Uncharacterized_ACR_COG1678_putative/Pfam:PF02622

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE54_LEIDO

TriTrypDb:

LdBPK_282930.1 , LdCL_280034400 , LDHU3_28.3920

Length:

606

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE54

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008233	peptidase activity	3	1
GO:0008236	serine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0017171	serine hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.597
CLV_NRD_NRD_1	208	210	PF00675	0.420
CLV_NRD_NRD_1	282	284	PF00675	0.521
CLV_NRD_NRD_1	458	460	PF00675	0.564
CLV_NRD_NRD_1	567	569	PF00675	0.814
CLV_NRD_NRD_1	597	599	PF00675	0.716
CLV_PCSK_FUR_1	436	440	PF00082	0.534
CLV_PCSK_KEX2_1	148	150	PF00082	0.595
CLV_PCSK_KEX2_1	208	210	PF00082	0.420
CLV_PCSK_KEX2_1	24	26	PF00082	0.750
CLV_PCSK_KEX2_1	282	284	PF00082	0.521
CLV_PCSK_KEX2_1	438	440	PF00082	0.560
CLV_PCSK_KEX2_1	457	459	PF00082	0.473
CLV_PCSK_KEX2_1	597	599	PF00082	0.595
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.750
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.672
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.595
CLV_PCSK_SKI1_1	150	154	PF00082	0.591
CLV_PCSK_SKI1_1	178	182	PF00082	0.602
CLV_PCSK_SKI1_1	209	213	PF00082	0.366
CLV_PCSK_SKI1_1	25	29	PF00082	0.764
CLV_PCSK_SKI1_1	61	65	PF00082	0.418
CLV_PCSK_SKI1_1	9	13	PF00082	0.656
CLV_PCSK_SKI1_1	93	97	PF00082	0.498
DEG_APCC_DBOX_1	3	11	PF00400	0.710
DEG_Nend_Nbox_1	1	3	PF02207	0.603
DEG_SPOP_SBC_1	10	14	PF00917	0.713
DEG_SPOP_SBC_1	302	306	PF00917	0.666
DEG_SPOP_SBC_1	313	317	PF00917	0.558
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.525
DOC_MAPK_DCC_7	97	107	PF00069	0.588
DOC_MAPK_FxFP_2	230	233	PF00069	0.463
DOC_MAPK_gen_1	101	109	PF00069	0.614
DOC_MAPK_gen_1	182	190	PF00069	0.640
DOC_MAPK_gen_1	53	62	PF00069	0.541
DOC_MAPK_MEF2A_6	101	109	PF00069	0.544
DOC_MAPK_MEF2A_6	53	62	PF00069	0.509
DOC_PP1_RVXF_1	373	379	PF00149	0.416
DOC_PP1_RVXF_1	59	65	PF00149	0.537
DOC_PP2B_LxvP_1	80	83	PF13499	0.514
DOC_PP4_FxxP_1	230	233	PF00568	0.463
DOC_PP4_FxxP_1	260	263	PF00568	0.559
DOC_PP4_FxxP_1	332	335	PF00568	0.552
DOC_USP7_MATH_1	11	15	PF00917	0.698
DOC_USP7_MATH_1	184	188	PF00917	0.580
DOC_USP7_MATH_1	200	204	PF00917	0.427
DOC_USP7_MATH_1	27	31	PF00917	0.651
DOC_USP7_MATH_1	303	307	PF00917	0.714
DOC_USP7_MATH_1	308	312	PF00917	0.704
DOC_USP7_MATH_1	314	318	PF00917	0.660
DOC_USP7_MATH_1	323	327	PF00917	0.334
DOC_USP7_MATH_1	370	374	PF00917	0.441
DOC_USP7_MATH_1	530	534	PF00917	0.790
DOC_USP7_MATH_1	591	595	PF00917	0.807
DOC_USP7_UBL2_3	16	20	PF12436	0.772
DOC_USP7_UBL2_3	593	597	PF12436	0.757
DOC_WW_Pin1_4	139	144	PF00397	0.449
DOC_WW_Pin1_4	158	163	PF00397	0.699
DOC_WW_Pin1_4	214	219	PF00397	0.549
DOC_WW_Pin1_4	283	288	PF00397	0.642
DOC_WW_Pin1_4	319	324	PF00397	0.651
DOC_WW_Pin1_4	33	38	PF00397	0.568
DOC_WW_Pin1_4	400	405	PF00397	0.407
DOC_WW_Pin1_4	442	447	PF00397	0.672
DOC_WW_Pin1_4	484	489	PF00397	0.650
DOC_WW_Pin1_4	498	503	PF00397	0.659
DOC_WW_Pin1_4	559	564	PF00397	0.737
LIG_14-3-3_CanoR_1	135	141	PF00244	0.570
