Tetratricopeptide repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IE47_LEIDO

TriTrypDb:

LdBPK_282740.1 , LdCL_280032500 , LDHU3_28.3720

Length:

1003

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE47

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.572
CLV_C14_Caspase3-7	268	272	PF00656	0.724
CLV_NRD_NRD_1	126	128	PF00675	0.555
CLV_NRD_NRD_1	130	132	PF00675	0.549
CLV_NRD_NRD_1	489	491	PF00675	0.676
CLV_NRD_NRD_1	525	527	PF00675	0.496
CLV_NRD_NRD_1	558	560	PF00675	0.602
CLV_NRD_NRD_1	822	824	PF00675	0.478
CLV_NRD_NRD_1	876	878	PF00675	0.655
CLV_NRD_NRD_1	888	890	PF00675	0.668
CLV_NRD_NRD_1	912	914	PF00675	0.721
CLV_PCSK_FUR_1	886	890	PF00082	0.700
CLV_PCSK_KEX2_1	126	128	PF00082	0.555
CLV_PCSK_KEX2_1	130	132	PF00082	0.549
CLV_PCSK_KEX2_1	489	491	PF00082	0.665
CLV_PCSK_KEX2_1	525	527	PF00082	0.496
CLV_PCSK_KEX2_1	558	560	PF00082	0.602
CLV_PCSK_KEX2_1	822	824	PF00082	0.478
CLV_PCSK_KEX2_1	875	877	PF00082	0.651
CLV_PCSK_KEX2_1	886	888	PF00082	0.681
CLV_PCSK_KEX2_1	912	914	PF00082	0.721
CLV_PCSK_PC7_1	126	132	PF00082	0.550
CLV_PCSK_PC7_1	554	560	PF00082	0.700
CLV_PCSK_SKI1_1	152	156	PF00082	0.509
CLV_PCSK_SKI1_1	334	338	PF00082	0.619
CLV_PCSK_SKI1_1	484	488	PF00082	0.523
CLV_PCSK_SKI1_1	525	529	PF00082	0.493
CLV_PCSK_SKI1_1	561	565	PF00082	0.716
CLV_PCSK_SKI1_1	664	668	PF00082	0.450
CLV_PCSK_SKI1_1	682	686	PF00082	0.477
CLV_PCSK_SKI1_1	741	745	PF00082	0.646
CLV_PCSK_SKI1_1	75	79	PF00082	0.471
CLV_PCSK_SKI1_1	809	813	PF00082	0.619
CLV_PCSK_SKI1_1	823	827	PF00082	0.420
CLV_PCSK_SKI1_1	844	848	PF00082	0.468
DEG_APCC_DBOX_1	129	137	PF00400	0.519
DEG_SPOP_SBC_1	282	286	PF00917	0.727
DEG_SPOP_SBC_1	391	395	PF00917	0.632
DEG_SPOP_SBC_1	405	409	PF00917	0.632
DOC_ANK_TNKS_1	188	195	PF00023	0.565
DOC_ANK_TNKS_1	538	545	PF00023	0.638
DOC_ANK_TNKS_1	943	950	PF00023	0.594
DOC_CKS1_1	922	927	PF01111	0.777
DOC_CKS1_1	971	976	PF01111	0.650
DOC_CYCLIN_RxL_1	329	342	PF00134	0.620
DOC_CYCLIN_RxL_1	4	12	PF00134	0.555
DOC_CYCLIN_RxL_1	661	670	PF00134	0.467
DOC_CYCLIN_RxL_1	841	851	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.502
DOC_MAPK_gen_1	126	136	PF00069	0.539
DOC_MAPK_gen_1	475	485	PF00069	0.628
DOC_MAPK_gen_1	525	532	PF00069	0.494
DOC_MAPK_gen_1	72	80	PF00069	0.574
DOC_MAPK_gen_1	822	828	PF00069	0.483
DOC_MAPK_MEF2A_6	478	487	PF00069	0.641
DOC_MAPK_MEF2A_6	525	534	PF00069	0.521
DOC_MAPK_NFAT4_5	525	533	PF00069	0.491
DOC_PP1_RVXF_1	842	849	PF00149	0.468
DOC_PP2B_LxvP_1	161	164	PF13499	0.513
DOC_PP2B_LxvP_1	374	377	PF13499	0.621
DOC_PP4_FxxP_1	774	777	PF00568	0.508
DOC_USP7_MATH_1	119	123	PF00917	0.718
DOC_USP7_MATH_1	276	280	PF00917	0.758
DOC_USP7_MATH_1	282	286	PF00917	0.671
DOC_USP7_MATH_1	375	379	PF00917	0.627
DOC_USP7_MATH_1	391	395	PF00917	0.648
