Mitochondrial_import_receptor_subunit_ATOM69_puta tive/GeneDB:LmjF.28.2170

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial import receptor subunit ATOM69, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE19_LEIDO

TriTrypDb:

LdBPK_282320.1 , LdCL_280028300 , LDHU3_28.3150

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0016020	membrane	2	3
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0032991	protein-containing complex	1	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3Q8IE19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE19

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.578
CLV_C14_Caspase3-7	475	479	PF00656	0.592
CLV_NRD_NRD_1	489	491	PF00675	0.393
CLV_NRD_NRD_1	585	587	PF00675	0.537
CLV_PCSK_KEX2_1	355	357	PF00082	0.319
CLV_PCSK_KEX2_1	489	491	PF00082	0.361
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.378
CLV_PCSK_SKI1_1	174	178	PF00082	0.526
CLV_PCSK_SKI1_1	236	240	PF00082	0.318
CLV_PCSK_SKI1_1	348	352	PF00082	0.281
CLV_PCSK_SKI1_1	355	359	PF00082	0.278
CLV_PCSK_SKI1_1	380	384	PF00082	0.289
CLV_PCSK_SKI1_1	39	43	PF00082	0.317
CLV_PCSK_SKI1_1	395	399	PF00082	0.271
CLV_PCSK_SKI1_1	414	418	PF00082	0.367
CLV_PCSK_SKI1_1	507	511	PF00082	0.462
CLV_PCSK_SKI1_1	620	624	PF00082	0.288
CLV_Separin_Metazoa	486	490	PF03568	0.660
DEG_APCC_DBOX_1	120	128	PF00400	0.573
DEG_SCF_FBW7_2	109	115	PF00400	0.525
DEG_SPOP_SBC_1	519	523	PF00917	0.664
DOC_CDC14_PxL_1	635	643	PF14671	0.408
DOC_CKS1_1	109	114	PF01111	0.525
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.332
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.484
DOC_MAPK_gen_1	118	126	PF00069	0.576
DOC_MAPK_gen_1	37	45	PF00069	0.519
DOC_MAPK_JIP1_4	37	43	PF00069	0.569
DOC_MAPK_MEF2A_6	37	45	PF00069	0.519
DOC_MAPK_MEF2A_6	489	496	PF00069	0.545
DOC_PP1_RVXF_1	57	64	PF00149	0.633
DOC_PP2B_LxvP_1	532	535	PF13499	0.665
DOC_PP2B_LxvP_1	99	102	PF13499	0.475
DOC_PP4_FxxP_1	571	574	PF00568	0.620
DOC_USP7_MATH_1	181	185	PF00917	0.680
DOC_USP7_MATH_1	251	255	PF00917	0.599
DOC_USP7_MATH_1	416	420	PF00917	0.585
DOC_USP7_MATH_1	429	433	PF00917	0.623
DOC_USP7_MATH_1	479	483	PF00917	0.532
DOC_USP7_MATH_1	539	543	PF00917	0.661
DOC_USP7_MATH_1	562	566	PF00917	0.679
DOC_USP7_MATH_1	67	71	PF00917	0.621
DOC_WW_Pin1_4	108	113	PF00397	0.616
DOC_WW_Pin1_4	343	348	PF00397	0.518
DOC_WW_Pin1_4	515	520	PF00397	0.691
LIG_14-3-3_CanoR_1	118	128	PF00244	0.576
LIG_14-3-3_CanoR_1	250	256	PF00244	0.570
