LeishMANIAdb
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Protein_kinase_putative/GeneDB:LmjF.27.0100

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein_kinase_putative/GeneDB:LmjF.27.0100
Gene product:
protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IE25_LEIDO
TriTrypDb:
LdBPK_270100.1 , LdCL_270005900 , LDHU3_27.0130
Length:
660

Annotations

LeishMANIAdb annotations

Acyltransferase involved in GPI anchor remodelling (homologue of yeast GUP1)

Annotations by Jardim et al.

Protein kinase, kinase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A0A3Q8IE25
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE25

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 26
GO:0006793 phosphorus metabolic process 3 26
GO:0006796 phosphate-containing compound metabolic process 4 26
GO:0006807 nitrogen compound metabolic process 2 26
GO:0008152 metabolic process 1 26
GO:0009987 cellular process 1 26
GO:0016310 phosphorylation 5 26
GO:0019538 protein metabolic process 3 26
GO:0036211 protein modification process 4 26
GO:0043170 macromolecule metabolic process 3 26
GO:0043412 macromolecule modification 4 26
GO:0044237 cellular metabolic process 2 26
GO:0044238 primary metabolic process 2 26
GO:0071704 organic substance metabolic process 2 26
GO:1901564 organonitrogen compound metabolic process 3 26
GO:0007165 signal transduction 2 2
GO:0035556 intracellular signal transduction 3 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0046777 protein autophosphorylation 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 26
GO:0003824 catalytic activity 1 26
GO:0004672 protein kinase activity 3 26
GO:0005488 binding 1 26
GO:0005524 ATP binding 5 26
GO:0016301 kinase activity 4 26
GO:0016740 transferase activity 2 26
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 26
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 26
GO:0017076 purine nucleotide binding 4 26
GO:0030554 adenyl nucleotide binding 5 26
GO:0032553 ribonucleotide binding 3 26
GO:0032555 purine ribonucleotide binding 4 26
GO:0032559 adenyl ribonucleotide binding 5 26
GO:0035639 purine ribonucleoside triphosphate binding 4 26
GO:0036094 small molecule binding 2 26
GO:0043167 ion binding 2 26
GO:0043168 anion binding 3 26
GO:0097159 organic cyclic compound binding 2 26
GO:0097367 carbohydrate derivative binding 2 26
GO:0140096 catalytic activity, acting on a protein 2 26
GO:1901265 nucleoside phosphate binding 3 26
GO:1901363 heterocyclic compound binding 2 26
GO:0004674 protein serine/threonine kinase activity 4 17
GO:0004707 MAP kinase activity 5 4
GO:0004683 calmodulin-dependent protein kinase activity 5 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 1
GO:0010857 calcium-dependent protein kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 81 85 PF00656 0.348
CLV_NRD_NRD_1 147 149 PF00675 0.300
CLV_NRD_NRD_1 366 368 PF00675 0.506
CLV_NRD_NRD_1 438 440 PF00675 0.602
