Cupin-like_domain/JmjC_domain_hydroxylase_putativ e/Pfam:PF13621/Pfam:PF02373

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cupin-like domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE56_LEIDO

TriTrypDb:

LdBPK_271240.1 , LdCL_270018900 , LDHU3_27.1920

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IE56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE56

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018195	peptidyl-arginine modification	6	1
GO:0018216	peptidyl-arginine methylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034969	histone arginine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0043985	histone H4-R3 methylation	7	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000976	transcription cis-regulatory region binding	5	1
GO:0000987	cis-regulatory region sequence-specific DNA binding	6	1
GO:0001067	transcription regulatory region nucleic acid binding	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.710
CLV_C14_Caspase3-7	312	316	PF00656	0.337
CLV_C14_Caspase3-7	362	366	PF00656	0.393
CLV_NRD_NRD_1	169	171	PF00675	0.626
CLV_NRD_NRD_1	224	226	PF00675	0.692
CLV_NRD_NRD_1	388	390	PF00675	0.322
CLV_NRD_NRD_1	422	424	PF00675	0.281
CLV_NRD_NRD_1	543	545	PF00675	0.413
CLV_NRD_NRD_1	581	583	PF00675	0.506
CLV_PCSK_FUR_1	578	582	PF00082	0.531
CLV_PCSK_KEX2_1	136	138	PF00082	0.627
CLV_PCSK_KEX2_1	143	145	PF00082	0.635
CLV_PCSK_KEX2_1	168	170	PF00082	0.549
CLV_PCSK_KEX2_1	20	22	PF00082	0.586
CLV_PCSK_KEX2_1	226	228	PF00082	0.712
CLV_PCSK_KEX2_1	388	390	PF00082	0.307
CLV_PCSK_KEX2_1	424	426	PF00082	0.266
CLV_PCSK_KEX2_1	543	545	PF00082	0.411
CLV_PCSK_KEX2_1	580	582	PF00082	0.507
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.634
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.659
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.684
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.683
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.266
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.542
CLV_PCSK_SKI1_1	169	173	PF00082	0.467
CLV_PCSK_SKI1_1	425	429	PF00082	0.266
CLV_PCSK_SKI1_1	514	518	PF00082	0.381
CLV_PCSK_SKI1_1	520	524	PF00082	0.444
DEG_APCC_DBOX_1	508	516	PF00400	0.400
DEG_Nend_UBRbox_3	1	3	PF02207	0.620
DEG_SPOP_SBC_1	236	240	PF00917	0.619
DOC_CDC14_PxL_1	60	68	PF14671	0.588
DOC_CKS1_1	447	452	PF01111	0.281
DOC_MAPK_gen_1	280	290	PF00069	0.289
DOC_MAPK_gen_1	423	429	PF00069	0.281
