Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE52_LEIDO

TriTrypDb:

LdBPK_300960.1 , LdCL_300014800 , LDHU3_30.1270

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.591
CLV_NRD_NRD_1	180	182	PF00675	0.612
CLV_NRD_NRD_1	410	412	PF00675	0.817
CLV_NRD_NRD_1	42	44	PF00675	0.537
CLV_NRD_NRD_1	458	460	PF00675	0.669
CLV_NRD_NRD_1	518	520	PF00675	0.497
CLV_NRD_NRD_1	553	555	PF00675	0.692
CLV_PCSK_FUR_1	516	520	PF00082	0.489
CLV_PCSK_KEX2_1	179	181	PF00082	0.612
CLV_PCSK_KEX2_1	226	228	PF00082	0.426
CLV_PCSK_KEX2_1	245	247	PF00082	0.482
CLV_PCSK_KEX2_1	410	412	PF00082	0.831
CLV_PCSK_KEX2_1	42	44	PF00082	0.537
CLV_PCSK_KEX2_1	458	460	PF00082	0.626
CLV_PCSK_KEX2_1	518	520	PF00082	0.497
CLV_PCSK_KEX2_1	553	555	PF00082	0.616
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.426
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.482
CLV_PCSK_SKI1_1	201	205	PF00082	0.640
CLV_PCSK_SKI1_1	272	276	PF00082	0.538
CLV_PCSK_SKI1_1	293	297	PF00082	0.416
CLV_PCSK_SKI1_1	395	399	PF00082	0.703
CLV_PCSK_SKI1_1	518	522	PF00082	0.579
CLV_PCSK_SKI1_1	619	623	PF00082	0.604
CLV_PCSK_SKI1_1	634	638	PF00082	0.387
CLV_PCSK_SKI1_1	89	93	PF00082	0.575
DEG_APCC_DBOX_1	105	113	PF00400	0.598
DEG_APCC_DBOX_1	271	279	PF00400	0.433
DEG_APCC_DBOX_1	517	525	PF00400	0.560
DEG_APCC_DBOX_1	633	641	PF00400	0.506
DEG_Nend_UBRbox_2	1	3	PF02207	0.649
DEG_SCF_FBW7_1	434	440	PF00400	0.643
DEG_SPOP_SBC_1	189	193	PF00917	0.600
DEG_SPOP_SBC_1	620	624	PF00917	0.529
DOC_CDC14_PxL_1	506	514	PF14671	0.506
DOC_CKS1_1	183	188	PF01111	0.570
DOC_CKS1_1	31	36	PF01111	0.651
DOC_CKS1_1	396	401	PF01111	0.656
DOC_CKS1_1	434	439	PF01111	0.640
DOC_CYCLIN_RxL_1	284	294	PF00134	0.413
DOC_CYCLIN_RxL_1	629	641	PF00134	0.514
DOC_CYCLIN_yClb5_NLxxxL_5	280	286	PF00134	0.394
DOC_MAPK_gen_1	164	171	PF00069	0.743
DOC_MAPK_gen_1	339	348	PF00069	0.508
DOC_MAPK_gen_1	516	524	PF00069	0.521
DOC_MAPK_MEF2A_6	516	524	PF00069	0.497
DOC_PP1_RVXF_1	285	292	PF00149	0.430
DOC_PP1_RVXF_1	321	327	PF00149	0.452
DOC_PP4_FxxP_1	31	34	PF00568	0.647
DOC_USP7_MATH_1	102	106	PF00917	0.642
DOC_USP7_MATH_1	113	117	PF00917	0.604
DOC_USP7_MATH_1	162	166	PF00917	0.678
DOC_USP7_MATH_1	189	193	PF00917	0.647
DOC_USP7_MATH_1	305	309	PF00917	0.635
DOC_USP7_MATH_1	364	368	PF00917	0.687
DOC_USP7_MATH_1	382	386	PF00917	0.543
DOC_USP7_MATH_1	406	410	PF00917	0.660
DOC_USP7_MATH_1	429	433	PF00917	0.664
DOC_USP7_MATH_1	451	455	PF00917	0.646
DOC_USP7_MATH_1	466	470	PF00917	0.568
DOC_USP7_MATH_1	475	479	PF00917	0.612
DOC_USP7_MATH_1	505	509	PF00917	0.537
