Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD-40 repeat protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IE21_LEIDO

TriTrypDb:

LdBPK_300420.1 , LdCL_300009300 , LDHU3_30.0590

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005654	nucleoplasm	2	1
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IE21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE21

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0031123	RNA 3'-end processing	7	12
GO:0031124	mRNA 3'-end processing	8	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006378	mRNA polyadenylation	7	1
GO:0043631	RNA polyadenylation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.479
CLV_NRD_NRD_1	155	157	PF00675	0.381
CLV_NRD_NRD_1	196	198	PF00675	0.566
CLV_NRD_NRD_1	358	360	PF00675	0.572
CLV_NRD_NRD_1	51	53	PF00675	0.673
CLV_NRD_NRD_1	65	67	PF00675	0.517
CLV_NRD_NRD_1	8	10	PF00675	0.711
CLV_PCSK_KEX2_1	155	157	PF00082	0.381
CLV_PCSK_KEX2_1	196	198	PF00082	0.566
CLV_PCSK_KEX2_1	366	368	PF00082	0.547
CLV_PCSK_KEX2_1	50	52	PF00082	0.683
CLV_PCSK_KEX2_1	65	67	PF00082	0.523
CLV_PCSK_KEX2_1	7	9	PF00082	0.717
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.547
CLV_PCSK_PC7_1	3	9	PF00082	0.772
CLV_PCSK_SKI1_1	155	159	PF00082	0.362
CLV_PCSK_SKI1_1	342	346	PF00082	0.337
CLV_PCSK_SKI1_1	366	370	PF00082	0.535
CLV_PCSK_SKI1_1	82	86	PF00082	0.451
DEG_APCC_DBOX_1	141	149	PF00400	0.408
DEG_APCC_DBOX_1	81	89	PF00400	0.507
DEG_Nend_UBRbox_2	1	3	PF02207	0.756
DOC_ANK_TNKS_1	335	342	PF00023	0.541
DOC_CKS1_1	141	146	PF01111	0.526
DOC_MAPK_gen_1	196	202	PF00069	0.526
DOC_PP1_RVXF_1	188	195	PF00149	0.368
DOC_PP1_RVXF_1	229	236	PF00149	0.371
DOC_PP1_RVXF_1	375	381	PF00149	0.378
DOC_PP1_RVXF_1	70	77	PF00149	0.470
DOC_PP4_FxxP_1	30	33	PF00568	0.751
DOC_PP4_FxxP_1	76	79	PF00568	0.546
DOC_USP7_MATH_1	266	270	PF00917	0.658
DOC_USP7_MATH_1	301	305	PF00917	0.479
DOC_USP7_MATH_1	382	386	PF00917	0.495
DOC_USP7_MATH_1	393	397	PF00917	0.341
DOC_USP7_UBL2_3	429	433	PF12436	0.616
DOC_WW_Pin1_4	140	145	PF00397	0.528
DOC_WW_Pin1_4	148	153	PF00397	0.439
DOC_WW_Pin1_4	440	445	PF00397	0.487
DOC_WW_Pin1_4	75	80	PF00397	0.550
DOC_WW_Pin1_4	90	95	PF00397	0.518
LIG_14-3-3_CanoR_1	156	166	PF00244	0.359
LIG_14-3-3_CanoR_1	359	363	PF00244	0.581
LIG_14-3-3_CanoR_1	51	59	PF00244	0.681
LIG_BRCT_BRCA1_1	26	30	PF00533	0.759
LIG_BRCT_BRCA1_1	384	388	PF00533	0.517
LIG_CSL_BTD_1	441	444	PF09270	0.496
LIG_deltaCOP1_diTrp_1	232	242	PF00928	0.391
LIG_eIF4E_1	104	110	PF01652	0.507
LIG_FHA_1	104	110	PF00498	0.238
LIG_FHA_1	123	129	PF00498	0.385
LIG_FHA_1	254	260	PF00498	0.435
LIG_FHA_1	350	356	PF00498	0.513
LIG_FHA_1	370	376	PF00498	0.234
LIG_FHA_1	408	414	PF00498	0.711
LIG_FHA_1	84	90	PF00498	0.477
LIG_FHA_2	359	365	PF00498	0.572
LIG_FHA_2	381	387	PF00498	0.526
LIG_FHA_2	389	395	PF00498	0.478
LIG_LIR_Apic_2	27	33	PF02991	0.745
