LeishMANIAdb
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Nitronate monooxygenase family protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nitronate monooxygenase family protein
Gene product:
enoyl-[acyl-carrier-protein] reductase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IE60_LEIDO
TriTrypDb:
LdBPK_340630.1 , LdCL_340011900 , LDHU3_34.1040
Length:
317

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, enoyl-[acyl-carrier-] reductase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 8
GO:0110165 cellular anatomical entity 1 8

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IE60
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE60

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0004497 monooxygenase activity 3 8
GO:0016491 oxidoreductase activity 2 8
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3 8
GO:0016703 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) 4 8
GO:0018580 nitronate monooxygenase activity 5 8
GO:0051213 dioxygenase activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 159 161 PF00675 0.341
CLV_NRD_NRD_1 244 246 PF00675 0.260
CLV_NRD_NRD_1 57 59 PF00675 0.341
CLV_PCSK_KEX2_1 212 214 PF00082 0.251
CLV_PCSK_KEX2_1 244 246 PF00082 0.292
CLV_PCSK_KEX2_1 57 59 PF00082 0.341
CLV_PCSK_PC1ET2_1 212 214 PF00082 0.251
CLV_PCSK_SKI1_1 121 125 PF00082 0.260
CLV_PCSK_SKI1_1 160 164 PF00082 0.269
CLV_PCSK_SKI1_1 233 237 PF00082 0.260
CLV_PCSK_SKI1_1 267 271 PF00082 0.296
CLV_PCSK_SKI1_1 300 304 PF00082 0.251
DEG_Nend_UBRbox_3 1 3 PF02207 0.432
DOC_MAPK_gen_1 64 71 PF00069 0.341
DOC_MAPK_MEF2A_6 160 169 PF00069 0.260
DOC_MAPK_MEF2A_6 64 73 PF00069 0.264
DOC_SPAK_OSR1_1 197 201 PF12202 0.341
DOC_USP7_UBL2_3 121 125 PF12436 0.260
DOC_USP7_UBL2_3 253 257 PF12436 0.298
DOC_USP7_UBL2_3 262 266 PF12436 0.267
DOC_USP7_UBL2_3 60 64 PF12436 0.264
DOC_WW_Pin1_4 95 100 PF00397 0.260
LIG_14-3-3_CanoR_1 5 10 PF00244 0.296
LIG_BRCT_BRCA1_1 45 49 PF00533 0.246
LIG_CaM_IQ_9 189 204 PF13499 0.260
LIG_FHA_1 101 107 PF00498 0.276
LIG_FHA_1 150 156 PF00498 0.260
LIG_FHA_2 273 279 PF00498 0.301
LIG_FHA_2 291 297 PF00498 0.189
LIG_LIR_Gen_1 221 231 PF02991 0.289
LIG_LIR_Gen_1 46 56 PF02991 0.246
LIG_LIR_Nem_3 221 226 PF02991 0.289
LIG_LIR_Nem_3 46 52 PF02991 0.246
LIG_LYPXL_yS_3 14 17 PF13949 0.260
LIG_SH2_STAT5 223 226 PF00017 0.274
LIG_SH3_3 162 168 PF00018 0.256
LIG_SH3_3 66 72 PF00018 0.230
LIG_SH3_3 9 15 PF00018 0.400
LIG_TRAF2_1 206 209 PF00917 0.251
LIG_TYR_ITIM 12 17 PF00017 0.260
MOD_CDK_SPK_2 95 100 PF00069 0.260
MOD_CK1_1 249 255 PF00069 0.290
MOD_CK1_1 31 37 PF00069 0.260
MOD_CK1_1 95 101 PF00069 0.260
MOD_CK2_1 202 208 PF00069 0.260
MOD_CK2_1 272 278 PF00069 0.412
MOD_CK2_1 290 296 PF00069 0.194
MOD_GlcNHglycan 176 179 PF01048 0.273
MOD_GlcNHglycan 203 207 PF01048 0.261
MOD_GlcNHglycan 24 27 PF01048 0.389
MOD_GlcNHglycan 248 251 PF01048 0.292
MOD_GlcNHglycan 285 288 PF01048 0.230
MOD_GlcNHglycan 30 33 PF01048 0.287
MOD_GlcNHglycan 94 97 PF01048 0.260
MOD_GSK3_1 198 205 PF00069 0.260
MOD_GSK3_1 91 98 PF00069 0.275
MOD_NEK2_1 246 251 PF00069 0.262
MOD_PIKK_1 100 106 PF00454 0.260
MOD_PIKK_1 198 204 PF00454 0.341
MOD_PKA_1 212 218 PF00069 0.319
MOD_PKA_1 244 250 PF00069 0.341
MOD_PKA_2 212 218 PF00069 0.319
MOD_PKA_2 244 250 PF00069 0.341
MOD_PKA_2 4 10 PF00069 0.219
MOD_Plk_1 148 154 PF00069 0.260
MOD_Plk_4 219 225 PF00069 0.260
MOD_Plk_4 5 11 PF00069 0.274
MOD_ProDKin_1 95 101 PF00069 0.260
MOD_SUMO_for_1 124 127 PF00179 0.260
MOD_SUMO_rev_2 82 90 PF00179 0.260
TRG_DiLeu_BaEn_3 86 92 PF01217 0.341
TRG_DiLeu_BaLyEn_6 165 170 PF01217 0.260
TRG_ENDOCYTIC_2 14 17 PF00928 0.260
TRG_ENDOCYTIC_2 223 226 PF00928 0.274
TRG_ENDOCYTIC_2 80 83 PF00928 0.274
TRG_ER_diArg_1 244 246 PF00400 0.260
TRG_ER_diArg_1 305 308 PF00400 0.399
TRG_ER_diArg_1 56 58 PF00400 0.341
TRG_Pf-PMV_PEXEL_1 244 248 PF00026 0.239

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKE9 Leptomonas seymouri 81% 100%
A4HAH1 Leishmania braziliensis 86% 100%
A4HBY5 Leishmania braziliensis 86% 100%
A4I9N1 Leishmania infantum 100% 100%
A5IR97 Staphylococcus aureus (strain JH9) 32% 89%
A6QFD2 Staphylococcus aureus (strain Newman) 31% 89%
A6U025 Staphylococcus aureus (strain JH1) 32% 89%
A8Z1H7 Staphylococcus aureus (strain USA300 / TCH1516) 31% 89%
B2TEK6 Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) 33% 87%
D0V3Y4 Pseudomonas sp. 33% 91%
E9B4N0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O05413 Bacillus subtilis (strain 168) 31% 91%
O06179 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 30% 85%
P71847 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 30% 89%
Q01284 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 26% 84%
Q0S7Q1 Rhodococcus jostii (strain RHA1) 30% 90%
Q2FIF3 Staphylococcus aureus (strain USA300) 31% 89%
Q2FZX9 Staphylococcus aureus (strain NCTC 8325 / PS 47) 31% 89%
Q49W60 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 34% 89%
Q4L4T4 Staphylococcus haemolyticus (strain JCSC1435) 31% 89%
Q4Q3E6 Leishmania major 97% 100%
Q5HHG4 Staphylococcus aureus (strain COL) 31% 89%
Q6GB05 Staphylococcus aureus (strain MSSA476) 32% 89%
Q6GIG7 Staphylococcus aureus (strain MRSA252) 32% 89%
Q8NXG7 Staphylococcus aureus (strain MW2) 31% 89%
Q99VF6 Staphylococcus aureus (strain N315) 32% 89%
Q9HWH9 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 32% 90%
Q9I4V0 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 34% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS