2OG-FeII_Oxy_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IE10_LEIDO

TriTrypDb:

LdBPK_282910.1 , LdCL_280034200 , LDHU3_28.3900

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3Q8IE10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE10

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0006996	organelle organization	4	11
GO:0007005	mitochondrion organization	5	11
GO:0007006	mitochondrial membrane organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0033554	cellular response to stress	3	11
GO:0046902	regulation of mitochondrial membrane permeability	4	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0061024	membrane organization	4	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090559	regulation of membrane permeability	3	11
GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	5	11
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.560
CLV_C14_Caspase3-7	81	85	PF00656	0.522
CLV_NRD_NRD_1	237	239	PF00675	0.454
CLV_NRD_NRD_1	260	262	PF00675	0.434
CLV_NRD_NRD_1	280	282	PF00675	0.377
CLV_NRD_NRD_1	6	8	PF00675	0.626
CLV_PCSK_KEX2_1	237	239	PF00082	0.454
CLV_PCSK_KEX2_1	260	262	PF00082	0.400
CLV_PCSK_KEX2_1	280	282	PF00082	0.377
CLV_PCSK_KEX2_1	6	8	PF00082	0.603
CLV_PCSK_PC7_1	2	8	PF00082	0.636
CLV_PCSK_SKI1_1	188	192	PF00082	0.344
CLV_PCSK_SKI1_1	2	6	PF00082	0.659
CLV_PCSK_SKI1_1	67	71	PF00082	0.370
DEG_Nend_UBRbox_1	1	4	PF02207	0.650
DOC_CYCLIN_RxL_1	2	13	PF00134	0.552
DOC_CYCLIN_yClb5_NLxxxL_5	118	127	PF00134	0.531
DOC_MAPK_gen_1	237	245	PF00069	0.514
DOC_MAPK_gen_1	260	269	PF00069	0.325
DOC_PP1_RVXF_1	151	157	PF00149	0.319
DOC_PP2B_LxvP_1	116	119	PF13499	0.552
DOC_PP4_FxxP_1	31	34	PF00568	0.370
DOC_PP4_FxxP_1	72	75	PF00568	0.406
DOC_USP7_MATH_1	128	132	PF00917	0.352
DOC_USP7_MATH_1	17	21	PF00917	0.449
DOC_WW_Pin1_4	245	250	PF00397	0.374
DOC_WW_Pin1_4	254	259	PF00397	0.394
DOC_WW_Pin1_4	270	275	PF00397	0.309
DOC_WW_Pin1_4	44	49	PF00397	0.459
LIG_14-3-3_CanoR_1	173	179	PF00244	0.361
LIG_14-3-3_CanoR_1	188	193	PF00244	0.323
LIG_14-3-3_CanoR_1	238	244	PF00244	0.510
LIG_14-3-3_CanoR_1	79	83	PF00244	0.513
LIG_deltaCOP1_diTrp_1	221	228	PF00928	0.319
LIG_FHA_1	11	17	PF00498	0.551
LIG_FHA_1	174	180	PF00498	0.453
LIG_FHA_1	263	269	PF00498	0.324
LIG_FHA_1	51	57	PF00498	0.408
LIG_FHA_2	108	114	PF00498	0.518
LIG_FHA_2	191	197	PF00498	0.438
LIG_FHA_2	60	66	PF00498	0.425
LIG_LIR_Apic_2	30	34	PF02991	0.399
LIG_LIR_Apic_2	53	58	PF02991	0.462
LIG_LIR_Apic_2	71	75	PF02991	0.413
LIG_LIR_Gen_1	100	108	PF02991	0.486
LIG_LIR_Gen_1	74	82	PF02991	0.342
LIG_LIR_LC3C_4	242	245	PF02991	0.454
LIG_LIR_Nem_3	256	262	PF02991	0.433
LIG_LIR_Nem_3	74	80	PF02991	0.359
LIG_LIR_Nem_3	96	101	PF02991	0.334
LIG_MAD2	2	10	PF02301	0.445
LIG_PALB2_WD40_1	72	80	PF16756	0.351
