Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IE86_LEIDO

TriTrypDb:

LdBPK_180750.1 , LdCL_180012600 , LDHU3_18.1000

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.452
CLV_C14_Caspase3-7	92	96	PF00656	0.581
CLV_NRD_NRD_1	141	143	PF00675	0.721
CLV_NRD_NRD_1	183	185	PF00675	0.692
CLV_NRD_NRD_1	230	232	PF00675	0.671
CLV_NRD_NRD_1	233	235	PF00675	0.647
CLV_NRD_NRD_1	420	422	PF00675	0.706
CLV_NRD_NRD_1	473	475	PF00675	0.633
CLV_NRD_NRD_1	539	541	PF00675	0.693
CLV_PCSK_FUR_1	231	235	PF00082	0.602
CLV_PCSK_KEX2_1	141	143	PF00082	0.721
CLV_PCSK_KEX2_1	183	185	PF00082	0.692
CLV_PCSK_KEX2_1	230	232	PF00082	0.671
CLV_PCSK_KEX2_1	233	235	PF00082	0.647
CLV_PCSK_KEX2_1	420	422	PF00082	0.706
CLV_PCSK_KEX2_1	473	475	PF00082	0.633
CLV_PCSK_KEX2_1	539	541	PF00082	0.693
CLV_PCSK_SKI1_1	265	269	PF00082	0.511
CLV_PCSK_SKI1_1	276	280	PF00082	0.482
CLV_PCSK_SKI1_1	474	478	PF00082	0.627
DEG_SPOP_SBC_1	60	64	PF00917	0.611
DEG_SPOP_SBC_1	86	90	PF00917	0.587
DOC_CYCLIN_RxL_1	241	252	PF00134	0.588
DOC_MAPK_gen_1	141	149	PF00069	0.668
DOC_MAPK_gen_1	33	41	PF00069	0.616
DOC_MAPK_MEF2A_6	141	149	PF00069	0.668
DOC_PP2B_LxvP_1	291	294	PF13499	0.592
DOC_PP4_FxxP_1	383	386	PF00568	0.648
DOC_PP4_FxxP_1	476	479	PF00568	0.654
DOC_PP4_FxxP_1	486	489	PF00568	0.602
DOC_PP4_FxxP_1	495	498	PF00568	0.504
DOC_PP4_FxxP_1	9	12	PF00568	0.602
DOC_USP7_MATH_1	100	104	PF00917	0.551
DOC_USP7_MATH_1	12	16	PF00917	0.630
DOC_USP7_MATH_1	148	152	PF00917	0.618
DOC_USP7_MATH_1	267	271	PF00917	0.530
DOC_USP7_MATH_1	386	390	PF00917	0.654
DOC_USP7_MATH_1	422	426	PF00917	0.654
DOC_USP7_MATH_1	504	508	PF00917	0.718
DOC_USP7_MATH_1	85	89	PF00917	0.678
DOC_WW_Pin1_4	14	19	PF00397	0.625
DOC_WW_Pin1_4	141	146	PF00397	0.683
DOC_WW_Pin1_4	213	218	PF00397	0.655
DOC_WW_Pin1_4	413	418	PF00397	0.691
DOC_WW_Pin1_4	431	436	PF00397	0.578
DOC_WW_Pin1_4	502	507	PF00397	0.715
LIG_14-3-3_CanoR_1	105	113	PF00244	0.653
LIG_14-3-3_CanoR_1	141	145	PF00244	0.739
LIG_14-3-3_CanoR_1	162	168	PF00244	0.638
LIG_14-3-3_CanoR_1	189	197	PF00244	0.532
LIG_14-3-3_CanoR_1	269	275	PF00244	0.617
LIG_14-3-3_CanoR_1	282	288	PF00244	0.489
LIG_14-3-3_CanoR_1	421	429	PF00244	0.626
LIG_14-3-3_CanoR_1	439	445	PF00244	0.532
LIG_14-3-3_CanoR_1	473	479	PF00244	0.684
LIG_14-3-3_CanoR_1	539	545	PF00244	0.647
LIG_Actin_WH2_2	254	271	PF00022	0.533
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_BIR_III_4	321	325	PF00653	0.624
LIG_BRCT_BRCA1_1	114	118	PF00533	0.557
LIG_deltaCOP1_diTrp_1	361	369	PF00928	0.518
LIG_deltaCOP1_diTrp_1	460	470	PF00928	0.673
LIG_EH1_1	47	55	PF00400	0.636
LIG_FHA_1	142	148	PF00498	0.618
LIG_FHA_1	23	29	PF00498	0.631
LIG_FHA_1	295	301	PF00498	0.620
LIG_FHA_1	49	55	PF00498	0.605
