FAD binding domain/NAD(P)-binding Rossmann-like domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE39_LEIDO

TriTrypDb:

LdBPK_262640.1 , LdCL_260032300 , LDHU3_26.3430

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE39

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	8
GO:0004497	monooxygenase activity	3	5
GO:0005488	binding	1	9
GO:0016491	oxidoreductase activity	2	8
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	2
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	2
GO:0018658	salicylate 1-monooxygenase activity	5	2
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0050660	flavin adenine dinucleotide binding	4	9
GO:0071949	FAD binding	5	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.397
CLV_NRD_NRD_1	147	149	PF00675	0.360
CLV_NRD_NRD_1	198	200	PF00675	0.348
CLV_NRD_NRD_1	20	22	PF00675	0.290
CLV_NRD_NRD_1	329	331	PF00675	0.487
CLV_NRD_NRD_1	386	388	PF00675	0.400
CLV_NRD_NRD_1	398	400	PF00675	0.429
CLV_PCSK_KEX2_1	147	149	PF00082	0.395
CLV_PCSK_KEX2_1	198	200	PF00082	0.420
CLV_PCSK_KEX2_1	20	22	PF00082	0.290
CLV_PCSK_KEX2_1	329	331	PF00082	0.387
CLV_PCSK_KEX2_1	386	388	PF00082	0.400
CLV_PCSK_KEX2_1	398	400	PF00082	0.429
CLV_PCSK_PC7_1	143	149	PF00082	0.420
CLV_PCSK_PC7_1	325	331	PF00082	0.385
CLV_PCSK_SKI1_1	143	147	PF00082	0.321
CLV_PCSK_SKI1_1	198	202	PF00082	0.321
CLV_PCSK_SKI1_1	301	305	PF00082	0.463
CLV_PCSK_SKI1_1	330	334	PF00082	0.355
CLV_PCSK_SKI1_1	401	405	PF00082	0.425
CLV_PCSK_SKI1_1	408	412	PF00082	0.419
CLV_PCSK_SKI1_1	60	64	PF00082	0.354
CLV_PCSK_SKI1_1	81	85	PF00082	0.356
DEG_APCC_DBOX_1	411	419	PF00400	0.510
DEG_Nend_UBRbox_1	1	4	PF02207	0.321
DEG_SPOP_SBC_1	207	211	PF00917	0.377
DOC_CDC14_PxL_1	29	37	PF14671	0.377
DOC_CYCLIN_RxL_1	194	205	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	318	324	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.532
DOC_MAPK_DCC_7	147	155	PF00069	0.420
DOC_MAPK_gen_1	147	155	PF00069	0.377
DOC_MAPK_gen_1	79	86	PF00069	0.315
DOC_MAPK_MEF2A_6	147	155	PF00069	0.420
DOC_MAPK_MEF2A_6	417	426	PF00069	0.488
DOC_PP2B_LxvP_1	311	314	PF13499	0.424
DOC_PP2B_LxvP_1	318	321	PF13499	0.406
DOC_PP2B_LxvP_1	365	368	PF13499	0.472
DOC_PP2B_LxvP_1	91	94	PF13499	0.384
DOC_USP7_MATH_1	109	113	PF00917	0.321
DOC_USP7_MATH_1	338	342	PF00917	0.401
DOC_USP7_UBL2_3	81	85	PF12436	0.384
DOC_WW_Pin1_4	263	268	PF00397	0.452
DOC_WW_Pin1_4	417	422	PF00397	0.468
LIG_14-3-3_CanoR_1	134	138	PF00244	0.321
LIG_14-3-3_CanoR_1	243	249	PF00244	0.408
LIG_14-3-3_CanoR_1	301	306	PF00244	0.452
LIG_14-3-3_CanoR_1	412	416	PF00244	0.472
LIG_14-3-3_CanoR_1	417	421	PF00244	0.529
LIG_14-3-3_CanoR_1	429	435	PF00244	0.462
LIG_14-3-3_CanoR_1	60	69	PF00244	0.248
LIG_Actin_WH2_2	130	145	PF00022	0.355
LIG_FHA_1	245	251	PF00498	0.473
LIG_FHA_1	313	319	PF00498	0.453
LIG_FHA_1	417	423	PF00498	0.494
LIG_LIR_Nem_3	127	133	PF02991	0.462
LIG_LIR_Nem_3	180	186	PF02991	0.323
LIG_LIR_Nem_3	294	298	PF02991	0.402
LIG_LIR_Nem_3	376	382	PF02991	0.388
LIG_LIR_Nem_3	51	56	PF02991	0.337
LIG_Pex14_2	375	379	PF04695	0.376
LIG_SH2_PTP2	130	133	PF00017	0.462
LIG_SH2_PTP2	39	42	PF00017	0.462
LIG_SH2_STAP1	43	47	PF00017	0.377
LIG_SH2_STAT3	393	396	PF00017	0.410
LIG_SH2_STAT3	436	439	PF00017	0.476
LIG_SH2_STAT5	130	133	PF00017	0.385
