Stress_responsive_A/B_Barrel_Domain_putative/Pfam:PF07876

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE23_LEIDO

TriTrypDb:

LdBPK_270600.1 , LdCL_270012500 , LDHU3_27.0980

Length:

110

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	13	17	PF00082	0.498
CLV_PCSK_SKI1_1	31	35	PF00082	0.526
CLV_PCSK_SKI1_1	90	94	PF00082	0.507
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DOC_MAPK_gen_1	31	41	PF00069	0.447
DOC_MAPK_MEF2A_6	93	102	PF00069	0.634
DOC_USP7_MATH_1	19	23	PF00917	0.553
DOC_USP7_MATH_1	26	30	PF00917	0.446
DOC_USP7_MATH_1	64	68	PF00917	0.522
DOC_USP7_UBL2_3	8	12	PF12436	0.546
DOC_WW_Pin1_4	46	51	PF00397	0.490
LIG_14-3-3_CanoR_1	44	50	PF00244	0.562
LIG_Actin_WH2_2	79	95	PF00022	0.518
LIG_FHA_1	60	66	PF00498	0.407
LIG_FHA_2	75	81	PF00498	0.498
LIG_LIR_Nem_3	48	54	PF02991	0.414
LIG_SH2_SRC	78	81	PF00017	0.467
LIG_SH2_STAP1	61	65	PF00017	0.442
LIG_SH2_STAT5	61	64	PF00017	0.443
LIG_SH3_3	92	98	PF00018	0.609
LIG_TRAF2_1	22	25	PF00917	0.546
MOD_CK1_1	68	74	PF00069	0.498
MOD_CK2_1	19	25	PF00069	0.546
MOD_CK2_1	74	80	PF00069	0.476
MOD_GlcNHglycan	70	73	PF01048	0.557
MOD_GSK3_1	55	62	PF00069	0.442
MOD_GSK3_1	64	71	PF00069	0.442
MOD_N-GLC_1	46	51	PF02516	0.488
MOD_NEK2_1	65	70	PF00069	0.504
MOD_NEK2_2	26	31	PF00069	0.531
MOD_PIKK_1	55	61	PF00454	0.512
MOD_ProDKin_1	46	52	PF00069	0.490
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.446
TRG_PTS1	107	110	PF00515	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6U1	Leptomonas seymouri	64%	99%
A0A0N0P783	Leptomonas seymouri	33%	86%
A0A0S4JUQ9	Bodo saltans	38%	100%
A0A0S4JVR8	Bodo saltans	37%	75%
A0A1X0P411	Trypanosomatidae	31%	100%
A0A1X0P4A0	Trypanosomatidae	35%	98%
A0A422NMP7	Trypanosoma rangeli	44%	96%
A4HFJ8	Leishmania braziliensis	67%	100%
D0A5S3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	99%
E9AHE6	Leishmania infantum	100%	100%
E9AYX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DA48	Trypanosoma cruzi	41%	96%