Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE40_LEIDO

TriTrypDb:

LdBPK_300750.1 , LdCL_300012600 , LDHU3_30.0960

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	296	298	PF00675	0.376
CLV_NRD_NRD_1	41	43	PF00675	0.513
CLV_NRD_NRD_1	75	77	PF00675	0.604
CLV_PCSK_KEX2_1	205	207	PF00082	0.474
CLV_PCSK_KEX2_1	269	271	PF00082	0.448
CLV_PCSK_KEX2_1	41	43	PF00082	0.513
CLV_PCSK_KEX2_1	74	76	PF00082	0.578
CLV_PCSK_KEX2_1	8	10	PF00082	0.426
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.497
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.483
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.426
CLV_PCSK_PC7_1	71	77	PF00082	0.711
CLV_PCSK_SKI1_1	109	113	PF00082	0.397
CLV_PCSK_SKI1_1	24	28	PF00082	0.530
CLV_PCSK_SKI1_1	42	46	PF00082	0.560
CLV_PCSK_SKI1_1	9	13	PF00082	0.421
DEG_MDM2_SWIB_1	112	120	PF02201	0.468
DEG_MDM2_SWIB_1	289	296	PF02201	0.380
DEG_SCF_FBW7_1	242	249	PF00400	0.524
DOC_CKS1_1	243	248	PF01111	0.474
DOC_CKS1_1	301	306	PF01111	0.482
DOC_CYCLIN_RxL_1	103	115	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	313	316	PF00134	0.489
DOC_MAPK_DCC_7	213	221	PF00069	0.590
DOC_MAPK_gen_1	204	212	PF00069	0.638
DOC_MAPK_gen_1	269	275	PF00069	0.476
DOC_MAPK_MEF2A_6	213	221	PF00069	0.558
DOC_MAPK_MEF2A_6	228	236	PF00069	0.357
DOC_PP1_RVXF_1	95	102	PF00149	0.416
DOC_PP2B_LxvP_1	313	316	PF13499	0.489
DOC_PP4_FxxP_1	27	30	PF00568	0.403
DOC_USP7_MATH_1	162	166	PF00917	0.530
DOC_USP7_MATH_1	174	178	PF00917	0.314
DOC_WW_Pin1_4	242	247	PF00397	0.463
DOC_WW_Pin1_4	300	305	PF00397	0.428
DOC_WW_Pin1_4	43	48	PF00397	0.655
DOC_WW_Pin1_4	66	71	PF00397	0.641
DOC_WW_Pin1_4	81	86	PF00397	0.645
LIG_14-3-3_CanoR_1	228	233	PF00244	0.399
LIG_14-3-3_CanoR_1	41	47	PF00244	0.640
LIG_Actin_WH2_2	37	55	PF00022	0.529
LIG_APCC_ABBAyCdc20_2	244	250	PF00400	0.514
LIG_BIR_II_1	1	5	PF00653	0.409
LIG_BRCT_BRCA1_1	45	49	PF00533	0.598
LIG_BRCT_BRCA1_1	97	101	PF00533	0.439
LIG_CtBP_PxDLS_1	304	308	PF00389	0.529
LIG_FHA_1	127	133	PF00498	0.467
LIG_FHA_1	23	29	PF00498	0.403
LIG_FHA_1	85	91	PF00498	0.600
LIG_FHA_2	113	119	PF00498	0.537
LIG_FHA_2	301	307	PF00498	0.414
LIG_LIR_Apic_2	25	30	PF02991	0.402
LIG_LIR_Apic_2	299	304	PF02991	0.465
LIG_LIR_Gen_1	115	123	PF02991	0.441
LIG_LIR_Gen_1	127	136	PF02991	0.486
LIG_LIR_Gen_1	245	256	PF02991	0.414
LIG_LIR_Nem_3	115	119	PF02991	0.425
LIG_LIR_Nem_3	245	251	PF02991	0.422
LIG_LIR_Nem_3	46	52	PF02991	0.688
LIG_LIR_Nem_3	98	104	PF02991	0.433
LIG_PCNA_PIPBox_1	141	150	PF02747	0.552
LIG_Pex14_2	112	116	PF04695	0.479
LIG_Pex14_2	289	293	PF04695	0.385
LIG_PTB_Apo_2	274	281	PF02174	0.458
LIG_REV1ctd_RIR_1	19	28	PF16727	0.404
LIG_SH2_CRK	104	108	PF00017	0.377
LIG_SH2_STAP1	291	295	PF00017	0.530
LIG_SH3_3	104	110	PF00018	0.410
