Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IE22_LEIDO

TriTrypDb:

LdCL_280036000 , LDHU3_28.4080

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.734
CLV_C14_Caspase3-7	408	412	PF00656	0.761
CLV_NRD_NRD_1	175	177	PF00675	0.431
CLV_NRD_NRD_1	263	265	PF00675	0.460
CLV_NRD_NRD_1	272	274	PF00675	0.437
CLV_NRD_NRD_1	305	307	PF00675	0.577
CLV_NRD_NRD_1	324	326	PF00675	0.685
CLV_NRD_NRD_1	359	361	PF00675	0.724
CLV_NRD_NRD_1	478	480	PF00675	0.539
CLV_NRD_NRD_1	53	55	PF00675	0.519
CLV_PCSK_FUR_1	273	277	PF00082	0.443
CLV_PCSK_KEX2_1	174	176	PF00082	0.566
CLV_PCSK_KEX2_1	272	274	PF00082	0.432
CLV_PCSK_KEX2_1	275	277	PF00082	0.430
CLV_PCSK_KEX2_1	305	307	PF00082	0.534
CLV_PCSK_KEX2_1	324	326	PF00082	0.636
CLV_PCSK_KEX2_1	361	363	PF00082	0.807
CLV_PCSK_KEX2_1	478	480	PF00082	0.539
CLV_PCSK_KEX2_1	52	54	PF00082	0.513
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.508
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.807
CLV_PCSK_PC7_1	474	480	PF00082	0.548
CLV_PCSK_SKI1_1	161	165	PF00082	0.488
CLV_PCSK_SKI1_1	168	172	PF00082	0.440
CLV_PCSK_SKI1_1	175	179	PF00082	0.367
CLV_PCSK_SKI1_1	285	289	PF00082	0.505
CLV_PCSK_SKI1_1	449	453	PF00082	0.565
DEG_COP1_1	130	138	PF00400	0.556
DEG_SCF_FBW7_1	7	14	PF00400	0.434
DEG_SPOP_SBC_1	227	231	PF00917	0.477
DEG_SPOP_SBC_1	342	346	PF00917	0.662
DEG_SPOP_SBC_1	450	454	PF00917	0.574
DOC_ANK_TNKS_1	73	80	PF00023	0.490
DOC_CKS1_1	135	140	PF01111	0.545
DOC_CKS1_1	251	256	PF01111	0.500
DOC_CYCLIN_RxL_1	165	172	PF00134	0.435
DOC_MAPK_gen_1	360	371	PF00069	0.689
DOC_MAPK_MEF2A_6	415	423	PF00069	0.610
DOC_MAPK_MEF2A_6	482	490	PF00069	0.636
DOC_PP2B_LxvP_1	35	38	PF13499	0.516
DOC_USP7_MATH_1	11	15	PF00917	0.511
DOC_USP7_MATH_1	136	140	PF00917	0.686
DOC_USP7_MATH_1	143	147	PF00917	0.490
DOC_USP7_MATH_1	226	230	PF00917	0.648
DOC_USP7_MATH_1	312	316	PF00917	0.686
DOC_USP7_MATH_1	317	321	PF00917	0.682
DOC_USP7_MATH_1	340	344	PF00917	0.751
DOC_USP7_MATH_1	356	360	PF00917	0.637
DOC_USP7_MATH_1	390	394	PF00917	0.699
DOC_USP7_MATH_1	433	437	PF00917	0.737
DOC_USP7_MATH_1	451	455	PF00917	0.558
DOC_USP7_MATH_1	458	462	PF00917	0.709
DOC_USP7_MATH_1	86	90	PF00917	0.761
DOC_WW_Pin1_4	134	139	PF00397	0.685
DOC_WW_Pin1_4	250	255	PF00397	0.482
DOC_WW_Pin1_4	3	8	PF00397	0.566
DOC_WW_Pin1_4	313	318	PF00397	0.655
DOC_WW_Pin1_4	373	378	PF00397	0.670
DOC_WW_Pin1_4	392	397	PF00397	0.698
