Vasohibin_putative/Pfam:PF14822

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vasohibin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE45_LEIDO

TriTrypDb:

LdBPK_270470.1 , LdCL_270009500 , LDHU3_27.0550

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3Q8IE45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE45

Function

Biological processes
Term	Name	Level	Count
GO:0022603	regulation of anatomical structure morphogenesis	4	7
GO:0045765	regulation of angiogenesis	5	7
GO:0050789	regulation of biological process	2	7
GO:0050793	regulation of developmental process	3	7
GO:0051239	regulation of multicellular organismal process	3	7
GO:0065007	biological regulation	1	7
GO:1901342	regulation of vasculature development	5	7
GO:2000026	regulation of multicellular organismal development	4	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.732
CLV_NRD_NRD_1	147	149	PF00675	0.346
CLV_NRD_NRD_1	240	242	PF00675	0.772
CLV_NRD_NRD_1	400	402	PF00675	0.526
CLV_NRD_NRD_1	422	424	PF00675	0.605
CLV_NRD_NRD_1	583	585	PF00675	0.807
CLV_PCSK_KEX2_1	221	223	PF00082	0.266
CLV_PCSK_KEX2_1	400	402	PF00082	0.526
CLV_PCSK_KEX2_1	417	419	PF00082	0.575
CLV_PCSK_KEX2_1	429	431	PF00082	0.712
CLV_PCSK_KEX2_1	463	465	PF00082	0.804
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.266
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.677
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.616
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.806
CLV_PCSK_SKI1_1	218	222	PF00082	0.419
CLV_PCSK_SKI1_1	287	291	PF00082	0.714
CLV_PCSK_SKI1_1	378	382	PF00082	0.526
CLV_PCSK_SKI1_1	423	427	PF00082	0.678
CLV_PCSK_SKI1_1	62	66	PF00082	0.346
CLV_PCSK_SKI1_1	81	85	PF00082	0.346
DEG_SIAH_1	482	490	PF03145	0.605
DEG_SPOP_SBC_1	334	338	PF00917	0.668
DOC_CKS1_1	575	580	PF01111	0.692
DOC_CKS1_1	604	609	PF01111	0.778
DOC_MAPK_gen_1	378	387	PF00069	0.508
DOC_MAPK_gen_1	460	469	PF00069	0.810
DOC_MAPK_gen_1	69	78	PF00069	0.619
DOC_MAPK_MEF2A_6	107	116	PF00069	0.530
DOC_PP1_RVXF_1	379	385	PF00149	0.613
DOC_PP2B_LxvP_1	318	321	PF13499	0.639
DOC_PP2B_LxvP_1	425	428	PF13499	0.782
DOC_PP2B_LxvP_1	467	470	PF13499	0.718
DOC_PP2B_LxvP_1	499	502	PF13499	0.731
DOC_PP4_FxxP_1	571	574	PF00568	0.798
DOC_PP4_FxxP_1	604	607	PF00568	0.656
DOC_USP7_MATH_1	158	162	PF00917	0.619
DOC_USP7_MATH_1	248	252	PF00917	0.807
DOC_USP7_MATH_1	28	32	PF00917	0.546
DOC_USP7_MATH_1	294	298	PF00917	0.729
DOC_USP7_MATH_1	327	331	PF00917	0.734
DOC_USP7_MATH_1	438	442	PF00917	0.721
DOC_USP7_MATH_1	481	485	PF00917	0.666
