Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IE88_LEIDO

TriTrypDb:

LdCL_270011000 , LDHU3_27.0790

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8IE88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.569
CLV_NRD_NRD_1	181	183	PF00675	0.523
CLV_NRD_NRD_1	198	200	PF00675	0.514
CLV_NRD_NRD_1	206	208	PF00675	0.605
CLV_NRD_NRD_1	267	269	PF00675	0.646
CLV_NRD_NRD_1	303	305	PF00675	0.516
CLV_NRD_NRD_1	318	320	PF00675	0.518
CLV_NRD_NRD_1	373	375	PF00675	0.462
CLV_NRD_NRD_1	378	380	PF00675	0.470
CLV_NRD_NRD_1	389	391	PF00675	0.366
CLV_NRD_NRD_1	433	435	PF00675	0.750
CLV_NRD_NRD_1	99	101	PF00675	0.482
CLV_PCSK_FUR_1	371	375	PF00082	0.475
CLV_PCSK_KEX2_1	110	112	PF00082	0.517
CLV_PCSK_KEX2_1	168	170	PF00082	0.487
CLV_PCSK_KEX2_1	238	240	PF00082	0.672
CLV_PCSK_KEX2_1	303	305	PF00082	0.559
CLV_PCSK_KEX2_1	324	326	PF00082	0.445
CLV_PCSK_KEX2_1	373	375	PF00082	0.447
CLV_PCSK_KEX2_1	378	380	PF00082	0.477
CLV_PCSK_KEX2_1	389	391	PF00082	0.501
CLV_PCSK_KEX2_1	433	435	PF00082	0.665
CLV_PCSK_KEX2_1	446	448	PF00082	0.646
CLV_PCSK_KEX2_1	99	101	PF00082	0.469
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.562
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.698
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.458
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.759
CLV_PCSK_PC7_1	369	375	PF00082	0.611
CLV_PCSK_SKI1_1	241	245	PF00082	0.490
CLV_PCSK_SKI1_1	303	307	PF00082	0.454
CLV_PCSK_SKI1_1	41	45	PF00082	0.531
DEG_APCC_DBOX_1	215	223	PF00400	0.577
DOC_CKS1_1	7	12	PF01111	0.498
DOC_CYCLIN_RxL_1	38	48	PF00134	0.538
DOC_MAPK_gen_1	324	332	PF00069	0.528
DOC_USP7_MATH_1	16	20	PF00917	0.527
DOC_USP7_MATH_1	380	384	PF00917	0.538
DOC_USP7_MATH_1	419	423	PF00917	0.593
DOC_USP7_MATH_1	450	454	PF00917	0.668
DOC_USP7_UBL2_3	17	21	PF12436	0.625
DOC_USP7_UBL2_3	208	212	PF12436	0.768
DOC_USP7_UBL2_3	241	245	PF12436	0.687
DOC_USP7_UBL2_3	320	324	PF12436	0.575
DOC_WW_Pin1_4	441	446	PF00397	0.740
DOC_WW_Pin1_4	453	458	PF00397	0.645
DOC_WW_Pin1_4	6	11	PF00397	0.582
LIG_14-3-3_CanoR_1	250	255	PF00244	0.626
LIG_14-3-3_CanoR_1	433	437	PF00244	0.670
LIG_14-3-3_CanoR_1	63	67	PF00244	0.435
LIG_14-3-3_CanoR_1	76	83	PF00244	0.483
LIG_FHA_1	168	174	PF00498	0.672
LIG_FHA_1	55	61	PF00498	0.558
LIG_FHA_2	435	441	PF00498	0.599
LIG_Integrin_isoDGR_2	137	139	PF01839	0.411
LIG_LIR_Nem_3	32	36	PF02991	0.420
LIG_MYND_1	6	10	PF01753	0.580
LIG_NRBOX	39	45	PF00104	0.521
LIG_PCNA_yPIPBox_3	310	322	PF02747	0.612
LIG_PDZ_Class_2	457	462	PF00595	0.681
LIG_RPA_C_Fungi	364	376	PF08784	0.565
LIG_SH2_CRK	448	452	PF00017	0.610
LIG_SH2_SRC	354	357	PF00017	0.484
LIG_SH2_STAP1	197	201	PF00017	0.654
LIG_SH2_STAP1	33	37	PF00017	0.411
LIG_SH2_STAP1	97	101	PF00017	0.579
LIG_SH2_STAT3	299	302	PF00017	0.464
LIG_SH2_STAT3	36	39	PF00017	0.488