DOC_USP7_MATH_1	405	409	PF00917	0.665
DOC_USP7_MATH_1	585	589	PF00917	0.570
DOC_USP7_MATH_1	842	846	PF00917	0.586
DOC_USP7_MATH_1	894	898	PF00917	0.756
DOC_USP7_MATH_2	219	225	PF00917	0.644
DOC_WW_Pin1_4	111	116	PF00397	0.586
DOC_WW_Pin1_4	269	274	PF00397	0.782
DOC_WW_Pin1_4	366	371	PF00397	0.643
DOC_WW_Pin1_4	426	431	PF00397	0.714
DOC_WW_Pin1_4	448	453	PF00397	0.601
DOC_WW_Pin1_4	502	507	PF00397	0.763
DOC_WW_Pin1_4	618	623	PF00397	0.660
DOC_WW_Pin1_4	761	766	PF00397	0.646
DOC_WW_Pin1_4	784	789	PF00397	0.481
DOC_WW_Pin1_4	906	911	PF00397	0.685
DOC_WW_Pin1_4	914	919	PF00397	0.797
DOC_WW_Pin1_4	921	926	PF00397	0.594
DOC_WW_Pin1_4	970	975	PF00397	0.646
LIG_14-3-3_CanoR_1	174	181	PF00244	0.524
LIG_14-3-3_CanoR_1	334	339	PF00244	0.759
LIG_14-3-3_CanoR_1	668	676	PF00244	0.377
LIG_14-3-3_CanoR_1	682	690	PF00244	0.479
LIG_14-3-3_CanoR_1	892	901	PF00244	0.609
LIG_Actin_WH2_2	545	563	PF00022	0.618
LIG_APCC_ABBA_1	165	170	PF00400	0.659
LIG_APCC_ABBAyCdc20_2	844	850	PF00400	0.472
LIG_BIR_II_1	1	5	PF00653	0.520
LIG_BIR_III_2	449	453	PF00653	0.568
LIG_BIR_III_4	280	284	PF00653	0.781
LIG_BRCT_BRCA1_1	341	345	PF00533	0.608
LIG_BRCT_BRCA1_1	844	848	PF00533	0.469
LIG_CaM_NSCaTE_8	575	582	PF13499	0.654
LIG_EH1_1	641	649	PF00400	0.637
LIG_EH1_1	659	667	PF00400	0.402
LIG_eIF4E_1	661	667	PF01652	0.486
LIG_FHA_1	695	701	PF00498	0.442
LIG_FHA_1	752	758	PF00498	0.515
LIG_FHA_2	140	146	PF00498	0.499
LIG_FHA_2	234	240	PF00498	0.637
LIG_FHA_2	284	290	PF00498	0.719
LIG_FHA_2	378	384	PF00498	0.804
LIG_FHA_2	499	505	PF00498	0.650
LIG_FHA_2	569	575	PF00498	0.553
LIG_FHA_2	906	912	PF00498	0.731
LIG_FHA_2	922	928	PF00498	0.604
LIG_Integrin_RGD_1	608	610	PF01839	0.614
LIG_LIR_Apic_2	771	777	PF02991	0.522
LIG_LIR_Gen_1	48	57	PF02991	0.425
LIG_LIR_Gen_1	935	945	PF02991	0.614
LIG_LIR_Nem_3	48	53	PF02991	0.440
LIG_LIR_Nem_3	935	940	PF02991	0.614
LIG_LIR_Nem_3	992	998	PF02991	0.552
LIG_LYPXL_S_1	80	84	PF13949	0.466
LIG_LYPXL_yS_3	81	84	PF13949	0.463
LIG_PCNA_APIM_2	129	135	PF02747	0.485
LIG_PCNA_yPIPBox_3	741	753	PF02747	0.593
LIG_Pex14_2	704	708	PF04695	0.413
LIG_REV1ctd_RIR_1	640	650	PF16727	0.549
LIG_RPA_C_Fungi	485	497	PF08784	0.540
LIG_SH2_CRK	535	539	PF00017	0.538
LIG_SH2_CRK	88	92	PF00017	0.460
LIG_SH2_NCK_1	88	92	PF00017	0.575
LIG_SH2_PTP2	810	813	PF00017	0.440
LIG_SH2_STAT5	132	135	PF00017	0.521
LIG_SH2_STAT5	149	152	PF00017	0.501
LIG_SH2_STAT5	168	171	PF00017	0.549
LIG_SH2_STAT5	313	316	PF00017	0.728
LIG_SH2_STAT5	463	466	PF00017	0.439
LIG_SH2_STAT5	661	664	PF00017	0.553
LIG_SH2_STAT5	810	813	PF00017	0.458
LIG_SH2_STAT5	816	819	PF00017	0.403
LIG_SH3_2	115	120	PF14604	0.602
LIG_SH3_3	112	118	PF00018	0.593
LIG_SH3_3	161	167	PF00018	0.502
LIG_SH3_3	203	209	PF00018	0.590
LIG_SH3_3	304	310	PF00018	0.587
LIG_SH3_3	350	356	PF00018	0.639
