GTPase activating protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activating protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE73_LEIDO

TriTrypDb:

LdBPK_301410.1 , LdCL_300019300 , LDHU3_30.1790

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE73

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043087	regulation of GTPase activity	5	1
GO:0043547	positive regulation of GTPase activity	6	1
GO:0044093	positive regulation of molecular function	3	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051345	positive regulation of hydrolase activity	5	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0090630	activation of GTPase activity	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0098772	molecular function regulator activity	1	5
GO:0005096	GTPase activator activity	4	1
GO:0008047	enzyme activator activity	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.675
CLV_C14_Caspase3-7	457	461	PF00656	0.351
CLV_NRD_NRD_1	124	126	PF00675	0.439
CLV_NRD_NRD_1	349	351	PF00675	0.308
CLV_NRD_NRD_1	533	535	PF00675	0.351
CLV_PCSK_KEX2_1	123	125	PF00082	0.443
CLV_PCSK_KEX2_1	533	535	PF00082	0.351
CLV_PCSK_KEX2_1	600	602	PF00082	0.420
CLV_PCSK_KEX2_1	70	72	PF00082	0.369
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.420
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.348
CLV_PCSK_SKI1_1	374	378	PF00082	0.279
CLV_PCSK_SKI1_1	513	517	PF00082	0.279
DEG_APCC_DBOX_1	157	165	PF00400	0.546
DEG_MDM2_SWIB_1	502	510	PF02201	0.279
DEG_SCF_FBW7_1	29	34	PF00400	0.537
DEG_SCF_FBW7_1	47	54	PF00400	0.585
DEG_SCF_TRCP1_1	149	154	PF00400	0.426
DOC_AGCK_PIF_1	499	504	PF00069	0.279
DOC_CKS1_1	172	177	PF01111	0.531
DOC_CKS1_1	43	48	PF01111	0.622
DOC_CYCLIN_RxL_1	371	380	PF00134	0.279
DOC_MAPK_gen_1	70	78	PF00069	0.401
DOC_MAPK_HePTP_8	487	499	PF00069	0.304
DOC_MAPK_MEF2A_6	490	499	PF00069	0.304
DOC_PP1_RVXF_1	372	378	PF00149	0.279
DOC_PP1_RVXF_1	85	92	PF00149	0.337
DOC_PP2B_LxvP_1	26	29	PF13499	0.666
DOC_PP2B_LxvP_1	264	267	PF13499	0.569
DOC_PP2B_LxvP_1	305	308	PF13499	0.605
DOC_PP2B_LxvP_1	395	398	PF13499	0.293
DOC_USP7_MATH_1	14	18	PF00917	0.626
DOC_USP7_MATH_1	241	245	PF00917	0.655
DOC_USP7_MATH_1	257	261	PF00917	0.597
DOC_USP7_MATH_1	265	269	PF00917	0.553
DOC_USP7_MATH_1	274	278	PF00917	0.504
DOC_USP7_MATH_1	354	358	PF00917	0.279
DOC_USP7_MATH_1	410	414	PF00917	0.258
DOC_USP7_MATH_1	62	66	PF00917	0.550
DOC_USP7_MATH_2	572	578	PF00917	0.450
DOC_USP7_UBL2_3	347	351	PF12436	0.351
DOC_WW_Pin1_4	167	172	PF00397	0.620
DOC_WW_Pin1_4	228	233	PF00397	0.578
DOC_WW_Pin1_4	255	260	PF00397	0.609
DOC_WW_Pin1_4	27	32	PF00397	0.747
DOC_WW_Pin1_4	36	41	PF00397	0.592
DOC_WW_Pin1_4	42	47	PF00397	0.541
DOC_WW_Pin1_4	49	54	PF00397	0.522
LIG_14-3-3_CanoR_1	158	162	PF00244	0.484
LIG_14-3-3_CanoR_1	273	279	PF00244	0.664
LIG_14-3-3_CanoR_1	4	12	PF00244	0.577
LIG_14-3-3_CanoR_1	533	538	PF00244	0.351
LIG_APCC_ABBA_1	495	500	PF00400	0.304
LIG_BRCT_BRCA1_1	585	589	PF00533	0.325
LIG_CtBP_PxDLS_1	207	211	PF00389	0.592
LIG_deltaCOP1_diTrp_1	101	110	PF00928	0.310
LIG_eIF4E_1	541	547	PF01652	0.279
LIG_FHA_1	168	174	PF00498	0.568
LIG_FHA_1	302	308	PF00498	0.669
LIG_FHA_1	33	39	PF00498	0.654
LIG_FHA_1	409	415	PF00498	0.279
LIG_FHA_1	419	425	PF00498	0.279
LIG_FHA_1	435	441	PF00498	0.279
LIG_FHA_1	449	455	PF00498	0.171
LIG_FHA_1	516	522	PF00498	0.279
LIG_FHA_1	571	577	PF00498	0.439
LIG_FHA_1	59	65	PF00498	0.494
LIG_FHA_2	455	461	PF00498	0.351
LIG_LIR_Gen_1	140	148	PF02991	0.400
LIG_LIR_Gen_1	422	433	PF02991	0.304
LIG_LIR_Gen_1	559	568	PF02991	0.367
LIG_LIR_LC3C_4	394	397	PF02991	0.279
LIG_LIR_Nem_3	101	106	PF02991	0.298
LIG_LIR_Nem_3	127	131	PF02991	0.344
LIG_LIR_Nem_3	134	139	PF02991	0.387
LIG_LIR_Nem_3	140	144	PF02991	0.401
LIG_LIR_Nem_3	422	428	PF02991	0.304
LIG_LIR_Nem_3	559	564	PF02991	0.454
LIG_Pex14_1	449	453	PF04695	0.279
LIG_Pex14_2	425	429	PF04695	0.304
LIG_Pex14_2	502	506	PF04695	0.279
LIG_SH2_CRK	488	492	PF00017	0.279
LIG_SH2_PTP2	561	564	PF00017	0.366
LIG_SH2_SRC	131	134	PF00017	0.358
LIG_SH2_STAP1	100	104	PF00017	0.296
LIG_SH2_STAP1	128	132	PF00017	0.329
LIG_SH2_STAP1	420	424	PF00017	0.351
LIG_SH2_STAP1	595	599	PF00017	0.355
LIG_SH2_STAT5	131	134	PF00017	0.357
LIG_SH2_STAT5	362	365	PF00017	0.312
LIG_SH2_STAT5	388	391	PF00017	0.279
LIG_SH2_STAT5	420	423	PF00017	0.279
LIG_SH2_STAT5	453	456	PF00017	0.279
LIG_SH2_STAT5	462	465	PF00017	0.279
LIG_SH2_STAT5	527	530	PF00017	0.279
LIG_SH2_STAT5	541	544	PF00017	0.279
LIG_SH2_STAT5	561	564	PF00017	0.215
LIG_SH3_3	170	176	PF00018	0.569
LIG_SH3_3	26	32	PF00018	0.606
LIG_SH3_3	294	300	PF00018	0.661
LIG_SH3_3	37	43	PF00018	0.534
LIG_SH3_3	479	485	PF00018	0.258
LIG_SUMO_SIM_anti_2	559	566	PF11976	0.377
LIG_SUMO_SIM_par_1	206	211	PF11976	0.531
LIG_TRAF2_1	529	532	PF00917	0.258
LIG_WW_1	485	488	PF00397	0.279
LIG_WW_2	297	300	PF00397	0.615
MOD_CDK_SPxxK_3	42	49	PF00069	0.655
MOD_CK1_1	177	183	PF00069	0.643
MOD_CK1_1	194	200	PF00069	0.580
MOD_CK1_1	260	266	PF00069	0.585
MOD_CK1_1	268	274	PF00069	0.609
MOD_CK1_1	27	33	PF00069	0.627
MOD_CK1_1	318	324	PF00069	0.567
MOD_CK1_1	333	339	PF00069	0.594
MOD_CK1_1	432	438	PF00069	0.304
MOD_CK1_1	6	12	PF00069	0.557
MOD_CK2_1	410	416	PF00069	0.293
MOD_CK2_1	526	532	PF00069	0.258
MOD_CK2_1	601	607	PF00069	0.513
MOD_DYRK1A_RPxSP_1	228	232	PF00069	0.567
MOD_GlcNHglycan	149	152	PF01048	0.436
MOD_GlcNHglycan	17	20	PF01048	0.694
MOD_GlcNHglycan	218	221	PF01048	0.693
MOD_GlcNHglycan	235	238	PF01048	0.560
MOD_GlcNHglycan	250	253	PF01048	0.639
MOD_GlcNHglycan	26	29	PF01048	0.532
MOD_GlcNHglycan	267	270	PF01048	0.576
MOD_GlcNHglycan	274	277	PF01048	0.563
