Putative GTPase activating protein for Arf family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE49_LEIDO

TriTrypDb:

LdBPK_290340.1 , LdCL_290008200 , LDHU3_29.0470

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE49

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	9
GO:0008047	enzyme activator activity	3	9
GO:0030234	enzyme regulator activity	2	9
GO:0030695	GTPase regulator activity	4	9
GO:0060589	nucleoside-triphosphatase regulator activity	3	9
GO:0098772	molecular function regulator activity	1	9
GO:0140677	molecular function activator activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.691
CLV_NRD_NRD_1	196	198	PF00675	0.438
CLV_NRD_NRD_1	25	27	PF00675	0.801
CLV_NRD_NRD_1	283	285	PF00675	0.708
CLV_PCSK_KEX2_1	25	27	PF00082	0.748
CLV_PCSK_KEX2_1	261	263	PF00082	0.667
CLV_PCSK_KEX2_1	283	285	PF00082	0.708
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.667
CLV_PCSK_PC7_1	279	285	PF00082	0.686
CLV_PCSK_SKI1_1	210	214	PF00082	0.455
DEG_APCC_DBOX_1	147	155	PF00400	0.438
DOC_CYCLIN_yClb5_NLxxxL_5	204	213	PF00134	0.575
DOC_USP7_MATH_1	177	181	PF00917	0.463
DOC_USP7_MATH_1	190	194	PF00917	0.397
DOC_USP7_MATH_1	380	384	PF00917	0.739
DOC_USP7_MATH_1	57	61	PF00917	0.764
DOC_USP7_UBL2_3	226	230	PF12436	0.637
DOC_USP7_UBL2_3	48	52	PF12436	0.799
DOC_WW_Pin1_4	238	243	PF00397	0.623
DOC_WW_Pin1_4	354	359	PF00397	0.755
DOC_WW_Pin1_4	375	380	PF00397	0.783
LIG_14-3-3_CanoR_1	113	118	PF00244	0.252
LIG_14-3-3_CanoR_1	148	152	PF00244	0.408
LIG_14-3-3_CanoR_1	244	253	PF00244	0.808
LIG_14-3-3_CanoR_1	289	296	PF00244	0.666
LIG_14-3-3_CanoR_1	316	322	PF00244	0.608
LIG_14-3-3_CanoR_1	94	103	PF00244	0.495
LIG_BIR_II_1	1	5	PF00653	0.708
LIG_BIR_III_2	249	253	PF00653	0.580
LIG_deltaCOP1_diTrp_1	314	324	PF00928	0.664
LIG_FHA_1	318	324	PF00498	0.663
LIG_FHA_1	383	389	PF00498	0.636
LIG_FHA_2	142	148	PF00498	0.357
LIG_FHA_2	165	171	PF00498	0.348
LIG_FHA_2	363	369	PF00498	0.809
LIG_FHA_2	64	70	PF00498	0.700
LIG_FHA_2	74	80	PF00498	0.659
LIG_Integrin_RGD_1	262	264	PF01839	0.657
LIG_LIR_Apic_2	219	225	PF02991	0.554
LIG_LIR_Gen_1	112	122	PF02991	0.333
LIG_LIR_Nem_3	112	117	PF02991	0.333
LIG_LIR_Nem_3	299	303	PF02991	0.641
LIG_PDZ_Class_2	384	389	PF00595	0.739
LIG_SH2_CRK	222	226	PF00017	0.586
LIG_SH2_STAP1	169	173	PF00017	0.357
LIG_SH2_STAP1	313	317	PF00017	0.662
LIG_SH3_3	236	242	PF00018	0.705
LIG_SH3_3	303	309	PF00018	0.576
LIG_SUMO_SIM_par_1	319	326	PF11976	0.676
LIG_SUMO_SIM_par_1	60	69	PF11976	0.572
LIG_TRAF2_1	309	312	PF00917	0.685
LIG_UBA3_1	156	164	PF00899	0.369
LIG_WRC_WIRS_1	191	196	PF05994	0.333
LIG_WRC_WIRS_1	300	305	PF05994	0.678
MOD_CDC14_SPxK_1	241	244	PF00782	0.625
MOD_CDK_SPxK_1	238	244	PF00069	0.625
MOD_CK1_1	291	297	PF00069	0.738
MOD_CK1_1	383	389	PF00069	0.705
MOD_CK2_1	147	153	PF00069	0.422
MOD_CK2_1	164	170	PF00069	0.227
MOD_CK2_1	322	328	PF00069	0.643
MOD_CK2_1	340	346	PF00069	0.741
MOD_CK2_1	362	368	PF00069	0.804
MOD_CK2_1	63	69	PF00069	0.705
MOD_Cter_Amidation	259	262	PF01082	0.688
MOD_GlcNHglycan	127	130	PF01048	0.387
MOD_GlcNHglycan	179	182	PF01048	0.441
MOD_GlcNHglycan	290	293	PF01048	0.672
MOD_GlcNHglycan	342	345	PF01048	0.767
MOD_GlcNHglycan	382	385	PF01048	0.661
MOD_GlcNHglycan	52	55	PF01048	0.748
MOD_GSK3_1	109	116	PF00069	0.340
MOD_GSK3_1	136	143	PF00069	0.357
MOD_GSK3_1	240	247	PF00069	0.686
MOD_GSK3_1	27	34	PF00069	0.760
MOD_GSK3_1	378	385	PF00069	0.531
MOD_GSK3_1	59	66	PF00069	0.800
MOD_N-GLC_1	362	367	PF02516	0.583
MOD_N-GLC_2	102	104	PF02516	0.346
MOD_PIKK_1	94	100	PF00454	0.415
MOD_PK_1	113	119	PF00069	0.357
MOD_PKA_2	112	118	PF00069	0.367
MOD_PKA_2	125	131	PF00069	0.344
MOD_PKA_2	147	153	PF00069	0.438
MOD_PKA_2	177	183	PF00069	0.438
MOD_PKA_2	243	249	PF00069	0.799
MOD_PKA_2	278	284	PF00069	0.719
MOD_PKA_2	288	294	PF00069	0.583
MOD_PKA_2	73	79	PF00069	0.677
MOD_Plk_1	362	368	PF00069	0.588
MOD_Plk_2-3	147	153	PF00069	0.438
MOD_Plk_4	164	170	PF00069	0.369
MOD_Plk_4	383	389	PF00069	0.627
MOD_ProDKin_1	238	244	PF00069	0.625
MOD_ProDKin_1	354	360	PF00069	0.755
MOD_ProDKin_1	375	381	PF00069	0.780
TRG_ENDOCYTIC_2	300	303	PF00928	0.687
TRG_NLS_MonoExtN_4	48	53	PF00514	0.815
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F7	Leptomonas seymouri	61%	100%
A0A1X0NZE9	Trypanosomatidae	45%	100%
A0A422N066	Trypanosoma rangeli	43%	100%
A4HH34	Leishmania braziliensis	68%	100%
A4I485	Leishmania infantum	99%	100%
E9ADN4	Leishmania major	90%	99%
E9AM46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%