LIG_14-3-3_CanoR_1	414	422	PF00244	0.521
LIG_14-3-3_CanoR_1	575	583	PF00244	0.693
LIG_Actin_WH2_2	398	416	PF00022	0.504
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BRCT_BRCA1_1	449	453	PF00533	0.476
LIG_BRCT_BRCA1_1	567	571	PF00533	0.668
LIG_BRCT_BRCA1_1	594	598	PF00533	0.623
LIG_EH1_1	616	624	PF00400	0.332
LIG_FHA_1	301	307	PF00498	0.526
LIG_FHA_1	332	338	PF00498	0.533
LIG_FHA_1	4	10	PF00498	0.636
LIG_FHA_1	40	46	PF00498	0.516
LIG_FHA_1	547	553	PF00498	0.656
LIG_FHA_1	56	62	PF00498	0.577
LIG_FHA_2	175	181	PF00498	0.755
LIG_FHA_2	20	26	PF00498	0.539
LIG_FHA_2	222	228	PF00498	0.607
LIG_FHA_2	229	235	PF00498	0.577
LIG_FHA_2	264	270	PF00498	0.508
LIG_LIR_Apic_2	568	574	PF02991	0.621
LIG_LIR_Nem_3	608	613	PF02991	0.318
LIG_MLH1_MIPbox_1	449	453	PF16413	0.490
LIG_NRBOX	164	170	PF00104	0.615
LIG_PCNA_PIPBox_1	405	414	PF02747	0.458
LIG_PCNA_yPIPBox_3	368	380	PF02747	0.544
LIG_PDZ_Class_1	646	651	PF00595	0.491
LIG_Pex14_2	382	386	PF04695	0.458
LIG_Rb_pABgroove_1	369	377	PF01858	0.541
LIG_SH2_CRK	341	345	PF00017	0.517
LIG_SH2_CRK	628	632	PF00017	0.355
LIG_SH2_CRK	66	70	PF00017	0.555
LIG_SH2_NCK_1	613	617	PF00017	0.294
LIG_SH2_NCK_1	628	632	PF00017	0.397
LIG_SH2_NCK_1	66	70	PF00017	0.499
LIG_SH2_SRC	476	479	PF00017	0.633
LIG_SH2_STAP1	613	617	PF00017	0.275
LIG_SH2_STAT3	391	394	PF00017	0.444
LIG_SH2_STAT5	391	394	PF00017	0.444
LIG_SH2_STAT5	452	455	PF00017	0.518
LIG_SH2_STAT5	476	479	PF00017	0.546
LIG_SH2_STAT5	613	616	PF00017	0.288
LIG_SH3_1	489	495	PF00018	0.589
LIG_SH3_3	122	128	PF00018	0.531
LIG_SH3_3	23	29	PF00018	0.606
LIG_SH3_3	381	387	PF00018	0.484
LIG_SH3_3	489	495	PF00018	0.623
LIG_TRAF2_1	423	426	PF00917	0.639
LIG_TRAF2_1	511	514	PF00917	0.677
LIG_UBA3_1	50	56	PF00899	0.540
MOD_CDK_SPK_2	343	348	PF00069	0.493
MOD_CK1_1	254	260	PF00069	0.569
MOD_CK1_1	361	367	PF00069	0.593
MOD_CK1_1	420	426	PF00069	0.603
MOD_CK1_1	565	571	PF00069	0.682
MOD_CK1_1	611	617	PF00069	0.403
MOD_CK1_1	629	635	PF00069	0.437
MOD_CK2_1	130	136	PF00069	0.664
MOD_CK2_1	174	180	PF00069	0.748
MOD_CK2_1	181	187	PF00069	0.769
MOD_CK2_1	19	25	PF00069	0.560
MOD_CK2_1	228	234	PF00069	0.605
MOD_CK2_1	254	260	PF00069	0.579
MOD_CK2_1	287	293	PF00069	0.588
MOD_CK2_1	420	426	PF00069	0.596
MOD_CK2_1	51	57	PF00069	0.635
MOD_GlcNHglycan	142	145	PF01048	0.565
MOD_GlcNHglycan	359	363	PF01048	0.353
MOD_GlcNHglycan	449	452	PF01048	0.263
MOD_GlcNHglycan	481	484	PF01048	0.343
MOD_GlcNHglycan	504	510	PF01048	0.463
MOD_GlcNHglycan	565	568	PF01048	0.507
