Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE17_LEIDO

TriTrypDb:

LdBPK_262320.1 , LdCL_260028900 , LDHU3_26.3040

Length:

120

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.524
CLV_PCSK_KEX2_1	4	6	PF00082	0.524
CLV_PCSK_SKI1_1	4	8	PF00082	0.504
CLV_PCSK_SKI1_1	75	79	PF00082	0.614
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DEG_SCF_FBW7_1	36	43	PF00400	0.614
DOC_CKS1_1	37	42	PF01111	0.614
DOC_MAPK_MEF2A_6	30	38	PF00069	0.609
DOC_USP7_MATH_1	54	58	PF00917	0.661
DOC_WW_Pin1_4	21	26	PF00397	0.548
DOC_WW_Pin1_4	36	41	PF00397	0.549
DOC_WW_Pin1_4	79	84	PF00397	0.585
LIG_14-3-3_CanoR_1	19	25	PF00244	0.480
LIG_BRCT_BRCA1_1	88	92	PF00533	0.543
LIG_deltaCOP1_diTrp_1	93	98	PF00928	0.537
LIG_EH1_1	97	105	PF00400	0.513
LIG_FHA_1	37	43	PF00498	0.609
LIG_FHA_1	61	67	PF00498	0.695
LIG_LIR_Nem_3	93	98	PF02991	0.620
LIG_MYND_1	33	37	PF01753	0.501
LIG_MYND_3	61	65	PF01753	0.648
LIG_NRBOX	73	79	PF00104	0.607
LIG_PCNA_PIPBox_1	85	94	PF02747	0.453
LIG_PCNA_yPIPBox_3	85	99	PF02747	0.551
LIG_SH2_CRK	17	21	PF00017	0.475
LIG_SH2_STAT5	17	20	PF00017	0.512
LIG_SH3_3	31	37	PF00018	0.509
LIG_SUMO_SIM_par_1	62	68	PF11976	0.717
LIG_SxIP_EBH_1	4	18	PF03271	0.528
MOD_CK1_1	57	63	PF00069	0.707
MOD_Cter_Amidation	2	5	PF01082	0.569
MOD_GlcNHglycan	110	113	PF01048	0.656
MOD_GSK3_1	36	43	PF00069	0.544
MOD_NEK2_1	103	108	PF00069	0.448
MOD_NEK2_1	20	25	PF00069	0.423
MOD_NEK2_1	42	47	PF00069	0.570
MOD_NEK2_1	7	12	PF00069	0.486
MOD_NEK2_1	77	82	PF00069	0.551
MOD_NEK2_1	86	91	PF00069	0.571
MOD_Plk_4	103	109	PF00069	0.650
MOD_ProDKin_1	21	27	PF00069	0.543
MOD_ProDKin_1	36	42	PF00069	0.547
MOD_ProDKin_1	79	85	PF00069	0.586
TRG_ENDOCYTIC_2	17	20	PF00928	0.470
TRG_ER_diArg_1	4	6	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I1	Leptomonas seymouri	36%	100%
A0A0N1I021	Leptomonas seymouri	78%	100%
A0A0S4J296	Bodo saltans	39%	99%
A0A1X0P697	Trypanosomatidae	36%	96%
A0A1X0P784	Trypanosomatidae	58%	100%
A0A3R7RT45	Trypanosoma rangeli	54%	100%
A4HA86	Leishmania braziliensis	35%	100%
A4HF75	Leishmania braziliensis	92%	100%
A4I2F8	Leishmania infantum	100%	100%
C9ZX39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AYL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q8W1	Leishmania major	97%	100%