOD_NEK2_1	345	350	PF00069	0.255
MOD_NEK2_1	36	41	PF00069	0.293
MOD_NEK2_1	78	83	PF00069	0.278
MOD_PIKK_1	266	272	PF00454	0.505
MOD_PIKK_1	354	360	PF00454	0.571
MOD_PKA_1	107	113	PF00069	0.448
MOD_PKA_1	119	125	PF00069	0.508
MOD_PKA_1	148	154	PF00069	0.516
MOD_PKA_1	229	235	PF00069	0.387
MOD_PKA_1	360	366	PF00069	0.638
MOD_PKA_2	107	113	PF00069	0.448
MOD_PKA_2	152	158	PF00069	0.573
MOD_PKA_2	229	235	PF00069	0.413
MOD_PKA_2	360	366	PF00069	0.638
MOD_PKA_2	86	92	PF00069	0.412
MOD_Plk_1	169	175	PF00069	0.487
MOD_Plk_1	251	257	PF00069	0.499
MOD_Plk_2-3	140	146	PF00069	0.437
MOD_Plk_4	140	146	PF00069	0.437
MOD_Plk_4	345	351	PF00069	0.375
MOD_Plk_4	78	84	PF00069	0.312
MOD_ProDKin_1	154	160	PF00069	0.494
MOD_ProDKin_1	275	281	PF00069	0.543
MOD_ProDKin_1	289	295	PF00069	0.465
MOD_ProDKin_1	38	44	PF00069	0.411
MOD_SUMO_rev_2	112	122	PF00179	0.528
MOD_SUMO_rev_2	56	64	PF00179	0.329
TRG_DiLeu_BaEn_2	42	48	PF01217	0.329
TRG_ENDOCYTIC_2	201	204	PF00928	0.364
TRG_ENDOCYTIC_2	220	223	PF00928	0.336
TRG_ENDOCYTIC_2	301	304	PF00928	0.344
TRG_ENDOCYTIC_2	31	34	PF00928	0.275
TRG_ER_diArg_1	107	109	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T6	Leptomonas seymouri	51%	100%
A4HHC4	Leishmania braziliensis	75%	100%
A4I4H0	Leishmania infantum	100%	100%
E9ADX1	Leishmania major	87%	99%
E9ALW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%