Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IE58_LEIDO

TriTrypDb:

LdBPK_220230.1 , LdCL_220008400 , LDHU3_22.0500

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE58

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.573
CLV_NRD_NRD_1	87	89	PF00675	0.620
CLV_NRD_NRD_1	95	97	PF00675	0.521
CLV_PCSK_KEX2_1	87	89	PF00082	0.620
CLV_PCSK_KEX2_1	94	96	PF00082	0.539
CLV_PCSK_SKI1_1	131	135	PF00082	0.595
CLV_PCSK_SKI1_1	137	141	PF00082	0.587
CLV_PCSK_SKI1_1	235	239	PF00082	0.644
DEG_APCC_DBOX_1	93	101	PF00400	0.593
DEG_Nend_UBRbox_2	1	3	PF02207	0.612
DOC_MAPK_gen_1	64	72	PF00069	0.573
DOC_MAPK_MEF2A_6	175	183	PF00069	0.413
DOC_MAPK_MEF2A_6	66	74	PF00069	0.573
DOC_PP1_RVXF_1	233	240	PF00149	0.566
DOC_WW_Pin1_4	146	151	PF00397	0.530
LIG_14-3-3_CanoR_1	110	115	PF00244	0.509
LIG_14-3-3_CanoR_1	171	179	PF00244	0.527
LIG_14-3-3_CanoR_1	94	104	PF00244	0.594
LIG_BIR_III_2	14	18	PF00653	0.516
LIG_BRCT_BRCA1_1	213	217	PF00533	0.498
LIG_BRCT_BRCA1_1	235	239	PF00533	0.568
LIG_FHA_1	190	196	PF00498	0.565
LIG_FHA_1	99	105	PF00498	0.545
LIG_FHA_2	114	120	PF00498	0.643
LIG_FHA_2	228	234	PF00498	0.603
LIG_LIR_Nem_3	156	160	PF02991	0.533
LIG_PAM2_1	148	160	PF00658	0.509
LIG_SH2_CRK	160	164	PF00017	0.576
LIG_SH2_CRK	67	71	PF00017	0.490
LIG_SH2_STAP1	191	195	PF00017	0.615
LIG_SH2_STAT3	60	63	PF00017	0.527
LIG_SH2_STAT5	160	163	PF00017	0.508
LIG_SH2_STAT5	191	194	PF00017	0.643
LIG_SH2_STAT5	60	63	PF00017	0.527
LIG_WRC_WIRS_1	20	25	PF05994	0.607
MOD_CK1_1	113	119	PF00069	0.523
MOD_CK1_1	145	151	PF00069	0.557
MOD_CK1_1	207	213	PF00069	0.594
MOD_CK1_1	3	9	PF00069	0.651
MOD_CK1_1	98	104	PF00069	0.541
MOD_CK2_1	113	119	PF00069	0.637
MOD_GlcNHglycan	2	5	PF01048	0.648
MOD_GSK3_1	131	138	PF00069	0.636
MOD_GSK3_1	140	147	PF00069	0.579
MOD_GSK3_1	207	214	PF00069	0.512
MOD_GSK3_1	76	83	PF00069	0.586
MOD_NEK2_1	142	147	PF00069	0.556
MOD_NEK2_1	159	164	PF00069	0.568
MOD_PIKK_1	113	119	PF00454	0.637
MOD_PIKK_1	76	82	PF00454	0.584
MOD_PKA_1	95	101	PF00069	0.573
MOD_PKA_2	170	176	PF00069	0.626
MOD_PKA_2	95	101	PF00069	0.573
MOD_Plk_4	19	25	PF00069	0.609
MOD_Plk_4	207	213	PF00069	0.552
MOD_Plk_4	56	62	PF00069	0.532
MOD_ProDKin_1	146	152	PF00069	0.524
TRG_DiLeu_BaEn_3	18	24	PF01217	0.566
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.521
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.548
TRG_ENDOCYTIC_2	160	163	PF00928	0.577
TRG_ENDOCYTIC_2	67	70	PF00928	0.490
TRG_ER_diArg_1	94	96	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HC84	Leishmania braziliensis	59%	95%
A4HZR3	Leishmania infantum	98%	100%
E9AVL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QBW0	Leishmania major	86%	100%