MOD_GlcNHglycan	317	320	PF01048	0.608
MOD_GlcNHglycan	332	335	PF01048	0.573
MOD_GlcNHglycan	356	359	PF01048	0.279
MOD_GlcNHglycan	431	434	PF01048	0.349
MOD_GlcNHglycan	6	9	PF01048	0.611
MOD_GlcNHglycan	64	67	PF01048	0.510
MOD_GSK3_1	104	111	PF00069	0.319
MOD_GSK3_1	113	120	PF00069	0.387
MOD_GSK3_1	147	154	PF00069	0.540
MOD_GSK3_1	156	163	PF00069	0.543
MOD_GSK3_1	167	174	PF00069	0.461
MOD_GSK3_1	187	194	PF00069	0.694
MOD_GSK3_1	228	235	PF00069	0.587
MOD_GSK3_1	253	260	PF00069	0.663
MOD_GSK3_1	268	275	PF00069	0.534
MOD_GSK3_1	27	34	PF00069	0.666
MOD_GSK3_1	311	318	PF00069	0.584
MOD_GSK3_1	333	340	PF00069	0.536
MOD_GSK3_1	408	415	PF00069	0.279
MOD_GSK3_1	47	54	PF00069	0.507
MOD_GSK3_1	513	520	PF00069	0.279
MOD_GSK3_1	570	577	PF00069	0.370
MOD_GSK3_1	58	65	PF00069	0.604
MOD_N-GLC_1	233	238	PF02516	0.674
MOD_N-GLC_1	460	465	PF02516	0.351
MOD_NEK2_1	104	109	PF00069	0.312
MOD_NEK2_1	147	152	PF00069	0.540
MOD_NEK2_1	208	213	PF00069	0.560
MOD_NEK2_1	272	277	PF00069	0.631
MOD_NEK2_1	280	285	PF00069	0.644
MOD_NEK2_1	332	337	PF00069	0.637
MOD_NEK2_1	377	382	PF00069	0.293
MOD_NEK2_1	454	459	PF00069	0.351
MOD_NEK2_1	515	520	PF00069	0.279
MOD_NEK2_2	595	600	PF00069	0.386
MOD_NMyristoyl	1	7	PF02799	0.539
MOD_PIKK_1	177	183	PF00454	0.539
MOD_PIKK_1	208	214	PF00454	0.600
MOD_PIKK_1	241	247	PF00454	0.689
MOD_PIKK_1	434	440	PF00454	0.351
MOD_PIKK_1	515	521	PF00454	0.279
MOD_PIKK_1	549	555	PF00454	0.304
MOD_PK_1	533	539	PF00069	0.351
MOD_PKA_1	533	539	PF00069	0.351
MOD_PKA_1	600	606	PF00069	0.446
MOD_PKA_2	157	163	PF00069	0.474
MOD_PKA_2	272	278	PF00069	0.644
MOD_PKA_2	3	9	PF00069	0.558
MOD_PKA_2	354	360	PF00069	0.279
MOD_PKA_2	533	539	PF00069	0.351
MOD_PKA_2	600	606	PF00069	0.492
MOD_Plk_1	595	601	PF00069	0.365
MOD_Plk_1	87	93	PF00069	0.337
MOD_Plk_2-3	574	580	PF00069	0.389
MOD_Plk_4	117	123	PF00069	0.432
MOD_Plk_4	333	339	PF00069	0.446
MOD_Plk_4	449	455	PF00069	0.279
MOD_Plk_4	468	474	PF00069	0.279
MOD_ProDKin_1	167	173	PF00069	0.623
MOD_ProDKin_1	228	234	PF00069	0.578
MOD_ProDKin_1	255	261	PF00069	0.610
MOD_ProDKin_1	27	33	PF00069	0.747
MOD_ProDKin_1	36	42	PF00069	0.590
MOD_ProDKin_1	47	53	PF00069	0.490
TRG_DiLeu_BaEn_2	100	106	PF01217	0.298
TRG_DiLeu_BaEn_2	372	378	PF01217	0.279
TRG_DiLeu_BaLyEn_6	519	524	PF01217	0.279
TRG_ENDOCYTIC_2	136	139	PF00928	0.470
TRG_ENDOCYTIC_2	488	491	PF00928	0.279
TRG_ENDOCYTIC_2	561	564	PF00928	0.366
TRG_ER_diArg_1	122	125	PF00400	0.384
TRG_ER_diArg_1	533	535	PF00400	0.351
TRG_NES_CRM1_1	580	592	PF08389	0.399
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K2	Leptomonas seymouri	56%	82%
A4HI87	Leishmania braziliensis	78%	100%
A4I5G6	Leishmania infantum	100%	100%
E9B0R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O59737	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q4Q7G9	Leishmania major	91%	100%