DOC_MAPK_gen_1	578	588	PF00069	0.487
DOC_MAPK_MEF2A_6	280	288	PF00069	0.314
DOC_MIT_MIM_1	300	310	PF04212	0.360
DOC_PP1_RVXF_1	423	430	PF00149	0.281
DOC_PP1_RVXF_1	512	519	PF00149	0.380
DOC_PP2B_LxvP_1	428	431	PF13499	0.266
DOC_PP2B_LxvP_1	61	64	PF13499	0.593
DOC_PP4_FxxP_1	281	284	PF00568	0.300
DOC_USP7_MATH_1	124	128	PF00917	0.746
DOC_USP7_MATH_1	201	205	PF00917	0.624
DOC_USP7_MATH_1	235	239	PF00917	0.692
DOC_USP7_MATH_1	399	403	PF00917	0.411
DOC_USP7_MATH_2	265	271	PF00917	0.505
DOC_USP7_UBL2_3	135	139	PF12436	0.728
DOC_WW_Pin1_4	116	121	PF00397	0.718
DOC_WW_Pin1_4	129	134	PF00397	0.643
DOC_WW_Pin1_4	145	150	PF00397	0.530
DOC_WW_Pin1_4	160	165	PF00397	0.581
DOC_WW_Pin1_4	199	204	PF00397	0.637
DOC_WW_Pin1_4	253	258	PF00397	0.608
DOC_WW_Pin1_4	323	328	PF00397	0.408
DOC_WW_Pin1_4	431	436	PF00397	0.325
DOC_WW_Pin1_4	446	451	PF00397	0.281
DOC_WW_Pin1_4	91	96	PF00397	0.502
LIG_14-3-3_CanoR_1	271	275	PF00244	0.484
LIG_14-3-3_CanoR_1	401	407	PF00244	0.281
LIG_14-3-3_CanoR_1	585	589	PF00244	0.590
LIG_14-3-3_CanoR_1	68	78	PF00244	0.444
LIG_AP2alpha_1	277	281	PF02296	0.393
LIG_BRCT_BRCA1_1	155	159	PF00533	0.633
LIG_BRCT_BRCA1_1	21	25	PF00533	0.580
LIG_BRCT_BRCA1_1	592	596	PF00533	0.512
LIG_CtBP_PxDLS_1	450	454	PF00389	0.281
LIG_deltaCOP1_diTrp_1	296	300	PF00928	0.360
LIG_FHA_1	240	246	PF00498	0.600
LIG_FHA_1	28	34	PF00498	0.587
LIG_FHA_1	323	329	PF00498	0.333
LIG_FHA_1	452	458	PF00498	0.285
LIG_FHA_2	331	337	PF00498	0.268
LIG_FHA_2	36	42	PF00498	0.645
LIG_FHA_2	533	539	PF00498	0.652
LIG_FHA_2	585	591	PF00498	0.515
LIG_LIR_Apic_2	279	284	PF02991	0.325
LIG_LIR_Apic_2	3	7	PF02991	0.541
LIG_LIR_Apic_2	367	373	PF02991	0.266
LIG_LIR_Gen_1	22	33	PF02991	0.635
LIG_LIR_Gen_1	379	390	PF02991	0.360
LIG_LIR_Gen_1	47	58	PF02991	0.450
LIG_LIR_Gen_1	74	85	PF02991	0.459
LIG_LIR_Nem_3	22	28	PF02991	0.621
LIG_LIR_Nem_3	261	266	PF02991	0.446
LIG_LIR_Nem_3	295	300	PF02991	0.272
LIG_LIR_Nem_3	30	34	PF02991	0.628
LIG_LIR_Nem_3	338	343	PF02991	0.267
LIG_LIR_Nem_3	357	363	PF02991	0.244
LIG_LIR_Nem_3	379	385	PF02991	0.281
LIG_LIR_Nem_3	47	53	PF02991	0.465
LIG_LIR_Nem_3	74	80	PF02991	0.487
LIG_LIR_Nem_3	94	100	PF02991	0.339
LIG_PCNA_yPIPBox_3	329	341	PF02747	0.373
LIG_PDZ_Class_2	595	600	PF00595	0.514
LIG_Pex14_1	456	460	PF04695	0.325
LIG_Pex14_2	100	104	PF04695	0.418
LIG_Pex14_2	277	281	PF04695	0.281
LIG_Pex14_2	356	360	PF04695	0.266
LIG_Pex14_2	548	552	PF04695	0.351
