RNA-binding protein 29, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 29, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE55_LEIDO

TriTrypDb:

LdBPK_180220.1 , LdCL_180007100 , LDHU3_18.0260

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IE55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE55

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006379	mRNA cleavage	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.707
CLV_NRD_NRD_1	358	360	PF00675	0.560
CLV_NRD_NRD_1	366	368	PF00675	0.615
CLV_NRD_NRD_1	75	77	PF00675	0.346
CLV_PCSK_KEX2_1	401	403	PF00082	0.813
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.813
CLV_PCSK_SKI1_1	134	138	PF00082	0.561
CLV_PCSK_SKI1_1	19	23	PF00082	0.311
CLV_PCSK_SKI1_1	27	31	PF00082	0.304
CLV_PCSK_SKI1_1	398	402	PF00082	0.700
CLV_PCSK_SKI1_1	64	68	PF00082	0.318
CLV_PCSK_SKI1_1	76	80	PF00082	0.346
CLV_Separin_Metazoa	356	360	PF03568	0.572
DEG_APCC_DBOX_1	133	141	PF00400	0.560
DEG_SCF_FBW7_1	1	8	PF00400	0.718
DOC_MAPK_gen_1	76	82	PF00069	0.546
DOC_MAPK_MEF2A_6	297	304	PF00069	0.622
DOC_PP2B_LxvP_1	203	206	PF13499	0.808
DOC_PP4_FxxP_1	334	337	PF00568	0.798
DOC_PP4_MxPP_1	265	268	PF00568	0.813
DOC_PP4_MxPP_1	286	289	PF00568	0.797
DOC_USP7_MATH_1	198	202	PF00917	0.629
DOC_USP7_MATH_1	382	386	PF00917	0.678
DOC_USP7_MATH_1	400	404	PF00917	0.703
DOC_USP7_UBL2_3	345	349	PF12436	0.679
DOC_USP7_UBL2_3	360	364	PF12436	0.499
DOC_USP7_UBL2_3	368	372	PF12436	0.621
DOC_USP7_UBL2_3	397	401	PF12436	0.724
DOC_USP7_UBL2_3	405	409	PF12436	0.715
DOC_WW_Pin1_4	1	6	PF00397	0.663
DOC_WW_Pin1_4	123	128	PF00397	0.626
DOC_WW_Pin1_4	148	153	PF00397	0.592
DOC_WW_Pin1_4	179	184	PF00397	0.839
LIG_Actin_WH2_2	14	29	PF00022	0.504
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_eIF4E_1	68	74	PF01652	0.546
LIG_FHA_1	341	347	PF00498	0.610
LIG_FHA_2	174	180	PF00498	0.707
LIG_FHA_2	33	39	PF00498	0.546
LIG_FHA_2	56	62	PF00498	0.526
LIG_Integrin_isoDGR_2	42	44	PF01839	0.346
LIG_LIR_Gen_1	352	362	PF02991	0.575
LIG_LIR_Nem_3	352	358	PF02991	0.577
LIG_LIR_Nem_3	8	13	PF02991	0.463
LIG_SH2_STAP1	365	369	PF00017	0.599
LIG_SH2_STAT5	13	16	PF00017	0.546
LIG_SH3_1	297	303	PF00018	0.717
LIG_SH3_3	265	271	PF00018	0.716
LIG_SH3_3	297	303	PF00018	0.709
LIG_SH3_3	84	90	PF00018	0.549
LIG_TRAF2_2	273	278	PF00917	0.759
LIG_UBA3_1	136	144	PF00899	0.577
LIG_WW_3	266	270	PF00397	0.740
MOD_CK1_1	175	181	PF00069	0.762
MOD_CK1_1	385	391	PF00069	0.724
MOD_CK2_1	400	406	PF00069	0.703
MOD_Cter_Amidation	74	77	PF01082	0.346
MOD_GlcNHglycan	1	4	PF01048	0.675
MOD_GlcNHglycan	166	169	PF01048	0.667
MOD_GlcNHglycan	184	187	PF01048	0.819
MOD_GlcNHglycan	196	199	PF01048	0.815
MOD_GlcNHglycan	210	213	PF01048	0.629
MOD_GlcNHglycan	259	262	PF01048	0.725
MOD_GlcNHglycan	321	324	PF01048	0.693
MOD_GlcNHglycan	383	387	PF01048	0.721
MOD_GlcNHglycan	388	391	PF01048	0.646
MOD_GSK3_1	1	8	PF00069	0.718
MOD_GSK3_1	171	178	PF00069	0.769
MOD_GSK3_1	194	201	PF00069	0.716
MOD_GSK3_1	204	211	PF00069	0.702
MOD_GSK3_1	382	389	PF00069	0.828
MOD_GSK3_1	400	407	PF00069	0.747
MOD_N-GLC_1	171	176	PF02516	0.739
MOD_NEK2_1	118	123	PF00069	0.666
MOD_NEK2_1	157	162	PF00069	0.565
MOD_NEK2_1	194	199	PF00069	0.726
MOD_NEK2_1	208	213	PF00069	0.676
MOD_NEK2_2	340	345	PF00069	0.663
MOD_Plk_1	17	23	PF00069	0.533
MOD_Plk_1	37	43	PF00069	0.546
MOD_Plk_2-3	55	61	PF00069	0.546
MOD_Plk_4	251	257	PF00069	0.701
MOD_Plk_4	32	38	PF00069	0.546
MOD_ProDKin_1	1	7	PF00069	0.653
MOD_ProDKin_1	123	129	PF00069	0.619
MOD_ProDKin_1	148	154	PF00069	0.586
MOD_ProDKin_1	179	185	PF00069	0.839
MOD_SUMO_rev_2	361	369	PF00179	0.586
MOD_SUMO_rev_2	389	399	PF00179	0.721
TRG_DiLeu_BaEn_1	132	137	PF01217	0.548
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.551
TRG_ENDOCYTIC_2	263	266	PF00928	0.740
TRG_ENDOCYTIC_2	68	71	PF00928	0.546
TRG_NLS_MonoExtC_3	400	405	PF00514	0.724
TRG_NLS_MonoExtN_4	398	405	PF00514	0.722
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P353	Leptomonas seymouri	54%	100%
A4HXP8	Leishmania infantum	100%	100%
E9AI57	Leishmania braziliensis	86%	100%
E9ARF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QE20	Leishmania major	95%	100%