Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE44_LEIDO

TriTrypDb:

LdBPK_180060.1 , LdCL_180005500 , LDHU3_18.0070

Length:

157

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IE44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.616
CLV_NRD_NRD_1	3	5	PF00675	0.440
CLV_NRD_NRD_1	42	44	PF00675	0.394
CLV_NRD_NRD_1	71	73	PF00675	0.386
CLV_PCSK_KEX2_1	3	5	PF00082	0.440
CLV_PCSK_KEX2_1	42	44	PF00082	0.394
CLV_PCSK_SKI1_1	137	141	PF00082	0.681
CLV_PCSK_SKI1_1	43	47	PF00082	0.386
DEG_MDM2_SWIB_1	94	102	PF02201	0.266
DEG_Nend_Nbox_1	1	3	PF02207	0.629
DEG_SCF_FBW7_2	110	116	PF00400	0.413
DOC_CKS1_1	110	115	PF01111	0.412
DOC_MAPK_gen_1	72	78	PF00069	0.582
DOC_PP1_RVXF_1	52	58	PF00149	0.625
DOC_USP7_MATH_1	17	21	PF00917	0.611
DOC_WW_Pin1_4	109	114	PF00397	0.397
DOC_WW_Pin1_4	15	20	PF00397	0.623
LIG_14-3-3_CanoR_1	3	8	PF00244	0.656
LIG_14-3-3_CanoR_1	42	46	PF00244	0.600
LIG_14-3-3_CanoR_1	72	79	PF00244	0.574
LIG_BRCT_BRCA1_1	84	88	PF00533	0.325
LIG_FHA_1	109	115	PF00498	0.399
LIG_FHA_2	138	144	PF00498	0.499
LIG_LIR_Gen_1	85	94	PF02991	0.300
LIG_LIR_Nem_3	100	106	PF02991	0.478
LIG_LIR_Nem_3	44	50	PF02991	0.616
LIG_LIR_Nem_3	85	91	PF02991	0.300
LIG_NRP_CendR_1	156	157	PF00754	0.605
LIG_Pex14_1	58	62	PF04695	0.685
LIG_Pex14_2	94	98	PF04695	0.266
LIG_SH2_CRK	47	51	PF00017	0.656
LIG_SH2_STAT5	106	109	PF00017	0.423
LIG_SH3_3	107	113	PF00018	0.401
LIG_TRAF2_1	140	143	PF00917	0.437
LIG_UBA3_1	45	54	PF00899	0.585
MOD_CDK_SPxK_1	15	21	PF00069	0.622
MOD_CK1_1	20	26	PF00069	0.625
MOD_CK2_1	137	143	PF00069	0.513
MOD_GSK3_1	104	111	PF00069	0.399
MOD_GSK3_1	78	85	PF00069	0.431
MOD_NEK2_1	78	83	PF00069	0.456
MOD_NEK2_2	41	46	PF00069	0.601
MOD_PIKK_1	137	143	PF00454	0.501
MOD_PIKK_1	151	157	PF00454	0.489
MOD_PIKK_1	71	77	PF00454	0.573
MOD_PKA_1	3	9	PF00069	0.657
MOD_PKA_2	122	128	PF00069	0.413
MOD_PKA_2	3	9	PF00069	0.716
MOD_PKA_2	41	47	PF00069	0.591
MOD_PKA_2	71	77	PF00069	0.646
MOD_PKB_1	135	143	PF00069	0.468
MOD_Plk_4	78	84	PF00069	0.470
MOD_Plk_4	97	103	PF00069	0.245
MOD_ProDKin_1	109	115	PF00069	0.399
MOD_ProDKin_1	15	21	PF00069	0.624
TRG_ENDOCYTIC_2	47	50	PF00928	0.627
TRG_ER_diArg_1	2	4	PF00400	0.643
TRG_ER_diArg_1	66	69	PF00400	0.594
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2S6	Leptomonas seymouri	90%	100%
A0A0S4JEX6	Bodo saltans	69%	100%
A0A1X0P6N4	Trypanosomatidae	83%	99%
A0A422NWS3	Trypanosoma rangeli	81%	99%
A4H9B1	Leishmania braziliensis	91%	100%
A4HXN2	Leishmania infantum	100%	100%
D0A009	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	99%
E9ARE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QE36	Leishmania major	95%	100%
V5AQ06	Trypanosoma cruzi	79%	99%