DOC_WW_Pin1_4	453	458	PF00397	0.630
LIG_14-3-3_CanoR_1	166	171	PF00244	0.481
LIG_14-3-3_CanoR_1	239	249	PF00244	0.419
LIG_14-3-3_CanoR_1	276	281	PF00244	0.412
LIG_14-3-3_CanoR_1	313	317	PF00244	0.637
LIG_14-3-3_CanoR_1	449	457	PF00244	0.548
LIG_14-3-3_CanoR_1	90	96	PF00244	0.569
LIG_Actin_WH2_2	105	123	PF00022	0.514
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_BIR_III_3	1	5	PF00653	0.597
LIG_BRCT_BRCA1_1	486	490	PF00533	0.640
LIG_BRCT_BRCA1_1	5	9	PF00533	0.457
LIG_Clathr_ClatBox_1	58	62	PF01394	0.608
LIG_deltaCOP1_diTrp_1	480	490	PF00928	0.633
LIG_eIF4E_1	438	444	PF01652	0.630
LIG_FHA_1	111	117	PF00498	0.580
LIG_FHA_1	130	136	PF00498	0.711
LIG_FHA_1	251	257	PF00498	0.502
LIG_FHA_1	272	278	PF00498	0.613
LIG_FHA_2	121	127	PF00498	0.563
LIG_FHA_2	241	247	PF00498	0.429
LIG_FHA_2	257	263	PF00498	0.463
LIG_FHA_2	398	404	PF00498	0.709
LIG_FHA_2	406	412	PF00498	0.747
LIG_FHA_2	429	435	PF00498	0.633
LIG_Integrin_RGD_1	364	366	PF01839	0.664
LIG_LIR_Apic_2	435	441	PF02991	0.650
LIG_LIR_Nem_3	150	156	PF02991	0.527
LIG_LIR_Nem_3	202	208	PF02991	0.601
LIG_MYND_1	441	445	PF01753	0.630
LIG_PDZ_Class_2	485	490	PF00595	0.639
LIG_Pex14_2	5	9	PF04695	0.457
LIG_Rb_pABgroove_1	165	173	PF01858	0.340
LIG_RPA_C_Fungi	301	313	PF08784	0.487
LIG_SH2_CRK	153	157	PF00017	0.458
LIG_SH2_NCK_1	438	442	PF00017	0.628
LIG_SH2_PTP2	447	450	PF00017	0.608
LIG_SH2_SRC	442	445	PF00017	0.599
LIG_SH2_STAT3	248	251	PF00017	0.458
LIG_SH2_STAT5	119	122	PF00017	0.611
LIG_SH2_STAT5	442	445	PF00017	0.622
LIG_SH2_STAT5	447	450	PF00017	0.638
LIG_SH3_3	132	138	PF00018	0.733
LIG_SUMO_SIM_anti_2	378	384	PF11976	0.805
LIG_SUMO_SIM_anti_2	398	403	PF11976	0.692
LIG_SUMO_SIM_par_1	378	384	PF11976	0.687
LIG_SUMO_SIM_par_1	400	406	PF11976	0.721
LIG_TRAF2_1	67	70	PF00917	0.485
MOD_CDK_SPK_2	7	12	PF00069	0.443
MOD_CK1_1	131	137	PF00069	0.699
MOD_CK1_1	139	145	PF00069	0.558
MOD_CK1_1	230	236	PF00069	0.519
MOD_CK1_1	3	9	PF00069	0.578
MOD_CK1_1	343	349	PF00069	0.653
MOD_CK1_1	466	472	PF00069	0.568
MOD_CK1_1	73	79	PF00069	0.672
MOD_CK1_1	89	95	PF00069	0.519
MOD_CK2_1	240	246	PF00069	0.442
MOD_CK2_1	256	262	PF00069	0.459
MOD_CK2_1	347	353	PF00069	0.647
MOD_CK2_1	381	387	PF00069	0.600
MOD_CK2_1	433	439	PF00069	0.663
MOD_GlcNHglycan	13	16	PF01048	0.403
MOD_GlcNHglycan	145	148	PF01048	0.518
MOD_GlcNHglycan	2	5	PF01048	0.597
MOD_GlcNHglycan	210	213	PF01048	0.558