DOC_USP7_MATH_1	531	535	PF00917	0.642
DOC_USP7_MATH_1	584	588	PF00917	0.660
DOC_USP7_MATH_1	620	624	PF00917	0.519
DOC_USP7_MATH_1	63	67	PF00917	0.636
DOC_USP7_MATH_1	81	85	PF00917	0.536
DOC_USP7_UBL2_3	307	311	PF12436	0.580
DOC_WW_Pin1_4	1	6	PF00397	0.656
DOC_WW_Pin1_4	131	136	PF00397	0.678
DOC_WW_Pin1_4	182	187	PF00397	0.656
DOC_WW_Pin1_4	204	209	PF00397	0.585
DOC_WW_Pin1_4	30	35	PF00397	0.675
DOC_WW_Pin1_4	360	365	PF00397	0.642
DOC_WW_Pin1_4	395	400	PF00397	0.630
DOC_WW_Pin1_4	433	438	PF00397	0.651
DOC_WW_Pin1_4	440	445	PF00397	0.620
DOC_WW_Pin1_4	470	475	PF00397	0.613
DOC_WW_Pin1_4	541	546	PF00397	0.604
DOC_WW_Pin1_4	547	552	PF00397	0.591
DOC_WW_Pin1_4	554	559	PF00397	0.763
DOC_WW_Pin1_4	57	62	PF00397	0.681
DOC_WW_Pin1_4	608	613	PF00397	0.761
DOC_WW_Pin1_4	77	82	PF00397	0.545
LIG_14-3-3_CanoR_1	164	171	PF00244	0.609
LIG_14-3-3_CanoR_1	180	186	PF00244	0.605
LIG_14-3-3_CanoR_1	190	199	PF00244	0.676
LIG_14-3-3_CanoR_1	323	329	PF00244	0.363
LIG_14-3-3_CanoR_1	370	376	PF00244	0.614
LIG_14-3-3_CanoR_1	404	409	PF00244	0.674
LIG_14-3-3_CanoR_1	465	474	PF00244	0.737
LIG_14-3-3_CanoR_1	553	557	PF00244	0.620
LIG_14-3-3_CanoR_1	593	599	PF00244	0.678
LIG_14-3-3_CanoR_1	607	612	PF00244	0.534
LIG_14-3-3_CanoR_1	619	628	PF00244	0.518
LIG_Actin_WH2_2	245	261	PF00022	0.370
LIG_Actin_WH2_2	333	349	PF00022	0.431
LIG_Actin_WH2_2	675	690	PF00022	0.444
LIG_APCC_ABBA_1	522	527	PF00400	0.585
LIG_BIR_III_4	96	100	PF00653	0.632
LIG_BRCT_BRCA1_1	556	560	PF00533	0.612
LIG_FHA_1	183	189	PF00498	0.665
LIG_FHA_1	235	241	PF00498	0.423
LIG_FHA_1	86	92	PF00498	0.639
LIG_FHA_2	219	225	PF00498	0.515
LIG_FHA_2	325	331	PF00498	0.371
LIG_FHA_2	35	41	PF00498	0.640
LIG_LIR_Apic_2	608	612	PF02991	0.613
LIG_LIR_Apic_2	664	669	PF02991	0.419
LIG_LIR_Nem_3	322	328	PF02991	0.432
LIG_LIR_Nem_3	544	549	PF02991	0.632
LIG_LRP6_Inhibitor_1	333	339	PF00058	0.433
LIG_Pex14_2	560	564	PF04695	0.601
LIG_RPA_C_Fungi	168	180	PF08784	0.589
LIG_SH2_CRK	546	550	PF00017	0.711
LIG_SH2_CRK	609	613	PF00017	0.612
LIG_SH2_SRC	228	231	PF00017	0.451
LIG_SH2_STAP1	643	647	PF00017	0.473
LIG_SH2_STAT3	285	288	PF00017	0.474
LIG_SH2_STAT3	540	543	PF00017	0.699
LIG_SH2_STAT5	130	133	PF00017	0.625
LIG_SH2_STAT5	228	231	PF00017	0.403
LIG_SH2_STAT5	248	251	PF00017	0.348
LIG_SH2_STAT5	285	288	PF00017	0.474
LIG_SH2_STAT5	320	323	PF00017	0.363
LIG_SH2_STAT5	325	328	PF00017	0.349
LIG_SH2_STAT5	675	678	PF00017	0.378
LIG_SH3_1	263	269	PF00018	0.563
LIG_SH3_2	485	490	PF14604	0.628
LIG_SH3_3	180	186	PF00018	0.571
LIG_SH3_3	202	208	PF00018	0.583
LIG_SH3_3	21	27	PF00018	0.524
