Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE27_LEIDO

TriTrypDb:

LdBPK_282490.1 , LdCL_280029900 , LDHU3_28.3360

Length:

904

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.651
CLV_C14_Caspase3-7	565	569	PF00656	0.599
CLV_C14_Caspase3-7	584	588	PF00656	0.552
CLV_C14_Caspase3-7	656	660	PF00656	0.661
CLV_C14_Caspase3-7	830	834	PF00656	0.563
CLV_MEL_PAP_1	449	455	PF00089	0.564
CLV_NRD_NRD_1	106	108	PF00675	0.667
CLV_NRD_NRD_1	113	115	PF00675	0.638
CLV_NRD_NRD_1	169	171	PF00675	0.613
CLV_NRD_NRD_1	338	340	PF00675	0.647
CLV_NRD_NRD_1	36	38	PF00675	0.616
CLV_NRD_NRD_1	380	382	PF00675	0.616
CLV_NRD_NRD_1	414	416	PF00675	0.691
CLV_NRD_NRD_1	420	422	PF00675	0.741
CLV_NRD_NRD_1	608	610	PF00675	0.548
CLV_NRD_NRD_1	649	651	PF00675	0.622
CLV_NRD_NRD_1	768	770	PF00675	0.623
CLV_NRD_NRD_1	79	81	PF00675	0.651
CLV_NRD_NRD_1	8	10	PF00675	0.585
CLV_PCSK_FUR_1	146	150	PF00082	0.584
CLV_PCSK_KEX2_1	106	108	PF00082	0.667
CLV_PCSK_KEX2_1	113	115	PF00082	0.638
CLV_PCSK_KEX2_1	148	150	PF00082	0.543
CLV_PCSK_KEX2_1	169	171	PF00082	0.605
CLV_PCSK_KEX2_1	338	340	PF00082	0.647
CLV_PCSK_KEX2_1	35	37	PF00082	0.604
CLV_PCSK_KEX2_1	380	382	PF00082	0.616
CLV_PCSK_KEX2_1	414	416	PF00082	0.691
CLV_PCSK_KEX2_1	420	422	PF00082	0.741
CLV_PCSK_KEX2_1	608	610	PF00082	0.548
CLV_PCSK_KEX2_1	649	651	PF00082	0.622
CLV_PCSK_KEX2_1	679	681	PF00082	0.617
CLV_PCSK_KEX2_1	79	81	PF00082	0.651
CLV_PCSK_KEX2_1	8	10	PF00082	0.589
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.540
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.617
CLV_PCSK_SKI1_1	114	118	PF00082	0.839
CLV_PCSK_SKI1_1	284	288	PF00082	0.500
CLV_PCSK_SKI1_1	344	348	PF00082	0.541
CLV_PCSK_SKI1_1	497	501	PF00082	0.563
CLV_PCSK_SKI1_1	734	738	PF00082	0.619
DEG_APCC_DBOX_1	283	291	PF00400	0.500
DEG_APCC_DBOX_1	351	359	PF00400	0.475
DEG_COP1_1	329	337	PF00400	0.583
DEG_SCF_FBW7_1	318	325	PF00400	0.648
DEG_SCF_TRCP1_1	529	535	PF00400	0.634
DEG_SPOP_SBC_1	322	326	PF00917	0.625
DEG_SPOP_SBC_1	40	44	PF00917	0.603
DEG_SPOP_SBC_1	665	669	PF00917	0.534
DOC_CKS1_1	164	169	PF01111	0.593
DOC_CKS1_1	183	188	PF01111	0.575
DOC_CKS1_1	319	324	PF01111	0.647
DOC_CKS1_1	819	824	PF01111	0.595
DOC_CYCLIN_yCln2_LP_2	246	249	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	557	563	PF00134	0.639
DOC_CYCLIN_yCln2_LP_2	571	577	PF00134	0.586
DOC_CYCLIN_yCln2_LP_2	898	904	PF00134	0.566
DOC_MAPK_MEF2A_6	724	731	PF00069	0.618
DOC_PP2B_LxvP_1	246	249	PF13499	0.537