LIG_SH3_3	214	220	PF00018	0.443
LIG_SH3_3	240	246	PF00018	0.416
LIG_SH3_3	53	59	PF00018	0.568
LIG_SH3_3	80	86	PF00018	0.603
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.503
LIG_SUMO_SIM_anti_2	233	238	PF11976	0.393
LIG_SUMO_SIM_par_1	197	203	PF11976	0.473
LIG_SxIP_EBH_1	56	67	PF03271	0.528
LIG_TRAF2_1	115	118	PF00917	0.492
LIG_UBA3_1	139	143	PF00899	0.358
LIG_UBA3_1	154	159	PF00899	0.366
LIG_WRC_WIRS_1	1	6	PF05994	0.410
MOD_CDK_SPK_2	66	71	PF00069	0.578
MOD_CDK_SPxxK_3	43	50	PF00069	0.648
MOD_CK1_1	179	185	PF00069	0.506
MOD_CK1_1	249	255	PF00069	0.397
MOD_CK1_1	300	306	PF00069	0.419
MOD_CK1_1	65	71	PF00069	0.616
MOD_CK1_1	84	90	PF00069	0.694
MOD_CK2_1	112	118	PF00069	0.541
MOD_CK2_1	181	187	PF00069	0.567
MOD_CK2_1	300	306	PF00069	0.419
MOD_Cter_Amidation	72	75	PF01082	0.658
MOD_GlcNHglycan	134	137	PF01048	0.512
MOD_GlcNHglycan	164	167	PF01048	0.457
MOD_GlcNHglycan	64	67	PF01048	0.646
MOD_GSK3_1	128	135	PF00069	0.420
MOD_GSK3_1	228	235	PF00069	0.398
MOD_GSK3_1	238	245	PF00069	0.466
MOD_GSK3_1	58	65	PF00069	0.644
MOD_N-GLC_1	162	167	PF02516	0.506
MOD_NEK2_1	11	16	PF00069	0.408
MOD_NEK2_1	112	117	PF00069	0.445
MOD_NEK2_1	128	133	PF00069	0.319
MOD_NEK2_1	20	25	PF00069	0.388
MOD_NEK2_1	200	205	PF00069	0.514
MOD_NEK2_1	260	265	PF00069	0.387
MOD_NEK2_1	4	9	PF00069	0.421
MOD_PIKK_1	11	17	PF00454	0.410
MOD_PIKK_1	176	182	PF00454	0.477
MOD_PK_1	228	234	PF00069	0.399
MOD_PKA_1	297	303	PF00069	0.385
MOD_PKA_2	227	233	PF00069	0.376
MOD_Plk_1	126	132	PF00069	0.339
MOD_Plk_1	249	255	PF00069	0.399
MOD_Plk_4	194	200	PF00069	0.471
MOD_Plk_4	232	238	PF00069	0.401
MOD_Plk_4	297	303	PF00069	0.368
MOD_ProDKin_1	242	248	PF00069	0.455
MOD_ProDKin_1	300	306	PF00069	0.443
MOD_ProDKin_1	43	49	PF00069	0.656
MOD_ProDKin_1	66	72	PF00069	0.643
MOD_ProDKin_1	81	87	PF00069	0.642
MOD_SUMO_rev_2	152	161	PF00179	0.498
MOD_SUMO_rev_2	233	242	PF00179	0.469
MOD_SUMO_rev_2	89	99	PF00179	0.500
TRG_DiLeu_BaEn_1	309	314	PF01217	0.458
TRG_DiLeu_BaEn_2	101	107	PF01217	0.384
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.515
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.498
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.534
TRG_ENDOCYTIC_2	104	107	PF00928	0.352
TRG_ENDOCYTIC_2	258	261	PF00928	0.369
TRG_ER_diArg_1	40	42	PF00400	0.512
TRG_ER_diArg_1	74	76	PF00400	0.585
TRG_ER_FFAT_1	165	177	PF00635	0.501
TRG_NLS_MonoExtC_3	203	209	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC7	Leptomonas seymouri	70%	100%
A0A0S4JDI3	Bodo saltans	35%	92%
A0A1X0P267	Trypanosomatidae	50%	100%
A0A422P4V6	Trypanosoma rangeli	49%	100%
A4I5A1	Leishmania infantum	100%	100%
C9ZQN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B0J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q7N5	Leishmania major	97%	100%