LIG_14-3-3_CanoR_1	148	153	PF00244	0.645
LIG_14-3-3_CanoR_1	185	189	PF00244	0.580
LIG_14-3-3_CanoR_1	236	241	PF00244	0.589
LIG_14-3-3_CanoR_1	25	33	PF00244	0.644
LIG_14-3-3_CanoR_1	282	288	PF00244	0.509
LIG_14-3-3_CanoR_1	371	375	PF00244	0.448
LIG_14-3-3_CanoR_1	382	392	PF00244	0.552
LIG_14-3-3_CanoR_1	489	494	PF00244	0.689
LIG_14-3-3_CanoR_1	568	575	PF00244	0.715
LIG_14-3-3_CanoR_1	85	95	PF00244	0.605
LIG_14-3-3_CanoR_1	9	17	PF00244	0.676
LIG_BIR_III_2	572	576	PF00653	0.768
LIG_BRCT_BRCA1_1	402	406	PF00533	0.404
LIG_BRCT_BRCA1_1	480	484	PF00533	0.573
LIG_deltaCOP1_diTrp_1	460	468	PF00928	0.550
LIG_DLG_GKlike_1	148	156	PF00625	0.621
LIG_DLG_GKlike_1	489	496	PF00625	0.719
LIG_EH_1	481	485	PF12763	0.475
LIG_EVH1_2	446	450	PF00568	0.687
LIG_FHA_1	17	23	PF00498	0.768
LIG_FHA_1	175	181	PF00498	0.634
LIG_FHA_1	192	198	PF00498	0.315
LIG_FHA_1	215	221	PF00498	0.448
LIG_FHA_1	229	235	PF00498	0.412
LIG_FHA_1	263	269	PF00498	0.487
LIG_FHA_1	348	354	PF00498	0.411
LIG_FHA_1	383	389	PF00498	0.433
LIG_FHA_1	554	560	PF00498	0.792
LIG_FHA_1	87	93	PF00498	0.556
LIG_FHA_2	16	22	PF00498	0.777
LIG_FHA_2	413	419	PF00498	0.650
LIG_GBD_Chelix_1	39	47	PF00786	0.484
LIG_LIR_Apic_2	227	233	PF02991	0.437
LIG_LIR_Gen_1	252	263	PF02991	0.536
LIG_LIR_Gen_1	460	470	PF02991	0.410
LIG_LIR_Gen_1	473	478	PF02991	0.428
LIG_LIR_Gen_1	487	498	PF02991	0.589
LIG_LIR_Nem_3	239	244	PF02991	0.556
LIG_LIR_Nem_3	252	258	PF02991	0.430
LIG_LIR_Nem_3	405	410	PF02991	0.466
LIG_LIR_Nem_3	42	47	PF02991	0.432
LIG_LIR_Nem_3	460	466	PF02991	0.406
LIG_LIR_Nem_3	473	477	PF02991	0.420
LIG_LIR_Nem_3	487	493	PF02991	0.528
LIG_PCNA_yPIPBox_3	61	74	PF02747	0.592
LIG_Pex14_2	241	245	PF04695	0.454
LIG_PTAP_UEV_1	584	589	PF05743	0.669
LIG_REV1ctd_RIR_1	150	156	PF16727	0.662
LIG_REV1ctd_RIR_1	404	412	PF16727	0.545
LIG_SH2_CRK	119	123	PF00017	0.526
LIG_SH2_CRK	44	48	PF00017	0.427
LIG_SH2_CRK	474	478	PF00017	0.502
LIG_SH2_GRB2like	119	122	PF00017	0.584
LIG_SH2_SRC	119	122	PF00017	0.584
LIG_SH2_STAP1	410	414	PF00017	0.699
LIG_SH2_STAP1	474	478	PF00017	0.540
LIG_SH2_STAP1	88	92	PF00017	0.554
LIG_SH2_STAT5	168	171	PF00017	0.677
LIG_SH2_STAT5	352	355	PF00017	0.406
LIG_SH2_STAT5	361	364	PF00017	0.437
LIG_SH2_STAT5	88	91	PF00017	0.473
LIG_SH3_1	154	160	PF00018	0.650
LIG_SH3_2	173	178	PF14604	0.694
LIG_SH3_3	154	160	PF00018	0.621
LIG_SH3_3	170	176	PF00018	0.667
LIG_SH3_3	446	452	PF00018	0.577
LIG_SH3_3	554	560	PF00018	0.800
LIG_SH3_3	582	588	PF00018	0.656
LIG_SH3_3	59	65	PF00018	0.521
LIG_SH3_3	73	79	PF00018	0.629
LIG_SH3_4	16	23	PF00018	0.698
LIG_SH3_CIN85_PxpxPR_1	162	167	PF14604	0.733
MOD_CDK_SPK_2	484	489	PF00069	0.650
MOD_CK1_1	139	145	PF00069	0.583
MOD_CK1_1	191	197	PF00069	0.547
MOD_CK1_1	276	282	PF00069	0.696
MOD_CK1_1	292	298	PF00069	0.678
MOD_CK1_1	317	323	PF00069	0.684
MOD_CK1_1	413	419	PF00069	0.724
MOD_CK2_1	351	357	PF00069	0.431
MOD_CK2_1	383	389	PF00069	0.581
MOD_CMANNOS	296	299	PF00535	0.600
MOD_Cter_Amidation	595	598	PF01082	0.598
MOD_DYRK1A_RPxSP_1	283	287	PF00069	0.645
MOD_GlcNHglycan	202	205	PF01048	0.677
MOD_GlcNHglycan	221	224	PF01048	0.259
