CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE28_LEIDO

TriTrypDb:

LdBPK_262500.1 , LdCL_260030800 , LDHU3_26.3220

Length:

227

Annotations

LeishMANIAdb annotations

A highly conserved Eukaryotic phosphatidylinositol biosynthesis enzyme. Potentially broadly distributed in membranes.

Annotations by Jardim et al.

Phospholipid biosynthesis, CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IE28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE28

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0019637	organophosphate metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006661	phosphatidylinositol biosynthetic process	6	1
GO:0044249	cellular biosynthetic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003881	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	11
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.571
CLV_C14_Caspase3-7	57	61	PF00656	0.225
CLV_NRD_NRD_1	129	131	PF00675	0.289
CLV_PCSK_KEX2_1	221	223	PF00082	0.299
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.299
CLV_PCSK_SKI1_1	15	19	PF00082	0.281
DOC_MAPK_HePTP_8	37	49	PF00069	0.357
DOC_MAPK_MEF2A_6	103	112	PF00069	0.412
DOC_MAPK_MEF2A_6	40	49	PF00069	0.283
DOC_PP1_RVXF_1	13	19	PF00149	0.514
DOC_PP4_FxxP_1	18	21	PF00568	0.322
DOC_USP7_MATH_1	8	12	PF00917	0.518
DOC_USP7_UBL2_3	131	135	PF12436	0.506
LIG_14-3-3_CanoR_1	103	111	PF00244	0.338
LIG_14-3-3_CanoR_1	122	128	PF00244	0.328
LIG_14-3-3_CanoR_1	153	158	PF00244	0.363
LIG_14-3-3_CanoR_1	83	92	PF00244	0.225
LIG_Actin_WH2_2	186	201	PF00022	0.348
LIG_APCC_ABBA_1	110	115	PF00400	0.268
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_Clathr_ClatBox_1	111	115	PF01394	0.225
LIG_Clathr_ClatBox_1	90	94	PF01394	0.357
LIG_deltaCOP1_diTrp_1	183	189	PF00928	0.248
LIG_eIF4E_1	42	48	PF01652	0.283
LIG_eIF4E_1	50	56	PF01652	0.357
LIG_FHA_1	103	109	PF00498	0.329
LIG_GBD_Chelix_1	29	37	PF00786	0.298
LIG_Integrin_isoDGR_2	151	153	PF01839	0.210
LIG_LIR_Gen_1	118	128	PF02991	0.236
LIG_LIR_Gen_1	163	173	PF02991	0.266
LIG_LIR_Gen_1	86	97	PF02991	0.347
LIG_LIR_Nem_3	139	145	PF02991	0.467
LIG_LIR_Nem_3	156	160	PF02991	0.160
LIG_LIR_Nem_3	163	169	PF02991	0.266
LIG_LIR_Nem_3	183	189	PF02991	0.098
LIG_LIR_Nem_3	41	45	PF02991	0.201
LIG_LIR_Nem_3	71	76	PF02991	0.377
LIG_LIR_Nem_3	86	92	PF02991	0.276
LIG_LYPXL_yS_3	42	45	PF13949	0.245
LIG_NRBOX	107	113	PF00104	0.235
LIG_PCNA_PIPBox_1	205	214	PF02747	0.519
LIG_PCNA_yPIPBox_3	146	158	PF02747	0.392
LIG_PCNA_yPIPBox_3	199	212	PF02747	0.418
LIG_Pex14_2	164	168	PF04695	0.375
LIG_SH2_CRK	104	108	PF00017	0.363
LIG_SH2_CRK	124	128	PF00017	0.455
LIG_SH2_CRK	175	179	PF00017	0.354
LIG_SH2_CRK	26	30	PF00017	0.228
LIG_SH2_GRB2like	149	152	PF00017	0.432
LIG_SH2_NCK_1	124	128	PF00017	0.440
LIG_SH2_NCK_1	175	179	PF00017	0.299
LIG_SH2_NCK_1	26	30	PF00017	0.223
LIG_SH2_PTP2	166	169	PF00017	0.304
LIG_SH2_SRC	149	152	PF00017	0.403
LIG_SH2_STAP1	104	108	PF00017	0.357
LIG_SH2_STAP1	124	128	PF00017	0.445
LIG_SH2_STAP1	175	179	PF00017	0.303
LIG_SH2_STAP1	187	191	PF00017	0.357
LIG_SH2_STAP1	26	30	PF00017	0.228
LIG_SH2_STAP1	50	54	PF00017	0.243
LIG_SH2_STAT5	104	107	PF00017	0.366
LIG_SH2_STAT5	149	152	PF00017	0.505
LIG_SH2_STAT5	166	169	PF00017	0.225
LIG_SH2_STAT5	36	39	PF00017	0.299
LIG_SH3_3	93	99	PF00018	0.255
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.205
LIG_SUMO_SIM_par_1	89	95	PF11976	0.274
LIG_TYR_ITIM	24	29	PF00017	0.257
LIG_WRC_WIRS_1	154	159	PF05994	0.160
MOD_GSK3_1	78	85	PF00069	0.423
MOD_NEK2_1	123	128	PF00069	0.414
MOD_PKA_1	130	136	PF00069	0.478
MOD_PKA_2	102	108	PF00069	0.276
MOD_PKA_2	82	88	PF00069	0.268
MOD_Plk_4	123	129	PF00069	0.399
MOD_Plk_4	137	143	PF00069	0.433
MOD_Plk_4	153	159	PF00069	0.437
MOD_Plk_4	29	35	PF00069	0.223
MOD_Plk_4	50	56	PF00069	0.299
MOD_Plk_4	92	98	PF00069	0.377
TRG_ENDOCYTIC_2	104	107	PF00928	0.363
TRG_ENDOCYTIC_2	124	127	PF00928	0.399
TRG_ENDOCYTIC_2	166	169	PF00928	0.266
TRG_ENDOCYTIC_2	175	178	PF00928	0.274
TRG_ENDOCYTIC_2	26	29	PF00928	0.275
TRG_ENDOCYTIC_2	42	45	PF00928	0.259
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.245

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH3	Leptomonas seymouri	76%	100%
A0A0S4JGZ0	Bodo saltans	52%	100%
A0A1X0P7E9	Trypanosomatidae	52%	100%
A0A3R7N3Q1	Trypanosoma rangeli	55%	100%
A4HF93	Leishmania braziliensis	79%	100%
C9ZX19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AHB8	Leishmania infantum	100%	100%
E9AYM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O14735	Homo sapiens	37%	100%
P06197	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P70500	Rattus norvegicus	37%	100%
Q10153	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	96%
Q4Q8U3	Leishmania major	92%	100%
Q59RA2	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	99%
Q8GUK6	Arabidopsis thaliana	43%	100%
Q8LBA6	Arabidopsis thaliana	39%	100%
Q8SX37	Drosophila melanogaster	35%	100%
Q8VDP6	Mus musculus	37%	100%