LIG_SH3_3	364	370	PF00018	0.628
LIG_SH3_3	79	85	PF00018	0.474
LIG_SH3_3	913	919	PF00018	0.770
LIG_SH3_3	968	974	PF00018	0.713
LIG_SH3_5	309	313	PF00018	0.693
LIG_SUMO_SIM_anti_2	198	205	PF11976	0.720
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.591
LIG_SUMO_SIM_par_1	372	380	PF11976	0.604
LIG_TRAF2_1	121	124	PF00917	0.591
LIG_TRAF2_1	257	260	PF00917	0.615
LIG_TRAF2_1	46	49	PF00917	0.493
LIG_TRAF2_2	444	449	PF00917	0.622
LIG_WW_3	117	121	PF00397	0.608
LIG_WW_3	969	973	PF00397	0.678
MOD_CDC14_SPxK_1	909	912	PF00782	0.708
MOD_CDK_SPK_2	111	116	PF00069	0.666
MOD_CDK_SPK_2	784	789	PF00069	0.524
MOD_CDK_SPxK_1	906	912	PF00069	0.701
MOD_CDK_SPxxK_3	761	768	PF00069	0.637
MOD_CDK_SPxxK_3	784	791	PF00069	0.580
MOD_CDK_SPxxK_3	906	913	PF00069	0.703
MOD_CK1_1	285	291	PF00069	0.754
MOD_CK1_1	293	299	PF00069	0.677
MOD_CK1_1	300	306	PF00069	0.550
MOD_CK1_1	42	48	PF00069	0.570
MOD_CK1_1	500	506	PF00069	0.592
MOD_CK1_1	586	592	PF00069	0.557
MOD_CK1_1	917	923	PF00069	0.722
MOD_CK1_1	929	935	PF00069	0.594
MOD_CK1_1	997	1003	PF00069	0.542
MOD_CK2_1	118	124	PF00069	0.601
MOD_CK2_1	197	203	PF00069	0.605
MOD_CK2_1	233	239	PF00069	0.636
MOD_CK2_1	377	383	PF00069	0.797
MOD_CK2_1	392	398	PF00069	0.536
MOD_CK2_1	42	48	PF00069	0.503
MOD_CK2_1	498	504	PF00069	0.656
MOD_CK2_1	568	574	PF00069	0.551
MOD_CK2_1	866	872	PF00069	0.518
MOD_CK2_1	905	911	PF00069	0.728
MOD_Cter_Amidation	873	876	PF01082	0.640
MOD_GlcNHglycan	181	184	PF01048	0.559
MOD_GlcNHglycan	232	236	PF01048	0.782
MOD_GlcNHglycan	289	293	PF01048	0.693
MOD_GlcNHglycan	395	398	PF01048	0.740
MOD_GlcNHglycan	414	417	PF01048	0.599
MOD_GlcNHglycan	435	438	PF01048	0.557
MOD_GlcNHglycan	44	47	PF01048	0.580
MOD_GlcNHglycan	464	467	PF01048	0.427
MOD_GlcNHglycan	535	538	PF01048	0.534
MOD_GlcNHglycan	580	583	PF01048	0.559
MOD_GlcNHglycan	585	588	PF01048	0.570
MOD_GlcNHglycan	594	597	PF01048	0.649
MOD_GlcNHglycan	896	899	PF01048	0.683
MOD_GlcNHglycan	932	935	PF01048	0.746
MOD_GlcNHglycan	937	940	PF01048	0.691
MOD_GlcNHglycan	961	964	PF01048	0.671
MOD_GlcNHglycan	984	988	PF01048	0.599
MOD_GSK3_1	179	186	PF00069	0.565
MOD_GSK3_1	281	288	PF00069	0.716
MOD_GSK3_1	293	300	PF00069	0.633
MOD_GSK3_1	313	320	PF00069	0.478
MOD_GSK3_1	406	413	PF00069	0.564
MOD_GSK3_1	450	457	PF00069	0.496
MOD_GSK3_1	498	505	PF00069	0.691
MOD_GSK3_1	533	540	PF00069	0.651
MOD_GSK3_1	583	590	PF00069	0.616
MOD_GSK3_1	614	621	PF00069	0.696
MOD_GSK3_1	917	924	PF00069	0.659
MOD_GSK3_1	926	933	PF00069	0.675
MOD_GSK3_1	959	966	PF00069	0.691
MOD_GSK3_1	979	986	PF00069	0.697
MOD_N-GLC_1	296	301	PF02516	0.745
MOD_N-GLC_2	56	58	PF02516	0.398
MOD_NEK2_1	202	207	PF00069	0.614
MOD_NEK2_1	233	238	PF00069	0.674
MOD_NEK2_1	406	411	PF00069	0.704
MOD_NEK2_1	433	438	PF00069	0.589
