Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IE11_LEIDO

TriTrypDb:

LdCL_270011300 , LDHU3_27.0820

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	211	213	PF00675	0.569
CLV_NRD_NRD_1	283	285	PF00675	0.541
CLV_NRD_NRD_1	30	32	PF00675	0.674
CLV_NRD_NRD_1	54	56	PF00675	0.668
CLV_PCSK_FUR_1	28	32	PF00082	0.707
CLV_PCSK_FUR_1	52	56	PF00082	0.637
CLV_PCSK_KEX2_1	108	110	PF00082	0.629
CLV_PCSK_KEX2_1	210	212	PF00082	0.580
CLV_PCSK_KEX2_1	283	285	PF00082	0.551
CLV_PCSK_KEX2_1	30	32	PF00082	0.667
CLV_PCSK_KEX2_1	54	56	PF00082	0.668
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.666
CLV_PCSK_PC7_1	207	213	PF00082	0.558
CLV_PCSK_SKI1_1	161	165	PF00082	0.602
CLV_PCSK_SKI1_1	243	247	PF00082	0.583
CLV_PCSK_SKI1_1	37	41	PF00082	0.640
DEG_APCC_DBOX_1	289	297	PF00400	0.472
DEG_Nend_Nbox_1	1	3	PF02207	0.772
DEG_SPOP_SBC_1	155	159	PF00917	0.543
DEG_SPOP_SBC_1	4	8	PF00917	0.673
DOC_CYCLIN_RxL_1	161	172	PF00134	0.630
DOC_MAPK_DCC_7	161	169	PF00069	0.642
DOC_MAPK_gen_1	108	117	PF00069	0.633
DOC_MAPK_gen_1	52	59	PF00069	0.727
DOC_MAPK_MEF2A_6	161	170	PF00069	0.728
DOC_USP7_MATH_1	154	158	PF00917	0.700
DOC_USP7_MATH_1	231	235	PF00917	0.674
DOC_USP7_MATH_1	238	242	PF00917	0.595
DOC_USP7_MATH_1	4	8	PF00917	0.761
DOC_WW_Pin1_4	129	134	PF00397	0.747
DOC_WW_Pin1_4	143	148	PF00397	0.544
LIG_14-3-3_CanoR_1	112	118	PF00244	0.654
LIG_14-3-3_CanoR_1	232	236	PF00244	0.696
LIG_14-3-3_CanoR_1	239	245	PF00244	0.570
LIG_14-3-3_CanoR_1	290	294	PF00244	0.470
LIG_Actin_WH2_2	69	87	PF00022	0.627
LIG_APCC_ABBA_1	186	191	PF00400	0.701
LIG_APCC_ABBAyCdc20_2	185	191	PF00400	0.702
LIG_BRCT_BRCA1_1	265	269	PF00533	0.583
LIG_BRCT_BRCA1_1	301	305	PF00533	0.618
LIG_FHA_1	136	142	PF00498	0.796
LIG_FHA_1	176	182	PF00498	0.541
LIG_FHA_1	215	221	PF00498	0.666
LIG_FHA_1	63	69	PF00498	0.722
LIG_FHA_2	11	17	PF00498	0.706
LIG_FHA_2	81	87	PF00498	0.702
LIG_FHA_2	94	100	PF00498	0.597
LIG_GBD_Chelix_1	274	282	PF00786	0.578
LIG_LIR_Gen_1	176	181	PF02991	0.523
LIG_LIR_Nem_3	176	180	PF02991	0.528
LIG_NRBOX	113	119	PF00104	0.740
LIG_PDZ_Class_1	309	314	PF00595	0.541
LIG_Pex14_1	173	177	PF04695	0.619
LIG_PTAP_UEV_1	215	220	PF05743	0.498
LIG_RPA_C_Fungi	279	291	PF08784	0.468
LIG_SH2_CRK	177	181	PF00017	0.598
LIG_SH2_CRK	26	30	PF00017	0.578
LIG_SH2_STAP1	177	181	PF00017	0.610
LIG_SH2_STAT5	177	180	PF00017	0.552
LIG_SH2_STAT5	38	41	PF00017	0.705
LIG_SH3_3	141	147	PF00018	0.572
