Methyltransferase domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE30_LEIDO

TriTrypDb:

LdBPK_171410.1 , LdCL_170020300 , LDHU3_17.1930

Length:

1048

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE30

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.646
CLV_C14_Caspase3-7	57	61	PF00656	0.474
CLV_NRD_NRD_1	1041	1043	PF00675	0.368
CLV_NRD_NRD_1	160	162	PF00675	0.423
CLV_NRD_NRD_1	168	170	PF00675	0.407
CLV_NRD_NRD_1	185	187	PF00675	0.497
CLV_NRD_NRD_1	517	519	PF00675	0.687
CLV_NRD_NRD_1	562	564	PF00675	0.753
CLV_NRD_NRD_1	799	801	PF00675	0.525
CLV_NRD_NRD_1	854	856	PF00675	0.547
CLV_NRD_NRD_1	893	895	PF00675	0.425
CLV_PCSK_FUR_1	166	170	PF00082	0.434
CLV_PCSK_FUR_1	560	564	PF00082	0.585
CLV_PCSK_KEX2_1	1041	1043	PF00082	0.368
CLV_PCSK_KEX2_1	160	162	PF00082	0.416
CLV_PCSK_KEX2_1	168	170	PF00082	0.413
CLV_PCSK_KEX2_1	185	187	PF00082	0.484
CLV_PCSK_KEX2_1	504	506	PF00082	0.621
CLV_PCSK_KEX2_1	517	519	PF00082	0.650
CLV_PCSK_KEX2_1	560	562	PF00082	0.755
CLV_PCSK_KEX2_1	674	676	PF00082	0.522
CLV_PCSK_KEX2_1	799	801	PF00082	0.525
CLV_PCSK_KEX2_1	893	895	PF00082	0.425
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.700
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.566
CLV_PCSK_PC7_1	795	801	PF00082	0.453
CLV_PCSK_SKI1_1	161	165	PF00082	0.496
CLV_PCSK_SKI1_1	539	543	PF00082	0.571
CLV_PCSK_SKI1_1	552	556	PF00082	0.692
CLV_PCSK_SKI1_1	583	587	PF00082	0.529
CLV_PCSK_SKI1_1	723	727	PF00082	0.421
CLV_PCSK_SKI1_1	774	778	PF00082	0.278
CLV_PCSK_SKI1_1	800	804	PF00082	0.490
CLV_PCSK_SKI1_1	832	836	PF00082	0.377
CLV_PCSK_SKI1_1	837	841	PF00082	0.337
CLV_PCSK_SKI1_1	92	96	PF00082	0.486
CLV_PCSK_SKI1_1	947	951	PF00082	0.520
CLV_PCSK_SKI1_1	99	103	PF00082	0.436
DEG_MDM2_SWIB_1	840	847	PF02201	0.465
DOC_ANK_TNKS_1	517	524	PF00023	0.717
DOC_ANK_TNKS_1	626	633	PF00023	0.562
DOC_CKS1_1	619	624	PF01111	0.660
DOC_CKS1_1	736	741	PF01111	0.551
DOC_CKS1_1	925	930	PF01111	0.523
DOC_CYCLIN_RxL_1	89	96	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.392
DOC_MAPK_gen_1	217	224	PF00069	0.432
DOC_MAPK_gen_1	324	332	PF00069	0.558
DOC_MAPK_gen_1	403	412	PF00069	0.619
DOC_MAPK_gen_1	580	590	PF00069	0.439
DOC_MAPK_gen_1	673	679	PF00069	0.478
DOC_MAPK_gen_1	721	730	PF00069	0.475
DOC_MAPK_gen_1	893	904	PF00069	0.423
DOC_MAPK_MEF2A_6	324	332	PF00069	0.620
DOC_MAPK_MEF2A_6	580	588	PF00069	0.483
DOC_MAPK_MEF2A_6	721	730	PF00069	0.492
DOC_MAPK_MEF2A_6	747	754	PF00069	0.379
DOC_MAPK_NFAT4_5	723	731	PF00069	0.522
DOC_PP1_RVXF_1	348	354	PF00149	0.487
DOC_PP1_RVXF_1	830	837	PF00149	0.411