DOC_USP7_MATH_1	544	548	PF00917	0.761
DOC_USP7_UBL2_3	221	225	PF12436	0.466
DOC_WW_Pin1_4	134	139	PF00397	0.500
DOC_WW_Pin1_4	220	225	PF00397	0.508
DOC_WW_Pin1_4	263	268	PF00397	0.717
DOC_WW_Pin1_4	316	321	PF00397	0.704
DOC_WW_Pin1_4	325	330	PF00397	0.756
DOC_WW_Pin1_4	407	412	PF00397	0.524
DOC_WW_Pin1_4	489	494	PF00397	0.686
DOC_WW_Pin1_4	540	545	PF00397	0.727
DOC_WW_Pin1_4	554	559	PF00397	0.631
DOC_WW_Pin1_4	574	579	PF00397	0.692
DOC_WW_Pin1_4	603	608	PF00397	0.784
DOC_WW_Pin1_4	614	619	PF00397	0.632
LIG_14-3-3_CanoR_1	111	117	PF00244	0.533
LIG_14-3-3_CanoR_1	133	138	PF00244	0.569
LIG_14-3-3_CanoR_1	464	468	PF00244	0.789
LIG_14-3-3_CanoR_1	584	594	PF00244	0.812
LIG_14-3-3_CanoR_1	595	604	PF00244	0.619
LIG_14-3-3_CanoR_1	62	68	PF00244	0.546
LIG_Actin_WH2_2	93	109	PF00022	0.530
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_BIR_III_2	560	564	PF00653	0.728
LIG_BRCT_BRCA1_1	304	308	PF00533	0.737
LIG_BRCT_BRCA1_1	600	604	PF00533	0.688
LIG_BRCT_BRCA1_1	74	78	PF00533	0.619
LIG_deltaCOP1_diTrp_1	198	203	PF00928	0.546
LIG_EH_1	15	19	PF12763	0.411
LIG_eIF4E_1	125	131	PF01652	0.546
LIG_EVH1_1	24	28	PF00568	0.619
LIG_EVH1_1	331	335	PF00568	0.581
LIG_FHA_1	101	107	PF00498	0.536
LIG_FHA_1	135	141	PF00498	0.522
LIG_FHA_2	103	109	PF00498	0.619
LIG_FHA_2	188	194	PF00498	0.546
LIG_FHA_2	359	365	PF00498	0.591
LIG_FHA_2	77	83	PF00498	0.546
LIG_GBD_Chelix_1	348	356	PF00786	0.575
LIG_LIR_Apic_2	568	574	PF02991	0.705
LIG_LIR_Apic_2	601	607	PF02991	0.663
LIG_LIR_Gen_1	161	169	PF02991	0.546
LIG_LIR_Gen_1	172	181	PF02991	0.546
LIG_LIR_Gen_1	353	362	PF02991	0.480
LIG_LIR_Gen_1	56	65	PF02991	0.546
LIG_LIR_Gen_1	94	102	PF02991	0.546
LIG_LIR_Nem_3	151	157	PF02991	0.589
LIG_LIR_Nem_3	161	166	PF02991	0.504
LIG_LIR_Nem_3	172	176	PF02991	0.546
LIG_LIR_Nem_3	198	204	PF02991	0.516
LIG_LIR_Nem_3	305	311	PF02991	0.730
LIG_LIR_Nem_3	343	348	PF02991	0.523
LIG_LIR_Nem_3	353	358	PF02991	0.478
LIG_LIR_Nem_3	364	370	PF02991	0.503
LIG_LIR_Nem_3	56	60	PF02991	0.546
LIG_LIR_Nem_3	63	67	PF02991	0.546
LIG_LIR_Nem_3	94	100	PF02991	0.511
LIG_MYND_1	263	267	PF01753	0.738
LIG_MYND_1	574	578	PF01753	0.689
LIG_NRP_CendR_1	619	620	PF00754	0.703
LIG_Pex14_2	604	608	PF04695	0.704
LIG_PTB_Apo_2	246	253	PF02174	0.745
LIG_Rb_LxCxE_1	86	108	PF01857	0.546
LIG_SH2_CRK	141	145	PF00017	0.546
LIG_SH2_CRK	154	158	PF00017	0.546
LIG_SH2_CRK	159	163	PF00017	0.546
LIG_SH2_CRK	345	349	PF00017	0.547
LIG_SH2_CRK	355	359	PF00017	0.412
LIG_SH2_CRK	367	371	PF00017	0.512
LIG_SH2_SRC	590	593	PF00017	0.732
LIG_SH2_STAP1	102	106	PF00017	0.619