CLV_NRD_NRD_1 55 57 PF00675 0.316
CLV_NRD_NRD_1 593 595 PF00675 0.554
CLV_NRD_NRD_1 618 620 PF00675 0.604
CLV_PCSK_FUR_1 591 595 PF00082 0.541
CLV_PCSK_KEX2_1 132 134 PF00082 0.300
CLV_PCSK_KEX2_1 326 328 PF00082 0.522
CLV_PCSK_KEX2_1 437 439 PF00082 0.583
CLV_PCSK_KEX2_1 55 57 PF00082 0.293
CLV_PCSK_KEX2_1 593 595 PF00082 0.540
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.300
CLV_PCSK_PC1ET2_1 326 328 PF00082 0.522
CLV_PCSK_PC1ET2_1 437 439 PF00082 0.628
CLV_PCSK_SKI1_1 121 125 PF00082 0.368
CLV_PCSK_SKI1_1 138 142 PF00082 0.304
CLV_PCSK_SKI1_1 215 219 PF00082 0.307
CLV_PCSK_SKI1_1 247 251 PF00082 0.329
CLV_PCSK_SKI1_1 281 285 PF00082 0.323
CLV_PCSK_SKI1_1 326 330 PF00082 0.547
CLV_PCSK_SKI1_1 33 37 PF00082 0.380
CLV_PCSK_SKI1_1 409 413 PF00082 0.589
CLV_PCSK_SKI1_1 646 650 PF00082 0.491
CLV_PCSK_SKI1_1 92 96 PF00082 0.345
DEG_APCC_DBOX_1 120 128 PF00400 0.343
DEG_Nend_UBRbox_2 1 3 PF02207 0.385
DEG_SPOP_SBC_1 388 392 PF00917 0.551
DEG_SPOP_SBC_1 520 524 PF00917 0.568
DOC_AGCK_PIF_2 77 82 PF00069 0.255
DOC_CYCLIN_RxL_1 212 221 PF00134 0.255
DOC_CYCLIN_yClb1_LxF_4 73 79 PF00134 0.255
DOC_MAPK_gen_1 138 147 PF00069 0.316
DOC_MAPK_gen_1 181 190 PF00069 0.337
DOC_MAPK_gen_1 24 32 PF00069 0.347
DOC_MAPK_gen_1 651 659 PF00069 0.508
DOC_MAPK_HePTP_8 178 190 PF00069 0.337
DOC_MAPK_JIP1_4 141 147 PF00069 0.268
DOC_MAPK_MEF2A_6 181 190 PF00069 0.337
DOC_MAPK_MEF2A_6 481 488 PF00069 0.526
DOC_PP2B_LxvP_1 396 399 PF13499 0.525
DOC_USP7_MATH_1 267 271 PF00917 0.273
DOC_USP7_MATH_1 353 357 PF00917 0.610
DOC_USP7_MATH_1 378 382 PF00917 0.484
DOC_USP7_MATH_1 400 404 PF00917 0.534
DOC_USP7_MATH_1 444 448 PF00917 0.563
DOC_USP7_MATH_1 472 476 PF00917 0.636
DOC_USP7_MATH_1 625 629 PF00917 0.532
DOC_USP7_UBL2_3 20 24 PF12436 0.272
DOC_USP7_UBL2_3 34 38 PF12436 0.273
DOC_WW_Pin1_4 101 106 PF00397 0.295
DOC_WW_Pin1_4 233 238 PF00397 0.300
DOC_WW_Pin1_4 338 343 PF00397 0.770
DOC_WW_Pin1_4 389 394 PF00397 0.601
DOC_WW_Pin1_4 401 406 PF00397 0.609
DOC_WW_Pin1_4 410 415 PF00397 0.673
DOC_WW_Pin1_4 476 481 PF00397 0.673
DOC_WW_Pin1_4 507 512 PF00397 0.824
DOC_WW_Pin1_4 521 526 PF00397 0.517
DOC_WW_Pin1_4 606 611 PF00397 0.652
DOC_WW_Pin1_4 639 644 PF00397 0.551
LIG_14-3-3_CanoR_1 253 257 PF00244 0.358
LIG_14-3-3_CanoR_1 291 298 PF00244 0.483
LIG_14-3-3_CanoR_1 354 361 PF00244 0.548
LIG_14-3-3_CanoR_1 593 603 PF00244 0.595
LIG_BIR_III_2 397 401 PF00653 0.521
LIG_BRCT_BRCA1_1 365 369 PF00533 0.546
LIG_eIF4E_1 183 189 PF01652 0.255
LIG_eIF4E_1 82 88 PF01652 0.302
LIG_FHA_1 173 179 PF00498 0.337
LIG_FHA_1 219 225 PF00498 0.396
LIG_FHA_1 236 242 PF00498 0.245
LIG_FHA_1 24 30 PF00498 0.288
LIG_FHA_1 428 434 PF00498 0.581
LIG_FHA_1 611 617 PF00498 0.578
LIG_FHA_1 652 658 PF00498 0.695
LIG_FHA_2 372 378 PF00498 0.508
LIG_FHA_2 39 45 PF00498 0.334
LIG_FHA_2 596 602 PF00498 0.535
LIG_IBAR_NPY_1 515 517 PF08397 0.542
LIG_LIR_Apic_2 180 186 PF02991 0.352
LIG_LIR_Apic_2 468 472 PF02991 0.550
