Flagellar radial spoke protein-like, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar radial spoke protein-like, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE67_LEIDO

TriTrypDb:

LdCL_290011600 , LDHU3_29.0960

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0001534	radial spoke	2	12
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3Q8IE67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE67

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	12
GO:0006996	organelle organization	4	12
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	11
GO:0030031	cell projection assembly	5	11
GO:0044782	cilium organization	5	11
GO:0060271	cilium assembly	6	11
GO:0060294	cilium movement involved in cell motility	5	12
GO:0070925	organelle assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	11
GO:0120036	plasma membrane bounded cell projection organization	5	11
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0001578	microtubule bundle formation	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0035082	axoneme assembly	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.436
CLV_NRD_NRD_1	220	222	PF00675	0.264
CLV_NRD_NRD_1	223	225	PF00675	0.265
CLV_NRD_NRD_1	35	37	PF00675	0.594
CLV_NRD_NRD_1	365	367	PF00675	0.318
CLV_NRD_NRD_1	607	609	PF00675	0.250
CLV_NRD_NRD_1	81	83	PF00675	0.480
CLV_PCSK_FUR_1	221	225	PF00082	0.310
CLV_PCSK_KEX2_1	220	222	PF00082	0.264
CLV_PCSK_KEX2_1	223	225	PF00082	0.265
CLV_PCSK_KEX2_1	365	367	PF00082	0.320
CLV_PCSK_KEX2_1	37	39	PF00082	0.475
CLV_PCSK_KEX2_1	80	82	PF00082	0.481
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.475
CLV_PCSK_SKI1_1	20	24	PF00082	0.690
DEG_APCC_DBOX_1	35	43	PF00400	0.638
DEG_COP1_1	458	468	PF00400	0.554
DEG_Nend_Nbox_1	1	3	PF02207	0.387
DEG_SCF_FBW7_1	42	48	PF00400	0.463
DOC_ANK_TNKS_1	701	708	PF00023	0.661
DOC_CDC14_PxL_1	487	495	PF14671	0.462
DOC_CKS1_1	32	37	PF01111	0.458
DOC_CKS1_1	42	47	PF01111	0.462
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	588	594	PF00134	0.554
DOC_MAPK_gen_1	13	21	PF00069	0.389
DOC_MAPK_MEF2A_6	13	21	PF00069	0.389
DOC_MAPK_MEF2A_6	95	104	PF00069	0.413
DOC_PP1_RVXF_1	622	629	PF00149	0.537
DOC_PP2B_LxvP_1	2	5	PF13499	0.378
DOC_PP2B_LxvP_1	213	216	PF13499	0.450
DOC_PP2B_LxvP_1	272	275	PF13499	0.537
DOC_PP2B_LxvP_1	422	425	PF13499	0.500
DOC_PP2B_LxvP_1	588	591	PF13499	0.554
DOC_PP2B_LxvP_1	667	670	PF13499	0.537
DOC_PP2B_LxvP_1	69	72	PF13499	0.414
DOC_SPAK_OSR1_1	95	99	PF12202	0.423
DOC_USP7_MATH_1	196	200	PF00917	0.514
DOC_USP7_MATH_1	368	372	PF00917	0.531
DOC_USP7_MATH_1	388	392	PF00917	0.320
DOC_USP7_MATH_1	565	569	PF00917	0.554
DOC_USP7_MATH_1	595	599	PF00917	0.496
DOC_USP7_MATH_1	642	646	PF00917	0.511
DOC_USP7_UBL2_3	515	519	PF12436	0.492
DOC_WW_Pin1_4	26	31	PF00397	0.689
DOC_WW_Pin1_4	401	406	PF00397	0.464
DOC_WW_Pin1_4	41	46	PF00397	0.654
DOC_WW_Pin1_4	568	573	PF00397	0.538
DOC_WW_Pin1_4	89	94	PF00397	0.584
LIG_14-3-3_CanoR_1	136	144	PF00244	0.554
