Peptidyl-prolyl cis-trans isomerase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE70_LEIDO

TriTrypDb:

LdBPK_220410.1 , LdCL_220010400 , LDHU3_22.0720

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IE70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE70

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	10
GO:0003824	catalytic activity	1	10
GO:0016853	isomerase activity	2	10
GO:0016859	cis-trans isomerase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.369
CLV_NRD_NRD_1	148	150	PF00675	0.297
CLV_NRD_NRD_1	361	363	PF00675	0.409
CLV_NRD_NRD_1	418	420	PF00675	0.256
CLV_PCSK_FUR_1	416	420	PF00082	0.194
CLV_PCSK_KEX2_1	144	146	PF00082	0.265
CLV_PCSK_KEX2_1	180	182	PF00082	0.555
CLV_PCSK_KEX2_1	360	362	PF00082	0.376
CLV_PCSK_KEX2_1	394	396	PF00082	0.301
CLV_PCSK_KEX2_1	418	420	PF00082	0.256
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.253
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.555
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.301
CLV_PCSK_PC7_1	140	146	PF00082	0.388
CLV_PCSK_SKI1_1	353	357	PF00082	0.494
CLV_PCSK_SKI1_1	412	416	PF00082	0.196
DEG_APCC_DBOX_1	394	402	PF00400	0.306
DEG_SPOP_SBC_1	255	259	PF00917	0.527
DEG_SPOP_SBC_1	264	268	PF00917	0.539
DOC_CKS1_1	373	378	PF01111	0.345
DOC_MAPK_gen_1	149	156	PF00069	0.341
DOC_MAPK_gen_1	392	400	PF00069	0.304
DOC_MAPK_MEF2A_6	149	156	PF00069	0.334
DOC_MAPK_MEF2A_6	362	371	PF00069	0.407
DOC_MAPK_MEF2A_6	81	89	PF00069	0.382
DOC_PP4_FxxP_1	60	63	PF00568	0.338
DOC_USP7_MATH_1	14	18	PF00917	0.383
DOC_USP7_MATH_1	155	159	PF00917	0.297
DOC_USP7_MATH_1	255	259	PF00917	0.770
DOC_USP7_MATH_1	264	268	PF00917	0.722
DOC_USP7_MATH_1	272	276	PF00917	0.603
DOC_USP7_MATH_1	304	308	PF00917	0.647
DOC_USP7_MATH_1	36	40	PF00917	0.411
DOC_WW_Pin1_4	241	246	PF00397	0.740
DOC_WW_Pin1_4	296	301	PF00397	0.561
DOC_WW_Pin1_4	369	374	PF00397	0.475
LIG_Actin_WH2_2	403	420	PF00022	0.306
LIG_BIR_II_1	1	5	PF00653	0.484
LIG_BIR_III_4	294	298	PF00653	0.569
LIG_BRCT_BRCA1_1	69	73	PF00533	0.529
LIG_CSL_BTD_1	373	376	PF09270	0.337
LIG_eIF4E_1	312	318	PF01652	0.392
LIG_FHA_1	134	140	PF00498	0.354
LIG_FHA_1	166	172	PF00498	0.479
LIG_FHA_1	272	278	PF00498	0.615
LIG_FHA_1	46	52	PF00498	0.500
LIG_FHA_2	258	264	PF00498	0.780
LIG_FHA_2	373	379	PF00498	0.470
LIG_FHA_2	403	409	PF00498	0.266
LIG_Integrin_RGD_1	395	397	PF01839	0.306
LIG_LIR_Apic_2	58	63	PF02991	0.339
LIG_LIR_Gen_1	384	391	PF02991	0.345
LIG_LIR_Nem_3	311	315	PF02991	0.526
LIG_LYPXL_yS_3	84	87	PF13949	0.369
LIG_SH2_CRK	312	316	PF00017	0.404
LIG_SH2_SRC	312	315	PF00017	0.413
LIG_SH2_STAP1	169	173	PF00017	0.475
LIG_SH2_STAT5	105	108	PF00017	0.308
LIG_SH2_STAT5	354	357	PF00017	0.383