LIG_LIR_Gen_1 2 10 PF02991 0.305
LIG_LIR_Nem_3 12 18 PF02991 0.259
LIG_LIR_Nem_3 161 165 PF02991 0.255
LIG_LIR_Nem_3 2 7 PF02991 0.294
LIG_LIR_Nem_3 255 259 PF02991 0.327
LIG_LIR_Nem_3 366 372 PF02991 0.505
LIG_LIR_Nem_3 75 80 PF02991 0.318
LIG_LYPXL_yS_3 113 116 PF13949 0.300
LIG_MYND_1 576 580 PF01753 0.513
LIG_NRBOX 644 650 PF00104 0.541
LIG_PTB_Apo_2 586 593 PF02174 0.546
LIG_PTB_Phospho_1 586 592 PF10480 0.546
LIG_SH2_CRK 254 258 PF00017 0.248
LIG_SH2_CRK 469 473 PF00017 0.561
LIG_SH2_NCK_1 469 473 PF00017 0.550
LIG_SH2_STAP1 4 8 PF00017 0.337
LIG_SH2_STAT3 119 122 PF00017 0.265
LIG_SH2_STAT3 572 575 PF00017 0.549
LIG_SH2_STAT5 129 132 PF00017 0.388
LIG_SH2_STAT5 135 138 PF00017 0.430
LIG_SH2_STAT5 177 180 PF00017 0.311
LIG_SH2_STAT5 254 257 PF00017 0.300
LIG_SH2_STAT5 370 373 PF00017 0.559
LIG_SH2_STAT5 40 43 PF00017 0.337
LIG_SH2_STAT5 572 575 PF00017 0.549
LIG_SH3_1 494 500 PF00018 0.510
LIG_SH3_3 106 112 PF00018 0.262
LIG_SH3_3 213 219 PF00018 0.340
LIG_SH3_3 282 288 PF00018 0.431
LIG_SH3_3 377 383 PF00018 0.540
LIG_SH3_3 43 49 PF00018 0.255
LIG_SH3_3 474 480 PF00018 0.626
LIG_SH3_3 489 495 PF00018 0.529
LIG_SH3_3 505 511 PF00018 0.513
LIG_SH3_3 570 576 PF00018 0.753
LIG_SH3_5 173 177 PF00018 0.255
LIG_SUMO_SIM_anti_2 319 325 PF11976 0.426
LIG_SUMO_SIM_anti_2 50 55 PF11976 0.236
LIG_SUMO_SIM_par_1 385 392 PF11976 0.521
LIG_TRAF2_1 237 240 PF00917 0.243
LIG_TRAF2_1 41 44 PF00917 0.255
LIG_TRFH_1 496 500 PF08558 0.495
LIG_TYR_ITIM 111 116 PF00017 0.278
LIG_UBA3_1 123 132 PF00899 0.337
LIG_UBA3_1 371 376 PF00899 0.508
LIG_UBA3_1 87 95 PF00899 0.334
MOD_CDC14_SPxK_1 404 407 PF00782 0.549
MOD_CDK_SPK_2 476 481 PF00069 0.596
MOD_CDK_SPK_2 507 512 PF00069 0.549
MOD_CDK_SPK_2 606 611 PF00069 0.548
MOD_CDK_SPxK_1 401 407 PF00069 0.554
MOD_CDK_SPxxK_3 639 646 PF00069 0.532
MOD_CK1_1 103 109 PF00069 0.239
MOD_CK1_1 23 29 PF00069 0.302
MOD_CK1_1 362 368 PF00069 0.783
MOD_CK1_1 392 398 PF00069 0.594
MOD_CK1_1 428 434 PF00069 0.666
MOD_CK1_1 440 446 PF00069 0.696
MOD_CK1_1 547 553 PF00069 0.566
MOD_CK1_1 561 567 PF00069 0.588
MOD_CK1_1 571 577 PF00069 0.601
MOD_CK1_1 596 602 PF00069 0.548
MOD_CK2_1 149 155 PF00069 0.279
MOD_CK2_1 233 239 PF00069 0.300
MOD_CK2_1 38 44 PF00069 0.280
MOD_CK2_1 564 570 PF00069 0.541
MOD_Cter_Amidation 435 438 PF01082 0.574
MOD_GlcNHglycan 105 108 PF01048 0.226
MOD_GlcNHglycan 150 154 PF01048 0.304
MOD_GlcNHglycan 261 264 PF01048 0.362
MOD_GlcNHglycan 313 316 PF01048 0.465
MOD_GlcNHglycan 474 477 PF01048 0.541
MOD_GlcNHglycan 488 491 PF01048 0.651
MOD_GlcNHglycan 528 531 PF01048 0.631
MOD_GlcNHglycan 560 563 PF01048 0.629
MOD_GlcNHglycan 598 601 PF01048 0.610
MOD_GlcNHglycan 634 638 PF01048 0.573
MOD_GlcNHglycan 654 657 PF01048 0.464
MOD_GSK3_1 172 179 PF00069 0.345
MOD_GSK3_1 229 236 PF00069 0.295
MOD_GSK3_1 353 360 PF00069 0.598
MOD_GSK3_1 388 395 PF00069 0.638
MOD_GSK3_1 425 432 PF00069 0.801
MOD_GSK3_1 440 447 PF00069 0.625