LIG_SH3_3	263	269	PF00018	0.569
LIG_SH3_3	3	9	PF00018	0.693
LIG_SH3_3	393	399	PF00018	0.661
LIG_SH3_3	428	434	PF00018	0.657
LIG_SH3_3	460	466	PF00018	0.590
LIG_SH3_3	479	485	PF00018	0.785
LIG_SH3_CIN85_PxpxPR_1	5	10	PF14604	0.621
LIG_SUMO_SIM_anti_2	108	113	PF11976	0.470
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.603
LIG_SxIP_EBH_1	111	121	PF03271	0.478
LIG_TRAF2_1	210	213	PF00917	0.651
LIG_TRAF2_1	220	223	PF00917	0.433
LIG_TRAF2_1	332	335	PF00917	0.470
LIG_UBA3_1	636	645	PF00899	0.507
MOD_CDC14_SPxK_1	550	553	PF00782	0.622
MOD_CDK_SPK_2	395	400	PF00069	0.627
MOD_CDK_SPK_2	608	613	PF00069	0.761
MOD_CDK_SPxK_1	547	553	PF00069	0.630
MOD_CDK_SPxxK_3	395	402	PF00069	0.635
MOD_CDK_SPxxK_3	541	548	PF00069	0.689
MOD_CK1_1	105	111	PF00069	0.615
MOD_CK1_1	191	197	PF00069	0.643
MOD_CK1_1	329	335	PF00069	0.390
MOD_CK1_1	356	362	PF00069	0.679
MOD_CK1_1	376	382	PF00069	0.655
MOD_CK1_1	390	396	PF00069	0.608
MOD_CK1_1	414	420	PF00069	0.682
MOD_CK1_1	432	438	PF00069	0.647
MOD_CK1_1	443	449	PF00069	0.586
MOD_CK1_1	46	52	PF00069	0.598
MOD_CK1_1	470	476	PF00069	0.650
MOD_CK1_1	478	484	PF00069	0.616
MOD_CK1_1	587	593	PF00069	0.704
MOD_CK2_1	162	168	PF00069	0.628
MOD_CK2_1	217	223	PF00069	0.528
MOD_CK2_1	329	335	PF00069	0.426
MOD_CK2_1	34	40	PF00069	0.717
MOD_GlcNHglycan	115	118	PF01048	0.601
MOD_GlcNHglycan	173	176	PF01048	0.664
MOD_GlcNHglycan	307	310	PF01048	0.569
MOD_GlcNHglycan	380	383	PF01048	0.722
MOD_GlcNHglycan	413	416	PF01048	0.666
MOD_GlcNHglycan	422	425	PF01048	0.715
MOD_GlcNHglycan	469	472	PF01048	0.639
MOD_GlcNHglycan	477	480	PF01048	0.676
MOD_GlcNHglycan	494	497	PF01048	0.578
MOD_GlcNHglycan	507	510	PF01048	0.503
MOD_GlcNHglycan	582	585	PF01048	0.684
MOD_GlcNHglycan	594	597	PF01048	0.529
MOD_GlcNHglycan	623	626	PF01048	0.520
MOD_GSK3_1	122	129	PF00069	0.700
MOD_GSK3_1	160	167	PF00069	0.587
MOD_GSK3_1	189	196	PF00069	0.692
MOD_GSK3_1	213	220	PF00069	0.693
MOD_GSK3_1	30	37	PF00069	0.696
MOD_GSK3_1	305	312	PF00069	0.549
MOD_GSK3_1	356	363	PF00069	0.637
MOD_GSK3_1	373	380	PF00069	0.650
MOD_GSK3_1	383	390	PF00069	0.725
MOD_GSK3_1	391	398	PF00069	0.625
MOD_GSK3_1	414	421	PF00069	0.701
MOD_GSK3_1	429	436	PF00069	0.725
MOD_GSK3_1	466	473	PF00069	0.670
MOD_GSK3_1	492	499	PF00069	0.695
MOD_GSK3_1	501	508	PF00069	0.726
MOD_GSK3_1	53	60	PF00069	0.677
MOD_GSK3_1	560	567	PF00069	0.618
MOD_GSK3_1	580	587	PF00069	0.598
MOD_GSK3_1	608	615	PF00069	0.630
MOD_GSK3_1	63	70	PF00069	0.673
MOD_GSK3_1	73	80	PF00069	0.572
MOD_GSK3_1	81	88	PF00069	0.569
MOD_N-GLC_1	34	39	PF02516	0.677