LIG_SH2_STAT5	386	389	PF00017	0.407
LIG_SH2_STAT5	95	98	PF00017	0.296
LIG_SH3_1	145	151	PF00018	0.306
LIG_SH3_1	361	367	PF00018	0.355
LIG_SH3_3	145	151	PF00018	0.306
LIG_SH3_3	26	32	PF00018	0.663
LIG_SH3_3	324	330	PF00018	0.412
LIG_SH3_3	361	367	PF00018	0.419
LIG_SH3_3	370	376	PF00018	0.333
LIG_SH3_3	419	425	PF00018	0.255
LIG_SH3_3	66	72	PF00018	0.396
LIG_SH3_3	79	85	PF00018	0.322
LIG_SH3_5	101	105	PF00018	0.256
LIG_SUMO_SIM_par_1	129	136	PF11976	0.297
LIG_SUMO_SIM_par_1	152	158	PF11976	0.388
LIG_TRAF2_1	375	378	PF00917	0.458
LIG_TYR_ITIM	82	87	PF00017	0.382
LIG_UBA3_1	317	325	PF00899	0.369
LIG_WRC_WIRS_1	1	6	PF05994	0.473
MOD_CK1_1	111	117	PF00069	0.282
MOD_CK1_1	165	171	PF00069	0.458
MOD_CK1_1	201	207	PF00069	0.730
MOD_CK1_1	235	241	PF00069	0.569
MOD_CK1_1	258	264	PF00069	0.523
MOD_CK1_1	372	378	PF00069	0.414
MOD_CK2_1	257	263	PF00069	0.638
MOD_CK2_1	296	302	PF00069	0.647
MOD_CK2_1	372	378	PF00069	0.358
MOD_Cter_Amidation	142	145	PF01082	0.332
MOD_GlcNHglycan	18	21	PF01048	0.490
MOD_GlcNHglycan	196	199	PF01048	0.602
MOD_GlcNHglycan	200	203	PF01048	0.564
MOD_GlcNHglycan	214	217	PF01048	0.474
MOD_GlcNHglycan	229	232	PF01048	0.505
MOD_GlcNHglycan	234	237	PF01048	0.683
MOD_GlcNHglycan	267	270	PF01048	0.643
MOD_GlcNHglycan	306	309	PF01048	0.682
MOD_GlcNHglycan	388	392	PF01048	0.306
MOD_GlcNHglycan	421	425	PF01048	0.442
MOD_GSK3_1	194	201	PF00069	0.679
MOD_GSK3_1	220	227	PF00069	0.581
MOD_GSK3_1	234	241	PF00069	0.525
MOD_GSK3_1	254	261	PF00069	0.774
MOD_GSK3_1	289	296	PF00069	0.637
MOD_NEK2_1	133	138	PF00069	0.258
MOD_NEK2_1	162	167	PF00069	0.342
MOD_PIKK_1	425	431	PF00454	0.388
MOD_PK_1	55	61	PF00069	0.393
MOD_PKA_2	255	261	PF00069	0.519
MOD_Plk_2-3	402	408	PF00069	0.266
MOD_Plk_4	155	161	PF00069	0.388
MOD_Plk_4	284	290	PF00069	0.694
MOD_Plk_4	55	61	PF00069	0.476
MOD_ProDKin_1	241	247	PF00069	0.735
MOD_ProDKin_1	296	302	PF00069	0.561
MOD_ProDKin_1	369	375	PF00069	0.476
TRG_DiLeu_BaEn_2	123	129	PF01217	0.297
TRG_ENDOCYTIC_2	312	315	PF00928	0.409
TRG_ENDOCYTIC_2	386	389	PF00928	0.407
TRG_ENDOCYTIC_2	84	87	PF00928	0.513
TRG_ENDOCYTIC_2	94	97	PF00928	0.416
TRG_ER_diArg_1	360	362	PF00400	0.504
TRG_ER_diArg_1	415	418	PF00400	0.300
TRG_NLS_MonoCore_2	391	396	PF00514	0.306
TRG_NLS_MonoExtC_3	391	397	PF00514	0.388
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSF6	Leptomonas seymouri	61%	100%
A0A0S4J8C1	Bodo saltans	35%	100%
A0A3R7K0E7	Trypanosoma rangeli	43%	100%
A4HC99	Leishmania braziliensis	78%	100%
C9ZRL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AVN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBU3	Leishmania major	93%	100%
V5BR42	Trypanosoma cruzi	42%	100%