MOD_GSK3_1 472 479 PF00069 0.563
MOD_GSK3_1 519 526 PF00069 0.595
MOD_GSK3_1 564 571 PF00069 0.697
MOD_GSK3_1 606 613 PF00069 0.686
MOD_N-GLC_1 400 405 PF02516 0.530
MOD_N-GLC_1 587 592 PF02516 0.640
MOD_N-GLC_1 606 611 PF02516 0.661
MOD_NEK2_1 361 366 PF00069 0.618
MOD_NEK2_1 371 376 PF00069 0.655
MOD_NEK2_1 429 434 PF00069 0.786
MOD_NEK2_1 486 491 PF00069 0.597
MOD_NEK2_1 587 592 PF00069 0.609
MOD_PIKK_1 437 443 PF00454 0.549
MOD_PIKK_1 571 577 PF00454 0.558
MOD_PK_1 229 235 PF00069 0.300
MOD_PKA_1 437 443 PF00069 0.599
MOD_PKA_1 593 599 PF00069 0.587
MOD_PKA_2 252 258 PF00069 0.313
MOD_PKA_2 290 296 PF00069 0.329
MOD_PKA_2 353 359 PF00069 0.583
MOD_PKA_2 437 443 PF00069 0.623
MOD_PKA_2 593 599 PF00069 0.742
MOD_PKA_2 610 616 PF00069 0.572
MOD_PKB_1 591 599 PF00069 0.521
MOD_Plk_1 357 363 PF00069 0.520
MOD_Plk_1 444 450 PF00069 0.737
MOD_Plk_1 547 553 PF00069 0.596
MOD_Plk_1 587 593 PF00069 0.609
MOD_Plk_4 229 235 PF00069 0.300
MOD_Plk_4 568 574 PF00069 0.628
MOD_Plk_4 582 588 PF00069 0.574
MOD_ProDKin_1 101 107 PF00069 0.295
MOD_ProDKin_1 233 239 PF00069 0.300
MOD_ProDKin_1 338 344 PF00069 0.770
MOD_ProDKin_1 389 395 PF00069 0.602
MOD_ProDKin_1 401 407 PF00069 0.610
MOD_ProDKin_1 410 416 PF00069 0.675
MOD_ProDKin_1 476 482 PF00069 0.676
MOD_ProDKin_1 507 513 PF00069 0.823
MOD_ProDKin_1 521 527 PF00069 0.515
MOD_ProDKin_1 606 612 PF00069 0.651
MOD_ProDKin_1 639 645 PF00069 0.550
MOD_SUMO_for_1 140 143 PF00179 0.308
MOD_SUMO_for_1 532 535 PF00179 0.499
MOD_SUMO_rev_2 560 569 PF00179 0.545
TRG_DiLeu_BaEn_4 43 49 PF01217 0.255
TRG_DiLeu_BaLyEn_6 106 111 PF01217 0.243
TRG_DiLeu_BaLyEn_6 599 604 PF01217 0.536
TRG_ENDOCYTIC_2 113 116 PF00928 0.274
TRG_ENDOCYTIC_2 4 7 PF00928 0.291
TRG_ER_diArg_1 406 409 PF00400 0.546
TRG_ER_diArg_1 54 56 PF00400 0.315
TRG_ER_diArg_1 592 594 PF00400 0.527
TRG_NES_CRM1_1 296 309 PF08389 0.243
TRG_NLS_MonoExtC_3 436 442 PF00514 0.550
TRG_NLS_MonoExtN_4 247 254 PF00514 0.243
TRG_NLS_MonoExtN_4 435 441 PF00514 0.553

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4E3 Leptomonas seymouri 57% 98%
A0A0S4J4B3 Bodo saltans 25% 100%
A0A3Q8IND3 Leishmania donovani 26% 100%
A0A3Q8IVR8 Leishmania donovani 33% 100%
A0A3R7K5U6 Trypanosoma rangeli 54% 100%
A0A3S5H6C8 Leishmania donovani 25% 100%
A0A3S7WQK7 Leishmania donovani 25% 100%
A0A3S7X8Z8 Leishmania donovani 23% 100%
A4H4S9 Leishmania braziliensis 25% 100%
A4H5L7 Leishmania braziliensis 25% 100%
A4HFC9 Leishmania braziliensis 82% 100%
A4HFF3 Leishmania braziliensis 24% 100%
A4HNT2 Leishmania braziliensis 35% 100%
A4HTV4 Leishmania infantum 25% 100%
A4HTV5 Leishmania infantum 25% 100%
A4I2K6 Leishmania infantum 100% 100%
A4IB02 Leishmania infantum 23% 100%
A4ICP8 Leishmania infantum 26% 100%
A4ICR2 Leishmania infantum 33% 100%
E9ACY7 Leishmania major 98% 100%
E9AET0 Leishmania major 24% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AYR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS