3,2-trans-enoyl-CoA isomerase, mitochondrial-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3,2-trans-enoyl-CoA isomerase, mitochondrial precursor-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IE71_LEIDO

TriTrypDb:

LdBPK_290010.1 , LdCL_290005000 , LDHU3_29.0010

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0005737	cytoplasm	2	1
GO:0020023	kinetoplast	2	1

Expansion

Sequence features

A0A3Q8IE71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE71

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006629	lipid metabolic process	3	3
GO:0006631	fatty acid metabolic process	4	3
GO:0006635	fatty acid beta-oxidation	6	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009062	fatty acid catabolic process	5	3
GO:0009987	cellular process	1	3
GO:0016042	lipid catabolic process	4	3
GO:0016054	organic acid catabolic process	4	3
GO:0019395	fatty acid oxidation	5	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0030258	lipid modification	4	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0034440	lipid oxidation	5	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044242	cellular lipid catabolic process	4	3
GO:0044248	cellular catabolic process	3	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044282	small molecule catabolic process	3	3
GO:0046395	carboxylic acid catabolic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:0072329	monocarboxylic acid catabolic process	6	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0016853	isomerase activity	2	25
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	5	4
GO:0004165	delta(3)-delta(2)-enoyl-CoA isomerase activity	5	11
GO:0016491	oxidoreductase activity	2	4
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	4
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	4
GO:0016860	intramolecular oxidoreductase activity	3	11
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	11
GO:0004300	enoyl-CoA hydratase activity	5	3
GO:0016829	lyase activity	2	3
GO:0016835	carbon-oxygen lyase activity	3	3
GO:0016836	hydro-lyase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.389
CLV_NRD_NRD_1	191	193	PF00675	0.277
CLV_NRD_NRD_1	253	255	PF00675	0.302
CLV_PCSK_KEX2_1	155	157	PF00082	0.389
CLV_PCSK_KEX2_1	253	255	PF00082	0.324
CLV_PCSK_PC7_1	151	157	PF00082	0.389
CLV_PCSK_SKI1_1	117	121	PF00082	0.336
CLV_PCSK_SKI1_1	254	258	PF00082	0.249
CLV_PCSK_SKI1_1	292	296	PF00082	0.563
DEG_APCC_DBOX_1	253	261	PF00400	0.335
DEG_Nend_UBRbox_1	1	4	PF02207	0.590
DOC_CKS1_1	260	265	PF01111	0.304
DOC_CKS1_1	53	58	PF01111	0.369
DOC_CYCLIN_RxL_1	232	241	PF00134	0.336
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.300
DOC_MAPK_gen_1	74	82	PF00069	0.214
DOC_MAPK_JIP1_4	160	166	PF00069	0.237
DOC_MAPK_MEF2A_6	160	168	PF00069	0.389
DOC_PP2B_LxvP_1	125	128	PF13499	0.299
DOC_PP2B_LxvP_1	202	205	PF13499	0.174
DOC_PP2B_LxvP_1	237	240	PF13499	0.386
DOC_PP4_FxxP_1	175	178	PF00568	0.389
DOC_PP4_FxxP_1	277	280	PF00568	0.418
DOC_USP7_MATH_1	25	29	PF00917	0.470
DOC_USP7_MATH_1	72	76	PF00917	0.406
DOC_USP7_UBL2_3	292	296	PF12436	0.599
DOC_WW_Pin1_4	238	243	PF00397	0.369
DOC_WW_Pin1_4	259	264	PF00397	0.312
DOC_WW_Pin1_4	33	38	PF00397	0.353
DOC_WW_Pin1_4	52	57	PF00397	0.284
LIG_14-3-3_CanoR_1	16	22	PF00244	0.627
LIG_14-3-3_CanoR_1	5	13	PF00244	0.525
LIG_FHA_1	163	169	PF00498	0.311
LIG_FHA_1	198	204	PF00498	0.363
LIG_FHA_1	25	31	PF00498	0.431
LIG_FHA_1	260	266	PF00498	0.267
LIG_LIR_Gen_1	113	122	PF02991	0.317
LIG_LIR_Gen_1	272	282	PF02991	0.346
LIG_LIR_Nem_3	106	111	PF02991	0.307
LIG_LIR_Nem_3	113	118	PF02991	0.295
LIG_LIR_Nem_3	270	276	PF02991	0.389
LIG_Pex14_2	108	112	PF04695	0.294
LIG_Pex14_2	115	119	PF04695	0.301
LIG_Pex14_2	273	277	PF04695	0.324
LIG_Pex14_2	58	62	PF04695	0.334
LIG_SH2_STAT3	111	114	PF00017	0.267
LIG_SH2_STAT5	180	183	PF00017	0.341
LIG_SH3_1	155	161	PF00018	0.482
LIG_SH3_3	155	161	PF00018	0.370
LIG_SH3_3	50	56	PF00018	0.394
LIG_SUMO_SIM_anti_2	26	36	PF11976	0.501
LIG_SUMO_SIM_anti_2	39	45	PF11976	0.377
LIG_SUMO_SIM_par_1	234	241	PF11976	0.389
LIG_SUMO_SIM_par_1	26	36	PF11976	0.379
LIG_SUMO_SIM_par_1	39	45	PF11976	0.247
LIG_WW_3	11	15	PF00397	0.409
MOD_CDK_SPK_2	52	57	PF00069	0.174
MOD_CDK_SPxxK_3	259	266	PF00069	0.304
MOD_CK1_1	75	81	PF00069	0.298
MOD_GlcNHglycan	47	50	PF01048	0.184
MOD_GlcNHglycan	59	62	PF01048	0.364
MOD_GlcNHglycan	77	80	PF01048	0.299
MOD_GlcNHglycan	90	93	PF01048	0.279
MOD_GSK3_1	12	19	PF00069	0.635
MOD_GSK3_1	20	27	PF00069	0.496
MOD_N-GLC_1	101	106	PF02516	0.237
MOD_NEK2_1	118	123	PF00069	0.298
MOD_NEK2_1	197	202	PF00069	0.477
MOD_NEK2_1	4	9	PF00069	0.522
MOD_OFUCOSY	3	8	PF10250	0.452
MOD_PIKK_1	101	107	PF00454	0.336
MOD_PIKK_1	110	116	PF00454	0.276
MOD_PIKK_1	264	270	PF00454	0.313
MOD_PKA_2	4	10	PF00069	0.521
MOD_PKA_2	75	81	PF00069	0.179
MOD_PKB_1	14	22	PF00069	0.663
MOD_Plk_4	176	182	PF00069	0.348
MOD_Plk_4	269	275	PF00069	0.249
MOD_ProDKin_1	238	244	PF00069	0.369
MOD_ProDKin_1	259	265	PF00069	0.312
MOD_ProDKin_1	33	39	PF00069	0.349
MOD_ProDKin_1	52	58	PF00069	0.284
TRG_ENDOCYTIC_2	150	153	PF00928	0.359
TRG_ENDOCYTIC_2	245	248	PF00928	0.326
TRG_ENDOCYTIC_2	274	277	PF00928	0.288
TRG_ER_diArg_1	13	16	PF00400	0.566
TRG_NLS_MonoExtC_3	282	288	PF00514	0.174
TRG_NLS_MonoExtN_4	280	287	PF00514	0.174
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.202