DOC_PP1_RVXF_1	839	845	PF00149	0.358
DOC_PP2B_LxvP_1	460	463	PF13499	0.594
DOC_PP2B_LxvP_1	7	10	PF13499	0.326
DOC_USP7_MATH_1	1016	1020	PF00917	0.516
DOC_USP7_MATH_1	3	7	PF00917	0.538
DOC_USP7_MATH_1	445	449	PF00917	0.638
DOC_USP7_MATH_1	593	597	PF00917	0.650
DOC_USP7_MATH_1	603	607	PF00917	0.640
DOC_USP7_MATH_1	72	76	PF00917	0.573
DOC_USP7_MATH_1	734	738	PF00917	0.607
DOC_USP7_UBL2_3	431	435	PF12436	0.452
DOC_WW_Pin1_4	1029	1034	PF00397	0.391
DOC_WW_Pin1_4	139	144	PF00397	0.676
DOC_WW_Pin1_4	458	463	PF00397	0.790
DOC_WW_Pin1_4	534	539	PF00397	0.722
DOC_WW_Pin1_4	561	566	PF00397	0.707
DOC_WW_Pin1_4	599	604	PF00397	0.751
DOC_WW_Pin1_4	605	610	PF00397	0.745
DOC_WW_Pin1_4	618	623	PF00397	0.460
DOC_WW_Pin1_4	735	740	PF00397	0.567
DOC_WW_Pin1_4	78	83	PF00397	0.563
DOC_WW_Pin1_4	784	789	PF00397	0.535
DOC_WW_Pin1_4	820	825	PF00397	0.546
DOC_WW_Pin1_4	921	926	PF00397	0.511
LIG_14-3-3_CanoR_1	242	248	PF00244	0.628
LIG_14-3-3_CanoR_1	286	291	PF00244	0.414
LIG_14-3-3_CanoR_1	530	538	PF00244	0.719
LIG_14-3-3_CanoR_1	539	544	PF00244	0.406
LIG_14-3-3_CanoR_1	651	655	PF00244	0.537
LIG_14-3-3_CanoR_1	70	78	PF00244	0.587
LIG_14-3-3_CanoR_1	747	751	PF00244	0.492
LIG_14-3-3_CanoR_1	769	778	PF00244	0.520
LIG_14-3-3_CanoR_1	799	809	PF00244	0.424
LIG_14-3-3_CanoR_1	828	836	PF00244	0.443
LIG_14-3-3_CanoR_1	947	956	PF00244	0.426
LIG_Actin_WH2_2	35	52	PF00022	0.415
LIG_APCC_ABBA_1	883	888	PF00400	0.473
LIG_APCC_ABBA_1	995	1000	PF00400	0.458
LIG_BRCT_BRCA1_1	74	78	PF00533	0.515
LIG_Clathr_ClatBox_1	587	591	PF01394	0.466
LIG_Clathr_ClatBox_1	988	992	PF01394	0.331
LIG_deltaCOP1_diTrp_1	69	78	PF00928	0.588
LIG_EH1_1	581	589	PF00400	0.526
LIG_EH1_1	982	990	PF00400	0.337
LIG_eIF4E_1	582	588	PF01652	0.530
LIG_FHA_1	157	163	PF00498	0.374
LIG_FHA_1	33	39	PF00498	0.499
LIG_FHA_1	407	413	PF00498	0.524
LIG_FHA_1	424	430	PF00498	0.381
LIG_FHA_1	455	461	PF00498	0.690
LIG_FHA_1	674	680	PF00498	0.531
LIG_FHA_1	736	742	PF00498	0.587
LIG_FHA_1	747	753	PF00498	0.446
LIG_FHA_1	802	808	PF00498	0.389
LIG_FHA_1	811	817	PF00498	0.406
LIG_FHA_1	867	873	PF00498	0.677
LIG_FHA_1	89	95	PF00498	0.567
LIG_FHA_1	903	909	PF00498	0.413
LIG_FHA_2	179	185	PF00498	0.443
LIG_FHA_2	226	232	PF00498	0.381
LIG_FHA_2	34	40	PF00498	0.503
LIG_FHA_2	361	367	PF00498	0.508
LIG_FHA_2	383	389	PF00498	0.538
LIG_FHA_2	402	408	PF00498	0.586
LIG_FHA_2	498	504	PF00498	0.609
LIG_FHA_2	938	944	PF00498	0.461
LIG_Integrin_RGD_1	405	407	PF01839	0.627
LIG_LIR_Apic_2	710	714	PF02991	0.476
LIG_LIR_Gen_1	311	321	PF02991	0.515
LIG_LIR_Gen_1	352	361	PF02991	0.458
