LeishMANIAdb
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TPR_MalT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_MalT domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IE15_LEIDO
TriTrypDb:
LdBPK_211710.1 * , LdCL_210022900 , LDHU3_21.2020
Length:
272

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE15
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 145 147 PF00675 0.339
CLV_NRD_NRD_1 223 225 PF00675 0.396
CLV_NRD_NRD_1 231 233 PF00675 0.373
CLV_PCSK_KEX2_1 145 147 PF00082 0.339
CLV_PCSK_KEX2_1 231 233 PF00082 0.399
CLV_PCSK_SKI1_1 146 150 PF00082 0.418
DEG_APCC_DBOX_1 145 153 PF00400 0.384
DOC_MAPK_MEF2A_6 22 31 PF00069 0.494
DOC_PP1_RVXF_1 119 126 PF00149 0.459
DOC_PP1_RVXF_1 223 230 PF00149 0.306
DOC_USP7_MATH_1 14 18 PF00917 0.384
DOC_USP7_MATH_1 74 78 PF00917 0.397
DOC_USP7_UBL2_3 85 89 PF12436 0.338
LIG_14-3-3_CanoR_1 145 149 PF00244 0.332
LIG_14-3-3_CanoR_1 224 230 PF00244 0.390
LIG_Actin_WH2_2 132 147 PF00022 0.498
LIG_Actin_WH2_2 20 37 PF00022 0.368
LIG_BIR_II_1 1 5 PF00653 0.444
LIG_BIR_III_4 235 239 PF00653 0.485
LIG_Clathr_ClatBox_1 49 53 PF01394 0.321
LIG_FHA_1 19 25 PF00498 0.359
LIG_FHA_2 180 186 PF00498 0.448
LIG_LIR_Gen_1 193 203 PF02991 0.360
LIG_LIR_Nem_3 193 199 PF02991 0.381
LIG_LIR_Nem_3 209 213 PF02991 0.400
LIG_LIR_Nem_3 96 101 PF02991 0.392
LIG_PCNA_yPIPBox_3 116 124 PF02747 0.281
LIG_Rb_LxCxE_1 47 66 PF01857 0.466
LIG_SH2_SRC 64 67 PF00017 0.501
LIG_SH2_STAP1 64 68 PF00017 0.424
LIG_SH2_STAT5 226 229 PF00017 0.314
LIG_UBA3_1 245 254 PF00899 0.398
LIG_WRC_WIRS_1 207 212 PF05994 0.351
MOD_CK1_1 147 153 PF00069 0.377
MOD_CK2_1 162 168 PF00069 0.468
MOD_CK2_1 179 185 PF00069 0.495
MOD_GlcNHglycan 131 134 PF01048 0.514
MOD_GlcNHglycan 16 19 PF01048 0.460
MOD_GlcNHglycan 234 239 PF01048 0.454
MOD_GSK3_1 14 21 PF00069 0.379
MOD_GSK3_1 154 161 PF00069 0.488
MOD_GSK3_1 162 169 PF00069 0.536
MOD_NEK2_1 144 149 PF00069 0.316
MOD_NEK2_1 152 157 PF00069 0.300
MOD_NEK2_1 52 57 PF00069 0.381
MOD_NEK2_2 219 224 PF00069 0.447
MOD_PIKK_1 214 220 PF00454 0.380
MOD_PIKK_1 52 58 PF00454 0.362
MOD_PKA_2 14 20 PF00069 0.465
MOD_PKA_2 144 150 PF00069 0.353
MOD_PKA_2 74 80 PF00069 0.469
MOD_Plk_4 179 185 PF00069 0.365
MOD_Plk_4 45 51 PF00069 0.383
MOD_Plk_4 74 80 PF00069 0.396
MOD_SUMO_rev_2 127 133 PF00179 0.376
MOD_SUMO_rev_2 165 175 PF00179 0.414
MOD_SUMO_rev_2 76 84 PF00179 0.491
TRG_DiLeu_BaEn_1 114 119 PF01217 0.454
TRG_DiLeu_BaEn_2 93 99 PF01217 0.354
TRG_ER_diArg_1 144 146 PF00400 0.356
TRG_NES_CRM1_1 94 106 PF08389 0.414

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVJ3 Leptomonas seymouri 73% 73%
A0A0S4JQG6 Bodo saltans 41% 76%
A0A1X0PAZ2 Trypanosomatidae 49% 87%
A0A3R7KWQ9 Trypanosoma rangeli 52% 87%
A4HC18 Leishmania braziliensis 90% 100%
A4HZE4 Leishmania infantum 100% 100%
C9ZMM7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 85%
E9AVD1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QC48 Leishmania major 94% 100%
V5BFW6 Trypanosoma cruzi 51% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS