RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE12_LEIDO

TriTrypDb:

LdBPK_300220.1 , LdCL_300007300 , LDHU3_30.0350

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE12

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0005515	protein binding	2	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0035091	phosphatidylinositol binding	4	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.748
CLV_C14_Caspase3-7	295	299	PF00656	0.637
CLV_C14_Caspase3-7	42	46	PF00656	0.564
CLV_NRD_NRD_1	163	165	PF00675	0.692
CLV_NRD_NRD_1	265	267	PF00675	0.693
CLV_NRD_NRD_1	27	29	PF00675	0.432
CLV_PCSK_KEX2_1	105	107	PF00082	0.582
CLV_PCSK_KEX2_1	163	165	PF00082	0.692
CLV_PCSK_KEX2_1	265	267	PF00082	0.693
CLV_PCSK_KEX2_1	27	29	PF00082	0.530
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.552
CLV_PCSK_SKI1_1	134	138	PF00082	0.486
CLV_PCSK_SKI1_1	193	197	PF00082	0.754
DEG_Nend_UBRbox_3	1	3	PF02207	0.521
DEG_SCF_FBW7_1	241	248	PF00400	0.738
DEG_SPOP_SBC_1	249	253	PF00917	0.761
DEG_SPOP_SBC_1	339	343	PF00917	0.628
DOC_CYCLIN_RxL_1	193	202	PF00134	0.754
DOC_MAPK_DCC_7	265	275	PF00069	0.714
DOC_MAPK_gen_1	114	123	PF00069	0.564
DOC_MAPK_HePTP_8	263	275	PF00069	0.582
DOC_MAPK_MEF2A_6	266	275	PF00069	0.714
DOC_PP1_RVXF_1	161	168	PF00149	0.669
DOC_PP2B_LxvP_1	215	218	PF13499	0.590
DOC_USP7_MATH_1	141	145	PF00917	0.519
DOC_USP7_MATH_1	249	253	PF00917	0.723
DOC_WW_Pin1_4	176	181	PF00397	0.555
DOC_WW_Pin1_4	237	242	PF00397	0.714
DOC_WW_Pin1_4	245	250	PF00397	0.712
DOC_WW_Pin1_4	264	269	PF00397	0.568
DOC_WW_Pin1_4	349	354	PF00397	0.773
LIG_14-3-3_CanoR_1	120	124	PF00244	0.457
LIG_14-3-3_CanoR_1	138	146	PF00244	0.259
LIG_14-3-3_CanoR_1	149	155	PF00244	0.560
LIG_APCC_ABBA_1	55	60	PF00400	0.529
LIG_BRCT_BRCA1_1	126	130	PF00533	0.456
LIG_Clathr_ClatBox_1	71	75	PF01394	0.537
LIG_FHA_1	113	119	PF00498	0.437
LIG_FHA_1	298	304	PF00498	0.705
LIG_FHA_1	342	348	PF00498	0.592
LIG_FHA_1	36	42	PF00498	0.482
LIG_FHA_1	52	58	PF00498	0.369
LIG_FHA_2	120	126	PF00498	0.478
LIG_FHA_2	353	359	PF00498	0.665
LIG_FHA_2	40	46	PF00498	0.558
LIG_LIR_Apic_2	322	328	PF02991	0.616
LIG_LIR_Apic_2	60	64	PF02991	0.496
LIG_LIR_Gen_1	125	131	PF02991	0.563
LIG_LIR_Gen_1	365	376	PF02991	0.571
LIG_LIR_Nem_3	125	129	PF02991	0.565
LIG_LIR_Nem_3	32	36	PF02991	0.583
LIG_LIR_Nem_3	365	371	PF02991	0.617
LIG_PTB_Apo_2	79	86	PF02174	0.561
LIG_SH2_CRK	126	130	PF00017	0.552
LIG_SH2_GRB2like	214	217	PF00017	0.591
LIG_SH2_NCK_1	325	329	PF00017	0.609
LIG_SH2_NCK_1	368	372	PF00017	0.568
LIG_SH2_NCK_1	61	65	PF00017	0.581
LIG_SH2_SRC	214	217	PF00017	0.591
LIG_SH2_SRC	325	328	PF00017	0.614
LIG_SH2_STAP1	126	130	PF00017	0.558
LIG_SH2_STAP1	83	87	PF00017	0.552
LIG_SH2_STAT3	93	96	PF00017	0.383
LIG_SH2_STAT5	214	217	PF00017	0.591
LIG_SH2_STAT5	3	6	PF00017	0.605
LIG_SH2_STAT5	58	61	PF00017	0.471
LIG_SH3_1	265	271	PF00018	0.677
LIG_SH3_1	28	34	PF00018	0.557
LIG_SH3_3	174	180	PF00018	0.598
LIG_SH3_3	191	197	PF00018	0.562
LIG_SH3_3	265	271	PF00018	0.772
LIG_SH3_3	28	34	PF00018	0.557
LIG_SUMO_SIM_par_1	70	75	PF11976	0.434
LIG_TYR_ITIM	124	129	PF00017	0.565
LIG_UBA3_1	175	181	PF00899	0.600
LIG_UBA3_1	99	105	PF00899	0.496
LIG_WRC_WIRS_1	143	148	PF05994	0.581
LIG_WW_2	271	274	PF00397	0.684
MOD_CDK_SPK_2	176	181	PF00069	0.606
MOD_CDK_SPK_2	241	246	PF00069	0.717
MOD_CK1_1	240	246	PF00069	0.714
MOD_CK1_1	248	254	PF00069	0.727
MOD_CK1_1	286	292	PF00069	0.745
MOD_CK1_1	341	347	PF00069	0.709
MOD_CK1_1	352	358	PF00069	0.651
MOD_CK2_1	119	125	PF00069	0.551
MOD_CK2_1	141	147	PF00069	0.506
MOD_CK2_1	176	182	PF00069	0.691
MOD_CK2_1	199	205	PF00069	0.725
MOD_CK2_1	352	358	PF00069	0.732
MOD_Cter_Amidation	263	266	PF01082	0.692
MOD_GlcNHglycan	139	142	PF01048	0.508
MOD_GlcNHglycan	189	192	PF01048	0.753
MOD_GlcNHglycan	201	204	PF01048	0.720
MOD_GlcNHglycan	218	221	PF01048	0.284
MOD_GlcNHglycan	289	292	PF01048	0.734
MOD_GlcNHglycan	309	312	PF01048	0.608
MOD_GlcNHglycan	346	350	PF01048	0.664
MOD_GSK3_1	137	144	PF00069	0.452
MOD_GSK3_1	225	232	PF00069	0.535
MOD_GSK3_1	233	240	PF00069	0.608
MOD_GSK3_1	241	248	PF00069	0.572
MOD_GSK3_1	250	257	PF00069	0.712
MOD_GSK3_1	283	290	PF00069	0.723
MOD_GSK3_1	297	304	PF00069	0.650
MOD_GSK3_1	334	341	PF00069	0.740
MOD_GSK3_1	345	352	PF00069	0.642
MOD_GSK3_1	35	42	PF00069	0.569
MOD_N-GLC_1	258	263	PF02516	0.734
MOD_N-GLC_1	307	312	PF02516	0.570
MOD_NEK2_1	124	129	PF00069	0.416
MOD_NEK2_1	137	142	PF00069	0.373
MOD_NEK2_1	186	191	PF00069	0.674
MOD_NEK2_1	198	203	PF00069	0.686
MOD_NEK2_1	297	302	PF00069	0.731
MOD_NEK2_1	50	55	PF00069	0.478
MOD_NEK2_2	225	230	PF00069	0.624
MOD_PIKK_1	112	118	PF00454	0.426
MOD_PIKK_1	283	289	PF00454	0.720
MOD_PKA_2	119	125	PF00069	0.551
MOD_PKA_2	137	143	PF00069	0.293
MOD_PKA_2	15	21	PF00069	0.525
MOD_Plk_1	124	130	PF00069	0.440
MOD_Plk_1	297	303	PF00069	0.607
MOD_Plk_2-3	39	45	PF00069	0.556
MOD_Plk_4	119	125	PF00069	0.561
MOD_Plk_4	150	156	PF00069	0.519
MOD_ProDKin_1	176	182	PF00069	0.561
MOD_ProDKin_1	237	243	PF00069	0.716
MOD_ProDKin_1	245	251	PF00069	0.713
MOD_ProDKin_1	264	270	PF00069	0.564
MOD_ProDKin_1	349	355	PF00069	0.772
TRG_DiLeu_BaEn_2	31	37	PF01217	0.487
TRG_ENDOCYTIC_2	126	129	PF00928	0.559
TRG_ENDOCYTIC_2	368	371	PF00928	0.707
TRG_ER_diArg_1	163	166	PF00400	0.684
TRG_ER_diArg_1	26	28	PF00400	0.421
TRG_NES_CRM1_1	94	108	PF08389	0.487
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JFL9	Bodo saltans	29%	92%
A4HHW6	Leishmania braziliensis	72%	100%
A4I516	Leishmania infantum	100%	100%
E9B0E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7T7	Leishmania major	88%	100%