LIG_Pex14_2	596	600	PF04695	0.519
LIG_SH2_CRK	370	374	PF00017	0.331
LIG_SH2_CRK	90	94	PF00017	0.512
LIG_SH2_GRB2like	412	415	PF00017	0.300
LIG_SH2_NCK_1	370	374	PF00017	0.281
LIG_SH2_PTP2	112	115	PF00017	0.512
LIG_SH2_PTP2	77	80	PF00017	0.536
LIG_SH2_STAP1	412	416	PF00017	0.281
LIG_SH2_STAP1	461	465	PF00017	0.266
LIG_SH2_STAT5	112	115	PF00017	0.525
LIG_SH2_STAT5	340	343	PF00017	0.272
LIG_SH2_STAT5	370	373	PF00017	0.344
LIG_SH2_STAT5	375	378	PF00017	0.306
LIG_SH2_STAT5	412	415	PF00017	0.281
LIG_SH2_STAT5	50	53	PF00017	0.574
LIG_SH2_STAT5	506	509	PF00017	0.301
LIG_SH2_STAT5	77	80	PF00017	0.405
LIG_SH2_STAT5	90	93	PF00017	0.463
LIG_SH2_STAT5	97	100	PF00017	0.328
LIG_SH3_3	246	252	PF00018	0.747
LIG_SH3_3	281	287	PF00018	0.300
LIG_SH3_3	321	327	PF00018	0.369
LIG_SH3_3	393	399	PF00018	0.393
LIG_SH3_3	444	450	PF00018	0.305
LIG_SUMO_SIM_par_1	286	292	PF11976	0.266
LIG_SUMO_SIM_par_1	449	455	PF11976	0.284
LIG_TRAF2_1	536	539	PF00917	0.531
LIG_TRFH_1	189	193	PF08558	0.452
LIG_WRC_WIRS_1	28	33	PF05994	0.439
LIG_WW_1	186	189	PF00397	0.582
MOD_CDC14_SPxK_1	326	329	PF00782	0.331
MOD_CDK_SPK_2	253	258	PF00069	0.730
MOD_CDK_SPxK_1	129	135	PF00069	0.637
MOD_CDK_SPxK_1	323	329	PF00069	0.411
MOD_CDK_SPxxK_3	129	136	PF00069	0.639
MOD_CK1_1	131	137	PF00069	0.699
MOD_CK1_1	204	210	PF00069	0.732
MOD_CK1_1	238	244	PF00069	0.658
MOD_CK1_1	270	276	PF00069	0.378
MOD_CK1_1	32	38	PF00069	0.572
MOD_CK1_1	402	408	PF00069	0.331
MOD_CK2_1	100	106	PF00069	0.461
MOD_CK2_1	135	141	PF00069	0.783
MOD_CK2_1	238	244	PF00069	0.753
MOD_CK2_1	270	276	PF00069	0.383
MOD_CK2_1	449	455	PF00069	0.266
MOD_CK2_1	532	538	PF00069	0.531
MOD_Cter_Amidation	421	424	PF01082	0.281
MOD_GlcNHglycan	154	158	PF01048	0.534
MOD_GlcNHglycan	207	210	PF01048	0.704
MOD_GlcNHglycan	213	217	PF01048	0.727
MOD_GlcNHglycan	319	322	PF01048	0.395
MOD_GlcNHglycan	382	385	PF01048	0.484
MOD_GlcNHglycan	401	404	PF01048	0.368
MOD_GlcNHglycan	440	443	PF01048	0.403
MOD_GlcNHglycan	526	529	PF01048	0.386
MOD_GlcNHglycan	592	595	PF01048	0.494
MOD_GSK3_1	100	107	PF00069	0.453
MOD_GSK3_1	124	131	PF00069	0.640
MOD_GSK3_1	135	142	PF00069	0.549
MOD_GSK3_1	199	206	PF00069	0.686
MOD_GSK3_1	235	242	PF00069	0.617
MOD_GSK3_1	288	295	PF00069	0.303
MOD_GSK3_1	313	320	PF00069	0.441
MOD_GSK3_1	32	39	PF00069	0.620
MOD_GSK3_1	496	503	PF00069	0.266
MOD_GSK3_1	534	541	PF00069	0.608
MOD_GSK3_1	590	597	PF00069	0.566
MOD_GSK3_1	67	74	PF00069	0.443