MOD_NEK2_1	583	588	PF00069	0.583
MOD_NEK2_1	737	742	PF00069	0.605
MOD_NEK2_1	848	853	PF00069	0.593
MOD_NEK2_1	905	910	PF00069	0.577
MOD_NEK2_1	926	931	PF00069	0.605
MOD_NEK2_1	994	999	PF00069	0.553
MOD_NEK2_2	2	7	PF00069	0.600
MOD_NEK2_2	677	682	PF00069	0.597
MOD_PIKK_1	313	319	PF00454	0.683
MOD_PIKK_1	377	383	PF00454	0.738
MOD_PIKK_1	848	854	PF00454	0.572
MOD_PK_1	912	918	PF00069	0.721
MOD_PKA_1	888	894	PF00069	0.651
MOD_PKA_1	912	918	PF00069	0.721
MOD_PKA_2	119	125	PF00069	0.618
MOD_PKA_2	221	227	PF00069	0.605
MOD_PKA_2	300	306	PF00069	0.774
MOD_PKA_2	339	345	PF00069	0.613
MOD_PKA_2	667	673	PF00069	0.378
MOD_PKA_2	888	894	PF00069	0.651
MOD_PKA_2	912	918	PF00069	0.721
MOD_PKB_1	886	894	PF00069	0.671
MOD_Plk_1	197	203	PF00069	0.602
MOD_Plk_1	357	363	PF00069	0.658
MOD_Plk_1	694	700	PF00069	0.442
MOD_Plk_2-3	417	423	PF00069	0.639
MOD_Plk_4	197	203	PF00069	0.685
MOD_Plk_4	290	296	PF00069	0.724
MOD_Plk_4	334	340	PF00069	0.569
MOD_Plk_4	866	872	PF00069	0.542
MOD_Plk_4	997	1003	PF00069	0.558
MOD_ProDKin_1	111	117	PF00069	0.590
MOD_ProDKin_1	269	275	PF00069	0.781
MOD_ProDKin_1	366	372	PF00069	0.646
MOD_ProDKin_1	426	432	PF00069	0.706
MOD_ProDKin_1	448	454	PF00069	0.592
MOD_ProDKin_1	502	508	PF00069	0.763
MOD_ProDKin_1	618	624	PF00069	0.660
MOD_ProDKin_1	761	767	PF00069	0.636
MOD_ProDKin_1	784	790	PF00069	0.478
MOD_ProDKin_1	906	912	PF00069	0.689
MOD_ProDKin_1	914	920	PF00069	0.798
MOD_ProDKin_1	921	927	PF00069	0.594
MOD_ProDKin_1	970	976	PF00069	0.647
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.740
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.715
TRG_DiLeu_BaLyEn_6	661	666	PF01217	0.369
TRG_DiLeu_BaLyEn_6	862	867	PF01217	0.509
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.595
TRG_DiLeu_BaLyEn_6	975	980	PF01217	0.640
TRG_DiLeu_LyEn_5	428	433	PF01217	0.566
TRG_ENDOCYTIC_2	535	538	PF00928	0.534
TRG_ENDOCYTIC_2	81	84	PF00928	0.463
TRG_ENDOCYTIC_2	88	91	PF00928	0.455
TRG_ER_diArg_1	125	127	PF00400	0.583
TRG_ER_diArg_1	129	131	PF00400	0.543
TRG_ER_diArg_1	319	322	PF00400	0.633
TRG_ER_diArg_1	489	491	PF00400	0.723
TRG_ER_diArg_1	525	527	PF00400	0.496
TRG_ER_diArg_1	538	541	PF00400	0.536
TRG_ER_diArg_1	558	561	PF00400	0.567
TRG_ER_diArg_1	788	791	PF00400	0.568
TRG_ER_diArg_1	821	823	PF00400	0.476
TRG_ER_diArg_1	863	866	PF00400	0.514
TRG_ER_diArg_1	875	877	PF00400	0.663
TRG_ER_diArg_1	885	888	PF00400	0.675
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	729	733	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	988	992	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B1	Leptomonas seymouri	54%	100%
A4HGV7	Leishmania braziliensis	76%	100%
A4I3Y7	Leishmania infantum	100%	100%
E9B077	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q808	Leishmania major	91%	100%