LIG_LIR_Gen_1	537	547	PF02991	0.643
LIG_LIR_Gen_1	60	69	PF02991	0.463
LIG_LIR_Gen_1	646	655	PF02991	0.529
LIG_LIR_Gen_1	780	791	PF02991	0.457
LIG_LIR_Gen_1	901	912	PF02991	0.440
LIG_LIR_Gen_1	965	976	PF02991	0.474
LIG_LIR_LC3C_4	207	210	PF02991	0.529
LIG_LIR_Nem_3	21	26	PF02991	0.371
LIG_LIR_Nem_3	311	316	PF02991	0.518
LIG_LIR_Nem_3	352	356	PF02991	0.456
LIG_LIR_Nem_3	493	499	PF02991	0.517
LIG_LIR_Nem_3	537	543	PF02991	0.651
LIG_LIR_Nem_3	60	66	PF02991	0.369
LIG_LIR_Nem_3	646	650	PF02991	0.541
LIG_LIR_Nem_3	780	786	PF02991	0.457
LIG_LIR_Nem_3	838	843	PF02991	0.410
LIG_LIR_Nem_3	877	883	PF02991	0.449
LIG_LIR_Nem_3	901	907	PF02991	0.457
LIG_LIR_Nem_3	96	101	PF02991	0.416
LIG_LIR_Nem_3	965	971	PF02991	0.388
LIG_MYND_1	885	889	PF01753	0.410
LIG_NRBOX	838	844	PF00104	0.451
LIG_Pex14_2	836	840	PF04695	0.461
LIG_Rb_pABgroove_1	1021	1029	PF01858	0.358
LIG_REV1ctd_RIR_1	833	841	PF16727	0.461
LIG_SH2_CRK	1036	1040	PF00017	0.402
LIG_SH2_CRK	582	586	PF00017	0.501
LIG_SH2_CRK	647	651	PF00017	0.579
LIG_SH2_SRC	915	918	PF00017	0.487
LIG_SH2_STAT5	283	286	PF00017	0.355
LIG_SH2_STAT5	41	44	PF00017	0.377
LIG_SH2_STAT5	488	491	PF00017	0.516
LIG_SH2_STAT5	540	543	PF00017	0.616
LIG_SH2_STAT5	577	580	PF00017	0.596
LIG_SH2_STAT5	62	65	PF00017	0.440
LIG_SH2_STAT5	647	650	PF00017	0.560
LIG_SH2_STAT5	915	918	PF00017	0.391
LIG_SH2_STAT5	926	929	PF00017	0.396
LIG_SH2_STAT5	996	999	PF00017	0.377
LIG_SH3_1	922	928	PF00018	0.540
LIG_SH3_3	459	465	PF00018	0.741
LIG_SH3_3	478	484	PF00018	0.439
LIG_SH3_3	616	622	PF00018	0.735
LIG_SH3_3	727	733	PF00018	0.484
LIG_SH3_3	738	744	PF00018	0.423
LIG_SH3_3	857	863	PF00018	0.653
LIG_SH3_3	878	884	PF00018	0.449
LIG_SH3_3	922	928	PF00018	0.540
LIG_SH3_4	99	106	PF00018	0.399
LIG_SUMO_SIM_anti_2	1017	1025	PF11976	0.402
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.462
LIG_SUMO_SIM_anti_2	204	211	PF11976	0.582
LIG_SUMO_SIM_anti_2	722	728	PF11976	0.510
LIG_SUMO_SIM_anti_2	806	811	PF11976	0.370
LIG_SUMO_SIM_anti_2	986	992	PF11976	0.334
LIG_SUMO_SIM_par_1	569	574	PF11976	0.436
LIG_SUMO_SIM_par_1	692	699	PF11976	0.460
LIG_SUMO_SIM_par_1	775	780	PF11976	0.457
LIG_SUMO_SIM_par_1	986	992	PF11976	0.334
LIG_TRAF2_1	151	154	PF00917	0.467
LIG_TRAF2_1	589	592	PF00917	0.493
LIG_TRAF2_1	940	943	PF00917	0.508
LIG_WRC_WIRS_1	968	973	PF05994	0.448
MOD_CDK_SPK_2	1029	1034	PF00069	0.391
MOD_CDK_SPK_2	534	539	PF00069	0.622
MOD_CDK_SPxxK_3	618	625	PF00069	0.666
MOD_CK1_1	137	143	PF00069	0.645
MOD_CK1_1	145	151	PF00069	0.492
MOD_CK1_1	194	200	PF00069	0.622
MOD_CK1_1	31	37	PF00069	0.539