LIG_SH2_STAT5	299	302	PF00017	0.568
LIG_SH2_STAT5	354	357	PF00017	0.554
LIG_SH2_STAT5	36	39	PF00017	0.488
LIG_SH2_STAT5	448	451	PF00017	0.560
LIG_SH3_2	7	12	PF14604	0.498
LIG_SH3_3	4	10	PF00018	0.537
LIG_TRAF2_1	164	167	PF00917	0.598
LIG_TRAF2_1	294	297	PF00917	0.404
LIG_TRAF2_1	309	312	PF00917	0.427
LIG_TRAF2_1	335	338	PF00917	0.546
LIG_ULM_U2AF65_1	238	243	PF00076	0.687
MOD_CDK_SPK_2	441	446	PF00069	0.575
MOD_CDK_SPxK_1	441	447	PF00069	0.579
MOD_CDK_SPxK_1	6	12	PF00069	0.582
MOD_CK1_1	237	243	PF00069	0.729
MOD_CK1_1	432	438	PF00069	0.707
MOD_CK1_1	453	459	PF00069	0.740
MOD_CK2_1	161	167	PF00069	0.598
MOD_CK2_1	332	338	PF00069	0.559
MOD_CK2_1	434	440	PF00069	0.685
MOD_CK2_1	453	459	PF00069	0.734
MOD_GlcNHglycan	334	337	PF01048	0.398
MOD_GlcNHglycan	68	71	PF01048	0.508
MOD_GlcNHglycan	77	80	PF01048	0.518
MOD_GSK3_1	246	253	PF00069	0.615
MOD_GSK3_1	419	426	PF00069	0.630
MOD_GSK3_1	432	439	PF00069	0.676
MOD_GSK3_1	62	69	PF00069	0.551
MOD_N-GLC_1	380	385	PF02516	0.537
MOD_NEK2_1	402	407	PF00069	0.461
MOD_NEK2_1	44	49	PF00069	0.596
MOD_NEK2_1	66	71	PF00069	0.518
MOD_NEK2_2	16	21	PF00069	0.521
MOD_PIKK_1	263	269	PF00454	0.625
MOD_PIKK_1	419	425	PF00454	0.687
MOD_PK_1	250	256	PF00069	0.691
MOD_PKA_1	21	27	PF00069	0.636
MOD_PKA_2	167	173	PF00069	0.656
MOD_PKA_2	234	240	PF00069	0.609
MOD_PKA_2	402	408	PF00069	0.554
MOD_PKA_2	423	429	PF00069	0.679
MOD_PKA_2	432	438	PF00069	0.700
MOD_PKA_2	62	68	PF00069	0.467
MOD_PKA_2	75	81	PF00069	0.496
MOD_Plk_1	155	161	PF00069	0.617
MOD_Plk_1	214	220	PF00069	0.577
MOD_Plk_1	380	386	PF00069	0.439
MOD_Plk_4	155	161	PF00069	0.591
MOD_Plk_4	250	256	PF00069	0.728
MOD_ProDKin_1	441	447	PF00069	0.743
MOD_ProDKin_1	453	459	PF00069	0.646
MOD_ProDKin_1	6	12	PF00069	0.582
MOD_SUMO_for_1	244	247	PF00179	0.682
MOD_SUMO_for_1	407	410	PF00179	0.515
MOD_SUMO_rev_2	135	144	PF00179	0.515
MOD_SUMO_rev_2	226	231	PF00179	0.716
MOD_SUMO_rev_2	287	294	PF00179	0.557
TRG_DiLeu_BaEn_1	301	306	PF01217	0.456
TRG_DiLeu_BaEn_1	356	361	PF01217	0.475
TRG_DiLeu_LyEn_5	301	306	PF01217	0.456
TRG_ENDOCYTIC_2	448	451	PF00928	0.575
TRG_ER_diArg_1	168	171	PF00400	0.570
TRG_ER_diArg_1	216	219	PF00400	0.663
TRG_ER_diArg_1	303	305	PF00400	0.573
TRG_ER_diArg_1	371	374	PF00400	0.481
TRG_ER_diArg_1	388	390	PF00400	0.514
TRG_ER_diArg_1	99	101	PF00400	0.473
TRG_NLS_MonoExtN_4	235	242	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN1	Leptomonas seymouri	60%	100%
A0A1X0P3Z6	Trypanosomatidae	30%	100%
A0A3R7MQZ8	Trypanosoma rangeli	33%	100%
A4HFI7	Leishmania braziliensis	74%	100%
D0A5R3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AD38	Leishmania major	92%	100%
E9AHD1	Leishmania infantum	100%	100%
E9AYW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BE50	Trypanosoma cruzi	28%	100%