Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IE62_LEIDO

TriTrypDb:

LdBPK_283100.1 , LdCL_280036300 , LDHU3_28.4110

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE62

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.595
CLV_NRD_NRD_1	121	123	PF00675	0.667
CLV_NRD_NRD_1	124	126	PF00675	0.629
CLV_NRD_NRD_1	21	23	PF00675	0.504
CLV_NRD_NRD_1	73	75	PF00675	0.593
CLV_NRD_NRD_1	86	88	PF00675	0.489
CLV_PCSK_KEX2_1	121	123	PF00082	0.667
CLV_PCSK_KEX2_1	21	23	PF00082	0.504
CLV_PCSK_KEX2_1	73	75	PF00082	0.593
CLV_PCSK_KEX2_1	86	88	PF00082	0.489
CLV_PCSK_SKI1_1	207	211	PF00082	0.441
CLV_PCSK_SKI1_1	224	228	PF00082	0.489
CLV_PCSK_SKI1_1	73	77	PF00082	0.588
DEG_APCC_DBOX_1	73	81	PF00400	0.602
DEG_SPOP_SBC_1	159	163	PF00917	0.590
DOC_CYCLIN_RxL_1	71	81	PF00134	0.454
DOC_MAPK_gen_1	21	29	PF00069	0.496
DOC_MAPK_gen_1	86	94	PF00069	0.540
DOC_PP1_RVXF_1	237	244	PF00149	0.480
DOC_USP7_MATH_1	159	163	PF00917	0.603
DOC_USP7_MATH_1	197	201	PF00917	0.595
DOC_USP7_MATH_1	45	49	PF00917	0.505
DOC_USP7_MATH_1	66	70	PF00917	0.508
DOC_WW_Pin1_4	154	159	PF00397	0.594
DOC_WW_Pin1_4	161	166	PF00397	0.600
LIG_14-3-3_CanoR_1	24	28	PF00244	0.620
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_BRCT_BRCA1_1	199	203	PF00533	0.473
LIG_Clathr_ClatBox_1	146	150	PF01394	0.529
LIG_FHA_1	105	111	PF00498	0.563
LIG_FHA_1	180	186	PF00498	0.624
LIG_FHA_1	24	30	PF00498	0.643
LIG_FHA_2	94	100	PF00498	0.630
LIG_LIR_Nem_3	200	206	PF02991	0.522
LIG_LIR_Nem_3	99	105	PF02991	0.614
LIG_REV1ctd_RIR_1	201	211	PF16727	0.494
LIG_SH2_NCK_1	194	198	PF00017	0.454
LIG_SH2_SRC	194	197	PF00017	0.448
LIG_SH3_2	120	125	PF14604	0.590
LIG_SH3_2	17	22	PF14604	0.525
LIG_SH3_3	117	123	PF00018	0.692
LIG_SH3_3	14	20	PF00018	0.532
LIG_SUMO_SIM_anti_2	142	148	PF11976	0.504
LIG_SUMO_SIM_anti_2	95	102	PF11976	0.558
LIG_SUMO_SIM_par_1	25	31	PF11976	0.523
LIG_TYR_ITIM	100	105	PF00017	0.537
MOD_CK1_1	154	160	PF00069	0.585
MOD_CK1_1	163	169	PF00069	0.606
MOD_CK1_1	213	219	PF00069	0.481
MOD_CK1_1	93	99	PF00069	0.631
MOD_CK2_1	173	179	PF00069	0.560
MOD_CK2_1	45	51	PF00069	0.532
MOD_GlcNHglycan	153	156	PF01048	0.609
MOD_GlcNHglycan	212	215	PF01048	0.458
MOD_GlcNHglycan	47	50	PF01048	0.569
MOD_GlcNHglycan	68	71	PF01048	0.661
MOD_GSK3_1	150	157	PF00069	0.610
MOD_GSK3_1	159	166	PF00069	0.528
MOD_GSK3_1	169	176	PF00069	0.581
MOD_GSK3_1	45	52	PF00069	0.537
MOD_GSK3_1	88	95	PF00069	0.603
MOD_N-GLC_1	59	64	PF02516	0.572
MOD_NEK2_1	140	145	PF00069	0.474
MOD_NEK2_1	151	156	PF00069	0.575
MOD_NEK2_1	88	93	PF00069	0.705
MOD_PIKK_1	169	175	PF00454	0.629
MOD_PIKK_1	186	192	PF00454	0.314
MOD_PKA_2	220	226	PF00069	0.588
MOD_PKA_2	23	29	PF00069	0.633
MOD_Plk_2-3	53	59	PF00069	0.607
MOD_Plk_4	140	146	PF00069	0.482
MOD_Plk_4	163	169	PF00069	0.588
MOD_Plk_4	173	179	PF00069	0.443
MOD_Plk_4	189	195	PF00069	0.458
MOD_Plk_4	23	29	PF00069	0.577
MOD_ProDKin_1	154	160	PF00069	0.596
MOD_ProDKin_1	161	167	PF00069	0.597
MOD_SUMO_for_1	217	220	PF00179	0.546
TRG_DiLeu_BaEn_1	142	147	PF01217	0.504
TRG_ENDOCYTIC_2	102	105	PF00928	0.634
TRG_ER_diArg_1	120	122	PF00400	0.668
TRG_ER_diArg_1	20	22	PF00400	0.504
TRG_ER_diArg_1	72	74	PF00400	0.605
TRG_ER_diArg_1	86	88	PF00400	0.482
TRG_NES_CRM1_1	136	150	PF08389	0.489
TRG_NLS_MonoExtN_4	122	129	PF00514	0.597
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6I3	Leptomonas seymouri	50%	95%
A4HGZ0	Leishmania braziliensis	82%	100%
A4I422	Leishmania infantum	99%	100%
E9B0A9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q7X5	Leishmania major	93%	100%