Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE08_LEIDO

TriTrypDb:

LdBPK_282140.1 , LdCL_280026500 , LDHU3_28.2920

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005811	lipid droplet	5	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8IE08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE08

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006996	organelle organization	4	1
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	1
GO:0016310	phosphorylation	5	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004645	1,4-alpha-oligoglucan phosphorylase activity	5	3
GO:0004672	protein kinase activity	3	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016757	glycosyltransferase activity	3	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.617
CLV_C14_Caspase3-7	391	395	PF00656	0.736
CLV_C14_Caspase3-7	617	621	PF00656	0.663
CLV_NRD_NRD_1	106	108	PF00675	0.376
CLV_NRD_NRD_1	218	220	PF00675	0.292
CLV_NRD_NRD_1	3	5	PF00675	0.397
CLV_NRD_NRD_1	396	398	PF00675	0.528
CLV_NRD_NRD_1	584	586	PF00675	0.553
CLV_NRD_NRD_1	677	679	PF00675	0.593
CLV_NRD_NRD_1	706	708	PF00675	0.545

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD19	Leptomonas seymouri	42%	98%
A4HGQ4	Leishmania braziliensis	66%	98%
A4I3S8	Leishmania infantum	99%	100%
E9B020	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4Q866	Leishmania major	90%	100%

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