LIG_SH2_STAP1	304	308	PF00017	0.737
LIG_SH2_STAT5	102	105	PF00017	0.619
LIG_SH3_3	22	28	PF00018	0.552
LIG_SH3_3	261	267	PF00018	0.767
LIG_SH3_3	326	332	PF00018	0.776
LIG_SH3_3	483	489	PF00018	0.685
LIG_SH3_3	521	527	PF00018	0.684
LIG_SH3_3	572	578	PF00018	0.711
LIG_SUMO_SIM_par_1	128	134	PF11976	0.546
LIG_SUMO_SIM_par_1	2	10	PF11976	0.521
LIG_TYR_ITIM	152	157	PF00017	0.583
LIG_TYR_ITIM	55	60	PF00017	0.546
LIG_UBA3_1	180	184	PF00899	0.619
LIG_WW_3	26	30	PF00397	0.546
LIG_WW_3	268	272	PF00397	0.729
MOD_CDC14_SPxK_1	617	620	PF00782	0.768
MOD_CDK_SPK_2	220	225	PF00069	0.477
MOD_CDK_SPK_2	574	579	PF00069	0.692
MOD_CDK_SPK_2	614	619	PF00069	0.693
MOD_CDK_SPxK_1	614	620	PF00069	0.773
MOD_CK1_1	115	121	PF00069	0.546
MOD_CK1_1	232	238	PF00069	0.732
MOD_CK1_1	251	257	PF00069	0.716
MOD_CK1_1	316	322	PF00069	0.707
MOD_CK1_1	325	331	PF00069	0.753
MOD_CK1_1	410	416	PF00069	0.527
MOD_CK1_1	505	511	PF00069	0.754
MOD_CK1_1	519	525	PF00069	0.718
MOD_CK1_1	53	59	PF00069	0.626
MOD_CK1_1	540	546	PF00069	0.717
MOD_CK1_1	562	568	PF00069	0.569
MOD_CK1_1	593	599	PF00069	0.721
MOD_CK1_1	72	78	PF00069	0.398
MOD_CK2_1	187	193	PF00069	0.546
MOD_CK2_1	220	226	PF00069	0.563
MOD_CK2_1	292	298	PF00069	0.807
MOD_CK2_1	358	364	PF00069	0.587
MOD_CK2_1	391	397	PF00069	0.655
MOD_CK2_1	562	568	PF00069	0.705
MOD_CK2_1	585	591	PF00069	0.818
MOD_CK2_1	76	82	PF00069	0.546
MOD_GlcNHglycan	273	277	PF01048	0.732
MOD_GlcNHglycan	286	290	PF01048	0.650
MOD_GlcNHglycan	393	396	PF01048	0.651
MOD_GlcNHglycan	40	43	PF01048	0.391
MOD_GlcNHglycan	412	415	PF01048	0.399
MOD_GlcNHglycan	438	441	PF01048	0.779
MOD_GlcNHglycan	442	445	PF01048	0.672
MOD_GlcNHglycan	452	455	PF01048	0.622
MOD_GlcNHglycan	483	486	PF01048	0.655
MOD_GlcNHglycan	507	510	PF01048	0.757
MOD_GlcNHglycan	511	514	PF01048	0.596
MOD_GlcNHglycan	540	543	PF01048	0.778
MOD_GlcNHglycan	546	549	PF01048	0.737
MOD_GlcNHglycan	598	601	PF01048	0.721
MOD_GSK3_1	144	151	PF00069	0.543
MOD_GSK3_1	216	223	PF00069	0.566
MOD_GSK3_1	228	235	PF00069	0.744
MOD_GSK3_1	248	255	PF00069	0.487
MOD_GSK3_1	292	299	PF00069	0.765
MOD_GSK3_1	309	316	PF00069	0.633
MOD_GSK3_1	436	443	PF00069	0.707
MOD_GSK3_1	458	465	PF00069	0.674
MOD_GSK3_1	505	512	PF00069	0.612
MOD_GSK3_1	540	547	PF00069	0.726
MOD_GSK3_1	590	597	PF00069	0.719
MOD_GSK3_1	598	605	PF00069	0.676
MOD_GSK3_1	606	613	PF00069	0.630
MOD_GSK3_1	72	79	PF00069	0.546
MOD_LATS_1	227	233	PF00433	0.657
MOD_LATS_1	239	245	PF00433	0.626
MOD_N-GLC_1	248	253	PF02516	0.821
MOD_N-GLC_1	325	330	PF02516	0.708
MOD_N-GLC_1	436	441	PF02516	0.750