LIG_SH3_3	213	219	PF00018	0.681
LIG_SUMO_SIM_par_1	166	172	PF11976	0.711
LIG_TYR_ITIM	175	180	PF00017	0.602
LIG_TYR_ITIM	24	29	PF00017	0.708
MOD_CDK_SPxxK_3	143	150	PF00069	0.558
MOD_CK1_1	146	152	PF00069	0.654
MOD_CK1_1	202	208	PF00069	0.601
MOD_CK1_1	241	247	PF00069	0.555
MOD_CK1_1	3	9	PF00069	0.671
MOD_CK1_1	93	99	PF00069	0.719
MOD_CK2_1	154	160	PF00069	0.716
MOD_CK2_1	4	10	PF00069	0.749
MOD_CK2_1	80	86	PF00069	0.615
MOD_CK2_1	93	99	PF00069	0.684
MOD_GlcNHglycan	2	5	PF01048	0.722
MOD_GlcNHglycan	204	207	PF01048	0.617
MOD_GlcNHglycan	258	261	PF01048	0.564
MOD_GlcNHglycan	265	268	PF01048	0.656
MOD_GlcNHglycan	301	304	PF01048	0.538
MOD_GSK3_1	129	136	PF00069	0.692
MOD_GSK3_1	2	9	PF00069	0.674
MOD_GSK3_1	58	65	PF00069	0.632
MOD_GSK3_1	86	93	PF00069	0.691
MOD_N-GLC_1	200	205	PF02516	0.549
MOD_N-GLC_1	299	304	PF02516	0.524
MOD_N-GLC_1	62	67	PF02516	0.728
MOD_NEK2_1	101	106	PF00069	0.570
MOD_NEK2_1	175	180	PF00069	0.525
MOD_NEK2_1	2	7	PF00069	0.681
MOD_NEK2_1	256	261	PF00069	0.573
MOD_PIKK_1	238	244	PF00454	0.594
MOD_PKA_2	231	237	PF00069	0.713
MOD_PKA_2	238	244	PF00069	0.589
MOD_PKA_2	289	295	PF00069	0.483
MOD_PKA_2	90	96	PF00069	0.732
MOD_Plk_1	136	142	PF00069	0.675
MOD_Plk_1	15	21	PF00069	0.578
MOD_Plk_1	175	181	PF00069	0.456
MOD_Plk_1	62	68	PF00069	0.725
MOD_Plk_1	80	86	PF00069	0.421
MOD_Plk_1	91	97	PF00069	0.467
MOD_Plk_2-3	15	21	PF00069	0.665
MOD_Plk_2-3	86	92	PF00069	0.663
MOD_Plk_4	113	119	PF00069	0.687
MOD_Plk_4	136	142	PF00069	0.776
MOD_Plk_4	176	182	PF00069	0.606
MOD_Plk_4	289	295	PF00069	0.562
MOD_ProDKin_1	129	135	PF00069	0.739
MOD_ProDKin_1	143	149	PF00069	0.544
MOD_SUMO_rev_2	70	79	PF00179	0.514
TRG_DiLeu_BaEn_1	53	58	PF01217	0.622
TRG_DiLeu_BaEn_2	264	270	PF01217	0.578
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.628
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.607
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.727
TRG_ENDOCYTIC_2	177	180	PF00928	0.577
TRG_ENDOCYTIC_2	26	29	PF00928	0.671
TRG_ER_diArg_1	183	186	PF00400	0.595
TRG_ER_diArg_1	210	212	PF00400	0.689
TRG_ER_diArg_1	28	31	PF00400	0.678
TRG_ER_diArg_1	282	284	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T8	Leptomonas seymouri	32%	100%
A4HFJ0	Leishmania braziliensis	66%	100%
E9AD41	Leishmania major	89%	100%
E9AHD4	Leishmania infantum	100%	100%
E9AYW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%