LIG_FHA_1	526	532	PF00498	0.630
LIG_FHA_2	162	168	PF00498	0.606
LIG_FHA_2	194	200	PF00498	0.588
LIG_FHA_2	342	348	PF00498	0.461
LIG_FHA_2	478	484	PF00498	0.678
LIG_FXI_DFP_1	467	471	PF00024	0.693
LIG_LIR_Apic_2	382	386	PF02991	0.645
LIG_LIR_Apic_2	483	489	PF02991	0.687
LIG_LIR_Apic_2	493	498	PF02991	0.577
LIG_LIR_Apic_2	532	537	PF02991	0.634
LIG_LIR_Apic_2	8	12	PF02991	0.603
LIG_LIR_Gen_1	150	159	PF02991	0.622
LIG_LIR_Gen_1	340	349	PF02991	0.519
LIG_LIR_Gen_1	361	372	PF02991	0.525
LIG_LIR_Gen_1	480	489	PF02991	0.684
LIG_LIR_Nem_3	150	156	PF02991	0.667
LIG_LIR_Nem_3	165	171	PF02991	0.499
LIG_LIR_Nem_3	340	345	PF02991	0.502
LIG_LIR_Nem_3	350	355	PF02991	0.444
LIG_LIR_Nem_3	361	367	PF02991	0.409
LIG_LIR_Nem_3	382	387	PF02991	0.649
LIG_LIR_Nem_3	480	485	PF02991	0.679
LIG_LIR_Nem_3	68	73	PF02991	0.667
LIG_NRBOX	203	209	PF00104	0.544
LIG_NRBOX	286	292	PF00104	0.580
LIG_PDZ_Class_1	540	545	PF00595	0.647
LIG_SH2_CRK	501	505	PF00017	0.633
LIG_SH2_CRK	534	538	PF00017	0.692
LIG_SH2_NCK_1	501	505	PF00017	0.687
LIG_SH2_STAP1	339	343	PF00017	0.515
LIG_SH2_STAP1	482	486	PF00017	0.685
LIG_SH2_STAT5	339	342	PF00017	0.544
LIG_SH2_STAT5	501	504	PF00017	0.687
LIG_SH2_STAT5	534	537	PF00017	0.694
LIG_SH2_STAT5	58	61	PF00017	0.630
LIG_SH3_1	142	148	PF00018	0.669
LIG_SH3_3	142	148	PF00018	0.669
LIG_SH3_3	182	188	PF00018	0.628
LIG_SH3_3	308	314	PF00018	0.679
LIG_SH3_3	446	452	PF00018	0.564
LIG_SH3_3	493	499	PF00018	0.638
LIG_SH3_3	500	506	PF00018	0.598
LIG_SUMO_SIM_anti_2	198	206	PF11976	0.558
LIG_SUMO_SIM_par_1	19	25	PF11976	0.615
LIG_SUMO_SIM_par_1	283	289	PF11976	0.558
LIG_TRAF2_1	209	212	PF00917	0.613
LIG_TRAF2_1	238	241	PF00917	0.663
LIG_TRAF2_1	29	32	PF00917	0.607
LIG_TRAF2_1	521	524	PF00917	0.664
LIG_TRAF2_1	79	82	PF00917	0.495
LIG_UBA3_1	257	263	PF00899	0.471
LIG_WRC_WIRS_1	149	154	PF05994	0.594
LIG_WRC_WIRS_1	352	357	PF05994	0.410
LIG_WRC_WIRS_1	6	11	PF05994	0.603
LIG_WW_1	498	501	PF00397	0.671
MOD_CDK_SPxxK_3	413	420	PF00069	0.666
MOD_CK1_1	112	118	PF00069	0.609
MOD_CK1_1	126	132	PF00069	0.612
MOD_CK1_1	176	182	PF00069	0.674
MOD_CK1_1	193	199	PF00069	0.427
MOD_CK1_1	239	245	PF00069	0.656
MOD_CK1_1	286	292	PF00069	0.601
MOD_CK1_1	323	329	PF00069	0.672
MOD_CK1_1	334	340	PF00069	0.437
MOD_CK1_1	507	513	PF00069	0.576
MOD_CK1_1	89	95	PF00069	0.611
MOD_CK2_1	105	111	PF00069	0.622
MOD_CK2_1	140	146	PF00069	0.683
MOD_CK2_1	161	167	PF00069	0.605
MOD_CK2_1	422	428	PF00069	0.725
MOD_CK2_1	431	437	PF00069	0.653
MOD_CK2_1	76	82	PF00069	0.651
MOD_CK2_1	87	93	PF00069	0.579
MOD_GlcNHglycan	1	4	PF01048	0.620
MOD_GlcNHglycan	125	128	PF01048	0.647
MOD_GlcNHglycan	321	325	PF01048	0.675
MOD_GlcNHglycan	375	378	PF01048	0.496
MOD_GlcNHglycan	388	391	PF01048	0.650