MOD_GlcNHglycan	579	582	PF01048	0.468
MOD_GlcNHglycan	590	593	PF01048	0.477
MOD_GlcNHglycan	628	631	PF01048	0.609
MOD_GlcNHglycan	90	93	PF01048	0.376
MOD_GSK3_1	126	133	PF00069	0.647
MOD_GSK3_1	216	223	PF00069	0.611
MOD_GSK3_1	226	233	PF00069	0.623
MOD_GSK3_1	251	258	PF00069	0.537
MOD_GSK3_1	296	303	PF00069	0.578
MOD_GSK3_1	339	346	PF00069	0.495
MOD_GSK3_1	416	423	PF00069	0.508
MOD_GSK3_1	505	512	PF00069	0.653
MOD_GSK3_1	51	58	PF00069	0.560
MOD_GSK3_1	514	521	PF00069	0.720
MOD_GSK3_1	588	595	PF00069	0.719
MOD_N-GLC_1	220	225	PF02516	0.423
MOD_N-GLC_1	296	301	PF02516	0.375
MOD_NEK2_1	119	124	PF00069	0.555
MOD_NEK2_1	263	268	PF00069	0.510
MOD_NEK2_1	358	363	PF00069	0.587
MOD_NEK2_1	466	471	PF00069	0.552
MOD_NEK2_1	51	56	PF00069	0.553
MOD_NEK2_1	626	631	PF00069	0.517
MOD_NEK2_2	605	610	PF00069	0.424
MOD_NEK2_2	646	651	PF00069	0.491
MOD_PIKK_1	119	125	PF00454	0.598
MOD_PIKK_1	244	250	PF00454	0.570
MOD_PIKK_1	251	257	PF00454	0.539
MOD_PIKK_1	263	269	PF00454	0.412
MOD_PIKK_1	339	345	PF00454	0.511
MOD_PIKK_1	509	515	PF00454	0.647
MOD_PK_1	46	52	PF00069	0.606
MOD_PKB_1	37	45	PF00069	0.561
MOD_Plk_1	216	222	PF00069	0.607
MOD_Plk_1	330	336	PF00069	0.501
MOD_Plk_1	39	45	PF00069	0.514
MOD_Plk_2-3	132	138	PF00069	0.627
MOD_Plk_2-3	287	293	PF00069	0.585
MOD_Plk_4	331	337	PF00069	0.483
MOD_Plk_4	417	423	PF00069	0.525
MOD_Plk_4	46	52	PF00069	0.506
MOD_Plk_4	605	611	PF00069	0.356
MOD_ProDKin_1	108	114	PF00069	0.619
MOD_ProDKin_1	343	349	PF00069	0.514
MOD_ProDKin_1	515	521	PF00069	0.691
MOD_SUMO_for_1	195	198	PF00179	0.595
MOD_SUMO_for_1	460	463	PF00179	0.519
MOD_SUMO_rev_2	175	184	PF00179	0.762
MOD_SUMO_rev_2	233	238	PF00179	0.602
MOD_SUMO_rev_2	499	509	PF00179	0.633
MOD_SUMO_rev_2	86	91	PF00179	0.639
TRG_DiLeu_BaEn_1	331	336	PF01217	0.498
TRG_ENDOCYTIC_2	341	344	PF00928	0.491
TRG_ENDOCYTIC_2	628	631	PF00928	0.328
TRG_ENDOCYTIC_2	66	69	PF00928	0.489
TRG_ER_diArg_1	36	39	PF00400	0.611
TRG_ER_diArg_1	488	490	PF00400	0.677
TRG_ER_diArg_1	583	586	PF00400	0.737
TRG_NLS_MonoExtC_3	209	215	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF2	Leptomonas seymouri	73%	100%
A0A0S4IMM1	Bodo saltans	43%	91%
A0A1X0NQQ8	Trypanosomatidae	49%	100%
A0A3R7RF21	Trypanosoma rangeli	49%	100%
A4HGS1	Leishmania braziliensis	89%	100%
D0A915	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	96%
E9B038	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q848	Leishmania major	98%	100%
V5BCV7	Trypanosoma cruzi	48%	100%