LIG_LIR_Apic_2	75	79	PF02991	0.552
LIG_LIR_Gen_1	165	174	PF02991	0.354
LIG_LIR_Gen_1	215	223	PF02991	0.360
LIG_LIR_Nem_3	165	169	PF02991	0.336
LIG_LIR_Nem_3	232	238	PF02991	0.461
LIG_LIR_Nem_3	290	296	PF02991	0.455
LIG_LIR_Nem_3	396	402	PF02991	0.409
LIG_PDZ_Class_2	482	487	PF00595	0.633
LIG_Pex14_1	213	217	PF04695	0.389
LIG_Pex14_2	26	30	PF04695	0.629
LIG_Pex14_2	53	57	PF04695	0.723
LIG_PTB_Apo_2	213	220	PF02174	0.515
LIG_SH2_CRK	296	300	PF00017	0.497
LIG_SH2_STAP1	105	109	PF00017	0.388
LIG_SH2_STAP1	146	150	PF00017	0.512
LIG_SH2_STAP1	95	99	PF00017	0.497
LIG_SH2_STAT3	146	149	PF00017	0.491
LIG_SH2_STAT5	105	108	PF00017	0.467
LIG_SH3_2	46	51	PF14604	0.726
LIG_SH3_3	35	41	PF00018	0.733
LIG_SH3_3	43	49	PF00018	0.644
LIG_TRAF2_1	466	469	PF00917	0.517
LIG_TYR_ITIM	397	402	PF00017	0.398
MOD_CDK_SPxxK_3	148	155	PF00069	0.487
MOD_CDK_SPxxK_3	75	82	PF00069	0.498
MOD_CK1_1	304	310	PF00069	0.391
MOD_CK1_1	318	324	PF00069	0.369
MOD_CK2_1	358	364	PF00069	0.572
MOD_CK2_1	449	455	PF00069	0.428
MOD_Cter_Amidation	153	156	PF01082	0.401
MOD_Cter_Amidation	194	197	PF01082	0.523
MOD_GlcNHglycan	152	155	PF01048	0.505
MOD_GlcNHglycan	202	205	PF01048	0.336
MOD_GlcNHglycan	248	252	PF01048	0.374
MOD_GlcNHglycan	26	29	PF01048	0.750
MOD_GlcNHglycan	345	348	PF01048	0.317
MOD_GlcNHglycan	451	454	PF01048	0.345
MOD_GSK3_1	108	115	PF00069	0.325
MOD_GSK3_1	118	125	PF00069	0.307
MOD_GSK3_1	218	225	PF00069	0.446
MOD_GSK3_1	262	269	PF00069	0.626
MOD_GSK3_1	326	333	PF00069	0.381
MOD_GSK3_1	345	352	PF00069	0.160
MOD_GSK3_1	89	96	PF00069	0.635
MOD_N-GLC_1	117	122	PF02516	0.490
MOD_N-GLC_1	128	133	PF02516	0.357
MOD_NEK2_1	157	162	PF00069	0.326
MOD_NEK2_1	212	217	PF00069	0.366
MOD_NEK2_1	299	304	PF00069	0.308
MOD_NEK2_1	387	392	PF00069	0.356
MOD_NEK2_1	449	454	PF00069	0.328
MOD_PIKK_1	122	128	PF00454	0.386
MOD_PIKK_1	301	307	PF00454	0.308
MOD_PIKK_1	326	332	PF00454	0.393
MOD_PIKK_1	358	364	PF00454	0.572
MOD_PKA_1	366	372	PF00069	0.559
MOD_PKA_2	318	324	PF00069	0.455
MOD_PKA_2	358	364	PF00069	0.572
MOD_PKA_2	366	372	PF00069	0.559
MOD_PKB_1	50	58	PF00069	0.728
MOD_Plk_1	128	134	PF00069	0.414
MOD_Plk_1	231	237	PF00069	0.379
MOD_Plk_4	393	399	PF00069	0.379
MOD_ProDKin_1	140	146	PF00069	0.522
MOD_ProDKin_1	148	154	PF00069	0.440
MOD_ProDKin_1	440	446	PF00069	0.353
MOD_ProDKin_1	75	81	PF00069	0.552
MOD_ProDKin_1	90	96	PF00069	0.515
MOD_SUMO_for_1	279	282	PF00179	0.435
MOD_SUMO_rev_2	173	181	PF00179	0.439
MOD_SUMO_rev_2	234	242	PF00179	0.465
MOD_SUMO_rev_2	277	281	PF00179	0.430
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.379
TRG_ENDOCYTIC_2	296	299	PF00928	0.366
TRG_ENDOCYTIC_2	399	402	PF00928	0.394
TRG_ER_diArg_1	155	157	PF00400	0.393
TRG_ER_diArg_1	49	52	PF00400	0.646
TRG_ER_diArg_1	6	9	PF00400	0.744
TRG_ER_diArg_1	64	66	PF00400	0.553
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	23%	93%
A0A0N1PBX5	Leptomonas seymouri	90%	100%