LIG_SH2_STAT5	141	144	PF00017	0.252
LIG_SH2_STAT5	149	152	PF00017	0.321
LIG_SH2_STAT5	39	42	PF00017	0.363
LIG_SH2_STAT5	393	396	PF00017	0.423
LIG_SH2_STAT5	43	46	PF00017	0.322
LIG_SH3_3	220	226	PF00018	0.507
LIG_SH3_3	318	324	PF00018	0.430
LIG_SUMO_SIM_par_1	419	425	PF11976	0.491
LIG_TRAF2_1	267	270	PF00917	0.424
LIG_WRC_WIRS_1	342	347	PF05994	0.411
MOD_CK1_1	11	17	PF00069	0.321
MOD_CK1_1	114	120	PF00069	0.323
MOD_CK1_1	210	216	PF00069	0.321
MOD_CK1_1	341	347	PF00069	0.433
MOD_CK1_1	432	438	PF00069	0.508
MOD_CK2_1	370	376	PF00069	0.458
MOD_GlcNHglycan	10	13	PF01048	0.321
MOD_GlcNHglycan	155	158	PF01048	0.460
MOD_GlcNHglycan	260	263	PF01048	0.385
MOD_GlcNHglycan	372	375	PF01048	0.528
MOD_GlcNHglycan	64	67	PF01048	0.347
MOD_GSK3_1	114	121	PF00069	0.477
MOD_GSK3_1	133	140	PF00069	0.198
MOD_GSK3_1	206	213	PF00069	0.305
MOD_GSK3_1	254	261	PF00069	0.520
MOD_GSK3_1	344	351	PF00069	0.466
MOD_GSK3_1	430	437	PF00069	0.458
MOD_NEK2_1	133	138	PF00069	0.321
MOD_NEK2_1	193	198	PF00069	0.405
MOD_NEK2_1	258	263	PF00069	0.382
MOD_NEK2_1	411	416	PF00069	0.431
MOD_NEK2_1	449	454	PF00069	0.496
MOD_NEK2_1	62	67	PF00069	0.413
MOD_PIKK_1	114	120	PF00454	0.377
MOD_PIKK_1	304	310	PF00454	0.448
MOD_PIKK_1	344	350	PF00454	0.543
MOD_PIKK_1	435	441	PF00454	0.507
MOD_PKA_1	401	407	PF00069	0.432
MOD_PKA_2	118	124	PF00069	0.420
MOD_PKA_2	133	139	PF00069	0.211
MOD_PKA_2	370	376	PF00069	0.502
MOD_PKA_2	394	400	PF00069	0.418
MOD_PKA_2	411	417	PF00069	0.467
MOD_PKB_1	399	407	PF00069	0.432
MOD_Plk_1	254	260	PF00069	0.524
MOD_Plk_1	348	354	PF00069	0.358
MOD_Plk_4	111	117	PF00069	0.345
MOD_Plk_4	137	143	PF00069	0.420
MOD_Plk_4	301	307	PF00069	0.491
MOD_Plk_4	341	347	PF00069	0.408
MOD_Plk_4	41	47	PF00069	0.352
MOD_Plk_4	411	417	PF00069	0.448
MOD_ProDKin_1	263	269	PF00069	0.465
MOD_ProDKin_1	417	423	PF00069	0.467
MOD_SUMO_for_1	447	450	PF00179	0.549
MOD_SUMO_rev_2	438	447	PF00179	0.517
TRG_DiLeu_BaEn_1	355	360	PF01217	0.319
TRG_DiLeu_BaEn_2	29	35	PF01217	0.321
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.420
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.442
TRG_ENDOCYTIC_2	130	133	PF00928	0.462
TRG_ENDOCYTIC_2	295	298	PF00928	0.448
TRG_ENDOCYTIC_2	382	385	PF00928	0.485
TRG_ENDOCYTIC_2	43	46	PF00928	0.345
TRG_ER_diArg_1	146	148	PF00400	0.395
TRG_ER_diArg_1	19	21	PF00400	0.284
TRG_ER_diArg_1	197	199	PF00400	0.420
TRG_ER_diArg_1	385	387	PF00400	0.378
TRG_ER_diArg_1	398	401	PF00400	0.426
TRG_NES_CRM1_1	273	285	PF08389	0.510
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0E3D8L6	Penicillium crustosum	24%	98%
A0A0N0P7X9	Leptomonas seymouri	83%	100%
A0A1X0P822	Trypanosomatidae	64%	100%
A1TFU9	Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1)	24%	100%
A4HFA5	Leishmania braziliensis	87%	100%
A4I2I2	Leishmania infantum	100%	100%
C9ZWZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AYP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
H1ZZA4	Stigmatella aurantiaca	25%	100%
Q02N79	Pseudomonas aeruginosa (strain UCBPP-PA14)	25%	100%
Q4Q8T0	Leishmania major	96%	100%
Q5EXK1	Klebsiella oxytoca	27%	100%
Q6F6Y2	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	24%	100%
Q9I0Q0	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	27%	100%
V5BGR2	Trypanosoma cruzi	66%	100%