MOD_NEK2_1	100	105	PF00069	0.546
MOD_NEK2_1	144	149	PF00069	0.543
MOD_NEK2_1	252	257	PF00069	0.742
MOD_NEK2_1	285	290	PF00069	0.791
MOD_NEK2_1	516	521	PF00069	0.685
MOD_NEK2_1	594	599	PF00069	0.791
MOD_NEK2_1	610	615	PF00069	0.548
MOD_NEK2_1	93	98	PF00069	0.546
MOD_NEK2_2	102	107	PF00069	0.569
MOD_NEK2_2	158	163	PF00069	0.619
MOD_OFUCOSY	559	566	PF10250	0.604
MOD_PIKK_1	10	16	PF00454	0.537
MOD_PIKK_1	100	106	PF00454	0.546
MOD_PK_1	50	56	PF00069	0.619
MOD_PKA_1	148	154	PF00069	0.546
MOD_PKA_1	241	247	PF00069	0.686
MOD_PKA_1	463	469	PF00069	0.805
MOD_PKA_2	28	34	PF00069	0.546
MOD_PKA_2	38	44	PF00069	0.546
MOD_PKA_2	391	397	PF00069	0.577
MOD_PKA_2	463	469	PF00069	0.805
MOD_PKA_2	594	600	PF00069	0.761
MOD_Plk_1	192	198	PF00069	0.546
MOD_Plk_1	216	222	PF00069	0.563
MOD_Plk_1	248	254	PF00069	0.742
MOD_Plk_1	314	320	PF00069	0.700
MOD_Plk_1	502	508	PF00069	0.717
MOD_Plk_1	93	99	PF00069	0.546
MOD_Plk_2-3	564	570	PF00069	0.706
MOD_Plk_4	148	154	PF00069	0.536
MOD_Plk_4	158	164	PF00069	0.518
MOD_Plk_4	495	501	PF00069	0.737
MOD_Plk_4	72	78	PF00069	0.546
MOD_Plk_4	93	99	PF00069	0.546
MOD_ProDKin_1	134	140	PF00069	0.500
MOD_ProDKin_1	220	226	PF00069	0.508
MOD_ProDKin_1	263	269	PF00069	0.714
MOD_ProDKin_1	316	322	PF00069	0.707
MOD_ProDKin_1	325	331	PF00069	0.753
MOD_ProDKin_1	407	413	PF00069	0.527
MOD_ProDKin_1	489	495	PF00069	0.688
MOD_ProDKin_1	540	546	PF00069	0.726
MOD_ProDKin_1	554	560	PF00069	0.632
MOD_ProDKin_1	574	580	PF00069	0.691
MOD_ProDKin_1	603	609	PF00069	0.783
MOD_ProDKin_1	614	620	PF00069	0.634
MOD_SUMO_for_1	116	119	PF00179	0.546
MOD_SUMO_rev_2	179	185	PF00179	0.619
MOD_SUMO_rev_2	410	419	PF00179	0.643
MOD_SUMO_rev_2	472	481	PF00179	0.688
TRG_DiLeu_BaEn_2	42	48	PF01217	0.619
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.469
TRG_ENDOCYTIC_2	125	128	PF00928	0.546
TRG_ENDOCYTIC_2	141	144	PF00928	0.546
TRG_ENDOCYTIC_2	154	157	PF00928	0.546
TRG_ENDOCYTIC_2	159	162	PF00928	0.546
TRG_ENDOCYTIC_2	173	176	PF00928	0.546
TRG_ENDOCYTIC_2	345	348	PF00928	0.503
TRG_ENDOCYTIC_2	355	358	PF00928	0.476
TRG_ENDOCYTIC_2	367	370	PF00928	0.506
TRG_ENDOCYTIC_2	57	60	PF00928	0.546
TRG_ER_diArg_1	132	135	PF00400	0.526
TRG_ER_diArg_1	400	402	PF00400	0.526
TRG_ER_diArg_1	618	620	PF00400	0.685
TRG_NLS_MonoExtC_3	422	427	PF00514	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY3	Leptomonas seymouri	49%	94%
A4HFH0	Leishmania braziliensis	74%	99%
A4I2N2	Leishmania infantum	99%	100%
E9AD23	Leishmania major	87%	99%
E9AYU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%