LIG_14-3-3_CanoR_1	20	30	PF00244	0.443
LIG_14-3-3_CanoR_1	41	45	PF00244	0.467
LIG_14-3-3_CanoR_1	446	455	PF00244	0.443
LIG_14-3-3_CanoR_1	540	545	PF00244	0.500
LIG_14-3-3_CanoR_1	57	62	PF00244	0.412
LIG_14-3-3_CanoR_1	641	647	PF00244	0.499
LIG_APCC_ABBAyCdc20_2	180	186	PF00400	0.532
LIG_BIR_III_4	161	165	PF00653	0.492
LIG_eIF4E_1	517	523	PF01652	0.450
LIG_EVH1_2	668	672	PF00568	0.414
LIG_FHA_1	143	149	PF00498	0.497
LIG_FHA_1	27	33	PF00498	0.442
LIG_FHA_1	417	423	PF00498	0.403
LIG_FHA_1	541	547	PF00498	0.550
LIG_FHA_1	631	637	PF00498	0.460
LIG_FHA_2	388	394	PF00498	0.516
LIG_FHA_2	516	522	PF00498	0.492
LIG_FHA_2	687	693	PF00498	0.461
LIG_LIR_Apic_2	693	699	PF02991	0.546
LIG_LIR_Gen_1	395	405	PF02991	0.462
LIG_LIR_Gen_1	645	651	PF02991	0.477
LIG_LIR_Nem_3	278	283	PF02991	0.484
LIG_LIR_Nem_3	297	303	PF02991	0.441
LIG_LIR_Nem_3	307	312	PF02991	0.421
LIG_LIR_Nem_3	395	400	PF02991	0.491
LIG_LIR_Nem_3	91	97	PF02991	0.588
LIG_MYND_1	491	495	PF01753	0.462
LIG_MYND_1	665	669	PF01753	0.431
LIG_NRBOX	7	13	PF00104	0.388
LIG_PDZ_Class_3	710	715	PF00595	0.726
LIG_Pex14_1	513	517	PF04695	0.450
LIG_PTAP_UEV_1	369	374	PF05743	0.492
LIG_RPA_C_Fungi	441	453	PF08784	0.423
LIG_SH2_CRK	280	284	PF00017	0.423
LIG_SH2_CRK	487	491	PF00017	0.318
LIG_SH2_CRK	663	667	PF00017	0.423
LIG_SH2_CRK	696	700	PF00017	0.554
LIG_SH2_GRB2like	266	269	PF00017	0.448
LIG_SH2_NCK_1	63	67	PF00017	0.452
LIG_SH2_NCK_1	696	700	PF00017	0.554
LIG_SH2_PTP2	97	100	PF00017	0.413
LIG_SH2_SRC	184	187	PF00017	0.337
LIG_SH2_SRC	663	666	PF00017	0.423
LIG_SH2_SRC	675	678	PF00017	0.448
LIG_SH2_SRC	696	699	PF00017	0.571
LIG_SH2_STAP1	309	313	PF00017	0.339
LIG_SH2_STAT5	266	269	PF00017	0.423
LIG_SH2_STAT5	312	315	PF00017	0.303
LIG_SH2_STAT5	439	442	PF00017	0.303
LIG_SH2_STAT5	517	520	PF00017	0.360
LIG_SH2_STAT5	621	624	PF00017	0.303
LIG_SH2_STAT5	63	66	PF00017	0.453
LIG_SH2_STAT5	675	678	PF00017	0.448
LIG_SH2_STAT5	74	77	PF00017	0.426
LIG_SH2_STAT5	97	100	PF00017	0.413
LIG_SH3_1	662	668	PF00018	0.423
LIG_SH3_1	695	701	PF00018	0.663
LIG_SH3_2	215	220	PF14604	0.303
LIG_SH3_3	212	218	PF00018	0.301
LIG_SH3_3	29	35	PF00018	0.439
LIG_SH3_3	367	373	PF00018	0.448
LIG_SH3_3	486	492	PF00018	0.311
LIG_SH3_3	570	576	PF00018	0.404
LIG_SH3_3	662	668	PF00018	0.305
LIG_SH3_3	673	679	PF00018	0.350
LIG_SH3_3	695	701	PF00018	0.544
LIG_TRAF2_1	373	376	PF00917	0.423
LIG_TRAF2_1	499	502	PF00917	0.317
LIG_TRAF2_1	545	548	PF00917	0.390
LIG_WRC_WIRS_1	197	202	PF05994	0.448
LIG_WRC_WIRS_1	456	461	PF05994	0.448
LIG_WW_2	665	668	PF00397	0.423
LIG_WW_3	214	218	PF00397	0.393
LIG_WW_3	699	703	PF00397	0.691
MOD_CDC14_SPxK_1	92	95	PF00782	0.413
MOD_CDK_SPK_2	31	36	PF00069	0.450
MOD_CDK_SPxK_1	31	37	PF00069	0.454
MOD_CDK_SPxK_1	89	95	PF00069	0.422
MOD_CDK_SPxxK_3	31	38	PF00069	0.457
MOD_CK1_1	568	574	PF00069	0.459
MOD_CK1_1	584	590	PF00069	0.267
MOD_CK1_1	67	73	PF00069	0.457
MOD_CK2_1	21	27	PF00069	0.620
MOD_CK2_1	515	521	PF00069	0.448