LIG_PCNA_PIPBox_1	87	96	PF02747	0.399
LIG_Pex14_1	51	55	PF04695	0.443
LIG_Pex14_2	72	76	PF04695	0.380
LIG_SH2_CRK	101	105	PF00017	0.425
LIG_SH2_NCK_1	101	105	PF00017	0.374
LIG_SH2_PTP2	212	215	PF00017	0.419
LIG_SH2_PTP2	55	58	PF00017	0.424
LIG_SH2_STAT5	144	147	PF00017	0.372
LIG_SH2_STAT5	212	215	PF00017	0.343
LIG_SH2_STAT5	55	58	PF00017	0.424
LIG_SH3_3	122	128	PF00018	0.500
LIG_SH3_3	13	19	PF00018	0.549
LIG_SH3_3	143	149	PF00018	0.390
LIG_SH3_3	192	198	PF00018	0.463
LIG_SH3_3	29	35	PF00018	0.393
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.398
LIG_TRAF2_1	35	38	PF00917	0.526
LIG_TRAF2_1	62	65	PF00917	0.426
MOD_CDK_SPxK_1	245	251	PF00069	0.438
MOD_CDK_SPxK_1	254	260	PF00069	0.353
MOD_CDK_SPxxK_3	254	261	PF00069	0.441
MOD_CK1_1	172	178	PF00069	0.364
MOD_CK1_1	21	27	PF00069	0.398
MOD_CK1_1	273	279	PF00069	0.440
MOD_CK2_1	190	196	PF00069	0.322
MOD_CK2_1	59	65	PF00069	0.402
MOD_GlcNHglycan	130	133	PF01048	0.398
MOD_GlcNHglycan	161	164	PF01048	0.359
MOD_GSK3_1	169	176	PF00069	0.367
MOD_GSK3_1	17	24	PF00069	0.463
MOD_N-GLC_1	173	178	PF02516	0.331
MOD_NEK2_1	159	164	PF00069	0.419
MOD_NEK2_1	190	195	PF00069	0.346
MOD_NEK2_1	262	267	PF00069	0.396
MOD_NEK2_1	97	102	PF00069	0.387
MOD_PIKK_1	102	108	PF00454	0.363
MOD_PKA_2	172	178	PF00069	0.388
MOD_PKA_2	78	84	PF00069	0.518
MOD_Plk_1	10	16	PF00069	0.545
MOD_Plk_1	262	268	PF00069	0.386
MOD_Plk_1	65	71	PF00069	0.543
MOD_Plk_2-3	59	65	PF00069	0.430
MOD_Plk_2-3	78	84	PF00069	0.500
MOD_Plk_4	18	24	PF00069	0.443
MOD_Plk_4	239	245	PF00069	0.507
MOD_Plk_4	27	33	PF00069	0.437
MOD_Plk_4	273	279	PF00069	0.491
MOD_Plk_4	65	71	PF00069	0.439
MOD_ProDKin_1	245	251	PF00069	0.380
MOD_ProDKin_1	254	260	PF00069	0.395
MOD_ProDKin_1	270	276	PF00069	0.313
MOD_ProDKin_1	44	50	PF00069	0.455
MOD_SUMO_rev_2	59	69	PF00179	0.482
TRG_DiLeu_BaEn_1	200	205	PF01217	0.365
TRG_DiLeu_BaEn_1	65	70	PF01217	0.337
TRG_DiLeu_BaEn_4	65	71	PF01217	0.391
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.690
TRG_ENDOCYTIC_2	101	104	PF00928	0.327
TRG_ENDOCYTIC_2	212	215	PF00928	0.345
TRG_ENDOCYTIC_2	259	262	PF00928	0.437
TRG_ENDOCYTIC_2	94	97	PF00928	0.328
TRG_ER_diArg_1	217	220	PF00400	0.436
TRG_ER_diArg_1	236	238	PF00400	0.262
TRG_ER_diArg_1	259	261	PF00400	0.480
TRG_ER_diArg_1	280	283	PF00400	0.598
TRG_ER_diArg_1	5	7	PF00400	0.632
TRG_NES_CRM1_1	234	246	PF08389	0.432
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYL5	Leptomonas seymouri	77%	98%
A0A0S4JCJ0	Bodo saltans	48%	89%
A0A1X0NR19	Trypanosomatidae	60%	100%
A4HGX4	Leishmania braziliensis	85%	100%
A4I404	Leishmania infantum	100%	100%
D0A901	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B094	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
Q4Q7Z1	Leishmania major	96%	100%
V5B945	Trypanosoma cruzi	58%	100%