MOD_CK1_1	320	326	PF00069	0.557
MOD_CK1_1	534	540	PF00069	0.700
MOD_CK1_1	602	608	PF00069	0.667
MOD_CK1_1	820	826	PF00069	0.509
MOD_CK1_1	861	867	PF00069	0.549
MOD_CK1_1	918	924	PF00069	0.505
MOD_CK2_1	178	184	PF00069	0.477
MOD_CK2_1	312	318	PF00069	0.566
MOD_CK2_1	382	388	PF00069	0.651
MOD_CK2_1	389	395	PF00069	0.579
MOD_CK2_1	561	567	PF00069	0.731
MOD_CK2_1	78	84	PF00069	0.571
MOD_CK2_1	937	943	PF00069	0.461
MOD_Cter_Amidation	853	856	PF01082	0.535
MOD_GlcNHglycan	1017	1021	PF01048	0.536
MOD_GlcNHglycan	1044	1047	PF01048	0.577
MOD_GlcNHglycan	11	14	PF01048	0.438
MOD_GlcNHglycan	137	140	PF01048	0.654
MOD_GlcNHglycan	193	196	PF01048	0.652
MOD_GlcNHglycan	243	246	PF01048	0.679
MOD_GlcNHglycan	28	31	PF01048	0.554
MOD_GlcNHglycan	380	383	PF01048	0.751
MOD_GlcNHglycan	447	450	PF01048	0.687
MOD_GlcNHglycan	50	53	PF01048	0.506
MOD_GlcNHglycan	555	558	PF01048	0.680
MOD_GlcNHglycan	605	608	PF01048	0.789
MOD_GlcNHglycan	635	638	PF01048	0.657
MOD_GlcNHglycan	771	774	PF01048	0.288
MOD_GlcNHglycan	829	832	PF01048	0.430
MOD_GlcNHglycan	863	866	PF01048	0.607
MOD_GlcNHglycan	917	920	PF01048	0.480
MOD_GlcNHglycan	95	98	PF01048	0.459
MOD_GSK3_1	135	142	PF00069	0.607
MOD_GSK3_1	190	197	PF00069	0.491
MOD_GSK3_1	21	28	PF00069	0.431
MOD_GSK3_1	282	289	PF00069	0.390
MOD_GSK3_1	312	319	PF00069	0.484
MOD_GSK3_1	378	385	PF00069	0.707
MOD_GSK3_1	454	461	PF00069	0.741
MOD_GSK3_1	530	537	PF00069	0.746
MOD_GSK3_1	599	606	PF00069	0.695
MOD_GSK3_1	669	676	PF00069	0.576
MOD_GSK3_1	742	749	PF00069	0.548
MOD_GSK3_1	801	808	PF00069	0.400
MOD_GSK3_1	898	905	PF00069	0.461
MOD_GSK3_1	917	924	PF00069	0.512
MOD_GSK3_1	999	1006	PF00069	0.496
MOD_N-GLC_1	454	459	PF02516	0.760
MOD_N-GLC_1	479	484	PF02516	0.582
MOD_N-GLC_1	769	774	PF02516	0.280
MOD_N-GLC_2	763	765	PF02516	0.271
MOD_NEK2_1	208	213	PF00069	0.591
MOD_NEK2_1	225	230	PF00069	0.256
MOD_NEK2_1	25	30	PF00069	0.533
MOD_NEK2_1	316	321	PF00069	0.559
MOD_NEK2_1	371	376	PF00069	0.556
MOD_NEK2_1	401	406	PF00069	0.685
MOD_NEK2_1	48	53	PF00069	0.400
MOD_NEK2_1	529	534	PF00069	0.783
MOD_NEK2_1	54	59	PF00069	0.381
MOD_NEK2_1	633	638	PF00069	0.683
MOD_NEK2_1	768	773	PF00069	0.477
MOD_NEK2_1	777	782	PF00069	0.481
MOD_NEK2_1	810	815	PF00069	0.385
MOD_NEK2_1	835	840	PF00069	0.384
MOD_NEK2_1	88	93	PF00069	0.476
MOD_NEK2_1	902	907	PF00069	0.385
MOD_NEK2_1	972	977	PF00069	0.353
MOD_NEK2_1	984	989	PF00069	0.318
MOD_NEK2_2	406	411	PF00069	0.622
MOD_NEK2_2	72	77	PF00069	0.446
MOD_OFUCOSY	27	32	PF10250	0.419
MOD_OFUCOSY	368	375	PF10250	0.487
MOD_PIKK_1	194	200	PF00454	0.475
MOD_PIKK_1	208	214	PF00454	0.418