MOD_N-GLC_1	129	134	PF02516	0.664
MOD_N-GLC_1	410	415	PF02516	0.266
MOD_N-GLC_1	418	423	PF02516	0.266
MOD_NEK2_1	100	105	PF00069	0.433
MOD_NEK2_1	205	210	PF00069	0.784
MOD_NEK2_1	317	322	PF00069	0.393
MOD_NEK2_1	496	501	PF00069	0.266
MOD_NEK2_1	522	527	PF00069	0.386
MOD_NEK2_1	69	74	PF00069	0.463
MOD_NEK2_2	29	34	PF00069	0.637
MOD_OFUCOSY	67	73	PF10250	0.476
MOD_PIKK_1	500	506	PF00454	0.266
MOD_PKA_1	135	141	PF00069	0.712
MOD_PKA_1	313	319	PF00069	0.331
MOD_PKA_2	100	106	PF00069	0.456
MOD_PKA_2	267	273	PF00069	0.384
MOD_PKA_2	305	311	PF00069	0.373
MOD_PKA_2	584	590	PF00069	0.626
MOD_PKA_2	67	73	PF00069	0.442
MOD_Plk_1	496	502	PF00069	0.272
MOD_Plk_2-3	359	365	PF00069	0.403
MOD_Plk_2-3	534	540	PF00069	0.543
MOD_Plk_4	180	186	PF00069	0.447
MOD_Plk_4	313	319	PF00069	0.469
MOD_Plk_4	359	365	PF00069	0.316
MOD_Plk_4	584	590	PF00069	0.621
MOD_Plk_4	93	99	PF00069	0.554
MOD_ProDKin_1	116	122	PF00069	0.722
MOD_ProDKin_1	129	135	PF00069	0.645
MOD_ProDKin_1	145	151	PF00069	0.525
MOD_ProDKin_1	160	166	PF00069	0.577
MOD_ProDKin_1	199	205	PF00069	0.640
MOD_ProDKin_1	253	259	PF00069	0.594
MOD_ProDKin_1	323	329	PF00069	0.408
MOD_ProDKin_1	431	437	PF00069	0.325
MOD_ProDKin_1	446	452	PF00069	0.281
MOD_ProDKin_1	91	97	PF00069	0.505
MOD_SUMO_rev_2	138	145	PF00179	0.765
TRG_AP2beta_CARGO_1	379	389	PF09066	0.300
TRG_ENDOCYTIC_2	112	115	PF00928	0.630
TRG_ENDOCYTIC_2	188	191	PF00928	0.459
TRG_ENDOCYTIC_2	473	476	PF00928	0.266
TRG_ENDOCYTIC_2	50	53	PF00928	0.574
TRG_ENDOCYTIC_2	77	80	PF00928	0.390
TRG_ENDOCYTIC_2	90	93	PF00928	0.457
TRG_ENDOCYTIC_2	97	100	PF00928	0.385
TRG_ER_diArg_1	167	170	PF00400	0.648
TRG_ER_diArg_1	388	390	PF00400	0.316
TRG_ER_diArg_1	423	426	PF00400	0.281
TRG_ER_diArg_1	543	546	PF00400	0.475
TRG_ER_diArg_1	581	583	PF00400	0.570
TRG_ER_FFAT_2	379	387	PF00635	0.210
TRG_NES_CRM1_1	52	65	PF08389	0.494
TRG_NLS_MonoExtC_3	134	139	PF00514	0.632
TRG_NLS_MonoExtN_4	133	140	PF00514	0.697
TRG_NLS_MonoExtN_4	223	229	PF00514	0.674
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D1	Leptomonas seymouri	74%	100%
A0A0S4JT19	Bodo saltans	46%	100%
A0A1X0P469	Trypanosomatidae	51%	100%
A0A422NFR7	Trypanosoma rangeli	51%	100%
A4HFQ9	Leishmania braziliensis	85%	99%
A4I2T5	Leishmania infantum	100%	100%
D0A601	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ADB3	Leishmania major	94%	100%
E9AZ38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BL30	Trypanosoma cruzi	51%	100%