MOD_N-GLC_1	440	445	PF02516	0.666
MOD_N-GLC_1	74	79	PF02516	0.800
MOD_NEK2_1	171	176	PF00069	0.668
MOD_NEK2_1	188	193	PF00069	0.536
MOD_NEK2_1	217	222	PF00069	0.511
MOD_NEK2_1	291	296	PF00069	0.357
MOD_NEK2_1	324	329	PF00069	0.398
MOD_NEK2_1	340	345	PF00069	0.317
MOD_NEK2_1	353	358	PF00069	0.525
MOD_NEK2_1	564	569	PF00069	0.608
MOD_NEK2_1	591	596	PF00069	0.642
MOD_NEK2_1	67	72	PF00069	0.613
MOD_NEK2_2	122	127	PF00069	0.612
MOD_PIKK_1	173	179	PF00454	0.576
MOD_PIKK_1	193	199	PF00454	0.560
MOD_PIKK_1	218	224	PF00454	0.528
MOD_PIKK_1	53	59	PF00454	0.661
MOD_PIKK_1	539	545	PF00454	0.666
MOD_PK_1	404	410	PF00069	0.576
MOD_PKA_2	105	111	PF00069	0.677
MOD_PKA_2	126	132	PF00069	0.642
MOD_PKA_2	189	195	PF00069	0.696
MOD_PKA_2	340	346	PF00069	0.455
MOD_PKA_2	376	382	PF00069	0.669
MOD_PKA_2	390	396	PF00069	0.628
MOD_PKA_2	552	558	PF00069	0.601
MOD_PKA_2	592	598	PF00069	0.712
MOD_PKA_2	612	618	PF00069	0.512
MOD_PKB_1	179	187	PF00069	0.608
MOD_PKB_1	87	95	PF00069	0.577
MOD_Plk_1	329	335	PF00069	0.390
MOD_Plk_1	564	570	PF00069	0.672
MOD_Plk_4	126	132	PF00069	0.618
MOD_Plk_4	281	287	PF00069	0.440
MOD_Plk_4	291	297	PF00069	0.417
MOD_Plk_4	452	458	PF00069	0.667
MOD_Plk_4	525	531	PF00069	0.476
MOD_ProDKin_1	1	7	PF00069	0.654
MOD_ProDKin_1	131	137	PF00069	0.679
MOD_ProDKin_1	182	188	PF00069	0.655
MOD_ProDKin_1	204	210	PF00069	0.582
MOD_ProDKin_1	30	36	PF00069	0.675
MOD_ProDKin_1	360	366	PF00069	0.642
MOD_ProDKin_1	395	401	PF00069	0.630
MOD_ProDKin_1	433	439	PF00069	0.653
MOD_ProDKin_1	440	446	PF00069	0.618
MOD_ProDKin_1	470	476	PF00069	0.615
MOD_ProDKin_1	541	547	PF00069	0.606
MOD_ProDKin_1	554	560	PF00069	0.763
MOD_ProDKin_1	57	63	PF00069	0.683
MOD_ProDKin_1	608	614	PF00069	0.757
MOD_ProDKin_1	77	83	PF00069	0.546
MOD_SUMO_rev_2	308	316	PF00179	0.472
TRG_DiLeu_BaEn_4	212	218	PF01217	0.572
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.595
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.579
TRG_ENDOCYTIC_2	325	328	PF00928	0.446
TRG_ENDOCYTIC_2	546	549	PF00928	0.637
TRG_ER_diArg_1	179	181	PF00400	0.582
TRG_ER_diArg_1	338	341	PF00400	0.438
TRG_ER_diArg_1	41	43	PF00400	0.513
TRG_ER_diArg_1	457	459	PF00400	0.672
TRG_ER_diArg_1	516	519	PF00400	0.488
TRG_ER_diArg_1	631	634	PF00400	0.531
TRG_ER_diArg_1	87	90	PF00400	0.572
TRG_Pf-PMV_PEXEL_1	634	638	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8T3	Leptomonas seymouri	36%	100%
A4HI45	Leishmania braziliensis	54%	98%
A4I5C1	Leishmania infantum	98%	100%
E9B0L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q7L3	Leishmania major	87%	100%