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4C8	Leptomonas seymouri	33%	84%
A0A0N1PBS2	Leptomonas seymouri	67%	99%
A0A0N1PCQ9	Leptomonas seymouri	31%	100%
A0A0S4IKH3	Bodo saltans	35%	86%
A0A0S4JA19	Bodo saltans	47%	88%
A0A1X0NRI1	Trypanosomatidae	33%	80%
A0A3Q8IIZ5	Leishmania donovani	27%	100%
A0A3Q8IV04	Leishmania donovani	25%	100%
A0A3R7N7B2	Trypanosoma rangeli	25%	100%
A0A3S7X4R5	Leishmania donovani	36%	87%
A0A3S7X4T7	Leishmania donovani	35%	87%
A0A422N418	Trypanosoma rangeli	39%	86%
A0A422NUW6	Trypanosoma rangeli	47%	100%
A1KN36	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	26%	100%
A4HH09	Leishmania braziliensis	78%	100%
A4HJK3	Leishmania braziliensis	35%	86%
A4HJK8	Leishmania braziliensis	32%	100%
A4HJL5	Leishmania braziliensis	35%	86%
A4I438	Leishmania infantum	99%	100%
A4I4U5	Leishmania infantum	27%	100%
A4I708	Leishmania infantum	36%	87%
A4I738	Leishmania infantum	35%	85%
A4YI89	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	28%	100%
A5U753	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	26%	100%
A9JS71	Xenopus laevis	27%	100%
C9ZKS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	95%
C9ZLJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZWP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	83%
E9ADK3	Leishmania major	93%	100%
E9AE93	Leishmania major	27%	100%
E9AEL3	Leishmania major	24%	100%
E9AHU0	Leishmania infantum	25%	100%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AM78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B226	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	87%
E9B233	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	87%
E9B5S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
F1LU71	Rattus norvegicus	28%	94%
F4JML5	Arabidopsis thaliana	27%	98%
O04469	Arabidopsis thaliana	25%	100%
O23300	Arabidopsis thaliana	26%	100%
P14604	Rattus norvegicus	24%	100%
P23965	Rattus norvegicus	33%	100%
P30084	Homo sapiens	27%	100%
P34559	Caenorhabditis elegans	25%	100%
P42125	Mus musculus	34%	100%
P42126	Homo sapiens	33%	98%
P53526	Mycobacterium leprae (strain TN)	27%	100%
P9WNN2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WNN3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
P9WNN6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WNN7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
Q13825	Homo sapiens	29%	87%
Q2HJD5	Bos taurus	25%	97%
Q2TBT3	Bos taurus	27%	100%
Q3TLP5	Mus musculus	26%	100%
Q4Q628	Leishmania major	36%	85%
Q4Q636	Leishmania major	38%	78%
Q52995	Rhizobium meliloti (strain 1021)	26%	100%
Q54HG7	Dictyostelium discoideum	29%	98%
Q589W8	Alternaria alternata	25%	100%
Q58DM8	Bos taurus	24%	100%
Q5HQC3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	24%	100%
Q5R4W0	Pongo abelii	23%	98%
Q5R646	Pongo abelii	27%	100%
Q6AYG5	Rattus norvegicus	29%	99%
Q6NL24	Arabidopsis thaliana	26%	100%
Q7TXE1	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	100%
Q7U004	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	100%
Q86YB7	Homo sapiens	27%	100%
Q8BH95	Mus musculus	25%	100%
Q8CPQ4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
Q96VB3	Alternaria alternata	25%	100%
Q9D7J9	Mus musculus	29%	99%
Q9D9V3	Mus musculus	29%	92%
Q9JLZ3	Mus musculus	28%	94%
Q9P4U9	Alternaria alternata	26%	100%
Q9TM10	Cyanidium caldarium	23%	100%
V5B2L9	Trypanosoma cruzi	36%	76%
V5BK92	Trypanosoma cruzi	47%	100%
V5DTT7	Trypanosoma cruzi	27%	100%