Vesicle-associated_membrane_protein_putative/Gene DB:LmjF.21.1290

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vesicle-associated membrane protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE03_LEIDO

TriTrypDb:

LdBPK_211530.1 , LdCL_210020800 , LDHU3_21.1810

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IE03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE03

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.614
CLV_NRD_NRD_1	98	100	PF00675	0.433
CLV_PCSK_KEX2_1	98	100	PF00082	0.446
CLV_PCSK_SKI1_1	113	117	PF00082	0.429
CLV_PCSK_SKI1_1	136	140	PF00082	0.404
CLV_PCSK_SKI1_1	219	223	PF00082	0.460
CLV_PCSK_SKI1_1	23	27	PF00082	0.397
CLV_PCSK_SKI1_1	245	249	PF00082	0.716
DOC_MAPK_gen_1	154	162	PF00069	0.574
DOC_MAPK_gen_1	68	76	PF00069	0.666
DOC_MAPK_MEF2A_6	154	162	PF00069	0.598
DOC_PP4_FxxP_1	116	119	PF00568	0.701
DOC_PP4_FxxP_1	131	134	PF00568	0.541
DOC_PP4_FxxP_1	37	40	PF00568	0.634
DOC_USP7_MATH_1	147	151	PF00917	0.808
DOC_WW_Pin1_4	26	31	PF00397	0.688
LIG_14-3-3_CanoR_1	50	54	PF00244	0.627
LIG_14-3-3_CanoR_1	57	64	PF00244	0.600
LIG_BIR_II_1	1	5	PF00653	0.803
LIG_BIR_III_4	84	88	PF00653	0.594
LIG_CaM_IQ_9	197	212	PF13499	0.531
LIG_FHA_1	188	194	PF00498	0.531
LIG_FHA_1	27	33	PF00498	0.629
LIG_LIR_Apic_2	129	134	PF02991	0.616
LIG_LIR_Apic_2	34	40	PF02991	0.646
LIG_LIR_Gen_1	42	48	PF02991	0.629
LIG_LIR_Gen_1	58	66	PF02991	0.666
LIG_LIR_Gen_1	75	86	PF02991	0.585
LIG_LIR_Nem_3	42	47	PF02991	0.631
LIG_LIR_Nem_3	58	64	PF02991	0.662
LIG_PCNA_yPIPBox_3	124	136	PF02747	0.660
LIG_Pex14_2	112	116	PF04695	0.595
LIG_SH2_CRK	13	17	PF00017	0.564
LIG_SH2_CRK	88	92	PF00017	0.637
LIG_SH2_STAT5	234	237	PF00017	0.460
LIG_SH3_3	114	120	PF00018	0.713
LIG_SH3_3	27	33	PF00018	0.629
LIG_TRAF2_1	70	73	PF00917	0.758
LIG_WRC_WIRS_1	234	239	PF05994	0.511
MOD_CK1_1	243	249	PF00069	0.729
MOD_CK1_1	49	55	PF00069	0.507
MOD_GlcNHglycan	143	146	PF01048	0.587
MOD_GlcNHglycan	149	152	PF01048	0.667
MOD_GlcNHglycan	253	256	PF01048	0.799
MOD_GlcNHglycan	51	54	PF01048	0.533
MOD_GlcNHglycan	58	61	PF01048	0.508
MOD_GSK3_1	246	253	PF00069	0.790
MOD_GSK3_1	31	38	PF00069	0.542
MOD_N-GLC_1	240	245	PF02516	0.542
MOD_N-GLC_1	62	67	PF02516	0.540
MOD_NEK2_1	140	145	PF00069	0.641
MOD_NEK2_1	200	205	PF00069	0.413
MOD_NEK2_1	211	216	PF00069	0.423
MOD_NEK2_1	56	61	PF00069	0.465
MOD_NEK2_2	212	217	PF00069	0.414
MOD_PIKK_1	246	252	PF00454	0.698
MOD_PKA_2	201	207	PF00069	0.378
MOD_PKA_2	49	55	PF00069	0.501
MOD_PKA_2	56	62	PF00069	0.456
MOD_Plk_1	72	78	PF00069	0.590
MOD_ProDKin_1	26	32	PF00069	0.594
MOD_SUMO_for_1	70	73	PF00179	0.537
MOD_SUMO_rev_2	150	156	PF00179	0.381
MOD_SUMO_rev_2	163	168	PF00179	0.532
TRG_DiLeu_BaEn_4	7	13	PF01217	0.617
TRG_ENDOCYTIC_2	13	16	PF00928	0.415
TRG_ENDOCYTIC_2	234	237	PF00928	0.460
TRG_ENDOCYTIC_2	78	81	PF00928	0.440
TRG_ENDOCYTIC_2	88	91	PF00928	0.429
TRG_NES_CRM1_1	106	118	PF08389	0.598
TRG_Pf-PMV_PEXEL_1	205	210	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P366	Leptomonas seymouri	80%	97%
A0A0S4JL59	Bodo saltans	45%	100%
A0A1X0NYJ8	Trypanosomatidae	57%	100%
A0A422NSS3	Trypanosoma rangeli	58%	100%
A4HBY4	Leishmania braziliensis	89%	100%
A4HZC6	Leishmania infantum	100%	100%
D0A159	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AVB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QC67	Leishmania major	96%	100%
V5BHA3	Trypanosoma cruzi	57%	100%