MOD_PIKK_1	645	651	PF00454	0.554
MOD_PIKK_1	902	908	PF00454	0.297
MOD_PIKK_1	948	954	PF00454	0.412
MOD_PK_1	856	862	PF00069	0.540
MOD_PKA_1	673	679	PF00069	0.546
MOD_PKA_1	893	899	PF00069	0.536
MOD_PKA_2	184	190	PF00069	0.559
MOD_PKA_2	225	231	PF00069	0.413
MOD_PKA_2	241	247	PF00069	0.602
MOD_PKA_2	529	535	PF00069	0.768
MOD_PKA_2	650	656	PF00069	0.377
MOD_PKA_2	746	752	PF00069	0.479
MOD_PKA_2	768	774	PF00069	0.548
MOD_PKA_2	827	833	PF00069	0.381
MOD_PKA_2	861	867	PF00069	0.639
MOD_PKA_2	893	899	PF00069	0.537
MOD_Plk_1	1016	1022	PF00069	0.464
MOD_Plk_1	317	323	PF00069	0.585
MOD_Plk_1	406	412	PF00069	0.665
MOD_Plk_1	479	485	PF00069	0.530
MOD_Plk_2-3	184	190	PF00069	0.441
MOD_Plk_2-3	389	395	PF00069	0.538
MOD_Plk_4	175	181	PF00069	0.449
MOD_Plk_4	270	276	PF00069	0.316
MOD_Plk_4	312	318	PF00069	0.566
MOD_Plk_4	352	358	PF00069	0.574
MOD_Plk_4	650	656	PF00069	0.435
MOD_Plk_4	746	752	PF00069	0.483
MOD_Plk_4	967	973	PF00069	0.379
MOD_Plk_4	984	990	PF00069	0.257
MOD_ProDKin_1	1029	1035	PF00069	0.387
MOD_ProDKin_1	139	145	PF00069	0.675
MOD_ProDKin_1	458	464	PF00069	0.789
MOD_ProDKin_1	534	540	PF00069	0.717
MOD_ProDKin_1	561	567	PF00069	0.706
MOD_ProDKin_1	599	605	PF00069	0.750
MOD_ProDKin_1	618	624	PF00069	0.461
MOD_ProDKin_1	735	741	PF00069	0.553
MOD_ProDKin_1	78	84	PF00069	0.563
MOD_ProDKin_1	784	790	PF00069	0.535
MOD_ProDKin_1	820	826	PF00069	0.541
MOD_ProDKin_1	921	927	PF00069	0.502
TRG_DiLeu_BaEn_1	722	727	PF01217	0.474
TRG_DiLeu_BaEn_1	986	991	PF01217	0.335
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.504
TRG_ENDOCYTIC_2	1036	1039	PF00928	0.402
TRG_ENDOCYTIC_2	434	437	PF00928	0.554
TRG_ENDOCYTIC_2	540	543	PF00928	0.616
TRG_ENDOCYTIC_2	582	585	PF00928	0.510
TRG_ENDOCYTIC_2	62	65	PF00928	0.484
TRG_ENDOCYTIC_2	647	650	PF00928	0.526
TRG_ER_diArg_1	160	162	PF00400	0.428
TRG_ER_diArg_1	166	169	PF00400	0.402
TRG_ER_diArg_1	327	330	PF00400	0.575
TRG_ER_diArg_1	516	518	PF00400	0.672
TRG_ER_diArg_1	560	563	PF00400	0.704
TRG_ER_diArg_1	680	683	PF00400	0.500
TRG_ER_diArg_1	892	894	PF00400	0.436
TRG_NES_CRM1_1	204	219	PF08389	0.486
TRG_NES_CRM1_1	986	1000	PF08389	0.341
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R1	Leptomonas seymouri	56%	100%
A0A0S4J6V1	Bodo saltans	33%	100%
A0A3R7LJI9	Trypanosoma rangeli	37%	100%
A4H976	Leishmania braziliensis	72%	100%
A4HXK8	Leishmania infantum	99%	100%
C9ZP99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ARA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QE60	Leishmania major	91%	100%
V5BET6	Trypanosoma cruzi	34%	100%