Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE41_LEIDO

TriTrypDb:

LdBPK_171590.1 , LdCL_170022400 , LdCL_210028400 , LDHU3_21.2680

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IE41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.638
CLV_C14_Caspase3-7	235	239	PF00656	0.575
CLV_PCSK_SKI1_1	179	183	PF00082	0.431
CLV_PCSK_SKI1_1	58	62	PF00082	0.553
CLV_PCSK_SKI1_1	63	67	PF00082	0.596
DEG_Nend_UBRbox_2	1	3	PF02207	0.439
DEG_ODPH_VHL_1	12	24	PF01847	0.430
DOC_USP7_MATH_1	108	112	PF00917	0.743
DOC_USP7_MATH_1	77	81	PF00917	0.718
DOC_USP7_MATH_1	85	89	PF00917	0.703
DOC_USP7_UBL2_3	100	104	PF12436	0.707
DOC_WW_Pin1_4	154	159	PF00397	0.758
DOC_WW_Pin1_4	63	68	PF00397	0.690
DOC_WW_Pin1_4	83	88	PF00397	0.738
LIG_14-3-3_CanoR_1	47	57	PF00244	0.663
LIG_FHA_1	191	197	PF00498	0.762
LIG_FHA_2	116	122	PF00498	0.610
LIG_LIR_Gen_1	16	27	PF02991	0.328
LIG_LIR_Gen_1	2	12	PF02991	0.466
LIG_LIR_Nem_3	16	22	PF02991	0.328
LIG_LIR_Nem_3	2	7	PF02991	0.451
LIG_SH2_CRK	17	21	PF00017	0.285
LIG_SH2_PTP2	19	22	PF00017	0.281
LIG_SH2_SRC	17	20	PF00017	0.403
LIG_SH2_STAP1	17	21	PF00017	0.328
LIG_SH2_STAT5	19	22	PF00017	0.500
LIG_SH3_2	158	163	PF14604	0.669
LIG_SH3_3	155	161	PF00018	0.819
LIG_SH3_3	3	9	PF00018	0.486
LIG_SH3_3	51	57	PF00018	0.624
LIG_TRAF2_1	147	150	PF00917	0.726
MOD_CDK_SPxK_1	154	160	PF00069	0.745
MOD_CDK_SPxxK_3	63	70	PF00069	0.693
MOD_CK1_1	192	198	PF00069	0.740
MOD_CK1_1	69	75	PF00069	0.700
MOD_GlcNHglycan	110	113	PF01048	0.493
MOD_GlcNHglycan	143	146	PF01048	0.503
MOD_GlcNHglycan	234	237	PF01048	0.444
MOD_GlcNHglycan	79	82	PF01048	0.617
MOD_GlcNHglycan	83	86	PF01048	0.531
MOD_GlcNHglycan	89	92	PF01048	0.515
MOD_GSK3_1	166	173	PF00069	0.723
MOD_GSK3_1	77	84	PF00069	0.711
MOD_N-GLC_1	154	159	PF02516	0.566
MOD_N-GLC_1	206	211	PF02516	0.465
MOD_NEK2_1	138	143	PF00069	0.723
MOD_NEK2_1	232	237	PF00069	0.632
MOD_Plk_1	115	121	PF00069	0.611
MOD_ProDKin_1	154	160	PF00069	0.757
MOD_ProDKin_1	63	69	PF00069	0.693
MOD_ProDKin_1	83	89	PF00069	0.739
TRG_DiLeu_BaEn_1	223	228	PF01217	0.684
TRG_DiLeu_BaEn_4	223	229	PF01217	0.656
TRG_ENDOCYTIC_2	17	20	PF00928	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR49	Leptomonas seymouri	44%	100%
A4H9A5	Leishmania braziliensis	60%	100%
A4HTR3	Leishmania infantum	95%	98%
A4HXM5	Leishmania infantum	100%	100%
C9ZUK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QBZ4	Leishmania major	86%	100%
Q4QE42	Leishmania major	86%	100%