A0A0S4J5T5	Bodo saltans	27%	90%
A0A0S4JFE0	Bodo saltans	56%	100%
A0A0S4KJ87	Bodo saltans	26%	81%
A0A1X0NVZ7	Trypanosomatidae	22%	93%
A0A1X0P2X5	Trypanosomatidae	64%	100%
A0A3Q8IGC4	Leishmania donovani	24%	93%
A0A3R7N6M9	Trypanosoma rangeli	23%	93%
A0A3R7NRU0	Trypanosoma rangeli	63%	100%
A4HHZ2	Leishmania braziliensis	92%	98%
A4I135	Leishmania infantum	24%	100%
A4I569	Leishmania infantum	98%	98%
B5X212	Salmo salar	22%	100%
B8AP31	Oryza sativa subsp. indica	24%	100%
C9ZQJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
C9ZW72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	79%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B0G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
G0SC29	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	23%	94%
O60907	Homo sapiens	21%	84%
O76071	Homo sapiens	23%	100%
P0CS46	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	68%
P0CS47	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	68%
P42841	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P49177	Arabidopsis thaliana	25%	100%
P49178	Zea mays	23%	100%
P78706	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	21%	81%
Q28DW0	Xenopus tropicalis	24%	100%
Q28I85	Xenopus tropicalis	23%	100%
Q2TZG4	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	31%	80%
Q32PJ6	Bos taurus	22%	100%
Q40687	Oryza sativa subsp. japonica	24%	100%
Q4I7X1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	27%	80%
Q4Q7R7	Leishmania major	97%	98%
Q4QAA4	Leishmania major	24%	100%
Q4R8H1	Macaca fascicularis	21%	86%
Q4V8C4	Rattus norvegicus	22%	100%
Q4X1Y0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	29%	95%
Q55DA2	Dictyostelium discoideum	21%	100%
Q58D20	Bos taurus	24%	100%
Q59WJ4	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	90%
Q5AZX0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	86%
Q5DFU0	Schistosoma japonicum	25%	100%
Q5M7T1	Rattus norvegicus	22%	100%
Q5RE95	Pongo abelii	22%	100%
Q5RFF8	Pongo abelii	24%	100%
Q6BVZ3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	28%	97%
Q6CGP9	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	92%
Q6CP71	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	100%
Q6FJS0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	29%	100%
Q6NLV4	Arabidopsis thaliana	32%	75%
Q75AV4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q7RY68	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	74%
Q7T0P4	Xenopus laevis	23%	100%
Q86VZ2	Homo sapiens	22%	100%
Q8VEJ4	Mus musculus	24%	100%
Q95RJ9	Drosophila melanogaster	25%	70%
Q99KN2	Mus musculus	23%	100%
Q9D7H2	Mus musculus	22%	100%
Q9FLX9	Arabidopsis thaliana	22%	100%
Q9FN19	Arabidopsis thaliana	22%	79%
Q9NVX2	Homo sapiens	24%	100%
Q9QXE7	Mus musculus	22%	92%
Q9UTN4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	96%
V5BEB2	Trypanosoma cruzi	24%	90%
V5DD51	Trypanosoma cruzi	64%	100%