MOD_GlcNHglycan	305	308	PF01048	0.771
MOD_GlcNHglycan	316	319	PF01048	0.730
MOD_GlcNHglycan	412	415	PF01048	0.578
MOD_GlcNHglycan	585	588	PF01048	0.720
MOD_GlcNHglycan	76	79	PF01048	0.583
MOD_GSK3_1	11	18	PF00069	0.663
MOD_GSK3_1	184	191	PF00069	0.638
MOD_GSK3_1	214	221	PF00069	0.493
MOD_GSK3_1	228	235	PF00069	0.357
MOD_GSK3_1	258	265	PF00069	0.540
MOD_GSK3_1	288	295	PF00069	0.711
MOD_GSK3_1	308	315	PF00069	0.534
MOD_GSK3_1	319	326	PF00069	0.568
MOD_GSK3_1	347	354	PF00069	0.452
MOD_GSK3_1	39	46	PF00069	0.585
MOD_GSK3_1	478	485	PF00069	0.569
MOD_NEK2_1	136	141	PF00069	0.465
MOD_NEK2_1	2	7	PF00069	0.619
MOD_NEK2_1	228	233	PF00069	0.445
MOD_NEK2_1	288	293	PF00069	0.658
MOD_NEK2_1	351	356	PF00069	0.421
MOD_NEK2_1	381	386	PF00069	0.538
MOD_NEK2_1	43	48	PF00069	0.539
MOD_NEK2_1	553	558	PF00069	0.764
MOD_NEK2_1	74	79	PF00069	0.563
MOD_NEK2_2	370	375	PF00069	0.468
MOD_PIKK_1	253	259	PF00454	0.470
MOD_PIKK_1	323	329	PF00454	0.432
MOD_PIKK_1	383	389	PF00454	0.484
MOD_PKA_1	148	154	PF00069	0.624
MOD_PKA_2	148	154	PF00069	0.630
MOD_PKA_2	184	190	PF00069	0.571
MOD_PKA_2	276	282	PF00069	0.618
MOD_PKA_2	370	376	PF00069	0.443
MOD_PKA_2	381	387	PF00069	0.549
MOD_PKA_2	488	494	PF00069	0.687
MOD_PKA_2	567	573	PF00069	0.769
MOD_PKA_2	86	92	PF00069	0.564
MOD_Plk_1	289	295	PF00069	0.720
MOD_Plk_1	49	55	PF00069	0.517
MOD_Plk_1	553	559	PF00069	0.806
MOD_Plk_1	97	103	PF00069	0.659
MOD_Plk_4	148	154	PF00069	0.632
MOD_Plk_4	191	197	PF00069	0.518
MOD_Plk_4	236	242	PF00069	0.587
MOD_Plk_4	289	295	PF00069	0.694
MOD_Plk_4	347	353	PF00069	0.437
MOD_Plk_4	402	408	PF00069	0.436
MOD_Plk_4	553	559	PF00069	0.801
MOD_ProDKin_1	139	145	PF00069	0.445
MOD_ProDKin_1	158	164	PF00069	0.700
MOD_ProDKin_1	214	220	PF00069	0.547
MOD_ProDKin_1	283	289	PF00069	0.640
MOD_ProDKin_1	319	325	PF00069	0.637
MOD_ProDKin_1	33	39	PF00069	0.561
MOD_ProDKin_1	400	406	PF00069	0.406
MOD_ProDKin_1	442	448	PF00069	0.674
MOD_ProDKin_1	484	490	PF00069	0.659
MOD_ProDKin_1	498	504	PF00069	0.663
MOD_ProDKin_1	559	565	PF00069	0.737
MOD_SUMO_rev_2	562	571	PF00179	0.803
TRG_DiLeu_BaEn_1	192	197	PF01217	0.400
TRG_DiLeu_BaEn_1	473	478	PF01217	0.448
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.462
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.431
TRG_ENDOCYTIC_2	119	122	PF00928	0.545
TRG_ENDOCYTIC_2	44	47	PF00928	0.432
TRG_ENDOCYTIC_2	474	477	PF00928	0.506
TRG_ENDOCYTIC_2	48	51	PF00928	0.427
TRG_ENDOCYTIC_2	88	91	PF00928	0.445
TRG_ER_diArg_1	133	136	PF00400	0.566
TRG_ER_diArg_1	208	210	PF00400	0.420
TRG_ER_diArg_1	456	459	PF00400	0.580
TRG_ER_diArg_1	85	88	PF00400	0.431
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	45	50	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F0	Leptomonas seymouri	71%	98%
A0A1X0NQL7	Trypanosomatidae	56%	100%
A0A422MYL5	Trypanosoma rangeli	50%	100%
A4HGX6	Leishmania braziliensis	86%	100%
A4I406	Leishmania infantum	100%	100%
D0A900	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B096	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q7Y9	Leishmania major	94%	100%
V5BI69	Trypanosoma cruzi	54%	100%