DOC_PP2B_LxvP_1	30	33	PF13499	0.542
DOC_PP2B_LxvP_1	571	574	PF13499	0.657
DOC_PP2B_LxvP_1	717	720	PF13499	0.610
DOC_PP2B_LxvP_1	898	901	PF13499	0.563
DOC_PP4_FxxP_1	180	183	PF00568	0.568
DOC_PP4_FxxP_1	838	841	PF00568	0.553
DOC_USP7_MATH_1	10	14	PF00917	0.583
DOC_USP7_MATH_1	118	122	PF00917	0.789
DOC_USP7_MATH_1	128	132	PF00917	0.515
DOC_USP7_MATH_1	197	201	PF00917	0.637
DOC_USP7_MATH_1	322	326	PF00917	0.737
DOC_USP7_MATH_1	373	377	PF00917	0.674
DOC_USP7_MATH_1	40	44	PF00917	0.656
DOC_USP7_MATH_1	424	428	PF00917	0.639
DOC_USP7_MATH_1	477	481	PF00917	0.643
DOC_USP7_MATH_1	586	590	PF00917	0.605
DOC_USP7_MATH_1	648	652	PF00917	0.634
DOC_USP7_MATH_1	66	70	PF00917	0.620
DOC_USP7_MATH_1	665	669	PF00917	0.498
DOC_USP7_MATH_1	754	758	PF00917	0.693
DOC_USP7_MATH_1	817	821	PF00917	0.638
DOC_USP7_MATH_1	880	884	PF00917	0.579
DOC_USP7_MATH_1	885	889	PF00917	0.591
DOC_USP7_MATH_1	891	895	PF00917	0.532
DOC_WW_Pin1_4	163	168	PF00397	0.599
DOC_WW_Pin1_4	182	187	PF00397	0.615
DOC_WW_Pin1_4	192	197	PF00397	0.595
DOC_WW_Pin1_4	223	228	PF00397	0.665
DOC_WW_Pin1_4	257	262	PF00397	0.539
DOC_WW_Pin1_4	311	316	PF00397	0.793
DOC_WW_Pin1_4	318	323	PF00397	0.664
DOC_WW_Pin1_4	327	332	PF00397	0.550
DOC_WW_Pin1_4	366	371	PF00397	0.599
DOC_WW_Pin1_4	400	405	PF00397	0.739
DOC_WW_Pin1_4	420	425	PF00397	0.512
DOC_WW_Pin1_4	483	488	PF00397	0.664
DOC_WW_Pin1_4	598	603	PF00397	0.531
DOC_WW_Pin1_4	681	686	PF00397	0.613
DOC_WW_Pin1_4	706	711	PF00397	0.672
DOC_WW_Pin1_4	73	78	PF00397	0.540
DOC_WW_Pin1_4	774	779	PF00397	0.590
DOC_WW_Pin1_4	818	823	PF00397	0.616
DOC_WW_Pin1_4	837	842	PF00397	0.509
DOC_WW_Pin1_4	99	104	PF00397	0.612
LIG_14-3-3_CanoR_1	153	159	PF00244	0.621
LIG_14-3-3_CanoR_1	170	180	PF00244	0.537
LIG_14-3-3_CanoR_1	201	207	PF00244	0.647
LIG_14-3-3_CanoR_1	3	7	PF00244	0.617
LIG_14-3-3_CanoR_1	391	400	PF00244	0.668
LIG_14-3-3_CanoR_1	533	537	PF00244	0.642
LIG_14-3-3_CanoR_1	559	564	PF00244	0.813
LIG_14-3-3_CanoR_1	624	629	PF00244	0.612
LIG_14-3-3_CanoR_1	663	673	PF00244	0.583
LIG_14-3-3_CanoR_1	701	706	PF00244	0.637
LIG_14-3-3_CanoR_1	734	739	PF00244	0.655
LIG_14-3-3_CanoR_1	8	18	PF00244	0.566
LIG_BIR_II_1	1	5	PF00653	0.724
LIG_BRCT_BRCA1_1	344	348	PF00533	0.555
LIG_BRCT_BRCA1_1	855	859	PF00533	0.606
LIG_DLG_GKlike_1	624	631	PF00625	0.620
LIG_eIF4E_1	293	299	PF01652	0.535
LIG_FHA_1	239	245	PF00498	0.598
LIG_FHA_1	322	328	PF00498	0.640
LIG_FHA_1	484	490	PF00498	0.612
LIG_FHA_1	712	718	PF00498	0.634