MOD_CK2_1	686	692	PF00069	0.422
MOD_GlcNHglycan	116	119	PF01048	0.415
MOD_GlcNHglycan	137	140	PF01048	0.448
MOD_GlcNHglycan	171	174	PF01048	0.399
MOD_GlcNHglycan	233	239	PF01048	0.399
MOD_GlcNHglycan	306	309	PF01048	0.317
MOD_GlcNHglycan	370	373	PF01048	0.362
MOD_GlcNHglycan	390	393	PF01048	0.286
MOD_GlcNHglycan	448	451	PF01048	0.423
MOD_GlcNHglycan	472	478	PF01048	0.360
MOD_GlcNHglycan	64	67	PF01048	0.581
MOD_GSK3_1	103	110	PF00069	0.343
MOD_GSK3_1	196	203	PF00069	0.388
MOD_GSK3_1	255	262	PF00069	0.385
MOD_GSK3_1	289	296	PF00069	0.458
MOD_GSK3_1	388	395	PF00069	0.284
MOD_GSK3_1	41	48	PF00069	0.466
MOD_GSK3_1	51	58	PF00069	0.440
MOD_GSK3_1	630	637	PF00069	0.382
MOD_GSK3_1	84	91	PF00069	0.454
MOD_LATS_1	55	61	PF00433	0.470
MOD_N-GLC_1	565	570	PF02516	0.360
MOD_NEK2_1	107	112	PF00069	0.417
MOD_NEK2_1	171	176	PF00069	0.396
MOD_NEK2_1	200	205	PF00069	0.448
MOD_NEK2_1	21	26	PF00069	0.444
MOD_NEK2_1	61	66	PF00069	0.455
MOD_NEK2_1	83	88	PF00069	0.437
MOD_NEK2_2	294	299	PF00069	0.388
MOD_NEK2_2	603	608	PF00069	0.283
MOD_PIKK_1	109	115	PF00454	0.422
MOD_PIKK_1	142	148	PF00454	0.410
MOD_PIKK_1	346	352	PF00454	0.409
MOD_PKA_2	135	141	PF00069	0.448
MOD_PKA_2	187	193	PF00069	0.412
MOD_PKA_2	368	374	PF00069	0.423
MOD_PKA_2	40	46	PF00069	0.467
MOD_PKA_2	416	422	PF00069	0.412
MOD_PKA_2	445	451	PF00069	0.306
MOD_PKA_2	539	545	PF00069	0.388
MOD_Plk_1	51	57	PF00069	0.649
MOD_Plk_1	584	590	PF00069	0.448
MOD_Plk_1	686	692	PF00069	0.388
MOD_Plk_4	103	109	PF00069	0.627
MOD_Plk_4	531	537	PF00069	0.308
MOD_Plk_4	64	70	PF00069	0.451
MOD_ProDKin_1	26	32	PF00069	0.692
MOD_ProDKin_1	401	407	PF00069	0.322
MOD_ProDKin_1	41	47	PF00069	0.654
MOD_ProDKin_1	568	574	PF00069	0.425
MOD_ProDKin_1	89	95	PF00069	0.585
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.386
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.380
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.388
TRG_ENDOCYTIC_2	266	269	PF00928	0.455
TRG_ENDOCYTIC_2	280	283	PF00928	0.352
TRG_ENDOCYTIC_2	487	490	PF00928	0.303
TRG_ENDOCYTIC_2	646	649	PF00928	0.359
TRG_ENDOCYTIC_2	97	100	PF00928	0.413
TRG_ER_diArg_1	12	15	PF00400	0.683
TRG_ER_diArg_1	219	221	PF00400	0.324
TRG_ER_diArg_1	222	224	PF00400	0.325
TRG_ER_diArg_1	35	38	PF00400	0.628
TRG_ER_diArg_1	365	367	PF00400	0.393
TRG_ER_diArg_1	414	417	PF00400	0.337
TRG_ER_diArg_1	80	82	PF00400	0.481
TRG_NLS_MonoExtN_4	35	40	PF00514	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q1	Leptomonas seymouri	70%	100%
A0A0S4JES8	Bodo saltans	40%	100%
A0A1X0P128	Trypanosomatidae	47%	100%
A0A3R7KK84	Trypanosoma rangeli	47%	100%
A4H732	Leishmania braziliensis	24%	100%
A4HH73	Leishmania braziliensis	83%	100%
A4I4B9	Leishmania infantum	99%	100%
C9ZL49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ADR8	Leishmania major	95%	100%
E9AM12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QGB1	Leishmania major	24%	100%
Q8BYM7	Mus musculus	25%	100%
V5B4W9	Trypanosoma cruzi	46%	100%