MOD_GlcNHglycan	224	227	PF01048	0.574
MOD_GlcNHglycan	345	348	PF01048	0.738
MOD_GlcNHglycan	349	352	PF01048	0.696
MOD_GlcNHglycan	383	386	PF01048	0.728
MOD_GlcNHglycan	391	395	PF01048	0.638
MOD_GlcNHglycan	434	438	PF01048	0.674
MOD_GlcNHglycan	465	468	PF01048	0.762
MOD_GlcNHglycan	75	78	PF01048	0.780
MOD_GSK3_1	139	146	PF00069	0.586
MOD_GSK3_1	222	229	PF00069	0.579
MOD_GSK3_1	3	10	PF00069	0.507
MOD_GSK3_1	313	320	PF00069	0.715
MOD_GSK3_1	343	350	PF00069	0.690
MOD_GSK3_1	381	388	PF00069	0.623
MOD_GSK3_1	449	456	PF00069	0.635
MOD_GSK3_1	85	92	PF00069	0.592
MOD_LATS_1	303	309	PF00433	0.481
MOD_N-GLC_1	90	95	PF02516	0.599
MOD_NEK2_1	208	213	PF00069	0.610
MOD_NEK2_1	256	261	PF00069	0.469
MOD_NEK2_2	319	324	PF00069	0.599
MOD_PIKK_1	107	113	PF00454	0.453
MOD_PIKK_1	136	142	PF00454	0.499
MOD_PIKK_1	256	262	PF00454	0.482
MOD_PIKK_1	27	33	PF00454	0.591
MOD_PIKK_1	466	472	PF00454	0.693
MOD_PKA_1	175	181	PF00069	0.490
MOD_PKA_1	305	311	PF00069	0.500
MOD_PKA_2	11	17	PF00069	0.457
MOD_PKA_2	120	126	PF00069	0.638
MOD_PKA_2	175	181	PF00069	0.430
MOD_PKA_2	271	277	PF00069	0.490
MOD_PKA_2	305	311	PF00069	0.636
MOD_PKA_2	312	318	PF00069	0.611
MOD_PKA_2	73	79	PF00069	0.568
MOD_PKA_2	89	95	PF00069	0.534
MOD_Plk_1	397	403	PF00069	0.688
MOD_Plk_1	433	439	PF00069	0.605
MOD_Plk_1	90	96	PF00069	0.439
MOD_Plk_2-3	428	434	PF00069	0.583
MOD_Plk_4	397	403	PF00069	0.794
MOD_ProDKin_1	134	140	PF00069	0.683
MOD_ProDKin_1	250	256	PF00069	0.484
MOD_ProDKin_1	3	9	PF00069	0.564
MOD_ProDKin_1	313	319	PF00069	0.656
MOD_ProDKin_1	373	379	PF00069	0.671
MOD_ProDKin_1	392	398	PF00069	0.700
MOD_ProDKin_1	453	459	PF00069	0.633
MOD_SUMO_rev_2	211	219	PF00179	0.593
TRG_DiLeu_BaEn_1	439	444	PF01217	0.627
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.594
TRG_ENDOCYTIC_2	153	156	PF00928	0.461
TRG_ENDOCYTIC_2	284	287	PF00928	0.544
TRG_ER_diArg_1	174	176	PF00400	0.539
TRG_ER_diArg_1	323	325	PF00400	0.698
TRG_ER_diArg_1	477	479	PF00400	0.546
TRG_ER_diArg_1	51	54	PF00400	0.536
TRG_NLS_MonoExtC_3	359	364	PF00514	0.692
TRG_NLS_MonoExtN_4	358	365	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYA9	Leptomonas seymouri	49%	100%
A0A1X0NQL1	Trypanosomatidae	28%	100%
A0A3R7JYS6	Trypanosoma rangeli	28%	100%
A4HGY7	Leishmania braziliensis	72%	99%
A4I419	Leishmania infantum	100%	100%
E9B0A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7X8	Leishmania major	91%	100%