LIG_FHA_1	754	760	PF00498	0.599
LIG_FHA_1	819	825	PF00498	0.639
LIG_FHA_2	421	427	PF00498	0.625
LIG_FHA_2	579	585	PF00498	0.617
LIG_FHA_2	652	658	PF00498	0.662
LIG_LIR_Apic_2	57	62	PF02991	0.570
LIG_LIR_Apic_2	73	77	PF02991	0.575
LIG_LIR_Gen_1	160	168	PF02991	0.562
LIG_LIR_Gen_1	345	355	PF02991	0.541
LIG_LIR_Nem_3	160	164	PF02991	0.675
LIG_LIR_Nem_3	345	351	PF02991	0.551
LIG_Pex14_1	789	793	PF04695	0.599
LIG_SH2_CRK	302	306	PF00017	0.549
LIG_SH2_CRK	59	63	PF00017	0.567
LIG_SH2_CRK	74	78	PF00017	0.556
LIG_SH2_GRB2like	84	87	PF00017	0.617
LIG_SH2_NCK_1	793	797	PF00017	0.546
LIG_SH2_SRC	84	87	PF00017	0.587
LIG_SH2_STAP1	793	797	PF00017	0.526
LIG_SH2_STAT3	141	144	PF00017	0.560
LIG_SH2_STAT3	293	296	PF00017	0.547
LIG_SH2_STAT3	611	614	PF00017	0.578
LIG_SH2_STAT5	417	420	PF00017	0.633
LIG_SH2_STAT5	47	50	PF00017	0.632
LIG_SH2_STAT5	611	614	PF00017	0.695
LIG_SH3_1	106	112	PF00018	0.646
LIG_SH3_1	316	322	PF00018	0.627
LIG_SH3_2	108	113	PF14604	0.682
LIG_SH3_2	196	201	PF14604	0.610
LIG_SH3_3	105	111	PF00018	0.746
LIG_SH3_3	180	186	PF00018	0.633
LIG_SH3_3	193	199	PF00018	0.558
LIG_SH3_3	21	27	PF00018	0.588
LIG_SH3_3	242	248	PF00018	0.548
LIG_SH3_3	316	322	PF00018	0.695
LIG_SH3_3	329	335	PF00018	0.709
LIG_SH3_3	402	408	PF00018	0.639
LIG_SH3_3	450	456	PF00018	0.665
LIG_SH3_3	512	518	PF00018	0.581
LIG_SH3_3	587	593	PF00018	0.608
LIG_SH3_3	717	723	PF00018	0.704
LIG_SH3_3	775	781	PF00018	0.623
LIG_SH3_3	816	822	PF00018	0.622
LIG_SH3_CIN85_PxpxPR_1	108	113	PF14604	0.663
LIG_SH3_CIN85_PxpxPR_1	315	320	PF14604	0.630
LIG_SUMO_SIM_par_1	870	876	PF11976	0.529
LIG_TRAF2_2	841	846	PF00917	0.574
LIG_WW_2	196	199	PF00397	0.597
LIG_WW_3	110	114	PF00397	0.670
LIG_WW_3	32	36	PF00397	0.606
MOD_CDC14_SPxK_1	330	333	PF00782	0.635
MOD_CDC14_SPxK_1	76	79	PF00782	0.523
MOD_CDK_SPK_2	311	316	PF00069	0.592
MOD_CDK_SPxK_1	163	169	PF00069	0.570
MOD_CDK_SPxK_1	327	333	PF00069	0.638
MOD_CDK_SPxK_1	73	79	PF00069	0.523
MOD_CDK_SPxxK_3	163	170	PF00069	0.617
MOD_CDK_SPxxK_3	73	80	PF00069	0.545
MOD_CDK_SPxxK_3	99	106	PF00069	0.634
MOD_CK1_1	154	160	PF00069	0.581
MOD_CK1_1	172	178	PF00069	0.785
MOD_CK1_1	2	8	PF00069	0.700
MOD_CK1_1	200	206	PF00069	0.626
MOD_CK1_1	226	232	PF00069	0.633
MOD_CK1_1	323	329	PF00069	0.685
MOD_CK1_1	369	375	PF00069	0.573
MOD_CK1_1	39	45	PF00069	0.659
MOD_CK1_1	394	400	PF00069	0.629
MOD_CK1_1	403	409	PF00069	0.627
MOD_CK1_1	478	484	PF00069	0.766
MOD_CK1_1	626	632	PF00069	0.681
MOD_CK1_1	651	657	PF00069	0.741
MOD_CK1_1	684	690	PF00069	0.769
MOD_CK1_1	70	76	PF00069	0.591
MOD_CK1_1	704	710	PF00069	0.500
MOD_CK1_1	772	778	PF00069	0.585
MOD_CK1_1	847	853	PF00069	0.630
MOD_CK2_1	559	565	PF00069	0.634
MOD_CK2_1	578	584	PF00069	0.496
MOD_CK2_1	651	657	PF00069	0.648
MOD_CK2_1	737	743	PF00069	0.705
MOD_CK2_1	891	897	PF00069	0.614
MOD_Cter_Amidation	677	680	PF01082	0.616
MOD_GlcNHglycan	12	15	PF01048	0.651
MOD_GlcNHglycan	120	123	PF01048	0.651
MOD_GlcNHglycan	130	133	PF01048	0.533
MOD_GlcNHglycan	175	178	PF01048	0.719
MOD_GlcNHglycan	180	183	PF01048	0.782
MOD_GlcNHglycan	223	226	PF01048	0.667
MOD_GlcNHglycan	335	338	PF01048	0.768
MOD_GlcNHglycan	344	347	PF01048	0.511
MOD_GlcNHglycan	38	41	PF01048	0.699
MOD_GlcNHglycan	43	46	PF01048	0.633
MOD_GlcNHglycan	434	437	PF01048	0.598
MOD_GlcNHglycan	476	480	PF01048	0.658
MOD_GlcNHglycan	529	532	PF01048	0.731
MOD_GlcNHglycan	631	634	PF01048	0.666
MOD_GlcNHglycan	646	649	PF01048	0.532
MOD_GlcNHglycan	668	671	PF01048	0.605
MOD_GlcNHglycan	676	679	PF01048	0.613
MOD_GlcNHglycan	69	72	PF01048	0.617
MOD_GlcNHglycan	691	695	PF01048	0.535
MOD_GlcNHglycan	696	699	PF01048	0.512
MOD_GlcNHglycan	703	706	PF01048	0.574
MOD_GlcNHglycan	739	742	PF01048	0.586
MOD_GlcNHglycan	756	759	PF01048	0.619
MOD_GlcNHglycan	801	804	PF01048	0.583
MOD_GlcNHglycan	814	817	PF01048	0.684
MOD_GlcNHglycan	878	881	PF01048	0.550
MOD_GlcNHglycan	882	885	PF01048	0.551
MOD_GSK3_1	114	121	PF00069	0.654
MOD_GSK3_1	169	176	PF00069	0.637
MOD_GSK3_1	178	185	PF00069	0.602
MOD_GSK3_1	197	204	PF00069	0.542
MOD_GSK3_1	318	325	PF00069	0.685
MOD_GSK3_1	36	43	PF00069	0.605
MOD_GSK3_1	369	376	PF00069	0.606
MOD_GSK3_1	420	427	PF00069	0.647
MOD_GSK3_1	478	485	PF00069	0.744
MOD_GSK3_1	644	651	PF00069	0.658
MOD_GSK3_1	66	73	PF00069	0.675
MOD_GSK3_1	686	693	PF00069	0.823
MOD_GSK3_1	700	707	PF00069	0.621
MOD_GSK3_1	730	737	PF00069	0.628
MOD_GSK3_1	749	756	PF00069	0.689
MOD_GSK3_1	849	856	PF00069	0.705
MOD_GSK3_1	876	883	PF00069	0.603
MOD_LATS_1	767	773	PF00433	0.623
MOD_N-GLC_1	128	133	PF02516	0.564
MOD_N-GLC_1	482	487	PF02516	0.581
MOD_N-GLC_1	891	896	PF02516	0.622
MOD_NEK2_1	495	500	PF00069	0.590
MOD_NEK2_1	55	60	PF00069	0.524
MOD_NEK2_1	576	581	PF00069	0.664
MOD_NEK2_1	690	695	PF00069	0.614
MOD_NEK2_1	700	705	PF00069	0.685
MOD_NEK2_1	844	849	PF00069	0.591
MOD_PIKK_1	140	146	PF00454	0.565
MOD_PIKK_1	151	157	PF00454	0.595
MOD_PIKK_1	259	265	PF00454	0.583
MOD_PIKK_1	47	53	PF00454	0.608
MOD_PIKK_1	478	484	PF00454	0.645
MOD_PKA_1	169	175	PF00069	0.612
MOD_PKA_1	36	42	PF00069	0.592
MOD_PKA_1	769	775	PF00069	0.629
MOD_PKA_2	169	175	PF00069	0.632
MOD_PKA_2	2	8	PF00069	0.645
MOD_PKA_2	200	206	PF00069	0.651
MOD_PKA_2	36	42	PF00069	0.592
MOD_PKA_2	532	538	PF00069	0.657
MOD_PKA_2	55	61	PF00069	0.518
MOD_PKA_2	623	629	PF00069	0.631
MOD_PKA_2	648	654	PF00069	0.628
MOD_PKA_2	665	671	PF00069	0.535
MOD_PKA_2	700	706	PF00069	0.638
MOD_PKB_1	622	630	PF00069	0.633
MOD_Plk_1	586	592	PF00069	0.606
MOD_Plk_1	844	850	PF00069	0.600
MOD_Plk_4	231	237	PF00069	0.653
MOD_Plk_4	239	245	PF00069	0.570
MOD_Plk_4	50	56	PF00069	0.588
MOD_Plk_4	844	850	PF00069	0.600
MOD_ProDKin_1	163	169	PF00069	0.600
MOD_ProDKin_1	182	188	PF00069	0.617
MOD_ProDKin_1	192	198	PF00069	0.597
MOD_ProDKin_1	223	229	PF00069	0.665
MOD_ProDKin_1	257	263	PF00069	0.530
MOD_ProDKin_1	311	317	PF00069	0.795
MOD_ProDKin_1	318	324	PF00069	0.664
MOD_ProDKin_1	327	333	PF00069	0.551
MOD_ProDKin_1	366	372	PF00069	0.600
MOD_ProDKin_1	400	406	PF00069	0.738
MOD_ProDKin_1	420	426	PF00069	0.513
MOD_ProDKin_1	483	489	PF00069	0.664
MOD_ProDKin_1	598	604	PF00069	0.523
MOD_ProDKin_1	681	687	PF00069	0.616
MOD_ProDKin_1	706	712	PF00069	0.669
MOD_ProDKin_1	73	79	PF00069	0.543
MOD_ProDKin_1	774	780	PF00069	0.588
MOD_ProDKin_1	818	824	PF00069	0.620
MOD_ProDKin_1	837	843	PF00069	0.509
MOD_ProDKin_1	99	105	PF00069	0.614
MOD_SUMO_rev_2	755	764	PF00179	0.560
TRG_DiLeu_BaEn_1	294	299	PF01217	0.486
TRG_DiLeu_BaEn_1	639	644	PF01217	0.713
TRG_DiLeu_BaEn_2	742	748	PF01217	0.598
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.556
TRG_DiLeu_BaLyEn_6	484	489	PF01217	0.615
TRG_DiLeu_BaLyEn_6	571	576	PF01217	0.622
TRG_DiLeu_LyEn_5	294	299	PF01217	0.486
TRG_ENDOCYTIC_2	302	305	PF00928	0.543
TRG_ENDOCYTIC_2	96	99	PF00928	0.577
TRG_ER_diArg_1	106	108	PF00400	0.663
TRG_ER_diArg_1	112	114	PF00400	0.641
TRG_ER_diArg_1	168	170	PF00400	0.640
TRG_ER_diArg_1	34	37	PF00400	0.606
TRG_ER_diArg_1	351	354	PF00400	0.502
TRG_ER_diArg_1	414	416	PF00400	0.689
TRG_ER_diArg_1	444	447	PF00400	0.746
TRG_ER_diArg_1	456	459	PF00400	0.617
TRG_ER_diArg_1	622	625	PF00400	0.698
TRG_ER_diArg_1	79	81	PF00400	0.617
TRG_ER_diArg_1	8	10	PF00400	0.598
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B6	Leptomonas seymouri	29%	100%
A4HGT6	Leishmania braziliensis	60%	100%
A4I3W3	Leishmania infantum	99%	100%
E9B053	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q832	Leishmania major	89%	100%