MOD_GlcNHglycan	413	416	PF01048	0.724
MOD_GlcNHglycan	492	495	PF01048	0.687
MOD_GlcNHglycan	513	516	PF01048	0.717
MOD_GSK3_1	105	112	PF00069	0.510
MOD_GSK3_1	126	133	PF00069	0.668
MOD_GSK3_1	137	144	PF00069	0.682
MOD_GSK3_1	189	196	PF00069	0.686
MOD_GSK3_1	203	210	PF00069	0.392
MOD_GSK3_1	267	274	PF00069	0.653
MOD_GSK3_1	333	340	PF00069	0.512
MOD_GSK3_1	409	416	PF00069	0.675
MOD_GSK3_1	48	55	PF00069	0.520
MOD_GSK3_1	507	514	PF00069	0.618
MOD_GSK3_1	61	68	PF00069	0.579
MOD_GSK3_1	85	92	PF00069	0.670
MOD_N-GLC_1	137	142	PF02516	0.669
MOD_N-GLC_1	190	195	PF02516	0.553
MOD_NEK2_1	113	118	PF00069	0.630
MOD_NEK2_1	203	208	PF00069	0.547
MOD_NEK2_1	268	273	PF00069	0.651
MOD_NEK2_1	332	337	PF00069	0.517
MOD_NEK2_1	341	346	PF00069	0.452
MOD_NEK2_1	54	59	PF00069	0.646
MOD_NEK2_1	61	66	PF00069	0.597
MOD_NEK2_2	100	105	PF00069	0.576
MOD_NEK2_2	379	384	PF00069	0.536
MOD_OFUCOSY	104	109	PF10250	0.635
MOD_PIKK_1	173	179	PF00454	0.662
MOD_PIKK_1	207	213	PF00454	0.549
MOD_PIKK_1	236	242	PF00454	0.671
MOD_PIKK_1	268	274	PF00454	0.551
MOD_PIKK_1	76	82	PF00454	0.651
MOD_PKA_2	140	146	PF00069	0.604
MOD_PKA_2	161	167	PF00069	0.605
MOD_PKA_2	193	199	PF00069	0.611
MOD_PKA_2	236	242	PF00069	0.671
MOD_PKA_2	268	274	PF00069	0.658
MOD_PKA_2	440	446	PF00069	0.597
MOD_PKA_2	511	517	PF00069	0.678
MOD_Plk_1	48	54	PF00069	0.635
MOD_Plk_2-3	161	167	PF00069	0.605
MOD_Plk_4	148	154	PF00069	0.676
MOD_Plk_4	203	209	PF00069	0.555
MOD_Plk_4	22	28	PF00069	0.473
MOD_Plk_4	256	262	PF00069	0.485
MOD_Plk_4	286	292	PF00069	0.607
MOD_Plk_4	334	340	PF00069	0.566
MOD_Plk_4	341	347	PF00069	0.478
MOD_Plk_4	379	385	PF00069	0.634
MOD_Plk_4	477	483	PF00069	0.679
MOD_Plk_4	5	11	PF00069	0.630
MOD_Plk_4	504	510	PF00069	0.639
MOD_ProDKin_1	14	20	PF00069	0.623
MOD_ProDKin_1	141	147	PF00069	0.679
MOD_ProDKin_1	213	219	PF00069	0.658
MOD_ProDKin_1	413	419	PF00069	0.691
MOD_ProDKin_1	431	437	PF00069	0.576
MOD_ProDKin_1	502	508	PF00069	0.716
MOD_SUMO_for_1	521	524	PF00179	0.664
TRG_DiLeu_LyEn_5	296	301	PF01217	0.542
TRG_ENDOCYTIC_2	467	470	PF00928	0.693
TRG_ENDOCYTIC_2	482	485	PF00928	0.514
TRG_ENDOCYTIC_2	58	61	PF00928	0.630
TRG_ER_diArg_1	183	185	PF00400	0.692
TRG_ER_diArg_1	229	231	PF00400	0.660
TRG_ER_diArg_1	420	422	PF00400	0.715
TRG_ER_diArg_1	439	442	PF00400	0.532
TRG_ER_diArg_1	472	474	PF00400	0.693
TRG_ER_diArg_1	539	542	PF00400	0.694
TRG_Pf-PMV_PEXEL_1	244	249	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	399	404	PF00026	0.677
TRG_Pf-PMV_PEXEL_1	421	426	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9I6	Leishmania braziliensis	59%	96%
A4HXU9	Leishmania infantum	99%	100%
E9ARL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QDW7	Leishmania major	85%	99%